CO4900054A1 - Pirroles sustituidos - Google Patents
Pirroles sustituidosInfo
- Publication number
- CO4900054A1 CO4900054A1 CO97042636A CO97042636A CO4900054A1 CO 4900054 A1 CO4900054 A1 CO 4900054A1 CO 97042636 A CO97042636 A CO 97042636A CO 97042636 A CO97042636 A CO 97042636A CO 4900054 A1 CO4900054 A1 CO 4900054A1
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- aryl
- hydrogen
- independently
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Un compuesto de la fórmula:en la que R1 y R1´ con independencia entre sí son alquilo, arilo, alquenilo o alquinilo; R2 y R2´ con independencia entre sí son hidrógeno o alquilo; R4 , R5 , R6 , R7 , R4´ , R5´ , R6´ y R7´ con independencia entre sí son hidrógeno,O ½CH2 OCR8 , CO2 R9 , CH2 OR10 , CHO, CH2 NR11 R12 , CON(R13 )2 , halógeno, ciano, arilo, alquilo, hidroxi, alcoxi, ariloxi, haloalquilo, nitro, amino, aralquiloxi, acilamino, monoalquilamino, dialquilamino, tio, alquiltio, alquilsulfinilo, alquilsulfonilo, arilsulfinilo, azida, fosfato o fosfonato, con la condición de que por lo menos uno de R4 , R5 , R6 y R7 y por lo menos uno de R4´ , R5´ , R6´ y R7´ sea distinto de hidrógeno; con la condición de que si R6 es metoxi, entonces R5 o R5´ no son metoxi; R8 es alquilo o arilo; R9 es alquilo o arilo; R10 es hidrógeno, alquilo o arilo; R11 y R12 con independencia entre sí son hidrógeno, alquilo, arilo, aralquilo o acilo; R13 es hidrógeno, alquilo, arilo o aralquilo; yuno de X e Y significa o y el otro significa O, S, (H, OH) o (H,H); así como los productos previos farmacéuticamente aceptables de los mismos o las sales farmacéuticamente aceptables de los compuestos ácidos de la fórmula I con bases o de los compuestos básicos de la fórmula I con ácidos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2207896P | 1996-07-29 | 1996-07-29 | |
| US4849697P | 1997-06-03 | 1997-06-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4900054A1 true CO4900054A1 (es) | 2000-03-27 |
Family
ID=26695475
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO97042636A CO4900054A1 (es) | 1996-07-29 | 1997-07-25 | Pirroles sustituidos |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6228877B1 (es) |
| EP (1) | EP0915870B1 (es) |
| JP (1) | JP2000516588A (es) |
| KR (1) | KR20000029640A (es) |
| CN (1) | CN1077571C (es) |
| AR (1) | AR007969A1 (es) |
| AT (1) | ATE224889T1 (es) |
| AU (1) | AU740011B2 (es) |
| BR (1) | BR9711607A (es) |
| CA (1) | CA2262089A1 (es) |
| CO (1) | CO4900054A1 (es) |
| DE (1) | DE69715870T2 (es) |
| DK (1) | DK0915870T3 (es) |
| ES (1) | ES2183163T3 (es) |
| HR (1) | HRP970415A2 (es) |
| MA (1) | MA24354A1 (es) |
| PE (1) | PE91598A1 (es) |
| PT (1) | PT915870E (es) |
| TR (1) | TR199900186T2 (es) |
| WO (1) | WO1998004551A1 (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE243693T1 (de) * | 1998-03-17 | 2003-07-15 | Hoffmann La Roche | Substituierte bisindolylmaleimide zur inhibierung der zellproliferation |
| US6350786B1 (en) * | 1998-09-22 | 2002-02-26 | Hoffmann-La Roche Inc. | Stable complexes of poorly soluble compounds in ionic polymers |
| MXPA02003667A (es) * | 1999-10-12 | 2002-08-30 | Hoffmann La Roche | Pirroles sustituidos como agentes antiproliferativos para tratamiento del cancer. |
| US6559164B1 (en) | 1999-10-12 | 2003-05-06 | Hoffmann-La Roche Inc. | Substituted pyrroles suitable for continuous infusion |
| US6313143B1 (en) | 1999-12-16 | 2001-11-06 | Hoffmann-La Roche Inc. | Substituted pyrroles |
| US6281356B1 (en) * | 1999-12-22 | 2001-08-28 | Hoffmann-La Roche Inc. | Substituted pyrroles |
| US6326501B1 (en) * | 2000-04-19 | 2001-12-04 | Hoffmann-La Roche Inc. | Methylation of indole compounds using dimethyl carbonate |
| US7129250B2 (en) * | 2000-05-19 | 2006-10-31 | Aegera Therapeutics Inc. | Neuroprotective and anti-proliferative compounds |
| CA2308994A1 (en) * | 2000-05-19 | 2001-11-19 | Aegera Therapeutics Inc. | Neuroprotective compounds |
| TW201041580A (en) | 2001-09-27 | 2010-12-01 | Alcon Inc | Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma |
| AU2002342193B2 (en) * | 2001-10-29 | 2006-10-26 | Nektar Therapeutics Al, Corporation | Polymer conjugates of protein kinase C inhibitors |
| CA2393720C (en) * | 2002-07-12 | 2010-09-14 | Eli Lilly And Company | Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride |
| RU2409579C2 (ru) | 2005-02-09 | 2011-01-20 | Аркьюл, Инк. | Композиции и способы лечения рака |
| CN101558062A (zh) * | 2006-12-19 | 2009-10-14 | 诺瓦提斯公司 | 作为激酶抑制剂的吲哚基马来酰亚胺衍生物 |
| JP5425060B2 (ja) * | 2007-06-22 | 2014-02-26 | アークル インコーポレイテッド | ピロリジノン、ピロリジン−２，５−ジオン、ピロリジンおよびチオスクシンイミド誘導体、癌の治療のための組成物および方法 |
| EP2173748B1 (en) | 2007-06-22 | 2011-08-31 | ArQule, Inc. | Indolyl pyrrolidines for the treatment of cancer |
| EP2173724B1 (en) | 2007-06-22 | 2012-12-05 | ArQule, Inc. | Quinazolinone compounds and methods of use thereof |
| GB201111427D0 (en) * | 2011-07-05 | 2011-08-17 | Amakem Nv | Novel bisindolylmaleimides, pan-pkc inhibitors |
| EP3741375A1 (en) | 2014-07-17 | 2020-11-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for treating neuromuscular junction-related diseases |
| WO2016207366A1 (en) | 2015-06-26 | 2016-12-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of viral infections |
| CN105777751B (zh) * | 2016-04-26 | 2018-12-11 | 浙江工业大学 | 一种双芳基马来酰亚胺类化合物及其药学上可接受的盐及其制备方法和应用 |
| CN107973785B (zh) * | 2017-11-27 | 2019-12-31 | 浙江工业大学上虞研究院有限公司 | 一种用于检测银离子的荧光探针及其制备方法和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ227850A (en) | 1988-02-10 | 1991-11-26 | Hoffmann La Roche | Indole substituted pyrrole derivatives; preparatory process and medicaments for use against inflammatory immunological, bronchopulmonary or vascular disorders |
| US5380746A (en) | 1989-05-05 | 1995-01-10 | Goedecke Aktiengesellschaft | Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them |
| CA2015996C (en) * | 1989-05-05 | 2001-08-28 | Hartmut Osswald | Bis-(1h-indol-3-yl)-maleinimide derivatives and their use as pharmaceuticals |
| JPH0539289A (ja) | 1991-02-15 | 1993-02-19 | Masahiro Irie | 無水マレイン酸誘導体およびその製造方法 |
| WO1993018765A1 (en) | 1992-03-20 | 1993-09-30 | The Wellcome Foundation Limited | Indole derivatives with antiviral activity |
| DE4217964A1 (de) | 1992-05-30 | 1993-12-02 | Goedecke Ag | Indolocarbazol-Imide und deren Verwendung |
-
1997
- 1997-07-15 PE PE1997000629A patent/PE91598A1/es not_active Application Discontinuation
- 1997-07-19 ES ES97918934T patent/ES2183163T3/es not_active Expired - Lifetime
- 1997-07-19 JP JP10508452A patent/JP2000516588A/ja not_active Ceased
- 1997-07-19 AU AU42963/97A patent/AU740011B2/en not_active Ceased
- 1997-07-19 CA CA002262089A patent/CA2262089A1/en not_active Abandoned
- 1997-07-19 TR TR1999/00186T patent/TR199900186T2/xx unknown
- 1997-07-19 PT PT97918934T patent/PT915870E/pt unknown
- 1997-07-19 CN CN97196783A patent/CN1077571C/zh not_active Expired - Fee Related
- 1997-07-19 WO PCT/EP1997/003888 patent/WO1998004551A1/en active IP Right Grant
- 1997-07-19 KR KR1019997000711A patent/KR20000029640A/ko active IP Right Grant
- 1997-07-19 BR BR9711607A patent/BR9711607A/pt not_active IP Right Cessation
- 1997-07-19 DE DE69715870T patent/DE69715870T2/de not_active Expired - Fee Related
- 1997-07-19 AT AT97918934T patent/ATE224889T1/de not_active IP Right Cessation
- 1997-07-19 EP EP97918934A patent/EP0915870B1/en not_active Expired - Lifetime
- 1997-07-19 DK DK97918934T patent/DK0915870T3/da active
- 1997-07-22 AR ARP970103308A patent/AR007969A1/es unknown
- 1997-07-25 HR HR60/048,496A patent/HRP970415A2/hr not_active Application Discontinuation
- 1997-07-25 CO CO97042636A patent/CO4900054A1/es unknown
- 1997-07-29 MA MA24743A patent/MA24354A1/fr unknown
-
1998
- 1998-12-22 US US09/218,404 patent/US6228877B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0915870A1 (en) | 1999-05-19 |
| KR20000029640A (ko) | 2000-05-25 |
| MA24354A1 (fr) | 1998-07-01 |
| CN1226248A (zh) | 1999-08-18 |
| AU4296397A (en) | 1998-02-20 |
| HRP970415A2 (en) | 1998-08-31 |
| DK0915870T3 (da) | 2003-02-03 |
| ATE224889T1 (de) | 2002-10-15 |
| AU740011B2 (en) | 2001-10-25 |
| CN1077571C (zh) | 2002-01-09 |
| WO1998004551A1 (en) | 1998-02-05 |
| PT915870E (pt) | 2003-01-31 |
| DE69715870D1 (de) | 2002-10-31 |
| BR9711607A (pt) | 1999-08-24 |
| JP2000516588A (ja) | 2000-12-12 |
| ES2183163T3 (es) | 2003-03-16 |
| AR007969A1 (es) | 1999-11-24 |
| PE91598A1 (es) | 1998-12-24 |
| TR199900186T2 (xx) | 1999-03-22 |
| EP0915870B1 (en) | 2002-09-25 |
| US6228877B1 (en) | 2001-05-08 |
| DE69715870T2 (de) | 2003-06-18 |
| CA2262089A1 (en) | 1998-02-05 |
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