HUP0302226A2 - Foszfodiészteráz inhibitorokként alkalmazható szubsztituált pirrolopiridinon-származékok, ezek intermedierjei és a vegyületeket tartalmazó gyógyszerkészítmények - Google Patents
Foszfodiészteráz inhibitorokként alkalmazható szubsztituált pirrolopiridinon-származékok, ezek intermedierjei és a vegyületeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0302226A2 HUP0302226A2 HU0302226A HUP0302226A HUP0302226A2 HU P0302226 A2 HUP0302226 A2 HU P0302226A2 HU 0302226 A HU0302226 A HU 0302226A HU P0302226 A HUP0302226 A HU P0302226A HU P0302226 A2 HUP0302226 A2 HU P0302226A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- group
- substituted
- nhra
- substituents
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- ORKUYZDMEWAUEZ-UHFFFAOYSA-N pyrrolo[3,2-b]pyridin-2-one Chemical class N1=CC=CC2=NC(=O)C=C21 ORKUYZDMEWAUEZ-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- -1 carboxy- Chemical class 0.000 abstract 11
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 6
- 125000001424 substituent group Chemical group 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 1
- 125000005090 alkenylcarbonyl group Chemical group 0.000 abstract 1
- 125000005087 alkynylcarbonyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 abstract 1
- 208000012201 sexual and gender identity disease Diseases 0.000 abstract 1
- 208000015891 sexual disease Diseases 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Gynecology & Obstetrics (AREA)
- Hematology (AREA)
- Pregnancy & Childbirth (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
A találmány tárgyát (I) vagy (II) általános képletű újpirrolopiridinon-származékok, a vegyületeket tartalmazógyógyszerkészítmények és szexuális zavarok kezelésére szolgálógyógyszerkészítmények előállítására való alkalmazásuk képezik. (I)vagy (II) általános képletű vegyület, ahol az általános képletekben R1jelentése hidrogénatom, karboxi-, -C(O)-(1-6 szénatomos alkil)-, -C(O)-(1-6 szénatomos alkoxi)-, -C(O)-NH-(1-6 szénatomos alkil)-NH2, -C(O)-NH-(1-6 szénatomos alkil)-NHRA, -C(O)-NH(1-6 szénatomos alkil)-N(RA)2,. -C(O)-NH2, -C(O)-NHRA, -C(O)-N(RA)2, -1-6 szénatomos alkil-NH2, -1-6 szénatomos alkil-NHRA, -1-6 szénatomos alkil-N(RA)2, -NH-1-6szénatomos alkil-N(RA) ahol is mindegyik RA jelentése egymástólfüggetlenül 1-6 szénatomos alkil-, aril-, 1-6 szénatomos aralkil- vagyheteroarilcsoport, ahol az aril-, aralkil- vagy heteroaril-csoportadott esetben 1-3 RB-csoporttal lehet szubsztituálva; R2 jelentése 5-10 szénatomos alkilcsoport, amely adott esetben egy-háromszubsztituenssel lehet szubsztituálva, amelyek egymástól függetlenül akövetkezők lehetnek: halogénatom, hidroxi-, nitro-, amino-, -NHRA vagy-N(RA)2-csoport); arilcsoport, amely adott esetben egy-háromszubsztituenssel lehet szubsztituálva, amely egymástól függetlenül RC-csoport lehet; cikloalkil-csoport, amely adott esetben egy-háromszubsztituenssel szubsztituált R3 jelentése hidrogénatom, 1-6szénatomos alkil-, 1-6 szénatomos alkilkarbonil-, 2-6 szénatomosalkenilkarbonil- vagy 2-6 szénatomos alkinilkarbonil-csoport; bjelentése 0-4 közötti egész szám; R4 jelentése egymástól függetlenülhalogénatom, hidroxi-, karboxi-, oxo-, nitro-, 1-6 szénatomos alkil-,1-6 szénatomos alkoxi-, 1-6 szénatomos alkoxikarbonil-,trifluormetil-, fenilcsoport, ahol a fenilcsoport adott esetben egy-három szubsztituenssel lehet szubsztituálva, amely egymástólfüggetlenül RD-csoport, fenilszulfonil-, naftil-, 1-6 szénatomosaralkil-, -O-aralkil-csoport, ahol az aralkil-csoport adott esetbenegy-három szubsztituenssel lehet szubsztituálva; c 0-4 közötti egészszám; R5 jelentése egymástól függetlenül halogénatom, nitro-,hidroxi-, 1-6 szénatomos alkil-, 1-6 szénatomos alkoxi-, -N(H)2, -NHRA, -N (RA)2, -ORA, -C(O)NH2, -C(O)NHRA, -C(O)N(RA)2, -NHC(O)RA, -SO2NHRA, -SO2N(RA)2-csoport, ahol RA jelentése a fenti, fenilcsoport,amely adott esetben egy-három szubsztituenssel szubsztituálva lehet; ajelentése 0 vagy 1; Y jelentése 1-6 szénatomos alkil-, -C(O)-, -(1-6szénatomos alkil) karbonil-, -(2-6 szénatomos alkenil) karbonil-, -(2-6 szénatomos alkinil) karbonil-, -karbonil (1-6 szénatomos alkil)-, -karbonil(2-6 szénatomos alkenil)-, -C(O)O-(1-6 szénatomos a1kil)-, -C(S)-, -SO2-, -(1-6 szénatomos alkil)szulfonil-, -szulfonil(1-6szénatomos alkil)-, -C(O)NH-, -C(O)NH-(1-6 szénatomos alkil)-csoport; Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20464600P | 2000-05-17 | 2000-05-17 | |
| PCT/US2001/014391 WO2001087882A2 (en) | 2000-05-17 | 2001-05-03 | Substituted pyrrolopyridinone derivatives useful as phosphodiesterase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0302226A2 true HUP0302226A2 (hu) | 2003-11-28 |
| HUP0302226A3 HUP0302226A3 (en) | 2012-12-28 |
Family
ID=22758822
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0302226A HUP0302226A3 (en) | 2000-05-17 | 2001-05-03 | Substituted pyrrolopyridinone dervatives useful as phosphodiesterse inhibitors, their intermediates and pharmaceutical compositions containing the compounds |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US6635638B2 (hu) |
| EP (1) | EP1296981B1 (hu) |
| JP (1) | JP5366349B2 (hu) |
| KR (2) | KR100854050B1 (hu) |
| CN (1) | CN1280291C (hu) |
| AR (1) | AR028575A1 (hu) |
| AT (1) | ATE278690T1 (hu) |
| AU (1) | AU6117801A (hu) |
| BG (1) | BG65925B1 (hu) |
| CA (1) | CA2409743C (hu) |
| CZ (1) | CZ20023945A3 (hu) |
| DE (1) | DE60106252T2 (hu) |
| ES (1) | ES2230316T3 (hu) |
| GE (1) | GEP20053510B (hu) |
| HK (1) | HK1054034B (hu) |
| HR (1) | HRP20020911B1 (hu) |
| HU (1) | HUP0302226A3 (hu) |
| IL (2) | IL152872A0 (hu) |
| MX (1) | MXPA02011425A (hu) |
| MY (1) | MY126917A (hu) |
| NO (1) | NO324843B1 (hu) |
| NZ (1) | NZ522732A (hu) |
| PL (1) | PL363150A1 (hu) |
| PT (1) | PT1296981E (hu) |
| RU (1) | RU2267490C2 (hu) |
| SK (1) | SK286992B6 (hu) |
| UA (1) | UA72611C2 (hu) |
| WO (1) | WO2001087882A2 (hu) |
| ZA (1) | ZA200210114B (hu) |
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| UA72611C2 (uk) * | 2000-05-17 | 2005-03-15 | Орто-Макнейл Фармацевтикал, Інк. | Похідні заміщеного піролопіридинону, корисні як інгібітори фосфодіестерази |
| AU2002249890A1 (en) * | 2001-02-12 | 2002-08-28 | Lilly Icos Llc | Carboline derivatives |
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| EP1448562B1 (en) * | 2001-11-14 | 2007-07-25 | Ortho-Mcneil Pharmaceutical Corp. | Substituted tetracyclic pyrroloquinolone derivatives useful as phosphodiesterase inhibitors |
| DE60317684D1 (de) * | 2002-06-19 | 2008-01-03 | Janssen Pharmaceutica Nv | SUBSTITUIERTE 2,4-DIHYDROPYRROLOc3,4BÜCHINOLIN-9-ONDERIVATE, DIE SICH ALS PHOSPHODIESTERASEINHIBITOREN EIGNEN |
| US7045652B2 (en) * | 2002-07-03 | 2006-05-16 | Pfizer Inc | Processes for preparing substituted aryl boronic acids |
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| US8076353B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Inhibition of VEGF translation |
| US8076352B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Administration of carboline derivatives useful in the treatment of cancer and other diseases |
| PL1737461T3 (pl) | 2004-03-15 | 2013-05-31 | Ptc Therapeutics Inc | Pochodne karbolinowe użyteczne w hamowaniu angiogenezy |
| WO2006093719A1 (en) * | 2005-02-25 | 2006-09-08 | Janssen Pharmaceutica, N.V. | An efficient and stereoselective process for large scale synthesis of 3-(r)-3- (2,3-dihydrobenzofuran-5-yl)-1,2,3,4- tetrahydropyrrolo{3,4-b}quinolin-9-one |
| JP2008531570A (ja) * | 2005-02-25 | 2008-08-14 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ３−（ｒ）−３−（２，３−ジヒドロベンゾフラン−５−イル）−１，２，３，４−テトラヒドロピロロ［３，４−ｂ］キノリン−９−オンの有効かつ立体選択的大規模合成方法 |
| CA2620333A1 (en) | 2005-08-26 | 2007-03-01 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
| EP2258358A3 (en) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
| EP1940389A2 (en) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
| CA2625210A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| MX2008014320A (es) | 2006-05-09 | 2009-03-25 | Braincells Inc | Neurogenesis mediada por el receptor de 5-hidroxitriptamina. |
| AU2007249399A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| MX2009002496A (es) | 2006-09-08 | 2009-07-10 | Braincells Inc | Combinaciones que contienen un derivado de 4-acilaminopiridina. |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| JP2012513464A (ja) | 2008-12-23 | 2012-06-14 | ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク | ホスホジエステラーゼ阻害剤及びその使用 |
| US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| RU2451686C1 (ru) * | 2010-12-27 | 2012-05-27 | Александр Васильевич Иващенко | ЗАМЕЩЕННЫЕ ГИДРИРОВАННЫЕ ТИЕНО-ПИРРОЛО [3,2-c] ПИРИДИНЫ, ЛИГАНДЫ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ИХ ПРИМЕНЕНИЯ |
| KR101236188B1 (ko) * | 2011-03-10 | 2013-02-22 | 한국화학연구원 | 신규한 피롤로피리디논 유도체 및 그의 ｍｃｈ 수용체-1 관련 질환에 대한 치료학적 용도 |
| US9012642B2 (en) | 2011-09-22 | 2015-04-21 | Viiv Healthcare Uk Limited | Pyrrolopyridinone compounds and methods for treating HIV |
| EP2804603A1 (en) | 2012-01-10 | 2014-11-26 | President and Fellows of Harvard College | Beta-cell replication promoting compounds and methods of their use |
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| US6248739B1 (en) | 1999-01-08 | 2001-06-19 | Pharmacia & Upjohn Company | Quinolinecarboxamides as antiviral agents |
| FR2792937B1 (fr) * | 1999-04-27 | 2001-08-10 | Cemaf | NOUVEAUX DERIVES DE PYRROLO-(3,4-b) QUINOLEINE, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION A TITRE DE MEDICAMENT |
| UA72611C2 (uk) * | 2000-05-17 | 2005-03-15 | Орто-Макнейл Фармацевтикал, Інк. | Похідні заміщеного піролопіридинону, корисні як інгібітори фосфодіестерази |
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2001
- 2001-03-05 UA UA2002119180A patent/UA72611C2/uk unknown
- 2001-05-02 US US09/847,749 patent/US6635638B2/en not_active Expired - Lifetime
- 2001-05-03 DE DE60106252T patent/DE60106252T2/de not_active Expired - Lifetime
- 2001-05-03 AU AU6117801A patent/AU6117801A/xx not_active Withdrawn
- 2001-05-03 AT AT01935050T patent/ATE278690T1/de active
- 2001-05-03 CA CA2409743A patent/CA2409743C/en not_active Expired - Fee Related
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- 2001-05-03 KR KR1020027015582A patent/KR20030031483A/ko not_active Application Discontinuation
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- 2001-05-03 EP EP01935050A patent/EP1296981B1/en not_active Expired - Lifetime
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- 2001-05-16 AR ARP010102325A patent/AR028575A1/es active IP Right Grant
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2002
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- 2002-11-15 IL IL152872A patent/IL152872A/en not_active IP Right Cessation
- 2002-11-18 BG BG107284A patent/BG65925B1/bg unknown
- 2002-11-18 NO NO20025525A patent/NO324843B1/no not_active IP Right Cessation
- 2002-12-12 ZA ZA200210114A patent/ZA200210114B/en unknown
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2003
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- 2003-09-08 HK HK03106376.8A patent/HK1054034B/zh not_active IP Right Cessation
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2004
- 2004-10-22 US US10/971,476 patent/US20050113402A1/en not_active Abandoned
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