DE69939749D1 - Aromatische heterocyclen mit hiv integrase inhibierenden eigenschaften - Google Patents

Aromatische heterocyclen mit hiv integrase inhibierenden eigenschaften

Info

Publication number
DE69939749D1
DE69939749D1 DE69939749T DE69939749T DE69939749D1 DE 69939749 D1 DE69939749 D1 DE 69939749D1 DE 69939749 T DE69939749 T DE 69939749T DE 69939749 T DE69939749 T DE 69939749T DE 69939749 D1 DE69939749 D1 DE 69939749D1
Authority
DE
Germany
Prior art keywords
aromatic heterocycles
hiv integrase
inhibiting properties
integrase inhibiting
properties
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69939749T
Other languages
English (en)
Inventor
Toshio Fujishita
Tomokazu Yoshinaga
Akihiko Sato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Application granted granted Critical
Publication of DE69939749D1 publication Critical patent/DE69939749D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
DE69939749T 1998-12-25 1999-12-17 Aromatische heterocyclen mit hiv integrase inhibierenden eigenschaften Expired - Lifetime DE69939749D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP37127098 1998-12-25
JP24747999 1999-09-01
PCT/JP1999/007101 WO2000039086A1 (fr) 1998-12-25 1999-12-17 Composes heterocycliques aromatiques possedant des activites inhibitrices de l'integrase du vih

Publications (1)

Publication Number Publication Date
DE69939749D1 true DE69939749D1 (de) 2008-11-27

Family

ID=26538287

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69939749T Expired - Lifetime DE69939749D1 (de) 1998-12-25 1999-12-17 Aromatische heterocyclen mit hiv integrase inhibierenden eigenschaften

Country Status (22)

Country Link
US (3) US6620841B1 (de)
EP (1) EP1142872B1 (de)
JP (1) JP3929244B2 (de)
KR (1) KR20010089708A (de)
CN (1) CN1178913C (de)
AP (1) AP2001002169A0 (de)
AT (1) ATE411286T1 (de)
AU (1) AU763040B2 (de)
BR (1) BR9916583A (de)
CA (1) CA2353961A1 (de)
CZ (1) CZ20012160A3 (de)
DE (1) DE69939749D1 (de)
HK (1) HK1042701A1 (de)
HU (1) HUP0201472A3 (de)
ID (1) ID29027A (de)
IL (1) IL143958A0 (de)
NO (1) NO20013179L (de)
NZ (1) NZ512184A (de)
PL (1) PL348596A1 (de)
RU (1) RU2225860C2 (de)
TR (1) TR200101886T2 (de)
WO (1) WO2000039086A1 (de)

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CA2338490A1 (en) 1998-07-27 2000-02-10 Sergio Altamura Diketoacid-derivatives as inhibitors of polymerases
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AU763231B2 (en) * 1999-06-02 2003-07-17 Shionogi & Co., Ltd. Novel processes for the preparation of substituted propenone derivatives
WO2001000578A1 (en) * 1999-06-25 2001-01-04 Merck & Co., Inc. 1-(aromatic- or heteroaromatic-substituted)-3-(heteroaromatic substituted)-1,3-propanediones and uses thereof
US20030171406A1 (en) * 2000-06-13 2003-09-11 Akihiko Sato Medicinal compositions containing propenone derivatives
EP1297834A4 (de) * 2000-06-14 2007-05-09 Shionogi & Co Enzyminhibitor mit zwei divalenten metallionen als aktiven zentren
WO2002038771A1 (fr) * 2000-11-09 2002-05-16 Shionogi & Co., Ltd. Integrases du hiv tolerantes aux medicaments
WO2003016275A1 (en) 2001-08-10 2003-02-27 Shionogi & Co., Ltd. Antiviral agent
CN102229605B (zh) * 2001-10-26 2015-01-14 Msd意大利有限公司 关于hiv整合酶的n-取代的羟基嘧啶酮甲酰胺抑制剂
TW200407132A (en) * 2001-11-15 2004-05-16 Shionogi & Co Process for producing 1-H-1,2,4-triazole-3-carboxylic acid ester
WO2003047564A1 (fr) * 2001-12-05 2003-06-12 Shionogi & Co., Ltd. Dérivé ayant une activité d'inhibition de l'intégrase du vih
WO2004024693A1 (ja) 2002-08-13 2004-03-25 Shionogi & Co., Ltd. Ｈｉｖインテグラーゼ阻害活性を有するヘテロ環化合物
AU2003301439A1 (en) 2002-10-16 2004-05-04 Gilead Sciences, Inc. Pre-organized tricyclic integrase inhibitor compounds
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US7250421B2 (en) * 2005-01-31 2007-07-31 University Of Georgia Research Foundation, Inc. Diketo acids with nucleobase scaffolds: anti-HIV replication inhibitors targeted at HIV integrase
JP2008542352A (ja) * 2005-06-01 2008-11-27 ビオアリアンス ファルマ キノリン化合物及び他のｈｉｖ感染治療薬を含む相乗作用のコンビネーション
EP2066670A2 (de) * 2006-05-16 2009-06-10 Gilead Sciences, Inc. Integraseinhibitoren
AU2007275805A1 (en) * 2006-07-19 2008-01-24 University Of Georgia Research Foundation, Inc. Pyridinone diketo acids: Inhibitors of HIV replication in combination therapy
WO2008041882A1 (fr) * 2006-10-03 2008-04-10 Viktor Veniaminovich Tets Procédé pour agir sur les virus au moyen d'une substance à base de 2,8-dithioxo-1h- pyrano[2,3-d;6,5-d'] dipyrimidine et de leurs analogues 10-aza (et variantes)
JP5562255B2 (ja) 2008-01-25 2014-07-30 キメリクス，インコーポレイテッド ウイルス感染を治療する方法
US8664255B2 (en) 2008-10-20 2014-03-04 The Texas A&M University System Inhibitors of mycobacterium tuberculosis malate synthase, methods of making and uses thereof
WO2011071849A2 (en) 2009-12-07 2011-06-16 University Of Georgia Research Foundation, Inc. Pyridinone hydroxycyclopentyl carboxamides: hiv integrase inhibitors with therapeutic applications
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CN101928258B (zh) * 2010-08-18 2014-10-29 杭州民生药业有限公司 1-(2-取代苯胺基-4-甲基-噻唑-5)-3-取代苯基-丙烯酮衍生物、制备方法及其制药用途
CA2832109C (en) 2011-06-10 2021-07-06 Oregon Health & Science University Cmv glycoproteins and recombinant vectors
WO2014026033A1 (en) 2012-08-08 2014-02-13 University Of Florida Research Foundation, Inc. Cross-reactive t cell epitopes of hiv, siv, and fiv for vaccines in humans and cats
LT3608325T (lt) 2012-12-21 2022-09-12 Gilead Sciences, Inc. Policikliniai karbamoilpiridono junginiai ir jų farmacinis naudojimas
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ES2859102T3 (es) 2013-07-12 2021-10-01 Gilead Sciences Inc Compuestos de carbamoilpiridona policíclica y su uso para el tratamiento de infecciones por VIH
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TW201613936A (en) 2014-06-20 2016-04-16 Gilead Sciences Inc Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide
TWI677489B (zh) 2014-06-20 2019-11-21 美商基利科學股份有限公司 多環型胺甲醯基吡啶酮化合物之合成
TWI695003B (zh) 2014-12-23 2020-06-01 美商基利科學股份有限公司 多環胺甲醯基吡啶酮化合物及其醫藥用途
TR201905009T4 (tr) 2015-04-02 2019-05-21 Gilead Sciences Inc Polisiklik-karbamoilpiridon bileşikleri ve bunların farmasötik kullanımları.
CN106905244B (zh) * 2017-02-27 2019-08-16 武汉工程大学 二芳基嘧啶-二酮酸类杂合型hiv-1抑制剂及其制备方法
CN114829357A (zh) * 2019-10-28 2022-07-29 中国科学院上海药物研究所 五元杂环氧代羧酸类化合物及其医药用途
CN111943899B (zh) * 2020-09-08 2023-04-21 河北凯诺中星科技有限公司 一种5-甲酸乙酯四氮唑的合成方法
CN113683574B (zh) * 2021-09-06 2023-11-17 上海晋鲁医药科技有限公司 一种合成1-甲基-1h-1,2,4-三唑-3-甲酸甲酯的方法

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Also Published As

Publication number Publication date
HUP0201472A3 (en) 2006-03-28
PL348596A1 (en) 2002-06-03
CA2353961A1 (en) 2000-07-06
NO20013179L (no) 2001-08-27
US20040002485A1 (en) 2004-01-01
CZ20012160A3 (cs) 2001-10-17
HK1042701A1 (zh) 2002-08-23
NZ512184A (en) 2003-08-29
TR200101886T2 (tr) 2001-12-21
EP1142872A1 (de) 2001-10-10
RU2225860C2 (ru) 2004-03-20
ATE411286T1 (de) 2008-10-15
CN1335834A (zh) 2002-02-13
EP1142872A4 (de) 2002-04-17
AU763040B2 (en) 2003-07-10
BR9916583A (pt) 2001-09-25
CN1178913C (zh) 2004-12-08
AU1797900A (en) 2000-07-31
HUP0201472A2 (hu) 2003-10-28
EP1142872B1 (de) 2008-10-15
WO2000039086A1 (fr) 2000-07-06
US7098201B2 (en) 2006-08-29
ID29027A (id) 2001-07-26
RU2001120016A (ru) 2003-12-10
US6645956B1 (en) 2003-11-11
US6620841B1 (en) 2003-09-16
KR20010089708A (ko) 2001-10-08
NO20013179D0 (no) 2001-06-22
AP2001002169A0 (en) 2001-06-30
IL143958A0 (en) 2002-04-21
JP3929244B2 (ja) 2007-06-13

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