DE69722003D1 - Substituierte bisindolylmaleimide zur inhibierung der zellproliferation - Google Patents

Substituierte bisindolylmaleimide zur inhibierung der zellproliferation

Info

Publication number
DE69722003D1
DE69722003D1 DE69722003T DE69722003T DE69722003D1 DE 69722003 D1 DE69722003 D1 DE 69722003D1 DE 69722003 T DE69722003 T DE 69722003T DE 69722003 T DE69722003 T DE 69722003T DE 69722003 D1 DE69722003 D1 DE 69722003D1
Authority
DE
Germany
Prior art keywords
cell proliferation
inhibiting cell
bisindolylmaleimides
substituted
substituted bisindolylmaleimides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69722003T
Other languages
English (en)
Other versions
DE69722003T2 (de
Inventor
Mary Huryn
Dalton Keith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of DE69722003D1 publication Critical patent/DE69722003D1/de
Publication of DE69722003T2 publication Critical patent/DE69722003T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69722003T 1996-07-29 1997-07-19 Substituierte bisindolylmaleimide zur inhibierung der zellproliferation Expired - Fee Related DE69722003T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2207996P 1996-07-29 1996-07-29
US22079P 1996-07-29
PCT/EP1997/003889 WO1998004552A1 (en) 1996-07-29 1997-07-19 Substituted bisindolylmaleimides for the inhibition of cell proliferation

Publications (2)

Publication Number Publication Date
DE69722003D1 true DE69722003D1 (de) 2003-06-18
DE69722003T2 DE69722003T2 (de) 2004-04-01

Family

ID=21807711

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69722003T Expired - Fee Related DE69722003T2 (de) 1996-07-29 1997-07-19 Substituierte bisindolylmaleimide zur inhibierung der zellproliferation

Country Status (23)

Country Link
US (2) US5856517A (de)
EP (1) EP0915872B1 (de)
JP (1) JP2000516589A (de)
KR (1) KR20000029637A (de)
CN (2) CN1151149C (de)
AR (1) AR008267A1 (de)
AT (1) ATE240318T1 (de)
AU (1) AU739742B2 (de)
BR (1) BR9711605A (de)
CA (1) CA2262092A1 (de)
CO (1) CO4900055A1 (de)
CY (1) CY2483B1 (de)
DE (1) DE69722003T2 (de)
DK (1) DK0915872T3 (de)
ES (1) ES2198001T3 (de)
HR (1) HRP970414A2 (de)
MA (1) MA24287A1 (de)
PE (1) PE91698A1 (de)
PT (1) PT915872E (de)
SA (1) SA97180473A (de)
TR (1) TR199900157T2 (de)
WO (1) WO1998004552A1 (de)
ZA (1) ZA976492B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE243693T1 (de) * 1998-03-17 2003-07-15 Hoffmann La Roche Substituierte bisindolylmaleimide zur inhibierung der zellproliferation
US6743785B2 (en) * 1999-12-16 2004-06-01 Eli Lilly And Company Agents and methods for the treatment of proliferative diseases
US6313143B1 (en) 1999-12-16 2001-11-06 Hoffmann-La Roche Inc. Substituted pyrroles
WO2001044247A2 (en) * 1999-12-16 2001-06-21 Eli Lilly And Company Agents and methods for the treatment of proliferative diseases
ES2220585T3 (es) * 1999-12-16 2004-12-16 Eli Lilly And Company Agentes y procedimiento para el tratamiento de enfermedades proliferativas.
US6281356B1 (en) 1999-12-22 2001-08-28 Hoffmann-La Roche Inc. Substituted pyrroles
TW201041580A (en) 2001-09-27 2010-12-01 Alcon Inc Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma
US20030139373A1 (en) * 2001-11-20 2003-07-24 Breimer Lars Holger Method for cancer therapy
TWI280128B (en) * 2002-05-22 2007-05-01 Smithkline Beecham Corp 3'-[(2Z)-[1-(3,4- dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid bis-(monoethanolamine)
US7012100B1 (en) * 2002-06-04 2006-03-14 Avolix Pharmaceuticals, Inc. Cell migration inhibiting compositions and methods and compositions for treating cancer
RU2409579C2 (ru) 2005-02-09 2011-01-20 Аркьюл, Инк. Композиции и способы лечения рака
CN101558062A (zh) * 2006-12-19 2009-10-14 诺瓦提斯公司 作为激酶抑制剂的吲哚基马来酰亚胺衍生物
JP5425060B2 (ja) 2007-06-22 2014-02-26 アークル インコーポレイテッド ピロリジノン、ピロリジン−２，５−ジオン、ピロリジンおよびチオスクシンイミド誘導体、癌の治療のための組成物および方法
EP2173724B1 (de) 2007-06-22 2012-12-05 ArQule, Inc. Chinazolinonverbindungen und verfahren zu ihrer anwendung
EP2173748B1 (de) 2007-06-22 2011-08-31 ArQule, Inc. Indolylpyrrolidine zur behandlung von krebs
JP2009035537A (ja) * 2007-07-10 2009-02-19 Nippon Synthetic Chem Ind Co Ltd:The Ｎ−置換アニリン誘導体及び１−置換インドール誘導体の製造方法
FR2927075A1 (fr) * 2008-02-04 2009-08-07 Centre Nat Rech Scient Molecules comprenant un squelette bis-(heteroaryl)maleimide, et leur utilisation dans l'inhibition d'enzymes
GB201111427D0 (en) * 2011-07-05 2011-08-17 Amakem Nv Novel bisindolylmaleimides, pan-pkc inhibitors
WO2015123365A1 (en) 2014-02-11 2015-08-20 Mitokinin Llc Compositions and methods using the same for treatment of neurodegenerative and mitochondrial disease
EP3741375A1 (de) 2014-07-17 2020-11-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Verfahren zur behandlung von erkrankungen in zusammenhang mit neuromuskulären verbindungen
WO2016207366A1 (en) 2015-06-26 2016-12-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of viral infections
KR20200019228A (ko) * 2017-06-21 2020-02-21 미토키닌, 인크. 신경퇴행성 및 미토콘드리아 질환의 치료를 위한 조성물 및 이를 사용하는 방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ227850A (en) * 1988-02-10 1991-11-26 Hoffmann La Roche Indole substituted pyrrole derivatives; preparatory process and medicaments for use against inflammatory immunological, bronchopulmonary or vascular disorders
US5380746A (en) * 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
CA2015996C (en) * 1989-05-05 2001-08-28 Hartmut Osswald Bis-(1h-indol-3-yl)-maleinimide derivatives and their use as pharmaceuticals
DE4005969A1 (de) * 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
JPH0539289A (ja) * 1991-02-15 1993-02-19 Masahiro Irie 無水マレイン酸誘導体およびその製造方法
WO1993018765A1 (en) * 1992-03-20 1993-09-30 The Wellcome Foundation Limited Indole derivatives with antiviral activity
DE4217964A1 (de) * 1992-05-30 1993-12-02 Goedecke Ag Indolocarbazol-Imide und deren Verwendung

Also Published As

Publication number Publication date
CN1495182A (zh) 2004-05-12
CO4900055A1 (es) 2000-03-27
AR008267A1 (es) 1999-12-29
KR20000029637A (ko) 2000-05-25
ES2198001T3 (es) 2004-01-16
TR199900157T2 (xx) 1999-04-21
BR9711605A (pt) 1999-08-24
US5856517A (en) 1999-01-05
DE69722003T2 (de) 2004-04-01
JP2000516589A (ja) 2000-12-12
CN1151149C (zh) 2004-05-26
AU3769097A (en) 1998-02-20
WO1998004552A1 (en) 1998-02-05
CA2262092A1 (en) 1998-02-05
DK0915872T3 (da) 2003-09-08
AU739742B2 (en) 2001-10-18
US6030994A (en) 2000-02-29
CN1226247A (zh) 1999-08-18
PT915872E (pt) 2003-09-30
EP0915872B1 (de) 2003-05-14
SA97180473A (ar) 2005-12-03
CY2483B1 (en) 2005-06-03
MA24287A1 (fr) 1998-04-01
PE91698A1 (es) 1998-12-24
EP0915872A1 (de) 1999-05-19
ZA976492B (en) 1998-01-29
HRP970414A2 (en) 1998-06-30
ATE240318T1 (de) 2003-05-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee