CO4900054A1 - Pirroles sustituidos - Google Patents
Pirroles sustituidosInfo
- Publication number
- CO4900054A1 CO4900054A1 CO97042636A CO97042636A CO4900054A1 CO 4900054 A1 CO4900054 A1 CO 4900054A1 CO 97042636 A CO97042636 A CO 97042636A CO 97042636 A CO97042636 A CO 97042636A CO 4900054 A1 CO4900054 A1 CO 4900054A1
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- aryl
- hydrogen
- independently
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Un compuesto de la fórmula:en la que R1 y R1´ con independencia entre sí son alquilo, arilo, alquenilo o alquinilo; R2 y R2´ con independencia entre sí son hidrógeno o alquilo; R4 , R5 , R6 , R7 , R4´ , R5´ , R6´ y R7´ con independencia entre sí son hidrógeno,O ½CH2 OCR8 , CO2 R9 , CH2 OR10 , CHO, CH2 NR11 R12 , CON(R13 )2 , halógeno, ciano, arilo, alquilo, hidroxi, alcoxi, ariloxi, haloalquilo, nitro, amino, aralquiloxi, acilamino, monoalquilamino, dialquilamino, tio, alquiltio, alquilsulfinilo, alquilsulfonilo, arilsulfinilo, azida, fosfato o fosfonato, con la condición de que por lo menos uno de R4 , R5 , R6 y R7 y por lo menos uno de R4´ , R5´ , R6´ y R7´ sea distinto de hidrógeno; con la condición de que si R6 es metoxi, entonces R5 o R5´ no son metoxi; R8 es alquilo o arilo; R9 es alquilo o arilo; R10 es hidrógeno, alquilo o arilo; R11 y R12 con independencia entre sí son hidrógeno, alquilo, arilo, aralquilo o acilo; R13 es hidrógeno, alquilo, arilo o aralquilo; yuno de X e Y significa o y el otro significa O, S, (H, OH) o (H,H); así como los productos previos farmacéuticamente aceptables de los mismos o las sales farmacéuticamente aceptables de los compuestos ácidos de la fórmula I con bases o de los compuestos básicos de la fórmula I con ácidos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2207896P | 1996-07-29 | 1996-07-29 | |
| US4849697P | 1997-06-03 | 1997-06-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4900054A1 true CO4900054A1 (es) | 2000-03-27 |
Family
ID=26695475
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO97042636A CO4900054A1 (es) | 1996-07-29 | 1997-07-25 | Pirroles sustituidos |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6228877B1 (es) |
| EP (1) | EP0915870B1 (es) |
| JP (1) | JP2000516588A (es) |
| KR (1) | KR20000029640A (es) |
| CN (1) | CN1077571C (es) |
| AR (1) | AR007969A1 (es) |
| AT (1) | ATE224889T1 (es) |
| AU (1) | AU740011B2 (es) |
| BR (1) | BR9711607A (es) |
| CA (1) | CA2262089A1 (es) |
| CO (1) | CO4900054A1 (es) |
| DE (1) | DE69715870T2 (es) |
| DK (1) | DK0915870T3 (es) |
| ES (1) | ES2183163T3 (es) |
| HR (1) | HRP970415A2 (es) |
| MA (1) | MA24354A1 (es) |
| PE (1) | PE91598A1 (es) |
| PT (1) | PT915870E (es) |
| TR (1) | TR199900186T2 (es) |
| WO (1) | WO1998004551A1 (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR200002580T2 (tr) * | 1998-03-17 | 2000-11-21 | F.Hoffmann-La Roche Ag | Hücre çoğalmasının engellenmesinde kullanılan ikameli bisindolimaleimitler |
| US6350786B1 (en) * | 1998-09-22 | 2002-02-26 | Hoffmann-La Roche Inc. | Stable complexes of poorly soluble compounds in ionic polymers |
| JP2003511449A (ja) * | 1999-10-12 | 2003-03-25 | エフ．ホフマン−ラ ロシュ アーゲー | 癌の処理のための抗増殖剤としての置換されたピロール |
| US6559164B1 (en) | 1999-10-12 | 2003-05-06 | Hoffmann-La Roche Inc. | Substituted pyrroles suitable for continuous infusion |
| US6313143B1 (en) * | 1999-12-16 | 2001-11-06 | Hoffmann-La Roche Inc. | Substituted pyrroles |
| US6281356B1 (en) * | 1999-12-22 | 2001-08-28 | Hoffmann-La Roche Inc. | Substituted pyrroles |
| US6326501B1 (en) * | 2000-04-19 | 2001-12-04 | Hoffmann-La Roche Inc. | Methylation of indole compounds using dimethyl carbonate |
| CA2308994A1 (en) * | 2000-05-19 | 2001-11-19 | Aegera Therapeutics Inc. | Neuroprotective compounds |
| US7129250B2 (en) * | 2000-05-19 | 2006-10-31 | Aegera Therapeutics Inc. | Neuroprotective and anti-proliferative compounds |
| TW201041580A (en) | 2001-09-27 | 2010-12-01 | Alcon Inc | Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma |
| EP1441772A2 (en) * | 2001-10-29 | 2004-08-04 | Nektar Therapeutics Al, Corporation | Polymer conjugates of protein kinase c inhibitors |
| CA2393720C (en) * | 2002-07-12 | 2010-09-14 | Eli Lilly And Company | Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride |
| US7713969B2 (en) | 2005-02-09 | 2010-05-11 | Arqule, Inc. | Compositions and methods for treatment of cancer |
| WO2008074752A2 (en) * | 2006-12-19 | 2008-06-26 | Novartis Ag | Indolylmaleimide derivatives as kinase inhibitors |
| CA2912546A1 (en) | 2007-06-22 | 2008-12-31 | Arqule, Inc. | Compositions and methods for treatment of cancer |
| EP2173724B1 (en) | 2007-06-22 | 2012-12-05 | ArQule, Inc. | Quinazolinone compounds and methods of use thereof |
| JP5425060B2 (ja) * | 2007-06-22 | 2014-02-26 | アークル インコーポレイテッド | ピロリジノン、ピロリジン−２，５−ジオン、ピロリジンおよびチオスクシンイミド誘導体、癌の治療のための組成物および方法 |
| GB201111427D0 (en) * | 2011-07-05 | 2011-08-17 | Amakem Nv | Novel bisindolylmaleimides, pan-pkc inhibitors |
| JP2017524739A (ja) | 2014-07-17 | 2017-08-31 | アンセルムＩｎｓｅｒｍ | 神経筋接合部関連疾患の処置方法 |
| WO2016207366A1 (en) | 2015-06-26 | 2016-12-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of viral infections |
| CN109535158B (zh) * | 2016-04-26 | 2021-04-23 | 浙江工业大学 | 一种双芳基马来酰亚胺类化合物及其药学上可接受的盐及其制备方法和应用 |
| CN107973785B (zh) * | 2017-11-27 | 2019-12-31 | 浙江工业大学上虞研究院有限公司 | 一种用于检测银离子的荧光探针及其制备方法和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ227850A (en) | 1988-02-10 | 1991-11-26 | Hoffmann La Roche | Indole substituted pyrrole derivatives; preparatory process and medicaments for use against inflammatory immunological, bronchopulmonary or vascular disorders |
| US5380746A (en) | 1989-05-05 | 1995-01-10 | Goedecke Aktiengesellschaft | Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them |
| IL94274A0 (en) * | 1989-05-05 | 1991-03-10 | Goedecke Ag | Maleinimide derivatives,process for the preparation thereof and pharmaceutical compositions containing the same |
| JPH0539289A (ja) | 1991-02-15 | 1993-02-19 | Masahiro Irie | 無水マレイン酸誘導体およびその製造方法 |
| WO1993018765A1 (en) | 1992-03-20 | 1993-09-30 | The Wellcome Foundation Limited | Indole derivatives with antiviral activity |
| DE4217964A1 (de) | 1992-05-30 | 1993-12-02 | Goedecke Ag | Indolocarbazol-Imide und deren Verwendung |
-
1997
- 1997-07-15 PE PE1997000629A patent/PE91598A1/es not_active Application Discontinuation
- 1997-07-19 AT AT97918934T patent/ATE224889T1/de not_active IP Right Cessation
- 1997-07-19 KR KR1019997000711A patent/KR20000029640A/ko active IP Right Grant
- 1997-07-19 ES ES97918934T patent/ES2183163T3/es not_active Expired - Lifetime
- 1997-07-19 BR BR9711607A patent/BR9711607A/pt not_active IP Right Cessation
- 1997-07-19 TR TR1999/00186T patent/TR199900186T2/xx unknown
- 1997-07-19 DE DE69715870T patent/DE69715870T2/de not_active Expired - Fee Related
- 1997-07-19 CN CN97196783A patent/CN1077571C/zh not_active Expired - Fee Related
- 1997-07-19 PT PT97918934T patent/PT915870E/pt unknown
- 1997-07-19 EP EP97918934A patent/EP0915870B1/en not_active Expired - Lifetime
- 1997-07-19 WO PCT/EP1997/003888 patent/WO1998004551A1/en active IP Right Grant
- 1997-07-19 DK DK97918934T patent/DK0915870T3/da active
- 1997-07-19 JP JP10508452A patent/JP2000516588A/ja not_active Ceased
- 1997-07-19 AU AU42963/97A patent/AU740011B2/en not_active Ceased
- 1997-07-19 CA CA002262089A patent/CA2262089A1/en not_active Abandoned
- 1997-07-22 AR ARP970103308A patent/AR007969A1/es unknown
- 1997-07-25 HR HR60/048,496A patent/HRP970415A2/hr not_active Application Discontinuation
- 1997-07-25 CO CO97042636A patent/CO4900054A1/es unknown
- 1997-07-29 MA MA24743A patent/MA24354A1/fr unknown
-
1998
- 1998-12-22 US US09/218,404 patent/US6228877B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1226248A (zh) | 1999-08-18 |
| DE69715870T2 (de) | 2003-06-18 |
| BR9711607A (pt) | 1999-08-24 |
| AU740011B2 (en) | 2001-10-25 |
| WO1998004551A1 (en) | 1998-02-05 |
| HRP970415A2 (en) | 1998-08-31 |
| AR007969A1 (es) | 1999-11-24 |
| PT915870E (pt) | 2003-01-31 |
| PE91598A1 (es) | 1998-12-24 |
| KR20000029640A (ko) | 2000-05-25 |
| DE69715870D1 (de) | 2002-10-31 |
| AU4296397A (en) | 1998-02-20 |
| CA2262089A1 (en) | 1998-02-05 |
| ES2183163T3 (es) | 2003-03-16 |
| EP0915870B1 (en) | 2002-09-25 |
| MA24354A1 (fr) | 1998-07-01 |
| CN1077571C (zh) | 2002-01-09 |
| TR199900186T2 (xx) | 1999-03-22 |
| EP0915870A1 (en) | 1999-05-19 |
| US6228877B1 (en) | 2001-05-08 |
| DK0915870T3 (da) | 2003-02-03 |
| JP2000516588A (ja) | 2000-12-12 |
| ATE224889T1 (de) | 2002-10-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CO4900054A1 (es) | Pirroles sustituidos | |
| CO4900055A1 (es) | 3,4-di-indolil pirroles | |
| ES2052704T3 (es) | Analogos de benzodiacepina. | |
| ES544523A0 (es) | Un procedimiento para la preparacion de derivados de benzodiazefinas. | |
| FR2733244B1 (fr) | Systeme de stabilisants a base de derives de polyalkylpiperidine | |
| NO995455D0 (no) | 4-Fenylpiperidinforbindelser | |
| PE20021019A1 (es) | Grupos azabiciclicos sustituidos | |
| CO5031247A1 (es) | Compuestos triciclicos sustituidos | |
| PT1064281E (pt) | Derivados de distamicina benzo-heterociclicos processo para os preparar e a sua utilizacao como agentes antitumorais | |
| PE27497A1 (es) | Derivados de 1,5 benzodiazepina | |
| ES2150613T3 (es) | Compuestos benzo-condensados de acepinona y piperidinona, utiles como inhibidores de ace y nep. | |
| CO4960660A1 (es) | Derivados de 5-aroil-pirrol-2-ilmetilareno, composiciones farmaceuticas que las contienen y metodos para la preparacion de estos compuestos | |
| ECSP972205A (es) | Pirroles sustituidos | |
| ECSP972206A (es) | Pirroles sustituidos | |
| ES2140552T3 (es) | Derivados indol como inhibidores de la 5-alfa-reductasa-1. | |
| PE25195A1 (es) | Sintesis de l-aspartil-d-aminoalcanoil-(s)-o-alquilbencil amida utilizada como endulzante artificial | |
| ES2129784T3 (es) | Procedimiento de preparacion de un compuesto intermediario de sintesis y su uso. | |
| DE69525145T2 (de) | Carbamoylmethylharnstoffderivate | |
| ECSP082418A (es) | Heterociclos biciclicos disustituidos, su preparacion y su utilizacion como medicamentos | |
| ES2187825T3 (es) | Procedimiento para sintetizar intermedios de la cadena lateral de carbapenem. | |
| EP0192951B1 (en) | 5-sulfonamido-1-aryl pyrazoles | |
| MX9203518A (es) | 9-amino-2-fenilbiciclo [3.3.1] nonanos y 9-amino-2-fenilbiciclo [3.3.1] non-2-enos y drogas que los contienen. | |
| AR007463A1 (es) | Colorantes monoazoicos sustituidos por grupos haloalquilcarbamato y sulfonilfluoruro | |
| ECSP982418A (es) | Heterociclos biciclicos- disustituidos, su preparacion y su utilizacion como medicamentos | |
| CO5550438A2 (es) | DERIVADOS DEL ACIDO 5,6,6a,1 1b-TETRAHIDRO-7OXA-5-AZABENZO [C] FLUORENO-6-CARBOXILICO SUSTITUIDOS COMO ANTAGONISTAS DE NMDA |