HUP0203640A2 - Eljárás obesitas-ellenes és antidiabetikus tulajdonságokkal rendelkező (aril-etanol)-amin-származékok előállítására - Google Patents

Eljárás obesitas-ellenes és antidiabetikus tulajdonságokkal rendelkező (aril-etanol)-amin-származékok előállítására

Info

Publication number
HUP0203640A2
HUP0203640A2 HU0203640A HUP0203640A HUP0203640A2 HU P0203640 A2 HUP0203640 A2 HU P0203640A2 HU 0203640 A HU0203640 A HU 0203640A HU P0203640 A HUP0203640 A HU P0203640A HU P0203640 A2 HUP0203640 A2 HU P0203640A2
Authority
HU
Hungary
Prior art keywords
group
general formula
alkyl
hydrogen
hydrogen atom
Prior art date
Application number
HU0203640A
Other languages
English (en)
Inventor
Ronnie Maxwell Lawrence
Alan Millar
Original Assignee
Glaxo Group Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd. filed Critical Glaxo Group Ltd.
Publication of HUP0203640A2 publication Critical patent/HUP0203640A2/hu
Publication of HUP0203640A3 publication Critical patent/HUP0203640A3/hu
Publication of HU229043B1 publication Critical patent/HU229043B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom

Abstract

A találmány (IA) általános képletvegyületek - amelyek képletében R1jelentése aríl-, piridil-, tiazolíl-, fenoxi-metil- vagypirimidinilcsoport, amelyek mindegyike adott esetben a következőcsoportból kiválasztott egy vagy több szubsztituenst hordoz:halogénatom, hidroxi-, alkoxi-, alkil-, hidroxi-metil-, trifluor-metil-, -NR6R6 és -NHSO2R6 csoport, ahol R6 jelentése hidrogénatomvagy alkilcsoport; R2 jelentése hidrogénatom vagy alkilcsoport; R3jelentése -CO2R7 általános képletű csoport, ahol R7 jelentésehidrogénatom vagy alkilcsoport; R4 és R5 jelentése egymástólfüggetlenül hidrogénatom, alkil-, alkoxi-karbonil-csoport; és Yjelentése nitrogénatom vagy metincsoport - vagy gyógyászatilagelfogadható sóik előállítási eljárására vonatkozik, amelynek során egy(II) általános képletű diamidot - amelynek képletében R1, R2, R4, R5és Y jelentése a fentiekben meghatározott, és R3 jelentése -CO2R7általános képletű csoport, ahol R7 jelentése 1-6 szénatomosalkilcsoport vagy gyógyászatilag elfogadható sóját redukálják, éskívánt esetben az így nyert (IA) általános képletű vegyületben lévő R7észtercsoportot hidrolizálva egy olyan (IA) általános képletűvegyületet állítanak elő, amelyben R7 jelentése hidrogénatom. Atalálmány kiterjed a találmány szerinti eljárásban alkalmazottintermedierekre és az előállítási eljárásaira is. Ó
HU0203640A 1999-12-11 2000-12-08 Eljárás obesitas-ellenes és antidiabetikus tulajdonságokkal rendelkezõ (aril-etanol)-amin-származékok elõállítására HU229043B1 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9929297.1A GB9929297D0 (en) 1999-12-11 1999-12-11 Process
PCT/GB2000/004697 WO2001042195A1 (en) 1999-12-11 2000-12-08 Process for the preparation of arylethanolamine derivatives having an anti-obesity and anti-diabetic properties

Publications (3)

Publication Number Publication Date
HUP0203640A2 true HUP0203640A2 (hu) 2003-02-28
HUP0203640A3 HUP0203640A3 (en) 2003-08-28
HU229043B1 HU229043B1 (hu) 2013-07-29

Family

ID=10866125

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0203640A HU229043B1 (hu) 1999-12-11 2000-12-08 Eljárás obesitas-ellenes és antidiabetikus tulajdonságokkal rendelkezõ (aril-etanol)-amin-származékok elõállítására

Country Status (23)

Country Link
US (1) US6548523B2 (hu)
EP (1) EP1235788B1 (hu)
JP (1) JP4903964B2 (hu)
KR (1) KR100683614B1 (hu)
CN (1) CN1224609C (hu)
AT (1) ATE292110T1 (hu)
AU (1) AU769387B2 (hu)
BR (1) BRPI0016187B1 (hu)
CA (1) CA2394117C (hu)
CZ (1) CZ303143B6 (hu)
DE (1) DE60019157T2 (hu)
ES (1) ES2236020T3 (hu)
GB (1) GB9929297D0 (hu)
HK (1) HK1045988B (hu)
HU (1) HU229043B1 (hu)
IL (1) IL149585A0 (hu)
NO (1) NO323239B1 (hu)
NZ (1) NZ518795A (hu)
PL (1) PL200540B1 (hu)
PT (1) PT1235788E (hu)
TR (1) TR200201528T2 (hu)
WO (1) WO2001042195A1 (hu)
ZA (1) ZA200204585B (hu)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10230147A1 (de) * 2001-10-09 2004-01-15 Profos Ag Verfahren zur unspezifischen Anreicherung von Bakterienzellen
US7158049B2 (en) * 2003-03-24 2007-01-02 Schlumberger Technology Corporation Wireless communication circuit
US8213085B2 (en) * 2008-01-18 2012-07-03 Visera Technologies Company Limited Image sensor device with high photosensitivity
US8778998B2 (en) 2009-04-10 2014-07-15 Auspex Pharmaceuticals, Inc. Biphenyl-3-carboxylic acid modulators of beta-3-adrenoreceptor
US9907767B2 (en) 2010-08-03 2018-03-06 Velicept Therapeutics, Inc. Pharmaceutical compositions and the treatment of overactive bladder
CA2807135C (en) 2010-08-03 2019-05-14 Altherx, Inc. Combinations of beta - 3 adrenergic receptor agonists and muscarinic receptor antagonists for treating overactive bladder
SG11201404776PA (en) 2012-02-09 2014-09-26 Altherx Inc Combination of muscarinic receptor antagonists and beta- 3 adrenoceptor agonists for treating overactive bladder
EP3226849A4 (en) 2014-12-03 2018-05-09 Velicept Therapeutics, Inc. Compositions and methods of using modified release solabegron for lower urinary tract symptoms
FI3365321T3 (fi) 2015-10-23 2024-01-02 B3Ar Therapeutics Inc Solabegron-Zwitterioni ja sen käyttöjä

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1551260A (en) 1976-02-09 1979-08-30 Allen & Hanburys Ltd Phenylethanolamine derivatives
JP2577222B2 (ja) * 1987-04-10 1997-01-29 興和株式会社 新規な置換アニリド誘導体
NO179246C (no) * 1991-11-20 1996-09-04 Sankyo Co Aromatiske amino-alkoholderivater og mellomprodukter til fremstilling derav
GB9525121D0 (en) * 1995-12-08 1996-02-07 Glaxo Group Ltd Chemical compounds
WO1999057098A2 (en) * 1998-05-01 1999-11-11 Abbott Laboratories Substituted beta-amino acid inhibitors of methionine aminopeptidase-2
GB9812709D0 (en) * 1998-06-13 1998-08-12 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
CN1409700A (zh) 2003-04-09
US20020198220A1 (en) 2002-12-26
CN1224609C (zh) 2005-10-26
ATE292110T1 (de) 2005-04-15
EP1235788A1 (en) 2002-09-04
HU229043B1 (hu) 2013-07-29
NO20022758D0 (no) 2002-06-10
AU2191101A (en) 2001-06-18
BRPI0016187B1 (pt) 2016-08-02
JP2003516383A (ja) 2003-05-13
CA2394117C (en) 2011-10-04
AU769387B2 (en) 2004-01-22
HK1045988B (zh) 2005-07-15
IL149585A0 (en) 2002-11-10
ZA200204585B (en) 2003-12-31
US6548523B2 (en) 2003-04-15
KR100683614B1 (ko) 2007-02-16
PT1235788E (pt) 2005-08-31
EP1235788B1 (en) 2005-03-30
PL200540B1 (pl) 2009-01-30
DE60019157T2 (de) 2006-02-02
BR0016187A (pt) 2002-08-13
HUP0203640A3 (en) 2003-08-28
NO323239B1 (no) 2007-02-05
NO20022758L (no) 2002-07-01
JP4903964B2 (ja) 2012-03-28
HK1045988A1 (en) 2002-12-20
DE60019157D1 (de) 2005-05-04
GB9929297D0 (en) 2000-02-02
CZ303143B6 (cs) 2012-05-02
ES2236020T3 (es) 2005-07-16
KR20020061636A (ko) 2002-07-24
PL356483A1 (en) 2004-06-28
TR200201528T2 (tr) 2002-09-23
CA2394117A1 (en) 2001-06-14
CZ20022017A3 (cs) 2003-01-15
NZ518795A (en) 2004-02-27
WO2001042195A1 (en) 2001-06-14

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MM4A Lapse of definitive patent protection due to non-payment of fees