HUP0001848A2 - NOS gátló 6-fenil-piridil-2-amin származékok - Google Patents
NOS gátló 6-fenil-piridil-2-amin származékokInfo
- Publication number
- HUP0001848A2 HUP0001848A2 HU0001848A HUP0001848A HUP0001848A2 HU P0001848 A2 HUP0001848 A2 HU P0001848A2 HU 0001848 A HU0001848 A HU 0001848A HU P0001848 A HUP0001848 A HU P0001848A HU P0001848 A2 HUP0001848 A2 HU P0001848A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- aralkyl
- alkyl group
- carbon
- carbon atoms
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 9
- -1 hydroxy, methyl Chemical group 0.000 abstract 9
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000004432 carbon atom Chemical group C* 0.000 abstract 6
- 229910052799 carbon Inorganic materials 0.000 abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- 108010021487 Nitric Oxide Synthase Proteins 0.000 abstract 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000001721 carbon Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001624 naphthyl group Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- CXWXQJXEFPUFDZ-UHFFFAOYSA-N tetralin Chemical group C1=CC=C2CCCCC2=C1 CXWXQJXEFPUFDZ-UHFFFAOYSA-N 0.000 abstract 2
- XDWUSBKLDNVDDQ-UHFFFAOYSA-N 6-phenylpyridin-2-amine Chemical class NC1=CC=CC(C=2C=CC=CC=2)=N1 XDWUSBKLDNVDDQ-UHFFFAOYSA-N 0.000 abstract 1
- 102000008299 Nitric Oxide Synthase Human genes 0.000 abstract 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Addiction (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
A találmány tárgya nitrogén-monoxid szintetáz enzimet (NOS) gátlóhatású, (I) általános képletű 6-fenil-piridin-2-il-amin-származékok,továbbá e vegyületeket tartalmazó gyógyászati készítmények, valamint avegyületek felhasználása központi idegrendszeri és másrendellenességek gyógyító és megelőző kezelésére. Az (I) általánosképletben R1 és R2 jelentése egymástól függetlenül hidrogénatom, hidroxi-,metil- vagy metoxicsoport; G jelentése egy (A) vagy (B) általános képletű csoport, ahol n egészszám, jelentése nulla vagy egy, és ahol Y jelentése NR3R4 általános képletű csoport, 1-6 szénatomos alkil-vagy aralkilcsoport, ahol az aralkilcsoportban lévő arilcsoport fenil-vagy naftilcsoport, és az aralkilcsoportban lévő alkilcsoport egyenesvagy elágazó szénláncú 1-6 szénatomot tartalmazó alkilcsoport, és aholaz említett aralkilcsoportban lévő 1-6 szénatomos alkilcsoport és azarilcsoport 0-3 szubsztituenst tartalmazhat, amelyek halogénatom,nitro-, hidroxi-, ciano-, amino-, 1-4 szénatomos alkoxi- vagy 1-4szénatomos alkil-amino-csoportok lehetnek; X jelentése nitrogénatom, ha Y jelentése 1-6 szénatomos alkil-,aralkil- vagy szubsztituált 1-6 szénatomos alkilcsoport, és Xjelentése CH-csoport, ha q egész szám, jelentése nulla, egy vagykettő, és R3 és R4 általános képletű csoportok jelentése egymástól függetlenül,hidrogénatom, 1-6 szénatomos alkilcsoport, tetrahidro-naftalin vagyaralkilcsoport, amely aralkil-csoportban lévő aril-csoport fenil- vagynaftilcsoport és az aralkilcsoportban lévő alkilcsoport egyenes vagyelágazó szénláncú 1-6 szénatomot tartalmazó alkilcsoport, és ahol azemlített aralkilcsoportban lévő 1-6 szénatomos alkilcsoport és atetrahidro-naftalin 0-3 szubsztituenst tartalmazhatnak, amelyekhalogénatom, nitro-, hidrox-, ciano-, amino-, 1-4 szénatomos alkoxivagy 1-4 szénatomos alkil-amino csoportok lehetnek, vagy R3 és R4 a hozzájuk kapcsolódó nitrogénatommal együtt egy piperazin-,piperidin-, vagy pirrolidin-gyűrűt vagy egy 6-14 tagú azabiciklusosgyűrűt alkotnak, amelyek közül 1-3 nitrogénatom és a többi szénatom. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3279396P | 1996-12-06 | 1996-12-06 | |
PCT/IB1997/001446 WO1998024766A1 (en) | 1996-12-06 | 1997-11-17 | 6-phenylpyridyl-2-amine derivatives useful as nos inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0001848A2 true HUP0001848A2 (hu) | 2001-04-28 |
HUP0001848A3 HUP0001848A3 (en) | 2002-03-28 |
Family
ID=21866837
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0001848A HUP0001848A3 (en) | 1996-12-06 | 1997-11-17 | 6-phenylpyridyl-2-amine derivatives useful as nos inhibitors |
Country Status (42)
Country | Link |
---|---|
US (3) | US6235750B1 (hu) |
EP (1) | EP0946512B1 (hu) |
JP (2) | JP3604399B2 (hu) |
KR (1) | KR100360633B1 (hu) |
CN (1) | CN1117077C (hu) |
AP (1) | AP848A (hu) |
AR (1) | AR010331A1 (hu) |
AT (1) | ATE251612T1 (hu) |
AU (2) | AU4791797A (hu) |
BG (1) | BG103540A (hu) |
BR (1) | BR9714381A (hu) |
CA (1) | CA2273479C (hu) |
CZ (1) | CZ293863B6 (hu) |
DE (1) | DE69725465T2 (hu) |
DK (1) | DK0946512T3 (hu) |
DZ (1) | DZ2361A1 (hu) |
EA (1) | EA002907B1 (hu) |
ES (1) | ES2206691T3 (hu) |
HN (2) | HN1997000027A (hu) |
HR (1) | HRP970664A2 (hu) |
HU (1) | HUP0001848A3 (hu) |
ID (1) | ID19056A (hu) |
IL (1) | IL130111A0 (hu) |
IS (1) | IS5053A (hu) |
MA (1) | MA26453A1 (hu) |
NO (1) | NO313517B1 (hu) |
NZ (1) | NZ335733A (hu) |
OA (1) | OA11123A (hu) |
PA (1) | PA8442201A1 (hu) |
PE (1) | PE46499A1 (hu) |
PL (1) | PL333918A1 (hu) |
PT (1) | PT946512E (hu) |
SI (1) | SI0946512T1 (hu) |
SK (1) | SK70899A3 (hu) |
TN (1) | TNSN97198A1 (hu) |
TR (1) | TR199901259T2 (hu) |
TW (1) | TW491840B (hu) |
UA (1) | UA59379C2 (hu) |
UY (1) | UY24799A1 (hu) |
WO (1) | WO1998024766A1 (hu) |
YU (1) | YU25399A (hu) |
ZA (1) | ZA9710906B (hu) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA49006C2 (uk) * | 1996-03-29 | 2002-09-16 | Файзер Інк. | Похідні 6-фенілпіридил-2-аміну, фармацевтична композиція, спосіб інгібування синтази оксиду нітрогену у ссавців та спосіб лікування |
HN1998000118A (es) * | 1997-08-27 | 1999-02-09 | Pfizer Prod Inc | 2 - aminopiridinas que contienen sustituyentes de anillos condensados. |
US20010049379A1 (en) | 1997-08-27 | 2001-12-06 | Lowe John Adams | 2-aminopyridines containing fused ring substituents |
HN1998000125A (es) | 1997-08-28 | 1999-02-09 | Pfizer Prod Inc | 2-aminopiridinas con sustituyentes alcoxi ramificados |
FR2791674A1 (fr) * | 1999-04-02 | 2000-10-06 | Sod Conseils Rech Applic | Nouveaux derives de 2-aminopyridines, leur utilisation en tant que medicaments et compositions pharmaceutiques les contenant |
AR019190A1 (es) * | 1998-07-08 | 2001-12-26 | Sod Conseils Rech Applic | Derivados de 2-aminopiridinas, productos intermedios para su preparacion, medicamentos y composiciones farmaceuticas que los contienen y su uso para preparar medicamentos |
FR2780971B1 (fr) * | 1998-07-08 | 2001-09-28 | Sod Conseils Rech Applic | Nouveaux derives de 2-aminopyridines, leur application en tant que medicaments et compositions pharmaceutiques les contenant |
CA2340200A1 (en) * | 1998-08-11 | 2000-02-24 | John Adams Lowe Iii | New pharmaceutical uses for nos inhibitors |
SE9803710L (sv) | 1998-09-25 | 2000-03-26 | A & Science Invest Ab | Användning av vissa substanser för behandling av nervrotsskador |
US7115557B2 (en) | 1998-09-25 | 2006-10-03 | Sciaticon Ab | Use of certain drugs for treating nerve root injury |
CZ20013036A3 (cs) | 1999-02-25 | 2002-03-13 | Pfizer Products Inc. | 2-aminopyridiny obsahující jako substituenty kondenzované kruhové skupiny |
MXPA01013452A (es) * | 1999-07-23 | 2002-07-02 | Shionogi & Co | Inhibodores de diferenciacion th2. |
FR2804429B1 (fr) * | 2000-01-31 | 2003-05-09 | Adir | Nouveaux derives de 4-sulfonamides piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
WO2002080853A2 (en) * | 2001-04-09 | 2002-10-17 | Bristol-Myers Squibb Company | Fused heterocyclic inhibitors of factor xa |
US20030045449A1 (en) * | 2001-08-15 | 2003-03-06 | Pfizer, Inc. | Pharmaceutical combinations for the treatment of neurodegenerative diseases |
CA2522323C (en) * | 2003-04-14 | 2009-09-15 | Pfizer Products Inc. | 3-azabicyclo[3.2.1]octane derivatives as opioid receptor ligands |
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WO1992014780A1 (en) | 1991-02-19 | 1992-09-03 | Akzo N.V. | Stabilized carbon monoxide-olefin copolymers |
WO1994014780A1 (en) * | 1992-12-18 | 1994-07-07 | The Wellcome Foundation Limited | Pyrimidine, pyridine, pteridinone and indazole derivatives as enzyme inhibitors |
US5621004A (en) | 1994-06-03 | 1997-04-15 | Robert W. Dunn | Method for treating emesis |
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UA49006C2 (uk) * | 1996-03-29 | 2002-09-16 | Файзер Інк. | Похідні 6-фенілпіридил-2-аміну, фармацевтична композиція, спосіб інгібування синтази оксиду нітрогену у ссавців та спосіб лікування |
US6093743A (en) | 1998-06-23 | 2000-07-25 | Medinox Inc. | Therapeutic methods employing disulfide derivatives of dithiocarbamates and compositions useful therefor |
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