ID26353A - Bisindolimaleimida tersubstitusi untuk inhibisi proliferasi sel - Google Patents

Bisindolimaleimida tersubstitusi untuk inhibisi proliferasi sel

Info

Publication number
ID26353A
ID26353A IDW20001730A ID20001730A ID26353A ID 26353 A ID26353 A ID 26353A ID W20001730 A IDW20001730 A ID W20001730A ID 20001730 A ID20001730 A ID 20001730A ID 26353 A ID26353 A ID 26353A
Authority
ID
Indonesia
Prior art keywords
bisindolimaleimide
substituted
cell proliferation
proliferation inhibition
inhibition
Prior art date
Application number
IDW20001730A
Other languages
English (en)
Indonesian (id)
Inventor
Urvashi Hooda Dhingra
Donna Mary Huryn
June Ke
Giuseppe Weber
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ID26353A publication Critical patent/ID26353A/id

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IDW20001730A 1998-03-17 1999-03-10 Bisindolimaleimida tersubstitusi untuk inhibisi proliferasi sel ID26353A (id)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7833198P 1998-03-17 1998-03-17

Publications (1)

Publication Number Publication Date
ID26353A true ID26353A (id) 2000-12-14

Family

ID=22143350

Family Applications (1)

Application Number Title Priority Date Filing Date
IDW20001730A ID26353A (id) 1998-03-17 1999-03-10 Bisindolimaleimida tersubstitusi untuk inhibisi proliferasi sel

Country Status (34)

Country Link
US (1) US6048887A (fr)
EP (1) EP1064279B1 (fr)
JP (2) JP5026633B2 (fr)
KR (1) KR100659411B1 (fr)
CN (1) CN1127500C (fr)
AR (1) AR018162A1 (fr)
AT (1) ATE243693T1 (fr)
AU (1) AU755673B2 (fr)
BR (1) BR9908882A (fr)
CA (1) CA2322689C (fr)
CO (1) CO5070675A1 (fr)
CZ (1) CZ299068B6 (fr)
DE (1) DE69909068T2 (fr)
DK (1) DK1064279T3 (fr)
ES (1) ES2203111T3 (fr)
HK (1) HK1036452A1 (fr)
HR (1) HRP20000585B1 (fr)
HU (1) HU228831B1 (fr)
ID (1) ID26353A (fr)
IL (1) IL138247A (fr)
MA (1) MA26613A1 (fr)
MY (1) MY121046A (fr)
NO (1) NO320306B1 (fr)
NZ (1) NZ506476A (fr)
PE (1) PE20000340A1 (fr)
PL (1) PL195323B1 (fr)
PT (1) PT1064279E (fr)
RS (1) RS49965B (fr)
RU (1) RU2208612C2 (fr)
SA (1) SA99191295B1 (fr)
TR (1) TR200002580T2 (fr)
TW (1) TW539676B (fr)
WO (1) WO1999047518A1 (fr)
ZA (1) ZA992072B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1064279E (pt) * 1998-03-17 2003-10-31 Hoffmann La Roche Bisindolilmaleimidas substituidas para a inibicao da proliferacao celular
US6350786B1 (en) * 1998-09-22 2002-02-26 Hoffmann-La Roche Inc. Stable complexes of poorly soluble compounds in ionic polymers
BR0014680A (pt) * 1999-10-12 2002-06-11 Hoffmann La Roche Pirróis substituìdos como agentes antiproliferativos para o tratamento de câncer
US6559164B1 (en) 1999-10-12 2003-05-06 Hoffmann-La Roche Inc. Substituted pyrroles suitable for continuous infusion
US6313143B1 (en) * 1999-12-16 2001-11-06 Hoffmann-La Roche Inc. Substituted pyrroles
US6281356B1 (en) * 1999-12-22 2001-08-28 Hoffmann-La Roche Inc. Substituted pyrroles
US6326501B1 (en) * 2000-04-19 2001-12-04 Hoffmann-La Roche Inc. Methylation of indole compounds using dimethyl carbonate
US7129250B2 (en) 2000-05-19 2006-10-31 Aegera Therapeutics Inc. Neuroprotective and anti-proliferative compounds
CA2308994A1 (fr) * 2000-05-19 2001-11-19 Aegera Therapeutics Inc. Composes neuroprotecteurs
US6469179B1 (en) 2000-10-03 2002-10-22 Hoffmann-La Roche Inc. Amorphous form of cell cycle inhibitor having improved solubility and bioavailability
US6482847B2 (en) 2000-10-03 2002-11-19 Hoffmann-La Roche Inc. Amorphous form of cell cycle inhibitor having improved solubility and bioavailability
US6548531B2 (en) 2001-02-09 2003-04-15 Hoffmann-La Roche Inc. Method for cancer therapy
WO2002102373A1 (fr) * 2001-06-15 2002-12-27 F. Hoffmann-La Roche Ag Procede d'administration d'un agent destine a la therapie du cancer
US20030139373A1 (en) * 2001-11-20 2003-07-24 Breimer Lars Holger Method for cancer therapy
WO2008117935A1 (fr) * 2007-03-28 2008-10-02 Industry-Academic Cooperation Foundation, Yonsei University Molécules activatrices des cellules nk, cellules nk et compositions pharmaceutiques contenant celles-ci
CN102924437B (zh) * 2012-11-19 2014-07-02 东华大学 3-哌嗪基-4-吲哚马来酰亚胺化合物及其制备和应用
WO2019000224A1 (fr) * 2017-06-27 2019-01-03 中国海洋大学 Dérivé de bisindolylmaléimide, son procédé de préparation et son utilisation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ227850A (en) * 1988-02-10 1991-11-26 Hoffmann La Roche Indole substituted pyrrole derivatives; preparatory process and medicaments for use against inflammatory immunological, bronchopulmonary or vascular disorders
US5380746A (en) * 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
DK0817627T3 (da) * 1993-12-23 2005-06-06 Lilly Co Eli Inhibitorer af proteinkinase C
PE91698A1 (es) * 1996-07-29 1998-12-24 Hoffmann La Roche Pirroles sustituidos
PE91598A1 (es) * 1996-07-29 1998-12-24 Hoffmann La Roche Pirroles sustituidos
PE91498A1 (es) * 1996-07-29 1998-12-22 Hoffmann La Roche Pirroles sustituidos
PT1064279E (pt) * 1998-03-17 2003-10-31 Hoffmann La Roche Bisindolilmaleimidas substituidas para a inibicao da proliferacao celular

Also Published As

Publication number Publication date
IL138247A0 (en) 2001-10-31
ZA992072B (en) 1999-09-22
BR9908882A (pt) 2000-11-21
YU55200A (sh) 2002-11-15
JP2010222366A (ja) 2010-10-07
CN1127500C (zh) 2003-11-12
KR100659411B1 (ko) 2006-12-18
PL195323B1 (pl) 2007-09-28
JP2002506864A (ja) 2002-03-05
RU2208612C2 (ru) 2003-07-20
HRP20000585B1 (en) 2009-02-28
PT1064279E (pt) 2003-10-31
WO1999047518A1 (fr) 1999-09-23
HRP20000585A2 (en) 2001-08-31
HUP0101258A3 (en) 2002-08-28
HU228831B1 (en) 2013-05-28
AU3409999A (en) 1999-10-11
AU755673B2 (en) 2002-12-19
US6048887A (en) 2000-04-11
CO5070675A1 (es) 2001-08-28
TW539676B (en) 2003-07-01
NZ506476A (en) 2003-12-19
TR200002580T2 (tr) 2000-11-21
NO20004579L (no) 2000-09-14
ES2203111T3 (es) 2004-04-01
CA2322689C (fr) 2008-11-25
PE20000340A1 (es) 2000-05-13
CA2322689A1 (fr) 1999-09-23
DE69909068D1 (de) 2003-07-31
HK1036452A1 (en) 2002-01-04
NO20004579D0 (no) 2000-09-14
EP1064279A1 (fr) 2001-01-03
HUP0101258A2 (hu) 2001-10-28
RS49965B (sr) 2008-09-29
MA26613A1 (fr) 2004-12-20
CN1293671A (zh) 2001-05-02
MY121046A (en) 2005-12-30
IL138247A (en) 2005-08-31
PL342964A1 (en) 2001-07-16
KR20010041995A (ko) 2001-05-25
EP1064279B1 (fr) 2003-06-25
CZ299068B6 (cs) 2008-04-16
ATE243693T1 (de) 2003-07-15
NO320306B1 (no) 2005-11-21
CZ20003384A3 (cs) 2000-12-13
SA99191295B1 (ar) 2006-04-26
AR018162A1 (es) 2001-10-31
DE69909068T2 (de) 2004-05-06
JP5026633B2 (ja) 2012-09-12
DK1064279T3 (da) 2003-10-06

Similar Documents

Publication Publication Date Title
ATE260248T1 (de) Zellproliferation inhibitoren
AU8419201A (en) Imidazolo-5-yl-2-anilino-pyrimidines as agents for the inhibition of the cell proliferation
CU23063A3 (es) Imidazotriazinonas 2-fenil sustituidas como inhibidores de fosfodiesterasas
NO20005916D0 (no) Pyrrolsubstituert 2-indolinon protein kinase inhibitorer
ID26353A (id) Bisindolimaleimida tersubstitusi untuk inhibisi proliferasi sel
DE69715870D1 (de) Substituierte bisindolylmaleimide zur inhibierung der zellproliferation
DE69722003D1 (de) Substituierte bisindolylmaleimide zur inhibierung der zellproliferation
ITMI992750A0 (it) Dispositivo per lavanda rettale
ID21195A (id) Sel sekunder
ATE252547T1 (de) Matrixmetalloproteinaseinhibitoren
DE69737060D1 (de) Substituierte bisindolylmaleimide zur inhibierung der zellproliferation
ID27364A (id) Metode untuk menghambat mrp1
MA24877A1 (fr) INHIBITEURS DE PROTéASES
ID23196A (id) Gandaran untuk lampuflouresen
ID26804A (id) Metode untuk menghambat mrp1
DE60036670D1 (de) Schaltung zur Sin(x)/x-Kompensation
ID17786A (id) Sel fotoelektrokima
IL150128A0 (en) Substituted bisindolymaleimides for the inhibition of cell proliferation
SI1064279T1 (en) Substituted bisindolylmaleimides for the inhibition of cell proliferation
FI981547A (fi) Haulikon lisälaite
ID23842A (id) Pelat untuk perangkat distribusi
SI1351958T1 (en) Imidazolo-5-yl-2-anilino-pyrimidines as agents for the inhibition of the cell proliferation
FIU980404U0 (fi) Mikroaaltouunin lautasteline
KR980000578U (ko) 회접시
GB9817656D0 (en) Scale inhibitors