PE20061080A1 - Compuestos derivados de piridotienopirimidina como inhibidores de fosfodiesterasa 4 - Google Patents
Compuestos derivados de piridotienopirimidina como inhibidores de fosfodiesterasa 4Info
- Publication number
- PE20061080A1 PE20061080A1 PE2005001378A PE2005001378A PE20061080A1 PE 20061080 A1 PE20061080 A1 PE 20061080A1 PE 2005001378 A PE2005001378 A PE 2005001378A PE 2005001378 A PE2005001378 A PE 2005001378A PE 20061080 A1 PE20061080 A1 PE 20061080A1
- Authority
- PE
- Peru
- Prior art keywords
- pyrane
- morpholin
- pyrimidin
- dihydro
- dimethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Ophthalmology & Optometry (AREA)
- Transplantation (AREA)
- Hematology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE R1 Y R2 SON H O ALQUILO(C1-C4); n ES 0 O 1; R3 ES ALQUILO(C1-C20), ARILO(C5-C14) MONOCICLICO O POLICICLICO, HETEROARILO DE 5 A 14 MIEMBROS QUE COMPRENDE AL MENOS UN ANILLO HETEROAROMATICO Y QUE CONTIENE UN HETEROATOMO SELECCIONADO DE O, S O N, OPCIONALMENTE SUSTITUIDOS CON HALOGENO, CF3, SO2NH2, ENTRE OTROS; R4 Y R5 SON H, ALQUILO(C1-C20), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 2,2-DIMETIL-5-MORFOLIN-4-IL-N-(2-FENETILETIL)-1,4-DIHIDRO-2H-PIRANO[4",3":4',5']PIRIDO[3',2':4,5]TIENO[3,2-d]PIRIMIDIN-8-AMINA, 2,2-DIMETIL-5-MORFOLIN-4-IL-N-(4-METILPIPERIDIN-1-IL)-1,4-DIHIDRO-2H-PIRANO[4",3":4',5']PIRIDO[3',2':4,5]TIENO[3,2-d]PIRIMIDIN-8-AMINA, 2,2-DIMETIL-5-MORFOLIN-4-IL-N-(2-DIETILAMINOETIL)-1,4-DIHIDRO-2H-PIRANO[4",3":4',5']PIRIDO[3',2':4,5]TIENO[3,2-d]PIRIMIDIN-8-AMINA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE LA FOSFODIESTERASA 4 SIENDO UTILES EN EL TRATAMIENTO DE ASMA, ENFERMEDAD PULMONAR OBSTRUCTIVA CRONICA, ARTRITIS REUMATOIDE, PSORIASIS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200402877A ES2259892B1 (es) | 2004-11-30 | 2004-11-30 | Nuevos derivados de piridotienopirimidina. |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20061080A1 true PE20061080A1 (es) | 2006-11-10 |
Family
ID=35064809
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2005001378A PE20061080A1 (es) | 2004-11-30 | 2005-11-28 | Compuestos derivados de piridotienopirimidina como inhibidores de fosfodiesterasa 4 |
Country Status (19)
Country | Link |
---|---|
US (1) | US20080207645A1 (es) |
EP (1) | EP1819712A1 (es) |
JP (1) | JP2008521854A (es) |
KR (1) | KR20070086652A (es) |
CN (1) | CN101068817A (es) |
AR (1) | AR052413A1 (es) |
AU (1) | AU2005311422A1 (es) |
BR (1) | BRPI0518117A (es) |
CA (1) | CA2588808A1 (es) |
ES (1) | ES2259892B1 (es) |
IL (1) | IL183141A0 (es) |
MX (1) | MX2007006172A (es) |
NO (1) | NO20073271L (es) |
PE (1) | PE20061080A1 (es) |
RU (1) | RU2007124493A (es) |
TW (1) | TW200631954A (es) |
UY (1) | UY29240A1 (es) |
WO (1) | WO2006058723A1 (es) |
ZA (1) | ZA200703700B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2281251B1 (es) * | 2005-07-27 | 2008-08-16 | Laboratorios Almirall S.A. | Nuevos derivados de pirido (3',2':4,5) furo (3,2-d) pirimidina. |
WO2012131297A1 (en) | 2011-03-28 | 2012-10-04 | Jonathan Bayldon Baell | Pyrido [3',2' :4,5] thieno [3, 2-d] pyrimidin- 4 - ylamine derivatives and their therapeutical use |
JP2015512862A (ja) | 2011-12-21 | 2015-04-30 | インヴィスタ テクノロジーズ エスアエルエル | 安定なエマルジョンを減じるための抽出溶媒制御 |
CN103242276B (zh) * | 2013-05-07 | 2014-07-16 | 白银安杰利生化科技有限公司 | 2,2-二甲基四氢-2h-吡喃-4-羧酸的合成方法 |
BR112018003417B1 (pt) | 2016-06-22 | 2023-10-24 | Vanderbilt University | Composto modulador alostérico positivo do receptor muscarínico de acetilcolina m4 e composição farmacêutica que o compreende |
MA46899A (fr) | 2016-11-07 | 2021-04-14 | Univ Vanderbilt | Modulateurs allostériques positifs du récepteur muscarinique de l'acétylcholine m4 |
MA46722A (fr) | 2016-11-07 | 2019-09-11 | Univ Vanderbilt | Modulateurs allostériques positifs du récepteur muscarinique à l'acétylcholine m4 |
JP7099725B2 (ja) | 2016-11-07 | 2022-07-12 | ヴァンダービルト ユニヴァーシティ | ムスカリン性アセチルコリンレセプターm4のポジティブアロステリック調節因子 |
TW201930311A (zh) | 2017-12-05 | 2019-08-01 | 泛德比爾特大學 | 蕈毒鹼型乙醯膽鹼受體m4之正向別構調節劑 |
US11376254B2 (en) | 2017-12-05 | 2022-07-05 | Vanderbilt University | Positive allosteric modulators of the muscarinic acetylcholine receptor M4 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19644228A1 (de) * | 1996-10-24 | 1998-04-30 | Merck Patent Gmbh | Thienopyrimidine |
DE19752952A1 (de) * | 1997-11-28 | 1999-06-02 | Merck Patent Gmbh | Thienopyrimidine |
DE19819023A1 (de) * | 1998-04-29 | 1999-11-04 | Merck Patent Gmbh | Thienopyrimidine |
KR20010105399A (ko) * | 1999-03-30 | 2001-11-28 | 쓰끼하시 다미까따 | 티에노피리미딘 화합물 및 그의 염, 및 그들의 제조 방법 |
-
2004
- 2004-11-30 ES ES200402877A patent/ES2259892B1/es not_active Expired - Fee Related
-
2005
- 2005-11-28 PE PE2005001378A patent/PE20061080A1/es not_active Application Discontinuation
- 2005-11-28 AR ARP050104957A patent/AR052413A1/es unknown
- 2005-11-29 UY UY29240A patent/UY29240A1/es unknown
- 2005-11-30 WO PCT/EP2005/012773 patent/WO2006058723A1/en active Application Filing
- 2005-11-30 CA CA002588808A patent/CA2588808A1/en not_active Abandoned
- 2005-11-30 EP EP05813317A patent/EP1819712A1/en not_active Withdrawn
- 2005-11-30 US US11/791,451 patent/US20080207645A1/en not_active Abandoned
- 2005-11-30 MX MX2007006172A patent/MX2007006172A/es not_active Application Discontinuation
- 2005-11-30 TW TW094142174A patent/TW200631954A/zh unknown
- 2005-11-30 AU AU2005311422A patent/AU2005311422A1/en not_active Abandoned
- 2005-11-30 RU RU2007124493/04A patent/RU2007124493A/ru not_active Application Discontinuation
- 2005-11-30 CN CNA2005800409703A patent/CN101068817A/zh active Pending
- 2005-11-30 BR BRPI0518117-8A patent/BRPI0518117A/pt not_active IP Right Cessation
- 2005-11-30 KR KR1020077014496A patent/KR20070086652A/ko not_active Application Discontinuation
- 2005-11-30 JP JP2007543766A patent/JP2008521854A/ja active Pending
-
2007
- 2007-05-08 ZA ZA200703700A patent/ZA200703700B/en unknown
- 2007-05-10 IL IL183141A patent/IL183141A0/en unknown
- 2007-06-26 NO NO20073271A patent/NO20073271L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN101068817A (zh) | 2007-11-07 |
ZA200703700B (en) | 2008-07-30 |
ES2259892A1 (es) | 2006-10-16 |
MX2007006172A (es) | 2007-07-13 |
NO20073271L (no) | 2007-06-26 |
RU2007124493A (ru) | 2009-01-10 |
KR20070086652A (ko) | 2007-08-27 |
WO2006058723A8 (en) | 2007-07-12 |
WO2006058723A1 (en) | 2006-06-08 |
AR052413A1 (es) | 2007-03-21 |
TW200631954A (en) | 2006-09-16 |
ES2259892B1 (es) | 2007-11-01 |
IL183141A0 (en) | 2007-09-20 |
UY29240A1 (es) | 2006-02-24 |
US20080207645A1 (en) | 2008-08-28 |
EP1819712A1 (en) | 2007-08-22 |
CA2588808A1 (en) | 2006-06-08 |
JP2008521854A (ja) | 2008-06-26 |
BRPI0518117A (pt) | 2008-11-04 |
AU2005311422A1 (en) | 2006-06-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE20061080A1 (es) | Compuestos derivados de piridotienopirimidina como inhibidores de fosfodiesterasa 4 | |
WO2005092895A3 (en) | Alpha aryl or heteroaryl methyl beta piperidino propanoic acid compounds as orl1-receptor antagonists | |
CL2004000917A1 (es) | Compuestos derivados de tiazol; procedimiento de preparacion; composicion farmaceutica; y su uso para el tratamiento de enfermedades mediadas por 3-cinasa de dosfatidilnositol tal como enfermedades respiratorias, alergias, artritis reumatoide, osteoa | |
NO20051694L (no) | Heterosykliske forbindelser | |
BR0308056A (pt) | Composto, pró-droga, método para a produção de um efeito antibacteriano em um animal de sangue quente, uso de um composto, composição farmacêutica, e, processo para a preparação de um composto | |
ATE437872T1 (de) | Proteinkinaseinhibitoren | |
ATE427932T1 (de) | 11beta-hsd1-inhibitoren | |
MA29649B1 (fr) | Nouveaux derives de 2,4- dianilinopyrimidines, leur preparation, a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk | |
PE20060479A1 (es) | Compuestos heteroaril-aril-ureas como inhibidores de la quinasa | |
TW200738682A (en) | Isoquinoline derivatives | |
ATE429427T1 (de) | Pyrimidinderivate als orexin-rezeptorantagonisten | |
BR0214809A (pt) | Compostos de pirimidina | |
TW200606151A (en) | Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions | |
HUP0400246A2 (hu) | 1,2,4-Trioxolánt tartalmazó maláriaellenes gyógyszerkészítmények és eljárás az előállításukra és az alkalmazásukra | |
PE20070362A1 (es) | COMPUESTOS DERIVADOS DE INDAZOL-4-IL-2,4-PIRIMIDINDIAMINA COMO INHIBIDORES DE TIROSINA QUINASA (QUINASA Syk) | |
PE20070438A1 (es) | Derivados de 4-fenil-pirimidina-6-sustituida-2-carbonitrilo como inhibidores de catepsina k y catepsina s | |
WO2005070884A3 (en) | Heterocyclic compounds useful as growth hormone secretagogues | |
WO2009010789A3 (en) | Pyrimidine derivatives 934 | |
PE20061078A1 (es) | Derivados de piridotienopirimidina como inhibidores de la fosfodiesterasa 4 (pde4) | |
TW200800962A (en) | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | |
TN2010000173A1 (fr) | Antagonistes de cgrp | |
NO20053018D0 (no) | Pyrazoloquinoliner med immunmodulerende aktivitet. | |
ATE435223T1 (de) | Pyrimidin-, chinazolin-, pteridin- und triazinderivate | |
MX2009010727A (es) | Heterociclos como antagonistas de orexina. | |
EA200501593A1 (ru) | Азабициклические производные в качестве антагонистов мускаринового рецептора |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Refusal |