MA24287A1 - Pyrroles substitues - Google Patents

Pyrroles substitues

Info

Publication number
MA24287A1
MA24287A1 MA24744A MA24744A MA24287A1 MA 24287 A1 MA24287 A1 MA 24287A1 MA 24744 A MA24744 A MA 24744A MA 24744 A MA24744 A MA 24744A MA 24287 A1 MA24287 A1 MA 24287A1
Authority
MA
Morocco
Prior art keywords
substituted pyrroles
pyrroles
substituted
Prior art date
Application number
MA24744A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA24287A1 publication Critical patent/MA24287A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
MA24744A 1996-07-29 1997-07-29 Pyrroles substitues MA24287A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2207996P 1996-07-29 1996-07-29

Publications (1)

Publication Number Publication Date
MA24287A1 true MA24287A1 (fr) 1998-04-01

Family

ID=21807711

Family Applications (1)

Application Number Title Priority Date Filing Date
MA24744A MA24287A1 (fr) 1996-07-29 1997-07-29 Pyrroles substitues

Country Status (23)

Country Link
US (2) US5856517A (fr)
EP (1) EP0915872B1 (fr)
JP (1) JP2000516589A (fr)
KR (1) KR20000029637A (fr)
CN (2) CN1495182A (fr)
AR (1) AR008267A1 (fr)
AT (1) ATE240318T1 (fr)
AU (1) AU739742B2 (fr)
BR (1) BR9711605A (fr)
CA (1) CA2262092A1 (fr)
CO (1) CO4900055A1 (fr)
CY (1) CY2483B1 (fr)
DE (1) DE69722003T2 (fr)
DK (1) DK0915872T3 (fr)
ES (1) ES2198001T3 (fr)
HR (1) HRP970414A2 (fr)
MA (1) MA24287A1 (fr)
PE (1) PE91698A1 (fr)
PT (1) PT915872E (fr)
SA (1) SA97180473A (fr)
TR (1) TR199900157T2 (fr)
WO (1) WO1998004552A1 (fr)
ZA (1) ZA976492B (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ299068B6 (cs) * 1998-03-17 2008-04-16 F. Hoffmann-La Roche Ag Substituovaný bisindolylmaleinimid a farmaceutický prostredek s jeho obsahem
US6867198B2 (en) 1999-12-16 2005-03-15 Eli Lilly And Company Agents and methods for the treatment of proliferative diseases
ATE267194T1 (de) * 1999-12-16 2004-06-15 Lilly Co Eli Medikamente geeignet zur behandlung von proliferativen erkrankungen
US6313143B1 (en) * 1999-12-16 2001-11-06 Hoffmann-La Roche Inc. Substituted pyrroles
US6743785B2 (en) * 1999-12-16 2004-06-01 Eli Lilly And Company Agents and methods for the treatment of proliferative diseases
US6281356B1 (en) 1999-12-22 2001-08-28 Hoffmann-La Roche Inc. Substituted pyrroles
TWI335221B (en) 2001-09-27 2011-01-01 Alcon Inc Inhibtors of glycogen synthase kinase-3 (gsk-3) for treating glaucoma
US20030139373A1 (en) * 2001-11-20 2003-07-24 Breimer Lars Holger Method for cancer therapy
MY142390A (en) * 2002-05-22 2010-11-30 Glaxosmithkline Llc 3' - [(2z)-[1-(3,4-dimethylphenyl)-1,5- dihydro-3- methyl-5-0xo-4h-pyrazol-4- ylidene]hydrazino]-2' -hydroxy -[1,1' -biphenyl]-3-carboxylic acid bis-(monoethanolamine)
US7012100B1 (en) * 2002-06-04 2006-03-14 Avolix Pharmaceuticals, Inc. Cell migration inhibiting compositions and methods and compositions for treating cancer
DK1846406T5 (da) 2005-02-09 2011-10-31 Arqule Inc Maleimidderivater, farmaceutiske sammensætninger og fremgangsmåder til behandling af cancer
EP2094689B1 (fr) * 2006-12-19 2013-04-03 Novartis AG Derivees de indolylmaleimide comme inhibiteurs de kinase
CA2704282A1 (fr) 2007-06-22 2008-12-31 Arqule, Inc. Composes de quinazolinone et leurs methodes d'utilisation
WO2009002807A2 (fr) 2007-06-22 2008-12-31 Arqule, Inc. Compositions et procédés de traitement du cancer
CN101801961B (zh) 2007-06-22 2014-09-24 艾科尔公司 吡咯烷酮、吡咯烷-2,5-二酮、吡咯烷和硫代琥珀酰亚胺衍生物、组合物以及治疗癌症的方法
JP2009035537A (ja) * 2007-07-10 2009-02-19 Nippon Synthetic Chem Ind Co Ltd:The Ｎ−置換アニリン誘導体及び１−置換インドール誘導体の製造方法
FR2927075A1 (fr) * 2008-02-04 2009-08-07 Centre Nat Rech Scient Molecules comprenant un squelette bis-(heteroaryl)maleimide, et leur utilisation dans l'inhibition d'enzymes
GB201111427D0 (en) * 2011-07-05 2011-08-17 Amakem Nv Novel bisindolylmaleimides, pan-pkc inhibitors
WO2015123365A1 (fr) 2014-02-11 2015-08-20 Mitokinin Llc Compositions et procedes les utilisant pour le traitement de maladie neurodegenerative et mitochondriale
JP2017524739A (ja) 2014-07-17 2017-08-31 アンセルムＩｎｓｅｒｍ 神経筋接合部関連疾患の処置方法
WO2016207366A1 (fr) 2015-06-26 2016-12-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes et compositions pharmaceutiques de traitement d'infections virales
KR20200019228A (ko) 2017-06-21 2020-02-21 미토키닌, 인크. 신경퇴행성 및 미토콘드리아 질환의 치료를 위한 조성물 및 이를 사용하는 방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK75289A3 (en) * 1988-02-10 1998-05-06 Hoffmann La Roche Substituted pyrroles, their use for producing a drug, and the drug on their base
CA2015996C (fr) * 1989-05-05 2001-08-28 Hartmut Osswald Derives de bis-(1h-indole-3-yl)-maleinimide et leur utilisation comme produits pharmaceutiques
US5380746A (en) * 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
DE4005969A1 (de) * 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
JPH0539289A (ja) * 1991-02-15 1993-02-19 Masahiro Irie 無水マレイン酸誘導体およびその製造方法
EP0630241A1 (fr) * 1992-03-20 1994-12-28 The Wellcome Foundation Limited Derives d'indole presentant une action antivirale
DE4217964A1 (de) * 1992-05-30 1993-12-02 Goedecke Ag Indolocarbazol-Imide und deren Verwendung

Also Published As

Publication number Publication date
CY2483B1 (en) 2005-06-03
PT915872E (pt) 2003-09-30
CO4900055A1 (es) 2000-03-27
CA2262092A1 (fr) 1998-02-05
TR199900157T2 (xx) 1999-04-21
WO1998004552A1 (fr) 1998-02-05
CN1226247A (zh) 1999-08-18
EP0915872A1 (fr) 1999-05-19
AU3769097A (en) 1998-02-20
US6030994A (en) 2000-02-29
DE69722003D1 (de) 2003-06-18
ES2198001T3 (es) 2004-01-16
DE69722003T2 (de) 2004-04-01
HRP970414A2 (en) 1998-06-30
AR008267A1 (es) 1999-12-29
SA97180473A (ar) 2005-12-03
EP0915872B1 (fr) 2003-05-14
US5856517A (en) 1999-01-05
PE91698A1 (es) 1998-12-24
AU739742B2 (en) 2001-10-18
ATE240318T1 (de) 2003-05-15
KR20000029637A (ko) 2000-05-25
DK0915872T3 (da) 2003-09-08
CN1151149C (zh) 2004-05-26
BR9711605A (pt) 1999-08-24
CN1495182A (zh) 2004-05-12
ZA976492B (en) 1998-01-29
JP2000516589A (ja) 2000-12-12

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