DE69715870T2 - Substituierte bisindolylmaleimide zur inhibierung der zellproliferation - Google Patents

Substituierte bisindolylmaleimide zur inhibierung der zellproliferation

Info

Publication number
DE69715870T2
DE69715870T2 DE69715870T DE69715870T DE69715870T2 DE 69715870 T2 DE69715870 T2 DE 69715870T2 DE 69715870 T DE69715870 T DE 69715870T DE 69715870 T DE69715870 T DE 69715870T DE 69715870 T2 DE69715870 T2 DE 69715870T2
Authority
DE
Germany
Prior art keywords
cell proliferation
inhibiting cell
bisindolylmaleimides
substituted
substituted bisindolylmaleimides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69715870T
Other languages
English (en)
Other versions
DE69715870D1 (de
Inventor
Hooda Dhingra
Mary Huryn
Dalton Keith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE69715870D1 publication Critical patent/DE69715870D1/de
Application granted granted Critical
Publication of DE69715870T2 publication Critical patent/DE69715870T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69715870T 1996-07-29 1997-07-19 Substituierte bisindolylmaleimide zur inhibierung der zellproliferation Expired - Fee Related DE69715870T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2207896P 1996-07-29 1996-07-29
US4849697P 1997-06-03 1997-06-03
PCT/EP1997/003888 WO1998004551A1 (en) 1996-07-29 1997-07-19 Substituted bisindolylmaleimides for the inhibition of cell proliferation

Publications (2)

Publication Number Publication Date
DE69715870D1 DE69715870D1 (de) 2002-10-31
DE69715870T2 true DE69715870T2 (de) 2003-06-18

Family

ID=26695475

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69715870T Expired - Fee Related DE69715870T2 (de) 1996-07-29 1997-07-19 Substituierte bisindolylmaleimide zur inhibierung der zellproliferation

Country Status (20)

Country Link
US (1) US6228877B1 (de)
EP (1) EP0915870B1 (de)
JP (1) JP2000516588A (de)
KR (1) KR20000029640A (de)
CN (1) CN1077571C (de)
AR (1) AR007969A1 (de)
AT (1) ATE224889T1 (de)
AU (1) AU740011B2 (de)
BR (1) BR9711607A (de)
CA (1) CA2262089A1 (de)
CO (1) CO4900054A1 (de)
DE (1) DE69715870T2 (de)
DK (1) DK0915870T3 (de)
ES (1) ES2183163T3 (de)
HR (1) HRP970415A2 (de)
MA (1) MA24354A1 (de)
PE (1) PE91598A1 (de)
PT (1) PT915870E (de)
TR (1) TR199900186T2 (de)
WO (1) WO1998004551A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1064279B1 (de) * 1998-03-17 2003-06-25 F.Hoffmann-La Roche Ag Substituierte bisindolylmaleimide zur inhibierung der zellproliferation
US6350786B1 (en) * 1998-09-22 2002-02-26 Hoffmann-La Roche Inc. Stable complexes of poorly soluble compounds in ionic polymers
WO2001027106A1 (en) * 1999-10-12 2001-04-19 F. Hoffmann-La Roche Ag Substituted pyrroles as antiproliferative agents for the treatment of cancer
US6559164B1 (en) 1999-10-12 2003-05-06 Hoffmann-La Roche Inc. Substituted pyrroles suitable for continuous infusion
US6313143B1 (en) 1999-12-16 2001-11-06 Hoffmann-La Roche Inc. Substituted pyrroles
US6281356B1 (en) * 1999-12-22 2001-08-28 Hoffmann-La Roche Inc. Substituted pyrroles
US6326501B1 (en) * 2000-04-19 2001-12-04 Hoffmann-La Roche Inc. Methylation of indole compounds using dimethyl carbonate
US7129250B2 (en) * 2000-05-19 2006-10-31 Aegera Therapeutics Inc. Neuroprotective and anti-proliferative compounds
CA2308994A1 (en) * 2000-05-19 2001-11-19 Aegera Therapeutics Inc. Neuroprotective compounds
TW201041580A (en) 2001-09-27 2010-12-01 Alcon Inc Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma
WO2003037384A2 (en) * 2001-10-29 2003-05-08 Nektar Therapeutics Al, Corporation Polymer conjugates of protein kinase c inhibitors
CA2393720C (en) 2002-07-12 2010-09-14 Eli Lilly And Company Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride
CA2599611C (en) 2005-02-09 2013-07-30 Chiang J. Li Meleimide derivatives, pharmaceutical compositions and methods for treatment of cancer
BRPI0720388A2 (pt) 2006-12-19 2014-01-14 Novartis Ag Derivados de indolilmaleimida
WO2009002806A1 (en) * 2007-06-22 2008-12-31 Arqule, Inc. Pyrrolidinone, pyrrolidine-2, 5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer
BRPI0813355A2 (pt) 2007-06-22 2014-12-30 Arqule Inc Compostos de quinazolinona e métodos de uso dos mesmos
CA2912546A1 (en) 2007-06-22 2008-12-31 Arqule, Inc. Compositions and methods for treatment of cancer
GB201111427D0 (en) * 2011-07-05 2011-08-17 Amakem Nv Novel bisindolylmaleimides, pan-pkc inhibitors
JP2017524739A (ja) 2014-07-17 2017-08-31 アンセルムＩｎｓｅｒｍ 神経筋接合部関連疾患の処置方法
WO2016207366A1 (en) 2015-06-26 2016-12-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of viral infections
CN109535158B (zh) * 2016-04-26 2021-04-23 浙江工业大学 一种双芳基马来酰亚胺类化合物及其药学上可接受的盐及其制备方法和应用
CN107973785B (zh) * 2017-11-27 2019-12-31 浙江工业大学上虞研究院有限公司 一种用于检测银离子的荧光探针及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK278989B6 (sk) * 1988-02-10 1998-05-06 F. Hoffmann-La Roche Ag Substituované pyroly, ich použitie na výrobu lieči
US5380746A (en) 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
IL94274A0 (en) * 1989-05-05 1991-03-10 Goedecke Ag Maleinimide derivatives,process for the preparation thereof and pharmaceutical compositions containing the same
JPH0539289A (ja) 1991-02-15 1993-02-19 Masahiro Irie 無水マレイン酸誘導体およびその製造方法
AU3761393A (en) 1992-03-20 1993-10-21 Wellcome Foundation Limited, The Indole derivatives with antiviral activity
DE4217964A1 (de) 1992-05-30 1993-12-02 Goedecke Ag Indolocarbazol-Imide und deren Verwendung

Also Published As

Publication number Publication date
BR9711607A (pt) 1999-08-24
TR199900186T2 (xx) 1999-03-22
EP0915870B1 (de) 2002-09-25
HRP970415A2 (en) 1998-08-31
PE91598A1 (es) 1998-12-24
AU740011B2 (en) 2001-10-25
AU4296397A (en) 1998-02-20
DE69715870D1 (de) 2002-10-31
ATE224889T1 (de) 2002-10-15
CN1077571C (zh) 2002-01-09
DK0915870T3 (da) 2003-02-03
US6228877B1 (en) 2001-05-08
JP2000516588A (ja) 2000-12-12
AR007969A1 (es) 1999-11-24
CA2262089A1 (en) 1998-02-05
EP0915870A1 (de) 1999-05-19
ES2183163T3 (es) 2003-03-16
PT915870E (pt) 2003-01-31
MA24354A1 (fr) 1998-07-01
CN1226248A (zh) 1999-08-18
CO4900054A1 (es) 2000-03-27
WO1998004551A1 (en) 1998-02-05
KR20000029640A (ko) 2000-05-25

Similar Documents

Publication Publication Date Title
DE69715870T2 (de) Substituierte bisindolylmaleimide zur inhibierung der zellproliferation
DE69722003D1 (de) Substituierte bisindolylmaleimide zur inhibierung der zellproliferation
NO992336D0 (no) Raf-kinase-inhibitorer
DE69716615T2 (de) Heterozyklische metalloproteaseinhibitoren
NO992347D0 (no) R°rgripeanordning
DE69705112T2 (de) Coralynanaloge als topoisomerase inhibitoren
NO984316D0 (no) Skjµreverkt°y
NO983462D0 (no) Isoleringsverkt°y
ID22713A (id) Peralatan untuk laminasi
NO992541D0 (no) R°rbeskytter
DE69909068D1 (de) Substituierte bisindolylmaleimide zur inhibierung der zellproliferation
NO990552D0 (no) Innrettingsverkt°y
NO983683L (no) R°rperforeringssystem
NO983116L (no) Svingd°r
DE69737060D1 (de) Substituierte bisindolylmaleimide zur inhibierung der zellproliferation
NO984943D0 (no) R°rledningslagring
NO990168D0 (no) R°rforsegling
DE59709331D1 (de) Schaltungsanordnung zur Offset-Kompensation
DE60023182D1 (de) Substituierte bisindolylmaleimide zur inhibierung der zellproliferation
DE29608620U1 (de) Meßstation zur Erfassung des winkelabhängigen Muskeltonus
DE69720957T2 (de) Ace-hemmer
DE29621379U1 (de) Schaftkappe
DE69702247D1 (de) Zusammensetzung zur inhibierung der polymerisierung
DE29603398U1 (de) Telefontester zur Prüfung der Telefonleitung
SI1064279T1 (en) Substituted bisindolylmaleimides for the inhibition of cell proliferation

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee