DE60213108D1 - SPIROCYCLISCHE 6,7-DIHYDRO-5H-PYRAZOLOc1,2-AÜPYRAZOL-1-ONE, DIE INFLAMMATORISCHE CYTOKINE STEUERN - Google Patents

SPIROCYCLISCHE 6,7-DIHYDRO-5H-PYRAZOLOc1,2-AÜPYRAZOL-1-ONE, DIE INFLAMMATORISCHE CYTOKINE STEUERN

Info

Publication number
DE60213108D1
DE60213108D1 DE60213108T DE60213108T DE60213108D1 DE 60213108 D1 DE60213108 D1 DE 60213108D1 DE 60213108 T DE60213108 T DE 60213108T DE 60213108 T DE60213108 T DE 60213108T DE 60213108 D1 DE60213108 D1 DE 60213108D1
Authority
DE
Germany
Prior art keywords
pyrazoloc1
atpyrazole
spirocyclic
dihydro
inflammatory cytokines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60213108T
Other languages
English (en)
Other versions
DE60213108T2 (de
Inventor
John Laufersweiler
Phillip Clark
Far-Jine Djung
Adam Golebiowski
Biswanath De
Andrew Brugel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Application granted granted Critical
Publication of DE60213108D1 publication Critical patent/DE60213108D1/de
Publication of DE60213108T2 publication Critical patent/DE60213108T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/20—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE60213108T 2001-09-20 2002-09-20 SPIROCYCLISCHE 6,7-DIHYDRO-5H-PYRAZOLOc1,2-AÜPYRAZOL-1-ONE, DIE INFLAMMATORISCHE CYTOKINE STEUERN Expired - Fee Related DE60213108T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32362501P 2001-09-20 2001-09-20
US323625P 2001-09-20
PCT/US2002/030133 WO2003024973A1 (en) 2001-09-20 2002-09-20 Spirocyclic-6,7-dihydro-5h-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines

Publications (2)

Publication Number Publication Date
DE60213108D1 true DE60213108D1 (de) 2006-08-24
DE60213108T2 DE60213108T2 (de) 2007-02-08

Family

ID=23259997

Family Applications (3)

Application Number Title Priority Date Filing Date
DE60218704T Expired - Lifetime DE60218704T2 (de) 2001-09-20 2002-09-20 6,7-dihydro-5h-pyrazolo1,2-a pyrazol-1-one zur kontrolle von entzündungsfördernden cytokinen
DE60202782T Expired - Lifetime DE60202782T2 (de) 2001-09-20 2002-09-20 Verbindungen, welche die freisetzung von cytokinen inhibieren
DE60213108T Expired - Fee Related DE60213108T2 (de) 2001-09-20 2002-09-20 SPIROCYCLISCHE 6,7-DIHYDRO-5H-PYRAZOLOc1,2-AÜPYRAZOL-1-ONE, DIE INFLAMMATORISCHE CYTOKINE STEUERN

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE60218704T Expired - Lifetime DE60218704T2 (de) 2001-09-20 2002-09-20 6,7-dihydro-5h-pyrazolo1,2-a pyrazol-1-one zur kontrolle von entzündungsfördernden cytokinen
DE60202782T Expired - Lifetime DE60202782T2 (de) 2001-09-20 2002-09-20 Verbindungen, welche die freisetzung von cytokinen inhibieren

Country Status (33)

Country Link
US (2) US6821971B2 (de)
EP (3) EP1427727B1 (de)
JP (3) JP2005504081A (de)
KR (4) KR20040035837A (de)
CN (3) CN1250551C (de)
AR (3) AR037237A1 (de)
AT (3) ATE332901T1 (de)
AU (2) AU2002334641B2 (de)
BR (3) BR0212905A (de)
CA (3) CA2461073A1 (de)
CO (3) CO5560590A2 (de)
CY (1) CY1106398T1 (de)
CZ (3) CZ2004345A3 (de)
DE (3) DE60218704T2 (de)
DK (2) DK1427728T3 (de)
EG (2) EG24363A (de)
ES (3) ES2282459T3 (de)
HK (2) HK1071366A1 (de)
HU (3) HUP0402500A3 (de)
IL (3) IL160741A0 (de)
MA (3) MA27064A1 (de)
MX (3) MXPA04002570A (de)
MY (2) MY129329A (de)
NO (2) NO20041594L (de)
NZ (3) NZ531123A (de)
PE (3) PE20030446A1 (de)
PL (3) PL370362A1 (de)
PT (3) PT1427732E (de)
RU (3) RU2278864C2 (de)
SA (1) SA03230529B1 (de)
SK (3) SK1482004A3 (de)
WO (3) WO2003024970A1 (de)
ZA (3) ZA200401260B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6730668B2 (en) * 2001-09-20 2004-05-04 The Procter & Gamble Company 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines
US6849627B2 (en) 2001-09-20 2005-02-01 The Procter & Gamble Company 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines
US7087615B2 (en) 2001-09-20 2006-08-08 The Procter & Gamble Company 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which provide analgesia
US7473695B2 (en) 2001-10-22 2009-01-06 Mitsubishi Tanabe Pharma Corporation 4-imidazolin-2-one compounds
US6677337B2 (en) * 2002-03-19 2004-01-13 The Procter & Gamble Company 1,2-dihydropyrazol-3-ones which controls inflammatory cytokines
CA2497007A1 (en) * 2002-09-09 2004-03-18 Amgen Inc. 1, 4, 5-substituted 1, 2-dihydro-pyrazol-3-one and 3-alkoxy-1h-pyrazole derivatives s tnf-alpha and interleukin lowering agents for the treatment of inflammations
ATE361296T1 (de) * 2003-04-03 2007-05-15 Merck Patent Gmbh Pyrazolidin-1,2-dicarbonsäure-1-((phenyl)-amid) 2-((phenyl)-amid) derivate als koagulationsfaktor xa inhibitoren zur behandlung von thrombosen
GB0308466D0 (en) 2003-04-11 2003-05-21 Novartis Ag Organic compounds
US7482356B2 (en) * 2003-11-10 2009-01-27 The Procter & Gamble Company Bicyclic pyrazolone cytokine inhibitors
KR20080111144A (ko) * 2006-04-18 2008-12-22 아보트 러보러터리즈 바닐로이드 수용체 서브타입 １(ｖｒ１)의 길항제 및 이의 용도
DE102008060549A1 (de) 2008-12-04 2010-06-10 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
EP2432767B1 (en) * 2009-05-19 2013-06-26 Dow AgroSciences LLC Compounds and methods for controlling fungi
WO2016205284A1 (en) 2015-06-15 2016-12-22 Cummins Inc. Combustion chamber elasticity device
WO2017151409A1 (en) 2016-02-29 2017-09-08 University Of Florida Research Foundation, Incorporated Chemotherapeutic methods
CN107033090B (zh) * 2017-05-16 2019-05-07 无锡捷化医药科技有限公司 一种1,2,3,4-四氢噌啉的制备方法
RU2721684C1 (ru) * 2019-09-06 2020-05-21 Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" Метил 2,3,8-триоксо-4-фенилтетрагидро-6Н-пиразоло[1,2-а]пирроло[2,3-c]пиразол-9а(1Н)-карбоксилаты
WO2023076133A1 (en) * 2021-10-27 2023-05-04 Merck Sharp & Dohme Llc Spirotricycle ripk1 inhibitors and methods of uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1054291A (de) 1963-02-26
GB1124982A (en) * 1965-02-09 1968-08-21 Lepetit Spa Diazabicyclo octanes and derivatives thereof
CH529154A (fr) 1969-10-27 1972-10-15 Lepetit Spa Procédé de préparation de pyrazolo (1,2-b) phtalazine-1,5 (10H)-diones
US5358924A (en) * 1991-03-21 1994-10-25 Bayer Aktiengesellschaft 3-hydroxy-4-aryl-5-oxo-pyrozoline derivatives, compositions and use
PT1210333E (pt) * 1999-09-07 2005-03-31 Syngenta Participations Ag P-tolil-heterociclos como herbicidas
US6730668B2 (en) * 2001-09-20 2004-05-04 The Procter & Gamble Company 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines

Also Published As

Publication number Publication date
RU2278864C2 (ru) 2006-06-27
PT1427728E (pt) 2007-05-31
CN1257905C (zh) 2006-05-31
DE60202782T2 (de) 2006-01-19
SK1482004A3 (en) 2004-08-03
CZ2004345A3 (cs) 2004-06-16
HUP0500752A2 (en) 2006-01-30
ATE356126T1 (de) 2007-03-15
KR20040035835A (ko) 2004-04-29
NZ531122A (en) 2005-09-30
PE20030430A1 (es) 2003-06-24
PL370415A1 (en) 2005-05-30
CZ2004358A3 (cs) 2004-07-14
WO2003024970A1 (en) 2003-03-27
HK1071565A1 (en) 2005-07-22
CO5560579A2 (es) 2005-09-30
HUP0402500A2 (hu) 2005-03-29
JP2005504082A (ja) 2005-02-10
ES2268154T3 (es) 2007-03-16
RU2004111806A (ru) 2005-03-27
NZ531123A (en) 2006-08-31
CA2461073A1 (en) 2003-03-27
ZA200401402B (en) 2004-08-27
CA2461071A1 (en) 2003-03-27
SK1502004A3 (en) 2004-09-08
MY129329A (en) 2007-03-30
DE60218704D1 (de) 2007-04-19
DK1427732T3 (da) 2006-10-30
KR20040035836A (ko) 2004-04-29
DE60202782D1 (de) 2005-03-03
MXPA04002569A (es) 2004-05-31
IL160682A0 (en) 2004-08-31
ATE332901T1 (de) 2006-08-15
HUP0402378A2 (hu) 2005-02-28
CN1555375A (zh) 2004-12-15
KR20040035837A (ko) 2004-04-29
HUP0402500A3 (en) 2008-10-28
ZA200401260B (en) 2004-08-30
AR037145A1 (es) 2004-10-27
PT1427727E (pt) 2005-06-30
RU2299885C2 (ru) 2007-05-27
BR0212905A (pt) 2004-10-13
DE60213108T2 (de) 2007-02-08
MA27064A1 (fr) 2004-12-20
JP2005504081A (ja) 2005-02-10
IL160741A0 (en) 2004-08-31
MXPA04002574A (es) 2004-06-18
PE20030474A1 (es) 2003-07-22
DE60218704T2 (de) 2007-11-08
CN1556811A (zh) 2004-12-22
JP2005504083A (ja) 2005-02-10
WO2003024971A1 (en) 2003-03-27
NZ531063A (en) 2007-08-31
CO5560589A2 (es) 2005-09-30
ES2237691T3 (es) 2005-08-01
BR0212716A (pt) 2004-08-03
HK1071366A1 (en) 2005-07-15
SK1492004A3 (en) 2004-11-03
AR037237A1 (es) 2004-11-03
EP1427732A1 (de) 2004-06-16
KR100623879B1 (ko) 2006-09-19
DK1427728T3 (da) 2007-07-09
CZ2004361A3 (cs) 2004-07-14
BR0212673A (pt) 2004-08-24
PL370351A1 (en) 2005-05-16
RU2272040C2 (ru) 2006-03-20
MA27066A1 (fr) 2004-12-20
CN1249066C (zh) 2006-04-05
EP1427727B1 (de) 2005-01-26
RU2004111803A (ru) 2005-10-10
CN1555379A (zh) 2004-12-15
PL370362A1 (en) 2005-05-16
PT1427732E (pt) 2006-12-29
CN1250551C (zh) 2006-04-12
IL160742A0 (en) 2004-08-31
ES2282459T3 (es) 2007-10-16
MY129069A (en) 2007-03-30
RU2004111805A (ru) 2005-04-10
NO20041594L (no) 2004-06-21
AU2002334641B2 (en) 2007-03-29
AR037502A1 (es) 2004-11-17
CO5560590A2 (es) 2005-09-30
MXPA04002570A (es) 2004-05-31
MA27065A1 (fr) 2004-12-20
EG24413A (en) 2009-05-25
EG24363A (en) 2009-03-04
WO2003024973A1 (en) 2003-03-27
NO20041605L (no) 2004-06-21
SA03230529B1 (ar) 2008-06-21
US6821971B2 (en) 2004-11-23
KR100656126B1 (ko) 2006-12-12
US20030105084A1 (en) 2003-06-05
EP1427727A1 (de) 2004-06-16
EP1427732B1 (de) 2006-07-12
KR20060036125A (ko) 2006-04-27
HUP0402378A3 (en) 2008-10-28
PE20030446A1 (es) 2003-07-21
AU2002327690B2 (en) 2006-07-20
EP1427728B1 (de) 2007-03-07
ZA200401403B (en) 2004-08-30
ATE287887T1 (de) 2005-02-15
CY1106398T1 (el) 2011-10-12
EP1427728A1 (de) 2004-06-16
US6566357B1 (en) 2003-05-20
CA2461072A1 (en) 2003-03-27

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