HUP0400654A2 - 4-Foszfo-diészteráz-inhibitorként ható 8-aril-kinolin-származékok és ezeket tartalmazó gyógyszerkészítmények - Google Patents

4-Foszfo-diészteráz-inhibitorként ható 8-aril-kinolin-származékok és ezeket tartalmazó gyógyszerkészítmények

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Publication number
HUP0400654A2
HUP0400654A2 HU0400654A HUP0400654A HUP0400654A2 HU P0400654 A2 HUP0400654 A2 HU P0400654A2 HU 0400654 A HU0400654 A HU 0400654A HU P0400654 A HUP0400654 A HU P0400654A HU P0400654 A2 HUP0400654 A2 HU P0400654A2
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Hungary
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group
alkyl
substituted
aryl
son
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HU0400654A
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English (en)
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Sophie-Dorothee Clas
David A. Conlon
Guo-Jie Ho
Elizabeth Kwong
Dwight Mcdonald
Helene Perrier
Roch Thibert
Anant Vailaya
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Merck & Co., Inc.
Merck Frosst Canada & Co.
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Publication of HUP0400654A2 publication Critical patent/HUP0400654A2/hu
Publication of HUP0400654A3 publication Critical patent/HUP0400654A3/hu

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    • C07D215/12Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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Abstract

A találmány 8-aril-kinolin-származékokra, különösen a 8-as helyzetbenhelyettesített alkenilcsoporttal szubsztituált arilcsoportottartalmazó 8-aril-kinolin-származékok sóira vonatkozik, amelyekgátolják a 4-foszfo-diészteráz enzim működését. A találmány szerinti8-aril-kinolin-származékok (I) általános képletében S1, S2 és S3jelentése egyaránt hidrogénatom; R1 jelentése hidrogénatom,hidroxilcsoport, halogénatom, karbonilcsoport, alkilcsoport,cikloalkilcsoport, alkenilcsoport, alkoxicsoport, arilcsoport,heteroarilcsoport, cianocsoport, heterocikloalkilcsoport,aminocsoport, alkil-amino-csoport, dialkil-amino-csoport, alkiloxi-alkil-csoport, (aril)-aminokarbonil-csoport, (heteroaril)-aminokarbonil-csoport, aril-amino-SOn-csoport, heteroaril-aminoSOn-csoport, alkil-amino-SOn-csoport, dialkil-amino-karbonil-csoport,alkilSOn-amino-csoport, alkil-SOn-csoport, di(alkil-amino)-C(CN)-O(alkil)-csoport vagy (alkil)-SOn(alkil)-csoport, azzal amegjegyzéssel, hogy a csoportok 1-5 egymástól függetlenszubsztituenssel adott esetben helyettesítve lehetnek; A jelentése CHképletű csoport; R2 és R3 jelentése - egymástól függetlenül -arilcsoport, heteroarilcsoport, hidrogénatom, halogénatom,cianocsoport, alkilcsoport, heterocikloalkilcsoport, alkoxicsoport,karbonilcsoport, karbamoilcsoport, (alkil)-SOn-(alkil)-csoport,dialkilamino-karbamoil-csoport vagy amino-alkil-acil-csoport, azzal amegjegyzéssel, hogy a csoportok adott esetben helyettesítve lehetnek1-5 olyan szubsztituenssel, amelyek maguk is lehetnek szubsztituáltak;R4 jelentése arilcsoport, alkilcsoport, heteroarilcsoport,cianocsoport, karbonilcsoport, karbamoilcsoport, (alkil)-SOn-(alkil)-csoport, dialkil-amino-karbonilcsoport vagy amino-acil-alkil-csoport,azzal a megjegyzéssel, hogy a csoportok 1-5 szubsztituenssel adottesetben helyettesítve lehetnek; és n jelentése 0, 1 vagy 2. Atalálmány kiterjed a vegyületeket tartalmazó gyógyszerkészítményekreis. Ó
HU0400654A 2000-12-20 2001-12-14 Substituted 8-arylquinoline phosphodiesterase 4 inhibitors and pharmaceutical compositions containing them HUP0400654A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25680300P 2000-12-20 2000-12-20
PCT/US2001/048674 WO2002069970A1 (en) 2000-12-20 2001-12-14 Substituted 8-arylquinoline phosphodiesterase-4 inhibitors

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HUP0400654A2 true HUP0400654A2 (hu) 2004-06-28
HUP0400654A3 HUP0400654A3 (en) 2011-07-28

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US (1) US6740666B2 (hu)
EP (1) EP1363635B1 (hu)
JP (1) JP2004521921A (hu)
KR (1) KR20030063456A (hu)
CN (1) CN100508978C (hu)
AR (1) AR035514A1 (hu)
AT (1) ATE428420T1 (hu)
AU (1) AU2001297603B2 (hu)
BG (1) BG107900A (hu)
BR (1) BR0116372A (hu)
CA (1) CA2431549A1 (hu)
CZ (1) CZ20031738A3 (hu)
DE (1) DE60138421D1 (hu)
DO (1) DOP2001000308A (hu)
EA (1) EA006607B1 (hu)
EE (1) EE200300266A (hu)
HU (1) HUP0400654A3 (hu)
IL (1) IL156479A0 (hu)
JO (1) JO2317B1 (hu)
MX (1) MXPA03005673A (hu)
MY (1) MY136792A (hu)
NO (1) NO20032807L (hu)
NZ (1) NZ526376A (hu)
PE (1) PE20020787A1 (hu)
PL (1) PL362564A1 (hu)
SK (1) SK7732003A3 (hu)
WO (1) WO2002069970A1 (hu)
ZA (1) ZA200304672B (hu)

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CN100508978C (zh) 2009-07-08
PL362564A1 (en) 2004-11-02
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BG107900A (bg) 2004-06-30
EP1363635B1 (en) 2009-04-15
HUP0400654A3 (en) 2011-07-28
AU2001297603B2 (en) 2006-02-16
NO20032807L (no) 2003-08-15
MXPA03005673A (es) 2003-10-06
PE20020787A1 (es) 2002-09-10
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