ES2198001T3 - Bisindolilmaleimidas sustituidas para la inhibicion de proliferacion celular. - Google Patents

Bisindolilmaleimidas sustituidas para la inhibicion de proliferacion celular.

Info

Publication number
ES2198001T3
ES2198001T3 ES97934498T ES97934498T ES2198001T3 ES 2198001 T3 ES2198001 T3 ES 2198001T3 ES 97934498 T ES97934498 T ES 97934498T ES 97934498 T ES97934498 T ES 97934498T ES 2198001 T3 ES2198001 T3 ES 2198001T3
Authority
ES
Spain
Prior art keywords
methyl
compound
hydrogen
alkyl
indole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97934498T
Other languages
English (en)
Spanish (es)
Inventor
Donna Mary Huryn
Dennis Dalton Keith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2198001T3 publication Critical patent/ES2198001T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ES97934498T 1996-07-29 1997-07-19 Bisindolilmaleimidas sustituidas para la inhibicion de proliferacion celular. Expired - Lifetime ES2198001T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2207996P 1996-07-29 1996-07-29
US22079P 1996-07-29

Publications (1)

Publication Number Publication Date
ES2198001T3 true ES2198001T3 (es) 2004-01-16

Family

ID=21807711

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97934498T Expired - Lifetime ES2198001T3 (es) 1996-07-29 1997-07-19 Bisindolilmaleimidas sustituidas para la inhibicion de proliferacion celular.

Country Status (23)

Country Link
US (2) US5856517A (pt)
EP (1) EP0915872B1 (pt)
JP (1) JP2000516589A (pt)
KR (1) KR20000029637A (pt)
CN (2) CN1151149C (pt)
AR (1) AR008267A1 (pt)
AT (1) ATE240318T1 (pt)
AU (1) AU739742B2 (pt)
BR (1) BR9711605A (pt)
CA (1) CA2262092A1 (pt)
CO (1) CO4900055A1 (pt)
CY (1) CY2483B1 (pt)
DE (1) DE69722003T2 (pt)
DK (1) DK0915872T3 (pt)
ES (1) ES2198001T3 (pt)
HR (1) HRP970414A2 (pt)
MA (1) MA24287A1 (pt)
PE (1) PE91698A1 (pt)
PT (1) PT915872E (pt)
SA (1) SA97180473A (pt)
TR (1) TR199900157T2 (pt)
WO (1) WO1998004552A1 (pt)
ZA (1) ZA976492B (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1064279E (pt) * 1998-03-17 2003-10-31 Hoffmann La Roche Bisindolilmaleimidas substituidas para a inibicao da proliferacao celular
EP1242420A2 (en) 1999-12-16 2002-09-25 Eli Lilly And Company Agents and methods for the treatment of proliferative diseases
ATE267194T1 (de) * 1999-12-16 2004-06-15 Lilly Co Eli Medikamente geeignet zur behandlung von proliferativen erkrankungen
US6743785B2 (en) * 1999-12-16 2004-06-01 Eli Lilly And Company Agents and methods for the treatment of proliferative diseases
US6313143B1 (en) * 1999-12-16 2001-11-06 Hoffmann-La Roche Inc. Substituted pyrroles
US6281356B1 (en) 1999-12-22 2001-08-28 Hoffmann-La Roche Inc. Substituted pyrroles
TW201041580A (en) 2001-09-27 2010-12-01 Alcon Inc Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma
US20030139373A1 (en) * 2001-11-20 2003-07-24 Breimer Lars Holger Method for cancer therapy
TWI280128B (en) * 2002-05-22 2007-05-01 Smithkline Beecham Corp 3'-[(2Z)-[1-(3,4- dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid bis-(monoethanolamine)
US7012100B1 (en) 2002-06-04 2006-03-14 Avolix Pharmaceuticals, Inc. Cell migration inhibiting compositions and methods and compositions for treating cancer
CN101941970B (zh) 2005-02-09 2013-08-21 艾科优公司 用于治疗癌症的meleimide衍生物、药物组合物以及方法
US8193236B2 (en) * 2006-12-19 2012-06-05 Novartis Ag Indolylmaleimide derivatives processes for their production and pharmaceutical compositions
US8304425B2 (en) 2007-06-22 2012-11-06 Arqule, Inc. Pyrrolidinone, pyrrolidine-2,5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer
CN101801969B (zh) 2007-06-22 2014-10-29 艾科尔公司 治疗癌症的吲哚基吡咯烷
EP2173724B1 (en) 2007-06-22 2012-12-05 ArQule, Inc. Quinazolinone compounds and methods of use thereof
JP2009035537A (ja) * 2007-07-10 2009-02-19 Nippon Synthetic Chem Ind Co Ltd:The Ｎ−置換アニリン誘導体及び１−置換インドール誘導体の製造方法
FR2927075A1 (fr) * 2008-02-04 2009-08-07 Centre Nat Rech Scient Molecules comprenant un squelette bis-(heteroaryl)maleimide, et leur utilisation dans l'inhibition d'enzymes
GB201111427D0 (en) * 2011-07-05 2011-08-17 Amakem Nv Novel bisindolylmaleimides, pan-pkc inhibitors
CA2939219C (en) 2014-02-11 2023-02-28 Mitokinin Llc Compositions and methods using the same for treatment of neurodegenerative and mitochondrial disease
JP2017524739A (ja) 2014-07-17 2017-08-31 アンセルムＩｎｓｅｒｍ 神経筋接合部関連疾患の処置方法
WO2016207366A1 (en) 2015-06-26 2016-12-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of viral infections
EP3641545A4 (en) * 2017-06-21 2021-02-24 Mitokinin, Inc. COMPOSITIONS AND METHODS USING THEM FOR THE TREATMENT OF NEURODEGENERATIVE AND MITOCHONDRIAL DISEASE

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ227850A (en) * 1988-02-10 1991-11-26 Hoffmann La Roche Indole substituted pyrrole derivatives; preparatory process and medicaments for use against inflammatory immunological, bronchopulmonary or vascular disorders
PT93947B (pt) * 1989-05-05 1996-11-29 Goedecke Ag Processo para a preparacao de novos derivados de maleinimidas e de composicoes farmaceuticas que os contem
US5380746A (en) * 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
DE4005969A1 (de) * 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
JPH0539289A (ja) * 1991-02-15 1993-02-19 Masahiro Irie 無水マレイン酸誘導体およびその製造方法
AU3761393A (en) * 1992-03-20 1993-10-21 Wellcome Foundation Limited, The Indole derivatives with antiviral activity
DE4217964A1 (de) * 1992-05-30 1993-12-02 Goedecke Ag Indolocarbazol-Imide und deren Verwendung

Also Published As

Publication number Publication date
EP0915872A1 (en) 1999-05-19
EP0915872B1 (en) 2003-05-14
DK0915872T3 (da) 2003-09-08
CN1151149C (zh) 2004-05-26
SA97180473A (ar) 2005-12-03
CN1226247A (zh) 1999-08-18
ATE240318T1 (de) 2003-05-15
WO1998004552A1 (en) 1998-02-05
DE69722003T2 (de) 2004-04-01
CA2262092A1 (en) 1998-02-05
CO4900055A1 (es) 2000-03-27
HRP970414A2 (en) 1998-06-30
AU739742B2 (en) 2001-10-18
AU3769097A (en) 1998-02-20
BR9711605A (pt) 1999-08-24
JP2000516589A (ja) 2000-12-12
AR008267A1 (es) 1999-12-29
US5856517A (en) 1999-01-05
CY2483B1 (en) 2005-06-03
PE91698A1 (es) 1998-12-24
TR199900157T2 (xx) 1999-04-21
CN1495182A (zh) 2004-05-12
US6030994A (en) 2000-02-29
ZA976492B (en) 1998-01-29
MA24287A1 (fr) 1998-04-01
KR20000029637A (ko) 2000-05-25
DE69722003D1 (de) 2003-06-18
PT915872E (pt) 2003-09-30

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