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Application filed by Arqule IncfiledCriticalArqule Inc
Priority to MYPI20095675priorityCriticalpatent/MY148385A/en
Publication of MY148385ApublicationCriticalpatent/MY148385A/en
THE PRESENT INVENTION RELATES TO PYRROLOQUINOLINYL-PYRROLE-2,5-DIONE COMPOUNDS AND PYRROLOQUINOLINYL-PYRROLIDINE-2,5-DIONE COMPOUNDS, AND METHODS OF PREPARATION OF THESE COMPOUNDS. THE PRESENT INVENTION ALSO RELATES TO PHARMACEUTICAL COMPOSITIONS COMPRISING PYRROLOQUINOLINYL-PYRROLE-2,5-DIONE COMPOUNDS AND PYRROLOQUINOLINYL-PYRROLIDINE-2,5-DIONE COMPOUNDS. THE PRESENT INVENTION PROVIDES METHODS OF TREATING A CELL PROLIFERATIVE DISORDER, SUCH AS A CANCER, BY ADMINISTERING TO A SUBJECT IN NEED THEREOF A THERAPEUTICALLY EFFECTIVE AMOUNT OF A PYRROLOQUINOLINYL-PYRROLE-2,5-DIONE COMPOUND OR PYRROLOQUINOLINYL-PYRROLIDINE-2,5-DIONE COMPOUND OF THE PRESENT INVENTION.
MYPI200956752007-08-062007-08-06Maleimide derivatives, pharmaceutical compositions and methods for treatment of cancer
MY148385A
(en)
A composition comprising (-) -trans-3- (5, 6-dihydro-4h-pyrrolo [3,2,1-ij] quinolin-l-yl)-4-(lh-indol-3-yl) pyrrolidine- 2, 5-dione in combination with a second anti-proliferative agent