HUP0302793A2 - Foszfodiészteráz 4 inhibitor hatású N-helyettesített anilin származékok, ezeket tartalmazó gyógyszerkészítmények és eljárás az előállításaikra - Google Patents

Foszfodiészteráz 4 inhibitor hatású N-helyettesített anilin származékok, ezeket tartalmazó gyógyszerkészítmények és eljárás az előállításaikra

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Publication number
HUP0302793A2
HUP0302793A2 HU0302793A HUP0302793A HUP0302793A2 HU P0302793 A2 HUP0302793 A2 HU P0302793A2 HU 0302793 A HU0302793 A HU 0302793A HU P0302793 A HUP0302793 A HU P0302793A HU P0302793 A2 HUP0302793 A2 HU P0302793A2
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Hungary
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group
alkyl group
optionally substituted
compounds
carbon atoms
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HU0302793A
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English (en)
Inventor
William Frederick Brubaker
Michael De Vivo
Hans-Jürgen Ernst Hess
Allen Hopper
Ruiping Liu
Richard A. Schumacher
Ashok Tehim
Axel Unterbeck
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Memory Pharmaceuticals Corporation
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Application filed by Memory Pharmaceuticals Corporation filed Critical Memory Pharmaceuticals Corporation
Publication of HUP0302793A2 publication Critical patent/HUP0302793A2/hu
Publication of HUP0302793A3 publication Critical patent/HUP0302793A3/hu

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/73—Unsubstituted amino or imino radicals
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Abstract

A jelen találmány tárgya PDE4 gátló hatással rendelkező újszerűvegyületek, például nitrogénatomon helyettesített anilin- és difenil-anilin-származékok. A jelen találmány szerinti vegyületek (I)általános képletűek, amely képletben R1, R2, R3 és R4 jelentése többekközött az alábbiakban meghatározott: R1 jelentése adott esetbenhelyettesített alkilcsoport; R2 jelentése adott esetben helyettesített1-12 szénatomos alkilcsoport, 3-10 szénatomos cikloalkilcsoport, 4-16szénatomos cikloalkil-alkilcsoport, 6-14 szénatomos arilcsoport, 5-14szénatomos karbociklusos csoport, telített, telítetlen 5-10 gyűrűbeliatomot tartalmazó heterogyűrűs csoport; R3 jelentése hidrogénatom,adott esetben helyettesített 1-8 szénatomos alkilcsoport, 7-19szénatomos aril-alkilcsoport, heteroaril-alkilcsoport; R4 jelentéseadott esetben helyettesített 6-14 szénatomos arilcsoport vagy 5-10gyűrűbeli atomot tartalmazó heteroarilcsoport. A találmány kiterjed avegyületeket tartalmazó gyógyszerkészítményekre, és a vegyületekelőállítására is. Ó
HU0302793A 2001-01-22 2002-01-22 N-substituted aniline derivatives useful as phosphodiesterase 4 inhibitors, pharmaceutical compositions containing them and process for their preparations HUP0302793A3 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US26265101P 2001-01-22 2001-01-22
US26719601P 2001-02-08 2001-02-08
US30614001P 2001-07-19 2001-07-19
PCT/US2002/001508 WO2002074726A2 (en) 2001-01-22 2002-01-22 Aniline derivatives useful as phosphodiesterase 4 inhibitors

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HUP0302793A2 true HUP0302793A2 (hu) 2003-11-28
HUP0302793A3 HUP0302793A3 (en) 2006-01-30

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EP (1) EP1353907A2 (hu)
JP (1) JP4223287B2 (hu)
KR (1) KR100856622B1 (hu)
CN (1) CN100378075C (hu)
AU (1) AU2002303078B2 (hu)
BG (1) BG108003A (hu)
BR (1) BR0206943A (hu)
CA (1) CA2435847A1 (hu)
CL (1) CL2004001165A1 (hu)
CZ (1) CZ20031986A3 (hu)
EE (1) EE05362B1 (hu)
HK (1) HK1066215A1 (hu)
HR (1) HRP20030662A2 (hu)
HU (1) HUP0302793A3 (hu)
IL (1) IL156958A0 (hu)
MA (1) MA25996A1 (hu)
MX (1) MXPA03006519A (hu)
NO (1) NO329548B1 (hu)
NZ (1) NZ527081A (hu)
PL (1) PL373301A1 (hu)
SK (1) SK9152003A3 (hu)
WO (1) WO2002074726A2 (hu)
YU (1) YU57603A (hu)
ZA (1) ZA200305623B (hu)

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US7153871B2 (en) 2001-01-22 2006-12-26 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors, including aminoindazole and aminobenzofuran analogs
DE60233111D1 (de) * 2001-02-14 2009-09-10 Karobio Ab Glucocorticoid-rezeptoren-modulatoren
WO2004009552A1 (en) 2002-07-19 2004-01-29 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors, including n-substituted aniline and diphenylamine analogs
CN101423497A (zh) 2002-07-19 2009-05-06 记忆药物公司 作为磷酸二酯酶4抑制剂的6-氨基-1h-吲唑和4-氨基苯并呋喃化合物
US7087625B2 (en) * 2002-11-19 2006-08-08 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors
AU2003286024A1 (en) * 2002-11-22 2004-06-18 Daniel Dube Use of phosphodiesterase-4 inhibitors as enhancers of cognition
CA2511502A1 (en) * 2002-12-27 2004-07-15 H. Lundbeck A/S 1,2,4-triaminobenzene derivatives,useful for treating disorders of the central nervous system
FR2856595B1 (fr) * 2003-06-27 2008-05-30 Exonhit Therapeutics Sa Methodes et compositions pour le traitement de deficits cognitifs.
US7776893B2 (en) 2003-09-05 2010-08-17 Nycomed Gmbh Use of PDE4 inhibitors for the treatment of diabetes mellitus
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