DK419086D0 - Heterocykliske substituerede indoler, mellemprodukter, fremgangsmaader til fremstilling heraf og laegemidler - Google Patents

Heterocykliske substituerede indoler, mellemprodukter, fremgangsmaader til fremstilling heraf og laegemidler

Info

Publication number
DK419086D0
DK419086D0 DK419086A DK419086A DK419086D0 DK 419086 D0 DK419086 D0 DK 419086D0 DK 419086 A DK419086 A DK 419086A DK 419086 A DK419086 A DK 419086A DK 419086 D0 DK419086 D0 DK 419086D0
Authority
DK
Denmark
Prior art keywords
intermediates
heteroatoms
alkyl
image
cyano
Prior art date
Application number
DK419086A
Other languages
English (en)
Other versions
DK419086A (da
Inventor
Alfred Mertens
Wolfgang Von Der Saal
Walter-Gunar Friebe
Bernd Mueller-Beckmann
Gisbert Sponer
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of DK419086D0 publication Critical patent/DK419086D0/da
Publication of DK419086A publication Critical patent/DK419086A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK419086A 1985-09-05 1986-09-02 Heterocykliske substituerede indoler, mellemprodukter, fremgangsmaader til fremstilling heraf og laegemidler DK419086A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853531658 DE3531658A1 (de) 1985-09-05 1985-09-05 Heterocyclisch substituierte indole, zwischenprodukte, verfahren zu ihrer herstellung und arzneimittel

Publications (2)

Publication Number Publication Date
DK419086D0 true DK419086D0 (da) 1986-09-02
DK419086A DK419086A (da) 1987-03-06

Family

ID=6280166

Family Applications (1)

Application Number Title Priority Date Filing Date
DK419086A DK419086A (da) 1985-09-05 1986-09-02 Heterocykliske substituerede indoler, mellemprodukter, fremgangsmaader til fremstilling heraf og laegemidler

Country Status (17)

Country Link
US (1) US4851406A (da)
EP (1) EP0223937B1 (da)
JP (1) JPS6256486A (da)
KR (1) KR870003099A (da)
AT (1) ATE73797T1 (da)
AU (1) AU572405B2 (da)
DD (1) DD258229A5 (da)
DE (2) DE3531658A1 (da)
DK (1) DK419086A (da)
ES (1) ES2001936A6 (da)
FI (1) FI863564A (da)
GR (1) GR862248B (da)
HU (1) HU197000B (da)
IL (1) IL79911A (da)
NZ (1) NZ217419A (da)
PT (1) PT83310B (da)
ZA (1) ZA866705B (da)

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FR2594438B1 (fr) * 1986-02-14 1990-01-26 Labaz Sanofi Nv Derives d'indolizine, leur procede de preparation ainsi que les compositions en contenant
DE3631085A1 (de) * 1986-09-12 1988-03-24 Boehringer Mannheim Gmbh Heterocyclisch substituierte indolinone, verfahren zu ihrer herstellung, arzneimittel sowie zwischenprodukte
DE3706427A1 (de) * 1987-02-27 1988-09-08 Boehringer Mannheim Gmbh Neue substituierte 3h-indole, zwischenprodukte, verfahren zu ihrer herstellung sowie arzneimittel
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
JP2597893B2 (ja) * 1988-07-21 1997-04-09 自動車機器株式会社 流体給排用接続筒を備えたシリンダとその製造方法および製造装置
DE3826855A1 (de) * 1988-08-06 1990-02-15 Cassella Ag 4,5-dihydro-3(2h)-pyridazinone, verfahren zu ihrer herstellung und ihre verwendung
US5238938A (en) * 1989-02-10 1993-08-24 Otsuka Pharmaceutical Co., Ltd. Indole derivatives
GB8903130D0 (en) * 1989-02-11 1989-03-30 Orion Yhtymae Oy Substituted pyridazinones
US5185332A (en) * 1989-02-11 1993-02-09 Orion-Yhtyma Oy Thiadiazines and pharmaceutical compositions thereof as well as method of use
PT95899A (pt) * 1989-11-17 1991-09-13 Glaxo Group Ltd Processo para a preparacao de derivados indole
IL98392A (en) * 1990-06-07 1996-01-19 Wellcome Found History of indole, their preparation and the pharmaceutical preparations containing them
US5189054A (en) * 1990-11-02 1993-02-23 Merrell Dow Pharmaceuticals Inc. 3-amidoindolyl derivatives and pharmaceutical compositions thereof
US5317103A (en) * 1991-01-15 1994-05-31 Merck Sharp & Dohme Limited Indole-substituted five-membered heteroaromatic compounds as 5-HT1 agonists
SK278998B6 (sk) * 1991-02-01 1998-05-06 Merck Sharp & Dohme Limited Deriváty imidazolu, triazolu a tetrazolu, spôsob i
US5183825A (en) * 1992-04-07 1993-02-02 American Home Products Corporation 4-arylmethyl-5-alkyl-3H-pyrazol-3-ones and hypoglycemic use
US5194435A (en) * 1992-04-07 1993-03-16 American Home Products Corporation 4-arylmethyl-5-alkyl-3h-pyrazol-3-ones
IL106445A (en) * 1992-07-30 1998-01-04 Merck Sharp & Dohme History of 1,2,4-Trans-Triazole 4-Transform, Preparation and Pharmaceutical Preparations Containing Them
AU699272B2 (en) * 1994-08-02 1998-11-26 Merck Sharp & Dohme Limited Azetidine, pyrrolidine and piperidine derivatives
US5523312A (en) * 1994-09-27 1996-06-04 Sterling Winthrop Inc. Antipicornaviral agents
JP2002502844A (ja) * 1998-02-03 2002-01-29 ベーリンガー インゲルハイム ファルマ コマンディトゲゼルシャフト ５員複素環縮合ベンゾ誘導体、その調製及び医薬品としてのそれらの使用
US6114532A (en) * 1998-02-03 2000-09-05 Boehringer Ingelheim Pharma Kg Bicyclic heterocycles, the preparation thereof, and their use as pharmaceuticals
GB9926250D0 (en) * 1999-11-06 2000-01-12 Knoll Ag Chemical process
FI20000577A0 (fi) * 2000-03-13 2000-03-13 Orion Yhtymae Oy Pyridatsinyylifenyylihydratsoneja
TWI224101B (en) * 2001-06-20 2004-11-21 Wyeth Corp Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1)
WO2003000253A1 (en) * 2001-06-20 2003-01-03 Wyeth Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
MXPA05006287A (es) * 2002-12-10 2005-09-08 Wyeth Corp Derivados de acido indoloxo-acetilaminoacetico sustituidos como inhibidores del inhibidor del activador de plasminogeno 1 (pai-1).
WO2004052853A2 (en) * 2002-12-10 2004-06-24 Wyeth Substituted 3-alkyl and 3-arylalkyl 1h-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
CN1726190A (zh) * 2002-12-10 2006-01-25 惠氏公司 作为纤溶酶原激活物抑制剂－1(pai－1)的抑制剂的取代3－羰基－1h－吲哚－1－基乙酸衍生物
CA2509191A1 (en) * 2002-12-10 2004-06-24 Wyeth Aryl, aryloxy, and alkyloxy substituted 1h-indol-3-yl glyoxylic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
UA80453C2 (en) * 2002-12-10 2007-09-25 Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1)
US7268159B2 (en) * 2003-09-25 2007-09-11 Wyeth Substituted indoles
US7420083B2 (en) * 2003-09-25 2008-09-02 Wyeth Substituted aryloximes
US7534894B2 (en) * 2003-09-25 2009-05-19 Wyeth Biphenyloxy-acids
US7411083B2 (en) 2003-09-25 2008-08-12 Wyeth Substituted acetic acid derivatives
US7582773B2 (en) * 2003-09-25 2009-09-01 Wyeth Substituted phenyl indoles
US7265148B2 (en) * 2003-09-25 2007-09-04 Wyeth Substituted pyrrole-indoles
US7332521B2 (en) * 2003-09-25 2008-02-19 Wyeth Substituted indoles
US7342039B2 (en) * 2003-09-25 2008-03-11 Wyeth Substituted indole oximes
US7141592B2 (en) * 2003-09-25 2006-11-28 Wyeth Substituted oxadiazolidinediones
US7446201B2 (en) * 2003-09-25 2008-11-04 Wyeth Substituted heteroaryl benzofuran acids
US7442805B2 (en) * 2003-09-25 2008-10-28 Wyeth Substituted sulfonamide-indoles
US7351726B2 (en) * 2003-09-25 2008-04-01 Wyeth Substituted oxadiazolidinediones
US7163954B2 (en) * 2003-09-25 2007-01-16 Wyeth Substituted naphthyl benzothiophene acids
US20050215626A1 (en) * 2003-09-25 2005-09-29 Wyeth Substituted benzofuran oximes
RU2007106868A (ru) * 2004-08-23 2008-09-27 Вайет (Us) Оксазол-нафтиловые кислоты и их применение в качестве модуляторов ингибитора активатора плазминогена-1 (pai) для лечения тромбоза и сердечно-сосудистых заболеваний
CN101044127A (zh) * 2004-08-23 2007-09-26 惠氏公司 用作纤溶酶原激活剂抑制剂－1的噻唑基－萘基酸
BRPI0514549A (pt) * 2004-08-23 2008-06-17 Wyeth Corp ácidos de pirrol-naftila como inibidores de pai-1
EP1919866A2 (en) * 2005-08-17 2008-05-14 Wyeth a Corporation of the State of Delaware Substituted indoles and use thereof
EP2970145B1 (en) 2013-03-11 2020-05-06 The Broad Institute, Inc. Compounds and compositions for the treatment of cancer

Family Cites Families (16)

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US3322786A (en) * 1965-10-07 1967-05-30 Merck & Co Inc 3-indolyl aliphatic acids
US3928380A (en) * 1973-03-29 1975-12-23 Sterling Drug Inc 1,1{40 -Spirobis(cyclopenta-{8 4,5-c{9 pyrroles)
DE2557341A1 (de) * 1975-12-19 1977-06-30 Hoechst Ag Basisch substituierte indolderivate und verfahren zu ihrer herstellung
US4144338A (en) * 1977-02-17 1979-03-13 Merck & Co., Inc. N-pyrimidinyl-N-dialkylaminoalkyl ureas
US4181665A (en) * 1977-10-31 1980-01-01 The Upjohn Company Isochroman
US4258185A (en) * 1978-10-17 1981-03-24 Yoshitomi Pharmaceutical Industries, Ltd. Pyridazinone compounds
DE2845220A1 (de) * 1978-10-17 1980-04-30 Yoshitomi Pharmaceutical Pyridazinon-derivate, ihre salze mit saeuren, verfahren zu ihrer herstellung und ihre verwendung bei der behandlung von thrombosen und hypertonie
DE3172252D1 (en) * 1980-11-14 1985-10-17 Ici Plc Heterocyclic compounds
JPS5785055A (en) * 1980-11-18 1982-05-27 Konishiroku Photo Ind Co Ltd Silver halide photographic recording material
DE3131146A1 (de) * 1981-08-06 1983-02-24 Boehringer Mannheim Gmbh, 6800 Mannheim Neue heteroaryloxypropanolamine, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
CA1199027A (en) * 1981-11-12 1986-01-07 Stuart D. Mills Heterocyclic derivatives of pyridazinone, thiadiazinone, oxadiazinone and triazinone
FR2530246B1 (fr) * 1982-07-16 1985-06-14 Delalande Sa Nouveaux derives pyrido indoliniques et pirido indoliques et leurs sels, ainsi que le procede de preparation et l'application en therapeutique de ces derives et sels
US4581356A (en) * 1983-03-22 1986-04-08 Fujisawa Pharmaceutical Co., Ltd. Triazine derivatives, and pharmaceutical compositions comprising the same
US4666902A (en) * 1983-06-20 1987-05-19 Cassella Aktiengesellschaft Tetrahydropyridazinone derivatives, processes for their preparation and their use
DE3421641A1 (de) * 1984-06-09 1985-12-12 Merck Patent Gmbh, 6100 Darmstadt Indolderivate
DK623586A (da) * 1985-12-27 1987-06-28 Eisai Co Ltd Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne

Also Published As

Publication number Publication date
ZA866705B (en) 1987-04-29
IL79911A0 (en) 1986-12-31
US4851406A (en) 1989-07-25
EP0223937A1 (de) 1987-06-03
FI863564A0 (fi) 1986-09-04
DE3684415D1 (de) 1992-04-23
EP0223937B1 (de) 1992-03-18
DK419086A (da) 1987-03-06
DD258229A5 (de) 1988-07-13
KR870003099A (ko) 1987-04-15
AU6216686A (en) 1987-03-12
DE3531658A1 (de) 1987-03-12
ATE73797T1 (de) 1992-04-15
NZ217419A (en) 1989-03-29
HUT41770A (en) 1987-05-28
JPS6256486A (ja) 1987-03-12
PT83310A (de) 1986-10-01
PT83310B (pt) 1989-01-17
AU572405B2 (en) 1988-05-05
HU197000B (en) 1989-02-28
ES2001936A6 (es) 1988-07-01
GR862248B (en) 1986-12-31
FI863564A (fi) 1987-03-06
IL79911A (en) 1991-04-15

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Legal Events

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