PE20030430A1 - 6,7-DIHIDRO-5H-PIRAZOLO[1,2-a]PIRAZOL-1-ONAS QUE CONTROLAN CITOQUINAS INFLAMATORIAS - Google Patents

6,7-DIHIDRO-5H-PIRAZOLO[1,2-a]PIRAZOL-1-ONAS QUE CONTROLAN CITOQUINAS INFLAMATORIAS

Info

Publication number
PE20030430A1
PE20030430A1 PE2002000923A PE2002000923A PE20030430A1 PE 20030430 A1 PE20030430 A1 PE 20030430A1 PE 2002000923 A PE2002000923 A PE 2002000923A PE 2002000923 A PE2002000923 A PE 2002000923A PE 20030430 A1 PE20030430 A1 PE 20030430A1
Authority
PE
Peru
Prior art keywords
alkyl
dihydro
pirazol
aryl
inflammatory cytokines
Prior art date
Application number
PE2002000923A
Other languages
English (en)
Inventor
Michael George Natchus
Michael Philip Clark
Biswanath Nmn De
Jane Far-Jine Djung
Matthew John Laufersweiler
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of PE20030430A1 publication Critical patent/PE20030430A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/20Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

SE REFIERE A PIRAZOLONAS BICICLICAS DE FORMULA I DONDE R ES O[CH2]kR3, NR4aR4b; R3 ES ALQUILO C1-C4, HIDROCARBILO, HETEROCICLILO, ARILO, ALQUILENARILO, HETEROARILO, ALQUILENHETEROARILO; k ES 0-5; R4a, R4b SON H, -[C(R5aR5b)]mR6; R5a, R5b SON H, OR7, N(R7)2, CO2R7, CON(R7)2, ALQUILO C1-C4; R6 ES H, OR7, N(R7)2, CO2R7, CON(R7)2, ALQUILO C1-C4, ARILO, HETEROARILO; R7 ES H, CATION SOLUBLE EN AGUA, ALQUILO C1-C4; m ES 0-5; R1 ES ARILO, HETEROARILO; R2 ES H, (CH2)jO(CH2)nR8, (CH2)jCO2R10, (CH2)jNR9aR9b; (CH2)jOCO2R10, (CH2)jCON(R10)2, (CH2)jOCON(R10)2; R8, R9a, R9b, R10 SON H, ALQUILO C1-C4, R9a, R9b FORMAN JUNTOS UN ANILLO CARBOCICLICO, HETEROCICLICO DE 3-7 MIEMBROS; DOS R10 FORMAN JUNTOS UN ANILLO CARBOCICLICO, HETEROCICLICO; j Y n SON 0-5; Z ES O, S, NR11, NOR11; R11 ES H, ALQUILO C1-C4. SON COMPUESTOS PREFERIDOS 2-(4-FLUOROFENIL)-3-(2-FENOXI-PIRIMIDIN-4-IL)-6,7-DIHIDRO-5H-PIRAZOLO-[1,2-a]PIRAZOL-1-ONA; N-(3-{4-[2-(4-FLUOROFENIL)-3-OXO-6,7-DIHIDRO-3H,5H-PIRAZOLO[1,2-a]PIRAZOL-1-IL]-PIRIMIDIN-2-ILOXI}-FENIL)ACETAMIDA, ENTRE OTROS. LOS COMPUESTOS INHIBEN LA LIBERACION EXTRACELULAR DE CITOQUINAS INFLAMATORIAS EN HUMANOS
PE2002000923A 2001-09-20 2002-09-20 6,7-DIHIDRO-5H-PIRAZOLO[1,2-a]PIRAZOL-1-ONAS QUE CONTROLAN CITOQUINAS INFLAMATORIAS PE20030430A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US32362501P 2001-09-20 2001-09-20

Publications (1)

Publication Number Publication Date
PE20030430A1 true PE20030430A1 (es) 2003-06-24

Family

ID=23259997

Family Applications (3)

Application Number Title Priority Date Filing Date
PE2002000923A PE20030430A1 (es) 2001-09-20 2002-09-20 6,7-DIHIDRO-5H-PIRAZOLO[1,2-a]PIRAZOL-1-ONAS QUE CONTROLAN CITOQUINAS INFLAMATORIAS
PE2002000924A PE20030446A1 (es) 2001-09-20 2002-09-20 6-7-DIHIDRO-5H-PIRAZOLO[1,2-a]PIRAZOL-1-ONAS ESPIROCICLICAS QUE CONTROLAN CITOQUINAS INFLAMATORIAS
PE2002000925A PE20030474A1 (es) 2001-09-20 2002-09-20 Compuesto que inhibe la liberacion de citoquinas inflamatorias

Family Applications After (2)

Application Number Title Priority Date Filing Date
PE2002000924A PE20030446A1 (es) 2001-09-20 2002-09-20 6-7-DIHIDRO-5H-PIRAZOLO[1,2-a]PIRAZOL-1-ONAS ESPIROCICLICAS QUE CONTROLAN CITOQUINAS INFLAMATORIAS
PE2002000925A PE20030474A1 (es) 2001-09-20 2002-09-20 Compuesto que inhibe la liberacion de citoquinas inflamatorias

Country Status (33)

Country Link
US (2) US6566357B1 (es)
EP (3) EP1427727B1 (es)
JP (3) JP2005504081A (es)
KR (4) KR100656126B1 (es)
CN (3) CN1257905C (es)
AR (3) AR037237A1 (es)
AT (3) ATE332901T1 (es)
AU (2) AU2002334641B2 (es)
BR (3) BR0212905A (es)
CA (3) CA2461073A1 (es)
CO (3) CO5560589A2 (es)
CY (1) CY1106398T1 (es)
CZ (3) CZ2004361A3 (es)
DE (3) DE60202782T2 (es)
DK (2) DK1427732T3 (es)
EG (2) EG24363A (es)
ES (3) ES2237691T3 (es)
HK (2) HK1071366A1 (es)
HU (3) HUP0402500A3 (es)
IL (3) IL160682A0 (es)
MA (3) MA27065A1 (es)
MX (3) MXPA04002574A (es)
MY (2) MY129069A (es)
NO (2) NO20041594L (es)
NZ (3) NZ531123A (es)
PE (3) PE20030430A1 (es)
PL (3) PL370362A1 (es)
PT (3) PT1427732E (es)
RU (3) RU2278864C2 (es)
SA (1) SA03230529B1 (es)
SK (3) SK1482004A3 (es)
WO (3) WO2003024971A1 (es)
ZA (3) ZA200401260B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6849627B2 (en) 2001-09-20 2005-02-01 The Procter & Gamble Company 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines
US6730668B2 (en) * 2001-09-20 2004-05-04 The Procter & Gamble Company 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines
US7087615B2 (en) 2001-09-20 2006-08-08 The Procter & Gamble Company 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which provide analgesia
US7473695B2 (en) * 2001-10-22 2009-01-06 Mitsubishi Tanabe Pharma Corporation 4-imidazolin-2-one compounds
US6677337B2 (en) * 2002-03-19 2004-01-13 The Procter & Gamble Company 1,2-dihydropyrazol-3-ones which controls inflammatory cytokines
MXPA05002513A (es) * 2002-09-09 2005-05-27 Amgen Inc Derivados de 3-alcoxi-1h-pirazol y 1,2-dihidro-pirazol-3-ona 1, 4, 5-sustituida, agentes que disminuyen la interleucina y el factor de necrosis tumoral alfa (tnf-alfa) para tratamiento de inflamaciones.
AU2004226281B2 (en) * 2003-04-03 2010-06-10 Merck Patent Gmbh Pyrazolidine-1,2-dicarboxyldiphenylamide derivatives as coagulation factor Xa inhibitors for the treatment of thromboses
GB0308466D0 (en) * 2003-04-11 2003-05-21 Novartis Ag Organic compounds
US7482356B2 (en) * 2003-11-10 2009-01-27 The Procter & Gamble Company Bicyclic pyrazolone cytokine inhibitors
EP2012778A4 (en) * 2006-04-18 2011-08-10 Abbott Lab VANILLOID RECEPTOR (VR1) SUBType 1 ANTAGONISTS AND USES THEREOF
DE102008060549A1 (de) 2008-12-04 2010-06-10 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
PT2432767E (pt) * 2009-05-19 2013-07-25 Dow Agrosciences Llc Compostos e métodos para controlo de fungos
EP3308059B1 (en) 2015-06-15 2021-05-26 Cummins, Inc. Combustion chamber elasticity device
WO2017151409A1 (en) 2016-02-29 2017-09-08 University Of Florida Research Foundation, Incorporated Chemotherapeutic methods
CN107033090B (zh) * 2017-05-16 2019-05-07 无锡捷化医药科技有限公司 一种1,2,3,4-四氢噌啉的制备方法
RU2721684C1 (ru) * 2019-09-06 2020-05-21 Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" Метил 2,3,8-триоксо-4-фенилтетрагидро-6Н-пиразоло[1,2-а]пирроло[2,3-c]пиразол-9а(1Н)-карбоксилаты
WO2023076133A1 (en) * 2021-10-27 2023-05-04 Merck Sharp & Dohme Llc Spirotricycle ripk1 inhibitors and methods of uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1054291A (es) * 1963-02-26
GB1124982A (en) * 1965-02-09 1968-08-21 Lepetit Spa Diazabicyclo octanes and derivatives thereof
CH529154A (fr) 1969-10-27 1972-10-15 Lepetit Spa Procédé de préparation de pyrazolo (1,2-b) phtalazine-1,5 (10H)-diones
US5358924A (en) * 1991-03-21 1994-10-25 Bayer Aktiengesellschaft 3-hydroxy-4-aryl-5-oxo-pyrozoline derivatives, compositions and use
CA2382435C (en) * 1999-09-07 2009-02-03 Syngenta Participations Ag Novel herbicidally active phenyl-substituted heterocycles
US6730668B2 (en) * 2001-09-20 2004-05-04 The Procter & Gamble Company 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines

Also Published As

Publication number Publication date
WO2003024973A1 (en) 2003-03-27
EP1427732A1 (en) 2004-06-16
DE60202782D1 (de) 2005-03-03
EP1427727B1 (en) 2005-01-26
NZ531063A (en) 2007-08-31
RU2004111806A (ru) 2005-03-27
HUP0402378A2 (hu) 2005-02-28
CN1250551C (zh) 2006-04-12
EP1427728A1 (en) 2004-06-16
BR0212673A (pt) 2004-08-24
SA03230529B1 (ar) 2008-06-21
CA2461071A1 (en) 2003-03-27
NO20041594L (no) 2004-06-21
ZA200401403B (en) 2004-08-30
MA27066A1 (fr) 2004-12-20
MY129069A (en) 2007-03-30
ES2268154T3 (es) 2007-03-16
JP2005504081A (ja) 2005-02-10
CN1555379A (zh) 2004-12-15
ES2237691T3 (es) 2005-08-01
ATE287887T1 (de) 2005-02-15
CA2461073A1 (en) 2003-03-27
RU2272040C2 (ru) 2006-03-20
BR0212716A (pt) 2004-08-03
IL160742A0 (en) 2004-08-31
AU2002327690B2 (en) 2006-07-20
HUP0500752A2 (en) 2006-01-30
US20030105084A1 (en) 2003-06-05
ES2282459T3 (es) 2007-10-16
KR100623879B1 (ko) 2006-09-19
ATE356126T1 (de) 2007-03-15
AR037237A1 (es) 2004-11-03
BR0212905A (pt) 2004-10-13
DK1427728T3 (da) 2007-07-09
IL160682A0 (en) 2004-08-31
RU2278864C2 (ru) 2006-06-27
AR037502A1 (es) 2004-11-17
CO5560590A2 (es) 2005-09-30
PL370351A1 (en) 2005-05-16
KR100656126B1 (ko) 2006-12-12
PL370362A1 (en) 2005-05-16
RU2004111803A (ru) 2005-10-10
DE60202782T2 (de) 2006-01-19
EG24413A (en) 2009-05-25
PE20030446A1 (es) 2003-07-21
WO2003024970A1 (en) 2003-03-27
KR20040035837A (ko) 2004-04-29
RU2004111805A (ru) 2005-04-10
EP1427728B1 (en) 2007-03-07
AU2002334641B2 (en) 2007-03-29
MA27064A1 (fr) 2004-12-20
CN1555375A (zh) 2004-12-15
DE60218704T2 (de) 2007-11-08
KR20040035835A (ko) 2004-04-29
MY129329A (en) 2007-03-30
PL370415A1 (en) 2005-05-30
EP1427732B1 (en) 2006-07-12
CY1106398T1 (el) 2011-10-12
SK1482004A3 (en) 2004-08-03
MXPA04002570A (es) 2004-05-31
ATE332901T1 (de) 2006-08-15
NO20041605L (no) 2004-06-21
CA2461072A1 (en) 2003-03-27
DE60218704D1 (de) 2007-04-19
WO2003024971A1 (en) 2003-03-27
JP2005504083A (ja) 2005-02-10
PT1427732E (pt) 2006-12-29
ZA200401402B (en) 2004-08-27
HK1071565A1 (en) 2005-07-22
SK1502004A3 (en) 2004-09-08
CO5560579A2 (es) 2005-09-30
NZ531123A (en) 2006-08-31
SK1492004A3 (en) 2004-11-03
IL160741A0 (en) 2004-08-31
MXPA04002574A (es) 2004-06-18
MA27065A1 (fr) 2004-12-20
DE60213108T2 (de) 2007-02-08
CZ2004345A3 (cs) 2004-06-16
CN1249066C (zh) 2006-04-05
RU2299885C2 (ru) 2007-05-27
HUP0402500A2 (hu) 2005-03-29
PE20030474A1 (es) 2003-07-22
HK1071366A1 (en) 2005-07-15
JP2005504082A (ja) 2005-02-10
KR20060036125A (ko) 2006-04-27
DK1427732T3 (da) 2006-10-30
AR037145A1 (es) 2004-10-27
MXPA04002569A (es) 2004-05-31
CN1556811A (zh) 2004-12-22
US6821971B2 (en) 2004-11-23
DE60213108D1 (de) 2006-08-24
CO5560589A2 (es) 2005-09-30
NZ531122A (en) 2005-09-30
CZ2004361A3 (cs) 2004-07-14
EP1427727A1 (en) 2004-06-16
HUP0402500A3 (en) 2008-10-28
EG24363A (en) 2009-03-04
KR20040035836A (ko) 2004-04-29
ZA200401260B (en) 2004-08-30
US6566357B1 (en) 2003-05-20
CZ2004358A3 (cs) 2004-07-14
HUP0402378A3 (en) 2008-10-28
CN1257905C (zh) 2006-05-31
PT1427728E (pt) 2007-05-31
PT1427727E (pt) 2005-06-30

Similar Documents

Publication Publication Date Title
PE20030430A1 (es) 6,7-DIHIDRO-5H-PIRAZOLO[1,2-a]PIRAZOL-1-ONAS QUE CONTROLAN CITOQUINAS INFLAMATORIAS
TR200400185T4 (tr) PDE 5 inhibitörleri olarak, 8-kuinolinkisantin ve 8-izokuinolinkisantin türevleri.
CO4960662A1 (es) Ciertos acidos 5-alquil-2-arilaminofenilaceticos y sus derivados
ATE296821T1 (de) Triarylimidazol-derivate als cytokin-inhibitoren
MX9302169A (es) Fenoxialquilisoxazolas de 1,2,4-oxadiazolilo y su uso como agentes antivirales.
MY104179A (en) Antidepressant n-substituted nicotinamide compounds.
ATE168102T1 (de) 1,4-benzodiazepinderivate und ihre verwendung als cck-modulatoren
ES2038678T3 (es) Procedimiento para la preparacion de n-(2-alquil-3-mercapto-glutaril)-alfamino-acidos.
NO159794C (no) Analogifremgangsm te ved fremstilling av terapeutisk virksomme 7-substituerte theofyllinderivater.
LV10619A (lv) Arstniecibas lidzekli
HUP0105407A2 (hu) Triazolo[1,5-a]kinolinszármazékok, eljárás előállításukra, ezeket tartalmazó gyógyszerkészítmények, valamint intermedierek
CO5080754A1 (es) Caspasas y apoptosis
PE20021012A1 (es) Compuestos de benzoilo
CO4750824A1 (es) Nuevos intermedios y su uso para preparar bisindolilmaleimidas con un puente n,n
CO5040091A1 (es) Derivados de urea
DK1021405T3 (da) Azetidinonderivater til behandling af HCMV-infektioner
CO5130024A1 (es) Derivados de azabicicloheptano n-sustituidos. .
PE20050578A1 (es) 6,7-DIHIDRO-5H-PIRAZOLO[1,2-a]PIRAZOL-1-ONA COMO INHIBIDORES DE LA LIBERACION EXTRACELULAR DE LAS CITOCINAS INFLAMATORIAS
TH14131EX (th) นิวคลีโอไซด์ ซึ่งมีสรรพคุณทางบำบัดรักษา
TH14131A (th) นิวคลีโอไซด์ ซึ่งมีสรรพคุณทางบำบัดรักษา
YU97992A (sh) Hipoglikemski tiazolidindioni i intermedijeri

Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed