DE69715870D1 - Substituierte bisindolylmaleimide zur inhibierung der zellproliferation - Google Patents

Substituierte bisindolylmaleimide zur inhibierung der zellproliferation

Info

Publication number
DE69715870D1
DE69715870D1 DE69715870T DE69715870T DE69715870D1 DE 69715870 D1 DE69715870 D1 DE 69715870D1 DE 69715870 T DE69715870 T DE 69715870T DE 69715870 T DE69715870 T DE 69715870T DE 69715870 D1 DE69715870 D1 DE 69715870D1
Authority
DE
Germany
Prior art keywords
cell proliferation
inhibiting cell
bisindolylmaleimides
substituted
substituted bisindolylmaleimides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69715870T
Other languages
English (en)
Other versions
DE69715870T2 (de
Inventor
Hooda Dhingra
Mary Huryn
Dalton Keith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE69715870D1 publication Critical patent/DE69715870D1/de
Application granted granted Critical
Publication of DE69715870T2 publication Critical patent/DE69715870T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
DE69715870T 1996-07-29 1997-07-19 Substituierte bisindolylmaleimide zur inhibierung der zellproliferation Expired - Fee Related DE69715870T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2207896P 1996-07-29 1996-07-29
US4849697P 1997-06-03 1997-06-03
PCT/EP1997/003888 WO1998004551A1 (en) 1996-07-29 1997-07-19 Substituted bisindolylmaleimides for the inhibition of cell proliferation

Publications (2)

Publication Number Publication Date
DE69715870D1 true DE69715870D1 (de) 2002-10-31
DE69715870T2 DE69715870T2 (de) 2003-06-18

Family

ID=26695475

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69715870T Expired - Fee Related DE69715870T2 (de) 1996-07-29 1997-07-19 Substituierte bisindolylmaleimide zur inhibierung der zellproliferation

Country Status (20)

Country Link
US (1) US6228877B1 (de)
EP (1) EP0915870B1 (de)
JP (1) JP2000516588A (de)
KR (1) KR20000029640A (de)
CN (1) CN1077571C (de)
AR (1) AR007969A1 (de)
AT (1) ATE224889T1 (de)
AU (1) AU740011B2 (de)
BR (1) BR9711607A (de)
CA (1) CA2262089A1 (de)
CO (1) CO4900054A1 (de)
DE (1) DE69715870T2 (de)
DK (1) DK0915870T3 (de)
ES (1) ES2183163T3 (de)
HR (1) HRP970415A2 (de)
MA (1) MA24354A1 (de)
PE (1) PE91598A1 (de)
PT (1) PT915870E (de)
TR (1) TR199900186T2 (de)
WO (1) WO1998004551A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2203111T3 (es) * 1998-03-17 2004-04-01 F. Hoffmann-La Roche Ag Maleimidas bisindol sustituidas para la inhibicion de proloferacion celular.
US6350786B1 (en) * 1998-09-22 2002-02-26 Hoffmann-La Roche Inc. Stable complexes of poorly soluble compounds in ionic polymers
RU2002110111A (ru) * 1999-10-12 2003-12-20 Ф.Хоффманн-Ля Рош Аг (Ch) Замещенные пирролы в качестве антипролиферативных средств для лечения рака
US6559164B1 (en) 1999-10-12 2003-05-06 Hoffmann-La Roche Inc. Substituted pyrroles suitable for continuous infusion
US6313143B1 (en) 1999-12-16 2001-11-06 Hoffmann-La Roche Inc. Substituted pyrroles
US6281356B1 (en) * 1999-12-22 2001-08-28 Hoffmann-La Roche Inc. Substituted pyrroles
US6326501B1 (en) * 2000-04-19 2001-12-04 Hoffmann-La Roche Inc. Methylation of indole compounds using dimethyl carbonate
US7129250B2 (en) * 2000-05-19 2006-10-31 Aegera Therapeutics Inc. Neuroprotective and anti-proliferative compounds
CA2308994A1 (en) * 2000-05-19 2001-11-19 Aegera Therapeutics Inc. Neuroprotective compounds
TWI335221B (en) 2001-09-27 2011-01-01 Alcon Inc Inhibtors of glycogen synthase kinase-3 (gsk-3) for treating glaucoma
MXPA04004026A (es) * 2001-10-29 2004-07-08 Nektar Therapeutics Al Corp Conjugados polimericos de inhibidores de la proteina quinasa c.
CA2393720C (en) * 2002-07-12 2010-09-14 Eli Lilly And Company Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride
DK1846406T5 (da) 2005-02-09 2011-10-31 Arqule Inc Maleimidderivater, farmaceutiske sammensætninger og fremgangsmåder til behandling af cancer
BRPI0720388A2 (pt) 2006-12-19 2014-01-14 Novartis Ag Derivados de indolilmaleimida
CA2912546A1 (en) 2007-06-22 2008-12-31 Arqule, Inc. Compositions and methods for treatment of cancer
WO2009002806A1 (en) * 2007-06-22 2008-12-31 Arqule, Inc. Pyrrolidinone, pyrrolidine-2, 5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer
MX2009013815A (es) 2007-06-22 2010-03-01 Arqule Inc Compuestos de quinazolinona y metodos de uso para los mismos.
GB201111427D0 (en) * 2011-07-05 2011-08-17 Amakem Nv Novel bisindolylmaleimides, pan-pkc inhibitors
EP3741375A1 (de) 2014-07-17 2020-11-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Verfahren zur behandlung von erkrankungen in zusammenhang mit neuromuskulären verbindungen
WO2016207366A1 (en) 2015-06-26 2016-12-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of viral infections
CN109535158B (zh) * 2016-04-26 2021-04-23 浙江工业大学 一种双芳基马来酰亚胺类化合物及其药学上可接受的盐及其制备方法和应用
CN107973785B (zh) * 2017-11-27 2019-12-31 浙江工业大学上虞研究院有限公司 一种用于检测银离子的荧光探针及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL89167A (en) 1988-02-10 1994-02-27 Hoffmann La Roche Substituted pyrroles, their manufacture and pharmaceutical compositions containing them
CA2015996C (en) * 1989-05-05 2001-08-28 Hartmut Osswald Bis-(1h-indol-3-yl)-maleinimide derivatives and their use as pharmaceuticals
US5380746A (en) 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
JPH0539289A (ja) 1991-02-15 1993-02-19 Masahiro Irie 無水マレイン酸誘導体およびその製造方法
JPH07504673A (ja) 1992-03-20 1995-05-25 ザ・ウエルカム・ファウンデーション・リミテッド 抗ウイルス活性を有するインドール誘導体
DE4217964A1 (de) 1992-05-30 1993-12-02 Goedecke Ag Indolocarbazol-Imide und deren Verwendung

Also Published As

Publication number Publication date
CN1077571C (zh) 2002-01-09
PT915870E (pt) 2003-01-31
CA2262089A1 (en) 1998-02-05
DK0915870T3 (da) 2003-02-03
KR20000029640A (ko) 2000-05-25
AR007969A1 (es) 1999-11-24
ES2183163T3 (es) 2003-03-16
CN1226248A (zh) 1999-08-18
MA24354A1 (fr) 1998-07-01
PE91598A1 (es) 1998-12-24
US6228877B1 (en) 2001-05-08
DE69715870T2 (de) 2003-06-18
BR9711607A (pt) 1999-08-24
EP0915870B1 (de) 2002-09-25
CO4900054A1 (es) 2000-03-27
EP0915870A1 (de) 1999-05-19
AU740011B2 (en) 2001-10-25
TR199900186T2 (xx) 1999-03-22
AU4296397A (en) 1998-02-20
ATE224889T1 (de) 2002-10-15
WO1998004551A1 (en) 1998-02-05
JP2000516588A (ja) 2000-12-12
HRP970415A2 (en) 1998-08-31

Similar Documents

Publication Publication Date Title
DE69715870D1 (de) Substituierte bisindolylmaleimide zur inhibierung der zellproliferation
DE69722003D1 (de) Substituierte bisindolylmaleimide zur inhibierung der zellproliferation
NO992336D0 (no) Raf-kinase-inhibitorer
DE69716615D1 (de) Heterozyklische metalloproteaseinhibitoren
NO992347D0 (no) R°rgripeanordning
DE69705112T2 (de) Coralynanaloge als topoisomerase inhibitoren
NO984316D0 (no) Skjµreverkt°y
NO983462D0 (no) Isoleringsverkt°y
ID22713A (id) Peralatan untuk laminasi
DE69909068D1 (de) Substituierte bisindolylmaleimide zur inhibierung der zellproliferation
NO990552D0 (no) Innrettingsverkt°y
NO983683L (no) R°rperforeringssystem
NO983116L (no) Svingd°r
DE69737060D1 (de) Substituierte bisindolylmaleimide zur inhibierung der zellproliferation
NO984943D0 (no) R°rledningslagring
NO990168D0 (no) R°rforsegling
DE59709331D1 (de) Schaltungsanordnung zur Offset-Kompensation
DE60023182D1 (de) Substituierte bisindolylmaleimide zur inhibierung der zellproliferation
DE29608620U1 (de) Meßstation zur Erfassung des winkelabhängigen Muskeltonus
DE69720957T2 (de) Ace-hemmer
NO963812D0 (no) Visningsplate
DE69702247T2 (de) Zusammensetzung zur inhibierung der polymerisierung
ATA196697A (de) Panzerungsplatte
DE29603398U1 (de) Telefontester zur Prüfung der Telefonleitung
SI1064279T1 (en) Substituted bisindolylmaleimides for the inhibition of cell proliferation

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee