CO5560590A2 - Compuestos que inhiben la liberacion de citosinas inflamatorias - Google Patents

Compuestos que inhiben la liberacion de citosinas inflamatorias

Info

Publication number
CO5560590A2
CO5560590A2 CO04021425A CO04021425A CO5560590A2 CO 5560590 A2 CO5560590 A2 CO 5560590A2 CO 04021425 A CO04021425 A CO 04021425A CO 04021425 A CO04021425 A CO 04021425A CO 5560590 A2 CO5560590 A2 CO 5560590A2
Authority
CO
Colombia
Prior art keywords
substituted
unsubstituted
hydrogen
alkyl
con
Prior art date
Application number
CO04021425A
Other languages
English (en)
Inventor
Matthew John Laufersweile
Jane Far-Jine Djung
Biswanath De
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of CO5560590A2 publication Critical patent/CO5560590A2/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/20Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

1.- Un compuesto que incluye todas las formas enantioméricas y diasterioméricas y las sales farmacéuticamente aceptables de las mismas; el compuesto corresponde a la fórmula: caracterizado porque R es: a) hidrógeno, b) -O[CH2]kR3; o c) -NR4aR4b;R3 es alquilo C1-C4 sustituido o no sustituido, hidrocarbilo cíclico sustituido o no sustituido, heterocíclico sustituido o no sustituido, arilo sustituido o no sustituido, heteroarilo sustituido o no sustituido; el subíndice k tiene un valor de 0 a 5;cada R4a y R4b es de manera independiente: a) hidrógeno; o b) -[C(R5aR5b)]xR6;cada R5a y R5b es en forma independiente hidrógeno, -OR7, -N(R7)2, CO2R7, -CON(R7)2, alquilo C1-C4Iineal, ramificado, o cíclico, y sus mezclas;R6 es -O7, -N(R7)2, -CO2R7, -CON(R7)2; alquilo C1-C4 sustituido o no sustituido, lineal, ramificado o cíclico y sus mezclas; R7 es hidrógeno, un catión soluble en agua, alquilo C1-C4 o arilo sustituido o no substituido; el subíndice x tiene un valor de 0 a 5;R1 es: a) arilo sustituido o no sustituido; o b) heteroarilo sustituido o no sustituido;las unidades R2a y R2b se seleccionan independientemente a partir del grupo que comprende: a) hidrógeno, b) -O(CH2)jR8; c) -(CH2)j NR9aR9b; d) -(CH2)j CO2R10; e) -(CH2)j CO2R10 f) -(CH2)j CON(R10)2; g) dos unidades R2a o R2b del mismo átomo de carbono pueden unirse para formar una unidad carbonilo; h) un R2a y un R2b se unen para formar un doble enlace; i) un R2a y un R2b se unen para formar un anillo sustituido o no sustituido que comprende 4 a 8 átomos, ...
CO04021425A 2001-09-20 2004-03-09 Compuestos que inhiben la liberacion de citosinas inflamatorias CO5560590A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US32362501P 2001-09-20 2001-09-20

Publications (1)

Publication Number Publication Date
CO5560590A2 true CO5560590A2 (es) 2005-09-30

Family

ID=23259997

Family Applications (3)

Application Number Title Priority Date Filing Date
CO04021425A CO5560590A2 (es) 2001-09-20 2004-03-09 Compuestos que inhiben la liberacion de citosinas inflamatorias
CO04021424A CO5560589A2 (es) 2001-09-20 2004-03-09 6,7-dihidro-5h-pirazol[1,2-a]pirazol-1-onas que controlan citosinas inflamatorias
CO04023010A CO5560579A2 (es) 2001-09-20 2004-03-12 6,7-dihidro-5h-pirazolo[1,2-a]pirazol-1-onas espirociclicas que controlan la citosinas inflamatorias

Family Applications After (2)

Application Number Title Priority Date Filing Date
CO04021424A CO5560589A2 (es) 2001-09-20 2004-03-09 6,7-dihidro-5h-pirazol[1,2-a]pirazol-1-onas que controlan citosinas inflamatorias
CO04023010A CO5560579A2 (es) 2001-09-20 2004-03-12 6,7-dihidro-5h-pirazolo[1,2-a]pirazol-1-onas espirociclicas que controlan la citosinas inflamatorias

Country Status (33)

Country Link
US (2) US6566357B1 (es)
EP (3) EP1427728B1 (es)
JP (3) JP2005504082A (es)
KR (4) KR100623879B1 (es)
CN (3) CN1250551C (es)
AR (3) AR037237A1 (es)
AT (3) ATE356126T1 (es)
AU (2) AU2002334641B2 (es)
BR (3) BR0212905A (es)
CA (3) CA2461073A1 (es)
CO (3) CO5560590A2 (es)
CY (1) CY1106398T1 (es)
CZ (3) CZ2004361A3 (es)
DE (3) DE60202782T2 (es)
DK (2) DK1427732T3 (es)
EG (2) EG24413A (es)
ES (3) ES2282459T3 (es)
HK (2) HK1071366A1 (es)
HU (3) HUP0402378A3 (es)
IL (3) IL160741A0 (es)
MA (3) MA27066A1 (es)
MX (3) MXPA04002569A (es)
MY (2) MY129329A (es)
NO (2) NO20041594L (es)
NZ (3) NZ531123A (es)
PE (3) PE20030474A1 (es)
PL (3) PL370362A1 (es)
PT (3) PT1427727E (es)
RU (3) RU2272040C2 (es)
SA (1) SA03230529B1 (es)
SK (3) SK1502004A3 (es)
WO (3) WO2003024973A1 (es)
ZA (3) ZA200401260B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6849627B2 (en) 2001-09-20 2005-02-01 The Procter & Gamble Company 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines
US6730668B2 (en) * 2001-09-20 2004-05-04 The Procter & Gamble Company 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines
US7087615B2 (en) 2001-09-20 2006-08-08 The Procter & Gamble Company 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which provide analgesia
US7473695B2 (en) * 2001-10-22 2009-01-06 Mitsubishi Tanabe Pharma Corporation 4-imidazolin-2-one compounds
US6677337B2 (en) * 2002-03-19 2004-01-13 The Procter & Gamble Company 1,2-dihydropyrazol-3-ones which controls inflammatory cytokines
CA2497007A1 (en) * 2002-09-09 2004-03-18 Amgen Inc. 1, 4, 5-substituted 1, 2-dihydro-pyrazol-3-one and 3-alkoxy-1h-pyrazole derivatives s tnf-alpha and interleukin lowering agents for the treatment of inflammations
ATE361296T1 (de) * 2003-04-03 2007-05-15 Merck Patent Gmbh Pyrazolidin-1,2-dicarbonsäure-1-((phenyl)-amid) 2-((phenyl)-amid) derivate als koagulationsfaktor xa inhibitoren zur behandlung von thrombosen
GB0308466D0 (en) 2003-04-11 2003-05-21 Novartis Ag Organic compounds
US7482356B2 (en) * 2003-11-10 2009-01-27 The Procter & Gamble Company Bicyclic pyrazolone cytokine inhibitors
AU2007238071B2 (en) * 2006-04-18 2012-06-07 Abbvie Inc. Antagonists of the vanilloid receptor subtype 1 (VR1) and uses thereof
DE102008060549A1 (de) 2008-12-04 2010-06-10 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
DK2432767T3 (da) * 2009-05-19 2013-09-30 Dow Agrosciences Llc Forbindelser og fremgangsmåder til at kontrollere svampe
EP3308059B1 (en) 2015-06-15 2021-05-26 Cummins, Inc. Combustion chamber elasticity device
US20190060286A1 (en) 2016-02-29 2019-02-28 University Of Florida Research Foundation, Incorpo Chemotherapeutic Methods
CN107033090B (zh) * 2017-05-16 2019-05-07 无锡捷化医药科技有限公司 一种1,2,3,4-四氢噌啉的制备方法
RU2721684C1 (ru) * 2019-09-06 2020-05-21 Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" Метил 2,3,8-триоксо-4-фенилтетрагидро-6Н-пиразоло[1,2-а]пирроло[2,3-c]пиразол-9а(1Н)-карбоксилаты
EP4422621A1 (en) * 2021-10-27 2024-09-04 Merck Sharp & Dohme LLC Spirotricycle ripk1 inhibitors and methods of uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1054291A (es) * 1963-02-26
GB1124982A (en) * 1965-02-09 1968-08-21 Lepetit Spa Diazabicyclo octanes and derivatives thereof
CH529154A (fr) 1969-10-27 1972-10-15 Lepetit Spa Procédé de préparation de pyrazolo (1,2-b) phtalazine-1,5 (10H)-diones
US5358924A (en) * 1991-03-21 1994-10-25 Bayer Aktiengesellschaft 3-hydroxy-4-aryl-5-oxo-pyrozoline derivatives, compositions and use
PT1481970E (pt) * 1999-09-07 2006-07-31 Syngenta Participations Ag Novos herbicidas
US6730668B2 (en) * 2001-09-20 2004-05-04 The Procter & Gamble Company 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines

Also Published As

Publication number Publication date
EG24363A (en) 2009-03-04
EG24413A (en) 2009-05-25
MY129329A (en) 2007-03-30
CY1106398T1 (el) 2011-10-12
CZ2004345A3 (cs) 2004-06-16
ZA200401403B (en) 2004-08-30
RU2004111803A (ru) 2005-10-10
EP1427727A1 (en) 2004-06-16
DE60202782D1 (de) 2005-03-03
AR037145A1 (es) 2004-10-27
EP1427732A1 (en) 2004-06-16
HK1071366A1 (en) 2005-07-15
BR0212716A (pt) 2004-08-03
CO5560589A2 (es) 2005-09-30
US20030105084A1 (en) 2003-06-05
RU2299885C2 (ru) 2007-05-27
DE60218704T2 (de) 2007-11-08
MA27066A1 (fr) 2004-12-20
KR20040035837A (ko) 2004-04-29
RU2272040C2 (ru) 2006-03-20
SA03230529B1 (ar) 2008-06-21
CA2461072A1 (en) 2003-03-27
MXPA04002570A (es) 2004-05-31
BR0212905A (pt) 2004-10-13
US6821971B2 (en) 2004-11-23
PT1427727E (pt) 2005-06-30
AU2002327690B2 (en) 2006-07-20
KR100623879B1 (ko) 2006-09-19
SK1502004A3 (en) 2004-09-08
NZ531122A (en) 2005-09-30
AU2002334641B2 (en) 2007-03-29
CZ2004361A3 (cs) 2004-07-14
AR037237A1 (es) 2004-11-03
ES2268154T3 (es) 2007-03-16
RU2004111806A (ru) 2005-03-27
ZA200401260B (en) 2004-08-30
MA27064A1 (fr) 2004-12-20
SK1492004A3 (en) 2004-11-03
DK1427728T3 (da) 2007-07-09
KR20040035835A (ko) 2004-04-29
NZ531123A (en) 2006-08-31
KR20060036125A (ko) 2006-04-27
PE20030446A1 (es) 2003-07-21
HUP0500752A2 (en) 2006-01-30
DE60202782T2 (de) 2006-01-19
PL370415A1 (en) 2005-05-30
ZA200401402B (en) 2004-08-27
KR100656126B1 (ko) 2006-12-12
JP2005504083A (ja) 2005-02-10
CN1249066C (zh) 2006-04-05
ATE356126T1 (de) 2007-03-15
EP1427732B1 (en) 2006-07-12
KR20040035836A (ko) 2004-04-29
ES2237691T3 (es) 2005-08-01
AR037502A1 (es) 2004-11-17
IL160742A0 (en) 2004-08-31
HUP0402378A2 (hu) 2005-02-28
EP1427727B1 (en) 2005-01-26
HK1071565A1 (en) 2005-07-22
BR0212673A (pt) 2004-08-24
WO2003024970A1 (en) 2003-03-27
CA2461071A1 (en) 2003-03-27
JP2005504081A (ja) 2005-02-10
PE20030474A1 (es) 2003-07-22
US6566357B1 (en) 2003-05-20
CN1257905C (zh) 2006-05-31
DE60218704D1 (de) 2007-04-19
ES2282459T3 (es) 2007-10-16
CN1250551C (zh) 2006-04-12
SK1482004A3 (en) 2004-08-03
CA2461073A1 (en) 2003-03-27
RU2278864C2 (ru) 2006-06-27
WO2003024971A1 (en) 2003-03-27
PT1427732E (pt) 2006-12-29
IL160741A0 (en) 2004-08-31
NO20041605L (no) 2004-06-21
PT1427728E (pt) 2007-05-31
JP2005504082A (ja) 2005-02-10
MY129069A (en) 2007-03-30
WO2003024973A1 (en) 2003-03-27
HUP0402500A2 (hu) 2005-03-29
RU2004111805A (ru) 2005-04-10
CN1555375A (zh) 2004-12-15
IL160682A0 (en) 2004-08-31
MA27065A1 (fr) 2004-12-20
DE60213108T2 (de) 2007-02-08
HUP0402378A3 (en) 2008-10-28
CN1556811A (zh) 2004-12-22
HUP0402500A3 (en) 2008-10-28
MXPA04002569A (es) 2004-05-31
DK1427732T3 (da) 2006-10-30
CO5560579A2 (es) 2005-09-30
PL370351A1 (en) 2005-05-16
PL370362A1 (en) 2005-05-16
CN1555379A (zh) 2004-12-15
ATE332901T1 (de) 2006-08-15
MXPA04002574A (es) 2004-06-18
ATE287887T1 (de) 2005-02-15
PE20030430A1 (es) 2003-06-24
EP1427728A1 (en) 2004-06-16
NO20041594L (no) 2004-06-21
EP1427728B1 (en) 2007-03-07
CZ2004358A3 (cs) 2004-07-14
DE60213108D1 (de) 2006-08-24
NZ531063A (en) 2007-08-31

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