MX2009013815A - Compuestos de quinazolinona y metodos de uso para los mismos. - Google Patents
Compuestos de quinazolinona y metodos de uso para los mismos.Info
- Publication number
- MX2009013815A MX2009013815A MX2009013815A MX2009013815A MX2009013815A MX 2009013815 A MX2009013815 A MX 2009013815A MX 2009013815 A MX2009013815 A MX 2009013815A MX 2009013815 A MX2009013815 A MX 2009013815A MX 2009013815 A MX2009013815 A MX 2009013815A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- present
- compounds
- quinazolinone
- quinazolinone compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Abstract
La presente invención se refiere a compuestos de quinazolinona, y métodos de preparación de estos compuestos; la presente invención también se refiere a composiciones farmacéuticas que comprenden los compuestos de quinazolinona; la presente invención proporciona métodos para tratar un trastorno proliferativo celular, tal como cáncer, al administrar a un sujeto en necesidad del mismo, una cantidad terapéuticamente efectiva de un compuesto de quinazolinona de la presente invención.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US94583807P | 2007-06-22 | 2007-06-22 | |
PCT/US2008/067571 WO2009002808A2 (en) | 2007-06-22 | 2008-06-19 | Quinazolinone compounds and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009013815A true MX2009013815A (es) | 2010-03-01 |
Family
ID=39846620
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009013815A MX2009013815A (es) | 2007-06-22 | 2008-06-19 | Compuestos de quinazolinona y metodos de uso para los mismos. |
Country Status (13)
Country | Link |
---|---|
US (1) | US8232285B2 (es) |
EP (1) | EP2173724B1 (es) |
JP (1) | JP2010530885A (es) |
KR (1) | KR20100024494A (es) |
CN (1) | CN101801937A (es) |
AU (1) | AU2008268613A1 (es) |
BR (1) | BRPI0813355A2 (es) |
CA (1) | CA2704282A1 (es) |
IL (1) | IL202740A0 (es) |
MX (1) | MX2009013815A (es) |
TW (1) | TW200918069A (es) |
WO (1) | WO2009002808A2 (es) |
ZA (1) | ZA201000183B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8268807B2 (en) * | 2010-04-19 | 2012-09-18 | Sri International | Compositions and method for the treatment of multiple myeloma |
US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
MY175778A (en) | 2013-10-04 | 2020-07-08 | Infinity Pharmaceuticals Inc | Heterocyclic compounds and uses thereof |
WO2015051241A1 (en) | 2013-10-04 | 2015-04-09 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US20150132575A1 (en) * | 2013-11-14 | 2015-05-14 | Honeywell International Inc. | Luminescent fibers, articles including the same, and methods of forming the same |
SG11201607705XA (en) | 2014-03-19 | 2016-10-28 | Infinity Pharmaceuticals Inc | Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders |
WO2016054491A1 (en) | 2014-10-03 | 2016-04-07 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
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US10759806B2 (en) | 2016-03-17 | 2020-09-01 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as PI3K kinase inhibitors |
WO2017214269A1 (en) | 2016-06-08 | 2017-12-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
TW201825465A (zh) | 2016-09-23 | 2018-07-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
TW201815787A (zh) | 2016-09-23 | 2018-05-01 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
TW201813963A (zh) | 2016-09-23 | 2018-04-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
CN112334468A (zh) * | 2018-05-11 | 2021-02-05 | 美国卫生和人力服务部 | 喹啉化合物及其制备和作为抗疟疾剂的用途 |
CN113354590A (zh) * | 2020-03-05 | 2021-09-07 | 宁波康柏睿格医药科技有限公司 | 拮抗nod1/2受体信号通路的喹唑啉酮类化合物 |
Family Cites Families (72)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BG16042A3 (bg) | 1968-11-12 | 1972-05-20 | Nans Ott | Метод за получаване на нови 2(1н)-хиназолинони |
AU543928B2 (en) | 1981-01-16 | 1985-05-09 | Masayuki Ishikawa | 4(311)-quinazolinone derivatives |
US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
US5187167A (en) | 1986-03-27 | 1993-02-16 | Imperial Chemical Industries Plc | Pharmaceutical compositions comprising quinazolin-4-one derivatives |
GB8707053D0 (en) | 1987-03-25 | 1987-04-29 | Ici Plc | Anti-tumour agents |
NZ227850A (en) | 1988-02-10 | 1991-11-26 | Hoffmann La Roche | Indole substituted pyrrole derivatives; preparatory process and medicaments for use against inflammatory immunological, bronchopulmonary or vascular disorders |
GB8827820D0 (en) | 1988-11-29 | 1988-12-29 | Janssen Pharmaceutica Nv | (1h-azol-1-ylmethyl)substituted quinoline derivatives |
GB8827988D0 (en) | 1988-11-30 | 1989-01-05 | Smith Kline French Lab | Chemical compounds |
USRE36736E (en) | 1989-02-06 | 2000-06-13 | Hoffman-La Roche Inc. | Substituted pyrroles |
MC2096A1 (fr) | 1989-02-23 | 1991-02-15 | Hoffmann La Roche | Pyrroles substitues |
GB8904161D0 (en) | 1989-02-23 | 1989-04-05 | Hoffmann La Roche | Substituted pyrroles |
US5380746A (en) | 1989-05-05 | 1995-01-10 | Goedecke Aktiengesellschaft | Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them |
IL94274A0 (en) | 1989-05-05 | 1991-03-10 | Goedecke Ag | Maleinimide derivatives,process for the preparation thereof and pharmaceutical compositions containing the same |
DE4005969A1 (de) | 1990-02-26 | 1991-08-29 | Boehringer Mannheim Gmbh | Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten |
DE4005970A1 (de) | 1990-02-26 | 1991-08-29 | Boehringer Mannheim Gmbh | Neue trisubstituierte maleinimide, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten |
ZA913730B (en) | 1990-05-30 | 1992-02-26 | Ici Plc | Anti-tumor compounds |
US5292747A (en) | 1990-08-07 | 1994-03-08 | Hoffman-La Roche Inc. | Substituted pyrroles |
US5591842A (en) | 1991-11-29 | 1997-01-07 | Banyu Pharmaceutical Co., Ltd. | Indolopyrrolocarbazole derivatives |
AU671102B2 (en) | 1992-03-12 | 1996-08-15 | Smithkline Beecham Plc | Condensed indole derivatives as 5HT4-receptor antagonists |
EP0630241A1 (en) | 1992-03-20 | 1994-12-28 | The Wellcome Foundation Limited | Indole derivatives with antiviral activity |
US5721230A (en) | 1993-05-10 | 1998-02-24 | Hoffmann-La Roche Inc. | Substituted pyrroles |
ES2236702T3 (es) | 1993-12-23 | 2005-07-16 | Eli Lilly And Company | Inhibidores de la proteina quinasa c. |
US5545636A (en) | 1993-12-23 | 1996-08-13 | Eli Lilly And Company | Protein kinase C inhibitors |
US6524832B1 (en) | 1994-02-04 | 2003-02-25 | Arch Development Corporation | DNA damaging agents in combination with tyrosine kinase inhibitors |
WO1995024190A2 (en) | 1994-03-07 | 1995-09-14 | Sugen, Inc. | Receptor tyrosine kinase inhibitors for inhibiting cell proliferative disorders and compositions thereof |
WO1995030682A1 (fr) | 1994-05-09 | 1995-11-16 | Banyu Pharmaceutical Co., Ltd. | Derive d'indolopyrolocarbazole antitumoral |
IL110831A (en) | 1994-08-31 | 1998-12-27 | Hadasit Med Res Service | Pharmaceutical compositions containing quinazolinone derivatives for preventing restenosis |
US5591855A (en) | 1994-10-14 | 1997-01-07 | Cephalon, Inc. | Fused pyrrolocarbazoles |
IL112125A (en) | 1994-12-22 | 1998-02-08 | Hadasit Med Res Service | Quinazolinone-containing pharmaceutical compositions |
US5559228A (en) | 1995-03-30 | 1996-09-24 | Eli Lilly And Company | Synthesis of bisindolylmaleimides |
US5747498A (en) | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
CN1225634A (zh) | 1996-03-20 | 1999-08-11 | 伊莱利利公司 | 吲哚马来酰亚胺的合成 |
PE91598A1 (es) | 1996-07-29 | 1998-12-24 | Hoffmann La Roche | Pirroles sustituidos |
PE91698A1 (es) | 1996-07-29 | 1998-12-24 | Hoffmann La Roche | Pirroles sustituidos |
EA001392B1 (ru) | 1996-08-23 | 2001-02-26 | Эли Лилли Энд Компани | Синтез бисиндолилмалеимидов |
SE9603283D0 (sv) | 1996-09-10 | 1996-09-10 | Astra Ab | New compounds |
AU4920397A (en) | 1996-10-11 | 1998-05-11 | Chiron Corporation | Purine inhibitors of glycogen synthase kinase 3 (gsk3) |
US6028075A (en) | 1997-02-11 | 2000-02-22 | Pines; Mark | Quinazolinone containing pharmaceutical compositions for prevention of neovascularization and for treating malignancies |
US5859261A (en) | 1997-03-20 | 1999-01-12 | Eli Lilly And Company | Synthesis of indolylmaleimides |
US6184377B1 (en) | 1997-12-15 | 2001-02-06 | Sepracor Inc. | Compositions containing N-amino- and N-hydroxy-quinazolinones and methods for preparing libraries thereof |
BR9912612A (pt) | 1998-07-30 | 2001-11-20 | Japan Tobacco Inc | Composto de maleimida dissubstituìdo e seu usofarmacêutico |
US6589977B1 (en) | 1999-02-09 | 2003-07-08 | Sagami Chemical Research Center | Pyrrole derivatives and cell death inhibitors |
ES2263501T3 (es) | 1999-10-27 | 2006-12-16 | Cytokinetics, Inc. | Procedimiento y composiciones que utilizan quinazolinonas. |
US6545004B1 (en) | 1999-10-27 | 2003-04-08 | Cytokinetics, Inc. | Methods and compositions utilizing quinazolinones |
UA74803C2 (uk) | 1999-11-11 | 2006-02-15 | Осі Фармасьютікалз, Інк. | Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування |
WO2001044247A2 (en) | 1999-12-16 | 2001-06-21 | Eli Lilly And Company | Agents and methods for the treatment of proliferative diseases |
WO2001044235A2 (en) | 1999-12-16 | 2001-06-21 | Eli Lilly And Company | Agents and methods for the treatment of proliferative diseases |
US20030087949A1 (en) | 2000-03-30 | 2003-05-08 | Mikiko Sodeoka | Indolylpyrrole derivatives and cell death inhibitors |
IL152721A0 (en) | 2000-05-11 | 2003-06-24 | Consejo Superior Investigacion | Heterocyclic compounds and pharmaceutical compositions for inhibition of glycogen synthase kinase containing the same |
AU7785401A (en) | 2000-06-29 | 2002-01-14 | Long Island Jewish Res Inst | Modulators of cellular proliferation and angiogenesis, methods for use and identification thereof |
US7074824B2 (en) | 2001-07-31 | 2006-07-11 | Arqule, Inc. | Pharmaceutical compositions containing beta-lapachone, or derivatives or analogs thereof, and methods of using same |
US6962944B2 (en) | 2001-07-31 | 2005-11-08 | Arqule, Inc. | Pharmaceutical compositions containing beta-lapachone, or derivatives or analogs thereof, and methods of using same |
US7060705B2 (en) | 2001-11-07 | 2006-06-13 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
AU2002346471A1 (en) | 2001-11-20 | 2003-06-10 | Cytokinetics, Inc. | Process for the racemization of chiral quinazolinones |
AU2003219679B2 (en) | 2002-01-23 | 2009-02-26 | Texas Tech University | Mammalian migration inducting gene and methods for detection and inhibition of migrating tumor cells |
JP2005529076A (ja) | 2002-02-15 | 2005-09-29 | サイトキネティクス・インコーポレーテッド | キナゾリノンの合成 |
EP1483265B1 (en) | 2002-03-05 | 2006-11-22 | Eli Lilly And Company | Purine derivatives as kinase inhibitors |
EP1553931A4 (en) | 2002-05-09 | 2006-08-30 | Cytokinetics Inc | COMPOUNDS, COMPOSITIONS AND METHODS |
US20050203110A1 (en) * | 2002-05-23 | 2005-09-15 | Coleman Paul J. | Mitotic kinesin inhibitors |
US7038048B2 (en) * | 2002-05-23 | 2006-05-02 | Cytokinetics, Inc. | 3H-pyridopyrimidin-4-one compounds, compositions, and methods of their use |
EP1537089A4 (en) * | 2002-07-23 | 2008-04-16 | Cytokinetics Inc | CONNECTIONS, COMPOSITIONS AND PROCEDURES |
US20070059697A1 (en) | 2003-04-15 | 2007-03-15 | Avalon Pharmaceuticals, Inc | Determining cancer-linked genes and therapeutic targets using molecular cytogenetic methods |
US20050043233A1 (en) | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
EP2251343A1 (en) | 2003-05-15 | 2010-11-17 | Arqule, Inc. | Imidazothiazoles as p38-kinase-inhibitors |
US7345046B2 (en) | 2003-05-30 | 2008-03-18 | Chiron Corporation | Heteroaryl-fused pyrimidinyl compounds as anticancer agents |
PL1636593T3 (pl) | 2003-06-06 | 2009-08-31 | Genentech Inc | Modulowanie oddziaływania pomiędzy łańcuchem beta HGF i c-met. |
DE602004024536D1 (de) | 2003-07-07 | 2010-01-21 | Van Andel Res Inst | Hemmung der tumor-angiogenese durch eine kombination von thrombospondin-1 und hemmern des vaskulären endothel-wachstumsfaktors |
CA2548282A1 (en) | 2003-12-11 | 2005-06-30 | Genentech, Inc. | Methods and compositions for inhibiting c-met dimerization and activation |
CA2584368A1 (en) | 2004-10-19 | 2006-04-27 | Arqule, Inc. | Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 map kinase |
RU2547148C2 (ru) | 2005-02-09 | 2015-04-10 | Аркьюл, Инк. | Композиции и способы лечения рака |
PL1863519T3 (pl) | 2005-03-31 | 2014-03-31 | Massachusetts Gen Hospital | Modulowanie aktywności HGF/HGFR do leczenia obrzęku wskutek niedrożności naczyń chłonnych |
EP2013218A2 (en) | 2006-04-17 | 2009-01-14 | Arqule, Inc. | Raf inhibitors and their uses |
-
2008
- 2008-06-19 CA CA2704282A patent/CA2704282A1/en not_active Abandoned
- 2008-06-19 JP JP2010513424A patent/JP2010530885A/ja not_active Withdrawn
- 2008-06-19 US US12/142,762 patent/US8232285B2/en active Active
- 2008-06-19 AU AU2008268613A patent/AU2008268613A1/en not_active Abandoned
- 2008-06-19 EP EP08771527A patent/EP2173724B1/en active Active
- 2008-06-19 MX MX2009013815A patent/MX2009013815A/es not_active Application Discontinuation
- 2008-06-19 WO PCT/US2008/067571 patent/WO2009002808A2/en active Application Filing
- 2008-06-19 BR BRPI0813355-7A2A patent/BRPI0813355A2/pt not_active IP Right Cessation
- 2008-06-19 CN CN200880104552A patent/CN101801937A/zh active Pending
- 2008-06-19 KR KR1020107001013A patent/KR20100024494A/ko not_active Application Discontinuation
- 2008-06-20 TW TW097123156A patent/TW200918069A/zh unknown
-
2009
- 2009-12-15 IL IL202740A patent/IL202740A0/en unknown
-
2010
- 2010-01-11 ZA ZA2010/00183A patent/ZA201000183B/en unknown
Also Published As
Publication number | Publication date |
---|---|
IL202740A0 (en) | 2010-06-30 |
TW200918069A (en) | 2009-05-01 |
ZA201000183B (en) | 2011-03-30 |
WO2009002808A2 (en) | 2008-12-31 |
US8232285B2 (en) | 2012-07-31 |
JP2010530885A (ja) | 2010-09-16 |
EP2173724B1 (en) | 2012-12-05 |
CN101801937A (zh) | 2010-08-11 |
CA2704282A1 (en) | 2008-12-31 |
KR20100024494A (ko) | 2010-03-05 |
EP2173724A2 (en) | 2010-04-14 |
US20090130097A1 (en) | 2009-05-21 |
AU2008268613A1 (en) | 2008-12-31 |
BRPI0813355A2 (pt) | 2014-12-30 |
WO2009002808A3 (en) | 2009-07-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
HH | Correction or change in general | ||
FA | Abandonment or withdrawal |