BR9711605A - Bis-indolilmaleimidas substitu¡das para a inibi-Æo de prolifera-Æo de c-lula - Google Patents
Bis-indolilmaleimidas substitu¡das para a inibi-Æo de prolifera-Æo de c-lulaInfo
- Publication number
- BR9711605A BR9711605A BR9711605A BR9711605A BR9711605A BR 9711605 A BR9711605 A BR 9711605A BR 9711605 A BR9711605 A BR 9711605A BR 9711605 A BR9711605 A BR 9711605A BR 9711605 A BR9711605 A BR 9711605A
- Authority
- BR
- Brazil
- Prior art keywords
- indolylmaleimides
- inhibition
- bis
- substituted
- cell proliferation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2207996P | 1996-07-29 | 1996-07-29 | |
| PCT/EP1997/003889 WO1998004552A1 (en) | 1996-07-29 | 1997-07-19 | Substituted bisindolylmaleimides for the inhibition of cell proliferation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9711605A true BR9711605A (pt) | 1999-08-24 |
Family
ID=21807711
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9711605A BR9711605A (pt) | 1996-07-29 | 1997-07-19 | Bis-indolilmaleimidas substitu¡das para a inibi-Æo de prolifera-Æo de c-lula |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US5856517A (pt) |
| EP (1) | EP0915872B1 (pt) |
| JP (1) | JP2000516589A (pt) |
| KR (1) | KR20000029637A (pt) |
| CN (2) | CN1495182A (pt) |
| AR (1) | AR008267A1 (pt) |
| AT (1) | ATE240318T1 (pt) |
| AU (1) | AU739742B2 (pt) |
| BR (1) | BR9711605A (pt) |
| CA (1) | CA2262092A1 (pt) |
| CO (1) | CO4900055A1 (pt) |
| CY (1) | CY2483B1 (pt) |
| DE (1) | DE69722003T2 (pt) |
| DK (1) | DK0915872T3 (pt) |
| ES (1) | ES2198001T3 (pt) |
| HR (1) | HRP970414A2 (pt) |
| MA (1) | MA24287A1 (pt) |
| PE (1) | PE91698A1 (pt) |
| PT (1) | PT915872E (pt) |
| SA (1) | SA97180473A (pt) |
| TR (1) | TR199900157T2 (pt) |
| WO (1) | WO1998004552A1 (pt) |
| ZA (1) | ZA976492B (pt) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1064279B1 (en) * | 1998-03-17 | 2003-06-25 | F.Hoffmann-La Roche Ag | Substituted bisindolylmaleimides for the inhibition of cell proliferation |
| US6313143B1 (en) * | 1999-12-16 | 2001-11-06 | Hoffmann-La Roche Inc. | Substituted pyrroles |
| US6743785B2 (en) * | 1999-12-16 | 2004-06-01 | Eli Lilly And Company | Agents and methods for the treatment of proliferative diseases |
| DE60010934T2 (de) * | 1999-12-16 | 2005-05-19 | Eli Lilly And Co., Indianapolis | Medikamente geeignet zur Behandlung von proliferativen Erkrankungen |
| EP1242420A2 (en) | 1999-12-16 | 2002-09-25 | Eli Lilly And Company | Agents and methods for the treatment of proliferative diseases |
| US6281356B1 (en) | 1999-12-22 | 2001-08-28 | Hoffmann-La Roche Inc. | Substituted pyrroles |
| TW201041580A (en) | 2001-09-27 | 2010-12-01 | Alcon Inc | Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma |
| US20030139373A1 (en) * | 2001-11-20 | 2003-07-24 | Breimer Lars Holger | Method for cancer therapy |
| TWI280128B (en) * | 2002-05-22 | 2007-05-01 | Smithkline Beecham Corp | 3'-[(2Z)-[1-(3,4- dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid bis-(monoethanolamine) |
| US7012100B1 (en) | 2002-06-04 | 2006-03-14 | Avolix Pharmaceuticals, Inc. | Cell migration inhibiting compositions and methods and compositions for treating cancer |
| CA2599611C (en) | 2005-02-09 | 2013-07-30 | Chiang J. Li | Meleimide derivatives, pharmaceutical compositions and methods for treatment of cancer |
| BRPI0720388A2 (pt) * | 2006-12-19 | 2014-01-14 | Novartis Ag | Derivados de indolilmaleimida |
| CA2912546A1 (en) | 2007-06-22 | 2008-12-31 | Arqule, Inc. | Compositions and methods for treatment of cancer |
| BRPI0813355A2 (pt) | 2007-06-22 | 2014-12-30 | Arqule Inc | Compostos de quinazolinona e métodos de uso dos mesmos |
| WO2009002806A1 (en) | 2007-06-22 | 2008-12-31 | Arqule, Inc. | Pyrrolidinone, pyrrolidine-2, 5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer |
| JP2009035537A (ja) * | 2007-07-10 | 2009-02-19 | Nippon Synthetic Chem Ind Co Ltd:The | Ｎ−置換アニリン誘導体及び１−置換インドール誘導体の製造方法 |
| FR2927075A1 (fr) * | 2008-02-04 | 2009-08-07 | Centre Nat Rech Scient | Molecules comprenant un squelette bis-(heteroaryl)maleimide, et leur utilisation dans l'inhibition d'enzymes |
| GB201111427D0 (en) * | 2011-07-05 | 2011-08-17 | Amakem Nv | Novel bisindolylmaleimides, pan-pkc inhibitors |
| WO2015123365A1 (en) | 2014-02-11 | 2015-08-20 | Mitokinin Llc | Compositions and methods using the same for treatment of neurodegenerative and mitochondrial disease |
| JP2017524739A (ja) | 2014-07-17 | 2017-08-31 | アンセルムＩｎｓｅｒｍ | 神経筋接合部関連疾患の処置方法 |
| WO2016207366A1 (en) | 2015-06-26 | 2016-12-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of viral infections |
| WO2018237145A1 (en) * | 2017-06-21 | 2018-12-27 | Mitokinin, Inc. | COMPOSITIONS AND METHODS USING THEM FOR THE TREATMENT OF NEURODEGENERATIVE AND MITOCHONDRIAL DISEASE |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK278989B6 (sk) * | 1988-02-10 | 1998-05-06 | F. Hoffmann-La Roche Ag | Substituované pyroly, ich použitie na výrobu lieči |
| US5380746A (en) * | 1989-05-05 | 1995-01-10 | Goedecke Aktiengesellschaft | Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them |
| IL94274A0 (en) * | 1989-05-05 | 1991-03-10 | Goedecke Ag | Maleinimide derivatives,process for the preparation thereof and pharmaceutical compositions containing the same |
| DE4005969A1 (de) * | 1990-02-26 | 1991-08-29 | Boehringer Mannheim Gmbh | Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten |
| JPH0539289A (ja) * | 1991-02-15 | 1993-02-19 | Masahiro Irie | 無水マレイン酸誘導体およびその製造方法 |
| AU3761393A (en) * | 1992-03-20 | 1993-10-21 | Wellcome Foundation Limited, The | Indole derivatives with antiviral activity |
| DE4217964A1 (de) * | 1992-05-30 | 1993-12-02 | Goedecke Ag | Indolocarbazol-Imide und deren Verwendung |
-
1997
- 1997-07-15 PE PE1997000630A patent/PE91698A1/es not_active Application Discontinuation
- 1997-07-19 PT PT97934498T patent/PT915872E/pt unknown
- 1997-07-19 TR TR1999/00157T patent/TR199900157T2/xx unknown
- 1997-07-19 WO PCT/EP1997/003889 patent/WO1998004552A1/en active IP Right Grant
- 1997-07-19 KR KR1019997000706A patent/KR20000029637A/ko active IP Right Grant
- 1997-07-19 DK DK97934498T patent/DK0915872T3/da active
- 1997-07-19 ES ES97934498T patent/ES2198001T3/es not_active Expired - Lifetime
- 1997-07-19 AT AT97934498T patent/ATE240318T1/de not_active IP Right Cessation
- 1997-07-19 AU AU37690/97A patent/AU739742B2/en not_active Ceased
- 1997-07-19 JP JP10508453A patent/JP2000516589A/ja not_active Ceased
- 1997-07-19 BR BR9711605A patent/BR9711605A/pt not_active Application Discontinuation
- 1997-07-19 DE DE69722003T patent/DE69722003T2/de not_active Expired - Fee Related
- 1997-07-19 EP EP97934498A patent/EP0915872B1/en not_active Expired - Lifetime
- 1997-07-19 CA CA002262092A patent/CA2262092A1/en not_active Abandoned
- 1997-07-19 CN CNA031275400A patent/CN1495182A/zh active Pending
- 1997-07-19 CN CNB971967768A patent/CN1151149C/zh not_active Expired - Fee Related
- 1997-07-22 ZA ZA9706492A patent/ZA976492B/xx unknown
- 1997-07-22 AR ARP970103309A patent/AR008267A1/es not_active Application Discontinuation
- 1997-07-24 US US08/899,852 patent/US5856517A/en not_active Expired - Fee Related
- 1997-07-25 HR HR60/022,079A patent/HRP970414A2/hr not_active Application Discontinuation
- 1997-07-25 CO CO97042581A patent/CO4900055A1/es unknown
- 1997-07-29 MA MA24744A patent/MA24287A1/fr unknown
- 1997-10-06 SA SA97180473A patent/SA97180473A/ar unknown
-
1998
- 1998-10-05 US US09/166,766 patent/US6030994A/en not_active Expired - Fee Related
-
2004
- 2004-11-15 CY CY0400081A patent/CY2483B1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK0915872T3 (da) | 2003-09-08 |
| AU739742B2 (en) | 2001-10-18 |
| AR008267A1 (es) | 1999-12-29 |
| ATE240318T1 (de) | 2003-05-15 |
| US6030994A (en) | 2000-02-29 |
| TR199900157T2 (xx) | 1999-04-21 |
| CN1226247A (zh) | 1999-08-18 |
| ES2198001T3 (es) | 2004-01-16 |
| AU3769097A (en) | 1998-02-20 |
| CO4900055A1 (es) | 2000-03-27 |
| PE91698A1 (es) | 1998-12-24 |
| US5856517A (en) | 1999-01-05 |
| WO1998004552A1 (en) | 1998-02-05 |
| CA2262092A1 (en) | 1998-02-05 |
| ZA976492B (en) | 1998-01-29 |
| HRP970414A2 (en) | 1998-06-30 |
| KR20000029637A (ko) | 2000-05-25 |
| EP0915872B1 (en) | 2003-05-14 |
| JP2000516589A (ja) | 2000-12-12 |
| CY2483B1 (en) | 2005-06-03 |
| DE69722003T2 (de) | 2004-04-01 |
| CN1151149C (zh) | 2004-05-26 |
| MA24287A1 (fr) | 1998-04-01 |
| DE69722003D1 (de) | 2003-06-18 |
| EP0915872A1 (en) | 1999-05-19 |
| CN1495182A (zh) | 2004-05-12 |
| SA97180473A (ar) | 2005-12-03 |
| PT915872E (pt) | 2003-09-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: ALTERADA DE INT. CL. 7: C07D403/14, A61K 31/40 |
|
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PRESENTE PEDIDO DE PATENTE COMO INVENCAO DE ACORDO COM O ART. 8O DA LPI. |