DE60336734D1 - Sidasen - Google Patents

Sidasen

Info

Publication number
DE60336734D1
DE60336734D1 DE60336734T DE60336734T DE60336734D1 DE 60336734 D1 DE60336734 D1 DE 60336734D1 DE 60336734 T DE60336734 T DE 60336734T DE 60336734 T DE60336734 T DE 60336734T DE 60336734 D1 DE60336734 D1 DE 60336734D1
Authority
DE
Germany
Prior art keywords
compounds
methylthioadenosine
phosphorylases
infections
purine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60336734T
Other languages
English (en)
Inventor
Gary Brian Evans
Richard Hubert Furneaux
Dirk Henning Lenz
Vern L Schramm
Peter Charles Tyler
Olga Vladimirovna Zubkova
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IND RES Ltd
Industrial Research Ltd
Albert Einstein College of Medicine
Original Assignee
IND RES Ltd
Industrial Research Ltd
Albert Einstein College of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IND RES Ltd, Industrial Research Ltd, Albert Einstein College of Medicine filed Critical IND RES Ltd
Application granted granted Critical
Publication of DE60336734D1 publication Critical patent/DE60336734D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrane Compounds (AREA)
  • Seal Device For Vehicle (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE60336734T 2002-08-21 2003-08-21 Sidasen Expired - Lifetime DE60336734D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NZ52091902 2002-08-21
PCT/NZ2003/000186 WO2004018496A1 (en) 2002-08-21 2003-08-21 Inhibitors of nucleoside phosphorylases and nucleosidases

Publications (1)

Publication Number Publication Date
DE60336734D1 true DE60336734D1 (de) 2011-05-26

Family

ID=31944950

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60336734T Expired - Lifetime DE60336734D1 (de) 2002-08-21 2003-08-21 Sidasen

Country Status (18)

Country Link
US (2) US7553839B2 (de)
EP (1) EP1539783B1 (de)
JP (1) JP4682314B2 (de)
KR (1) KR101081226B1 (de)
CN (1) CN100379750C (de)
AT (1) ATE505474T1 (de)
AU (1) AU2003258911B2 (de)
BR (1) BRPI0313664B8 (de)
CA (1) CA2496698C (de)
CY (1) CY1111700T1 (de)
DE (1) DE60336734D1 (de)
DK (1) DK1539783T3 (de)
ES (1) ES2363766T3 (de)
HK (1) HK1085219A1 (de)
PT (1) PT1539783E (de)
RU (1) RU2330042C2 (de)
SI (1) SI1539783T1 (de)
WO (1) WO2004018496A1 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985848A (en) * 1997-10-14 1999-11-16 Albert Einstein College Of Medicine Of Yeshiva University Inhibitors of nucleoside metabolism
JP4430247B2 (ja) 1999-04-08 2010-03-10 インダストリアル リサーチ リミテッド ヌクレオシド代謝インヒビターの製造方法
DK1539783T3 (da) 2002-08-21 2011-06-20 Einstein Coll Med Inhibitorer af nucleosidphosphorylaser og nucleosidaser
NZ523970A (en) * 2003-02-04 2005-02-25 Ind Res Ltd Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases
US7557113B2 (en) 2003-08-26 2009-07-07 Teijin Pharma Limited Substituted pyrrolo[3,2-d]pyrimidine derivatives
CA2536887C (en) * 2003-08-26 2012-03-06 Teijin Pharma Limited Pyrrolopyrimidinone derivatives
NZ533360A (en) * 2004-06-04 2007-02-23 Ind Res Ltd Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds
EP1771452A4 (de) * 2004-07-27 2009-07-15 Biocryst Pharm Inc 5'-methylthioadenosin-phosphorylase- und 5'methylthioadenosin-/s-adenosylhomocystein-nucleosidase-hemmer
NZ540160A (en) * 2005-05-20 2008-03-28 Einstein Coll Med Inhibitors of nucleoside phosphorylases
WO2007016291A2 (en) * 2005-07-27 2007-02-08 Albert Einstein College Of Medicine Of Yeshiva University Transition state structure of 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidases
NZ544187A (en) * 2005-12-15 2008-07-31 Ind Res Ltd Deazapurine analogs of 1'-aza-l-nucleosides
US20090053221A1 (en) * 2006-01-17 2009-02-26 Cheung Nai-Kong V Immune response enhancing glucan
US8394950B2 (en) * 2006-02-22 2013-03-12 Industrial Research Limited Analogues of coformycin and their use for treating protozoan parasite infections
AU2006200809B2 (en) * 2006-02-24 2013-11-07 Albert Einstein College Of Medicine Of Yeshiva University Methods of treating cancer
US20110092521A1 (en) * 2006-02-24 2011-04-21 Richard Hubert Furneaux Methods of Treating Diseases Using Inhibitors of Nucleoside Phosphorylases and Nucleosidases
WO2007097647A1 (en) * 2006-02-24 2007-08-30 Albert Einstein College Of Medicine Of Yeshiva University Methods of treating cancer
CN101094080B (zh) * 2006-06-22 2012-06-20 华为技术有限公司 一种即按即通系统中的计费方法
CA2662626C (en) * 2006-09-07 2016-07-26 Industrial Research Limited Acyclic amine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase
ATE502038T1 (de) 2006-09-07 2011-04-15 Ind Res Ltd Azyklische amininhibitoren von nukleosidphosphorylasen und hydrolasen
CN101600711A (zh) * 2006-12-22 2009-12-09 工业研究有限公司 核苷酶和磷酸化酶抑制剂的氮杂环丁烷类似物
WO2009082247A1 (en) * 2007-12-21 2009-07-02 Industrial Research Limited Process for preparing immucillins having a methylene link
UA103195C2 (uk) 2008-08-11 2013-09-25 Глаксосмитклайн Ллк Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань
US20110190265A1 (en) * 2008-09-22 2011-08-04 Schramm Vern L Methods and compositions for treating bacterial infections by inhibiting quorum sensing
AU2010230008B2 (en) * 2009-03-24 2015-06-04 Biocryst Pharmaceuticals, Inc. Useful pharmaceutical salts of 7-[(3R, 4R)-3-Hydroxy-4-hydroxymethyl-pyrrolidin-1- ylmethyl]-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one
CA2768291C (en) * 2009-07-17 2018-03-27 Albert Einstein College Of Medicine Of Yeshiva University 3-hydroxypyrrolidine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase
US9290501B2 (en) 2010-11-29 2016-03-22 Albert Einstein College Of Medicine, Inc. Methods, assays and compounds for treating bacterial infections by inhibiting methylthioinosine phosphorylase
WO2012122532A2 (en) * 2011-03-09 2012-09-13 Biocryst Pharmaceuticals, Inc. Compositions and methods for treatment of hyperuricemia
RU2631482C2 (ru) 2011-07-22 2017-09-22 ГЛАКСОСМИТКЛАЙН ЭлЭлСи Композиция
US11186575B2 (en) 2012-08-07 2021-11-30 Alber Einslein College of Medicine Treatment of helicobacter pylori infections
WO2014031815A1 (en) 2012-08-24 2014-02-27 Glaxosmithkline Llc Pyrazolopyrimidine compounds
US9994574B2 (en) 2012-11-12 2018-06-12 Victoria Link Limited Salt and polymorphic forms of (3R,4S)-L-((4-amino-5H-pyrrolo[3,2,-d]pyrimidin-7-yl)methyl)-4(methylthiomethyl)pyrodin-3-ol(MTDIA)
EP2922550B1 (de) 2012-11-20 2017-04-19 Glaxosmithkline LLC Neuartige verbindungen
WO2014081645A1 (en) 2012-11-20 2014-05-30 Glaxosmithkline Llc Novel compounds
KR20150085081A (ko) 2012-11-20 2015-07-22 글락소스미스클라인 엘엘씨 신규 화합물
US9452217B2 (en) 2013-06-22 2016-09-27 Nitor Therapeutics Methods for potentiating immune response for the treatment of infectious diseases and cancer
NZ724103A (en) 2014-02-12 2020-07-31 Albert Einstein College Medicine Inc Treatment of h. pylori infections using mtan inhibitors
EP2913333A1 (de) * 2014-02-27 2015-09-02 Laboratoire Biodim 3H-Thieno[3,4]pyrimidin-4-on und Pyrrolopyrimidon-Verbindungen als Gram-Positive Antibakteria
CN108794628A (zh) * 2018-05-28 2018-11-13 广东工业大学 一种抗幽门螺杆菌的卵黄抗体制备方法及应用
GB202110403D0 (en) 2021-07-20 2021-09-01 Laevoroc Immunology Ulodesine Salt
GB202218782D0 (en) 2022-12-13 2023-01-25 Mehrling Thomas Purine nucleoside phosphorylase inhibitor for metabolic syndrome

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT61765A (en) * 1989-10-31 1993-03-01 Biocryst Inc Process for producing purine nucleoside phosphorylase inhibitors and pharmaceutical compositions comprising same as active ingredient
JPH07242668A (ja) * 1994-03-08 1995-09-19 Nippon Kayaku Co Ltd 新規なアゼチジン誘導体
JPH10507171A (ja) * 1994-10-05 1998-07-14 カイロサイエンス・リミテッド Ｐｎｐインヒビターとしてのプリンおよびグアニン化合物
ES2203683T3 (es) 1995-03-29 2004-04-16 Taiho Pharmaceutical Company Limited Derivados de uracilo, agentes de potencializacion de efecto antitumoral y agente antitumoral que incluye estos derivados.
WO1997031008A1 (en) * 1996-02-23 1997-08-28 Industrial Research Limited Enzyme detection/assay method and substrates
US5985848A (en) * 1997-10-14 1999-11-16 Albert Einstein College Of Medicine Of Yeshiva University Inhibitors of nucleoside metabolism
JP4430247B2 (ja) 1999-04-08 2010-03-10 インダストリアル リサーチ リミテッド ヌクレオシド代謝インヒビターの製造方法
US6448799B1 (en) * 1999-09-30 2002-09-10 Hitachi Electronics Engineering Co., Ltd. Timing adjustment method and apparatus for semiconductor IC tester
JP4110347B2 (ja) 1999-11-05 2008-07-02 大鵬薬品工業株式会社 抗ｈｉｖ剤
WO2002018371A1 (en) * 2000-08-29 2002-03-07 Industrial Research Limited Nucleoside metabolism inhibitors
US6458799B1 (en) 2000-08-31 2002-10-01 Biocryst Pharmaceuticals, Inc. Deazaguanine analog, preparation thereof and use thereof
US7098334B2 (en) * 2002-03-25 2006-08-29 Industrial Research Limited 4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases
DK1539783T3 (da) 2002-08-21 2011-06-20 Einstein Coll Med Inhibitorer af nucleosidphosphorylaser og nucleosidaser
NZ523970A (en) * 2003-02-04 2005-02-25 Ind Res Ltd Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases
NZ533360A (en) * 2004-06-04 2007-02-23 Ind Res Ltd Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds
EP1771452A4 (de) 2004-07-27 2009-07-15 Biocryst Pharm Inc 5'-methylthioadenosin-phosphorylase- und 5'methylthioadenosin-/s-adenosylhomocystein-nucleosidase-hemmer
NZ540160A (en) * 2005-05-20 2008-03-28 Einstein Coll Med Inhibitors of nucleoside phosphorylases
WO2007016291A2 (en) 2005-07-27 2007-02-08 Albert Einstein College Of Medicine Of Yeshiva University Transition state structure of 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidases
NZ544187A (en) * 2005-12-15 2008-07-31 Ind Res Ltd Deazapurine analogs of 1'-aza-l-nucleosides
US20110092521A1 (en) 2006-02-24 2011-04-21 Richard Hubert Furneaux Methods of Treating Diseases Using Inhibitors of Nucleoside Phosphorylases and Nucleosidases
WO2007097647A1 (en) 2006-02-24 2007-08-30 Albert Einstein College Of Medicine Of Yeshiva University Methods of treating cancer
CA2662626C (en) * 2006-09-07 2016-07-26 Industrial Research Limited Acyclic amine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase
ATE502038T1 (de) 2006-09-07 2011-04-15 Ind Res Ltd Azyklische amininhibitoren von nukleosidphosphorylasen und hydrolasen
WO2008039324A1 (en) * 2006-09-26 2008-04-03 Albert Einstein College Of Medicine Of Yeshiva University Transition state structure of human 5'-methylthioadenosine phosphorylase
CN101600711A (zh) * 2006-12-22 2009-12-09 工业研究有限公司 核苷酶和磷酸化酶抑制剂的氮杂环丁烷类似物
WO2009082247A1 (en) 2007-12-21 2009-07-02 Industrial Research Limited Process for preparing immucillins having a methylene link
US20110190265A1 (en) 2008-09-22 2011-08-04 Schramm Vern L Methods and compositions for treating bacterial infections by inhibiting quorum sensing
CA2768291C (en) 2009-07-17 2018-03-27 Albert Einstein College Of Medicine Of Yeshiva University 3-hydroxypyrrolidine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase

Also Published As

Publication number Publication date
RU2005107714A (ru) 2006-01-20
CN1692120A (zh) 2005-11-02
ATE505474T1 (de) 2011-04-15
EP1539783A1 (de) 2005-06-15
BR0313664A (pt) 2005-07-12
JP2006501239A (ja) 2006-01-12
CN100379750C (zh) 2008-04-09
HK1085219A1 (en) 2006-08-18
CA2496698A1 (en) 2004-03-04
AU2003258911B2 (en) 2009-11-19
KR101081226B1 (ko) 2011-11-07
SI1539783T1 (sl) 2011-08-31
WO2004018496A1 (en) 2004-03-04
JP4682314B2 (ja) 2011-05-11
CA2496698C (en) 2012-01-24
BRPI0313664B1 (pt) 2021-03-23
EP1539783A4 (de) 2010-05-19
AU2003258911A1 (en) 2004-03-11
US7553839B2 (en) 2009-06-30
ES2363766T3 (es) 2011-08-16
CY1111700T1 (el) 2015-10-07
US8173662B2 (en) 2012-05-08
KR20050093756A (ko) 2005-09-23
PT1539783E (pt) 2011-06-01
EP1539783B1 (de) 2011-04-13
US20060160765A1 (en) 2006-07-20
DK1539783T3 (da) 2011-06-20
US20090239885A1 (en) 2009-09-24
BRPI0313664B8 (pt) 2021-05-25
RU2330042C2 (ru) 2008-07-27

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