MA26613A1 - Pyrroles substitues - Google Patents

Pyrroles substitues

Info

Publication number
MA26613A1
MA26613A1 MA25492A MA25492A MA26613A1 MA 26613 A1 MA26613 A1 MA 26613A1 MA 25492 A MA25492 A MA 25492A MA 25492 A MA25492 A MA 25492A MA 26613 A1 MA26613 A1 MA 26613A1
Authority
MA
Morocco
Prior art keywords
substituted pyrroles
pyrroles
substituted
Prior art date
Application number
MA25492A
Other languages
English (en)
Inventor
Mary Huryn Donna
Ke June
Hooda Dhingra Urvashi
Federico Weber Giuseppe
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA26613A1 publication Critical patent/MA26613A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
MA25492A 1998-03-17 1999-03-12 Pyrroles substitues MA26613A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7833198P 1998-03-17 1998-03-17

Publications (1)

Publication Number Publication Date
MA26613A1 true MA26613A1 (fr) 2004-12-20

Family

ID=22143350

Family Applications (1)

Application Number Title Priority Date Filing Date
MA25492A MA26613A1 (fr) 1998-03-17 1999-03-12 Pyrroles substitues

Country Status (34)

Country Link
US (1) US6048887A (fr)
EP (1) EP1064279B1 (fr)
JP (2) JP5026633B2 (fr)
KR (1) KR100659411B1 (fr)
CN (1) CN1127500C (fr)
AR (1) AR018162A1 (fr)
AT (1) ATE243693T1 (fr)
AU (1) AU755673B2 (fr)
BR (1) BR9908882A (fr)
CA (1) CA2322689C (fr)
CO (1) CO5070675A1 (fr)
CZ (1) CZ299068B6 (fr)
DE (1) DE69909068T2 (fr)
DK (1) DK1064279T3 (fr)
ES (1) ES2203111T3 (fr)
HK (1) HK1036452A1 (fr)
HR (1) HRP20000585B1 (fr)
HU (1) HU228831B1 (fr)
ID (1) ID26353A (fr)
IL (1) IL138247A (fr)
MA (1) MA26613A1 (fr)
MY (1) MY121046A (fr)
NO (1) NO320306B1 (fr)
NZ (1) NZ506476A (fr)
PE (1) PE20000340A1 (fr)
PL (1) PL195323B1 (fr)
PT (1) PT1064279E (fr)
RS (1) RS49965B (fr)
RU (1) RU2208612C2 (fr)
SA (1) SA99191295B1 (fr)
TR (1) TR200002580T2 (fr)
TW (1) TW539676B (fr)
WO (1) WO1999047518A1 (fr)
ZA (1) ZA992072B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE243693T1 (de) * 1998-03-17 2003-07-15 Hoffmann La Roche Substituierte bisindolylmaleimide zur inhibierung der zellproliferation
US6350786B1 (en) * 1998-09-22 2002-02-26 Hoffmann-La Roche Inc. Stable complexes of poorly soluble compounds in ionic polymers
MXPA02003667A (es) * 1999-10-12 2002-08-30 Hoffmann La Roche Pirroles sustituidos como agentes antiproliferativos para tratamiento del cancer.
US6559164B1 (en) 1999-10-12 2003-05-06 Hoffmann-La Roche Inc. Substituted pyrroles suitable for continuous infusion
US6313143B1 (en) * 1999-12-16 2001-11-06 Hoffmann-La Roche Inc. Substituted pyrroles
US6281356B1 (en) * 1999-12-22 2001-08-28 Hoffmann-La Roche Inc. Substituted pyrroles
US6326501B1 (en) * 2000-04-19 2001-12-04 Hoffmann-La Roche Inc. Methylation of indole compounds using dimethyl carbonate
US7129250B2 (en) * 2000-05-19 2006-10-31 Aegera Therapeutics Inc. Neuroprotective and anti-proliferative compounds
CA2308994A1 (fr) * 2000-05-19 2001-11-19 Aegera Therapeutics Inc. Composes neuroprotecteurs
US6482847B2 (en) 2000-10-03 2002-11-19 Hoffmann-La Roche Inc. Amorphous form of cell cycle inhibitor having improved solubility and bioavailability
US6469179B1 (en) 2000-10-03 2002-10-22 Hoffmann-La Roche Inc. Amorphous form of cell cycle inhibitor having improved solubility and bioavailability
US6548531B2 (en) 2001-02-09 2003-04-15 Hoffmann-La Roche Inc. Method for cancer therapy
WO2002102373A1 (fr) * 2001-06-15 2002-12-27 F. Hoffmann-La Roche Ag Procede d'administration d'un agent destine a la therapie du cancer
US20030139373A1 (en) * 2001-11-20 2003-07-24 Breimer Lars Holger Method for cancer therapy
WO2008117935A1 (fr) * 2007-03-28 2008-10-02 Industry-Academic Cooperation Foundation, Yonsei University Molécules activatrices des cellules nk, cellules nk et compositions pharmaceutiques contenant celles-ci
CN102924437B (zh) * 2012-11-19 2014-07-02 东华大学 3-哌嗪基-4-吲哚马来酰亚胺化合物及其制备和应用
WO2019000224A1 (fr) * 2017-06-27 2019-01-03 中国海洋大学 Dérivé de bisindolylmaléimide, son procédé de préparation et son utilisation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ227850A (en) * 1988-02-10 1991-11-26 Hoffmann La Roche Indole substituted pyrrole derivatives; preparatory process and medicaments for use against inflammatory immunological, bronchopulmonary or vascular disorders
US5380746A (en) * 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
EP1449529B1 (fr) * 1993-12-23 2010-01-27 Eli Lilly And Company Inhibiteurs de la protéine-kinase c
PE91698A1 (es) * 1996-07-29 1998-12-24 Hoffmann La Roche Pirroles sustituidos
PE91598A1 (es) * 1996-07-29 1998-12-24 Hoffmann La Roche Pirroles sustituidos
PE91498A1 (es) * 1996-07-29 1998-12-22 Hoffmann La Roche Pirroles sustituidos
ATE243693T1 (de) * 1998-03-17 2003-07-15 Hoffmann La Roche Substituierte bisindolylmaleimide zur inhibierung der zellproliferation

Also Published As

Publication number Publication date
PL195323B1 (pl) 2007-09-28
SA99191295B1 (ar) 2006-04-26
ZA992072B (en) 1999-09-22
CN1293671A (zh) 2001-05-02
NO20004579L (no) 2000-09-14
MY121046A (en) 2005-12-30
RS49965B (sr) 2008-09-29
PE20000340A1 (es) 2000-05-13
CA2322689A1 (fr) 1999-09-23
IL138247A (en) 2005-08-31
PL342964A1 (en) 2001-07-16
AR018162A1 (es) 2001-10-31
CN1127500C (zh) 2003-11-12
CO5070675A1 (es) 2001-08-28
WO1999047518A1 (fr) 1999-09-23
KR20010041995A (ko) 2001-05-25
AU3409999A (en) 1999-10-11
HRP20000585B1 (en) 2009-02-28
ATE243693T1 (de) 2003-07-15
HRP20000585A2 (en) 2001-08-31
DK1064279T3 (da) 2003-10-06
CZ20003384A3 (cs) 2000-12-13
JP5026633B2 (ja) 2012-09-12
NO320306B1 (no) 2005-11-21
JP2002506864A (ja) 2002-03-05
YU55200A (sh) 2002-11-15
HK1036452A1 (en) 2002-01-04
HUP0101258A3 (en) 2002-08-28
DE69909068D1 (de) 2003-07-31
ES2203111T3 (es) 2004-04-01
IL138247A0 (en) 2001-10-31
TW539676B (en) 2003-07-01
HUP0101258A2 (hu) 2001-10-28
DE69909068T2 (de) 2004-05-06
AU755673B2 (en) 2002-12-19
JP2010222366A (ja) 2010-10-07
EP1064279A1 (fr) 2001-01-03
CA2322689C (fr) 2008-11-25
KR100659411B1 (ko) 2006-12-18
CZ299068B6 (cs) 2008-04-16
ID26353A (id) 2000-12-14
US6048887A (en) 2000-04-11
NZ506476A (en) 2003-12-19
TR200002580T2 (tr) 2000-11-21
EP1064279B1 (fr) 2003-06-25
HU228831B1 (en) 2013-05-28
PT1064279E (pt) 2003-10-31
NO20004579D0 (no) 2000-09-14
RU2208612C2 (ru) 2003-07-20
BR9908882A (pt) 2000-11-21

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