AR008267A1 - Pirroles sustituidos. - Google Patents
Pirroles sustituidos.Info
- Publication number
- AR008267A1 AR008267A1 ARP970103309A ARP970103309A AR008267A1 AR 008267 A1 AR008267 A1 AR 008267A1 AR P970103309 A ARP970103309 A AR P970103309A AR P970103309 A ARP970103309 A AR P970103309A AR 008267 A1 AR008267 A1 AR 008267A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- aryl
- aralkyl
- hydrogen
- independently
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Los compuestos de la fórmula I; R y R con independencia entre sí son alquilo, arilo, alquenilo, alquinilo; R y R con independencia entre sí sonhidrógeno o alquilo; R4, R5, R6 y R7 con independencia entre sí son CH300CR8, CO2R9, CH2OR10, CHO,CH 2NR11R12, CON(R13)2, hidrógeno, halógeno, ciano,alquilo, hidroxi, alcoxi, ariloxi, haloaquilo, nitro, amino, acilamino, aralquiloxi, monoalquilamino, dialquilamino, alquiltio, alquilsulfinilo oalquilsulonilo, con la condición de que porlo me nos uno de R4, R5, R6, o R7 sea ciano, CH2OOCR8, CO2R9, CH2OR10, CH2NR11R12, CHO o CON(R13)2; R8 esalquilo, aralquilo o arilo; R9 es alquilo, aralquilo o arilo; R10 es hidrógeno, alquilo, aralquilo o arilo; R11 y R12 con independencia entresí hid rógneo,alquilo, arilo, aralquilo o acilo; R13 es hidrógeno, alquilo, arilo, o aralquilo; y uno de X e Y significa O y el otro significa O, S, (H, OH) o(H, H); así como los productos previos farmacéuticamente aceptables de loscompuestos ácidos de la fórmula I con bases y/o de los compuestos básicos de lafórmula I con ácidos son agentes antiproliferativos útiles para el tratamiento del cancer.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2207996P | 1996-07-29 | 1996-07-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR008267A1 true AR008267A1 (es) | 1999-12-29 |
Family
ID=21807711
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970103309A AR008267A1 (es) | 1996-07-29 | 1997-07-22 | Pirroles sustituidos. |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US5856517A (es) |
| EP (1) | EP0915872B1 (es) |
| JP (1) | JP2000516589A (es) |
| KR (1) | KR20000029637A (es) |
| CN (2) | CN1151149C (es) |
| AR (1) | AR008267A1 (es) |
| AT (1) | ATE240318T1 (es) |
| AU (1) | AU739742B2 (es) |
| BR (1) | BR9711605A (es) |
| CA (1) | CA2262092A1 (es) |
| CO (1) | CO4900055A1 (es) |
| CY (1) | CY2483B1 (es) |
| DE (1) | DE69722003T2 (es) |
| DK (1) | DK0915872T3 (es) |
| ES (1) | ES2198001T3 (es) |
| HR (1) | HRP970414A2 (es) |
| MA (1) | MA24287A1 (es) |
| PE (1) | PE91698A1 (es) |
| PT (1) | PT915872E (es) |
| SA (1) | SA97180473A (es) |
| TR (1) | TR199900157T2 (es) |
| WO (1) | WO1998004552A1 (es) |
| ZA (1) | ZA976492B (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS49965B (sr) * | 1998-03-17 | 2008-09-29 | F.Hoffmann-La Roche Ag., | Supstituisani bisindolmaleimidi za inhibiciju ćelijske proliferacije |
| US6313143B1 (en) * | 1999-12-16 | 2001-11-06 | Hoffmann-La Roche Inc. | Substituted pyrroles |
| WO2001044247A2 (en) * | 1999-12-16 | 2001-06-21 | Eli Lilly And Company | Agents and methods for the treatment of proliferative diseases |
| US6743785B2 (en) * | 1999-12-16 | 2004-06-01 | Eli Lilly And Company | Agents and methods for the treatment of proliferative diseases |
| DE60010934T2 (de) * | 1999-12-16 | 2005-05-19 | Eli Lilly And Co., Indianapolis | Medikamente geeignet zur Behandlung von proliferativen Erkrankungen |
| US6281356B1 (en) | 1999-12-22 | 2001-08-28 | Hoffmann-La Roche Inc. | Substituted pyrroles |
| TW201041580A (en) | 2001-09-27 | 2010-12-01 | Alcon Inc | Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma |
| US20030139373A1 (en) * | 2001-11-20 | 2003-07-24 | Breimer Lars Holger | Method for cancer therapy |
| MY142390A (en) * | 2002-05-22 | 2010-11-30 | Glaxosmithkline Llc | 3' - [(2z)-[1-(3,4-dimethylphenyl)-1,5- dihydro-3- methyl-5-0xo-4h-pyrazol-4- ylidene]hydrazino]-2' -hydroxy -[1,1' -biphenyl]-3-carboxylic acid bis-(monoethanolamine) |
| US7012100B1 (en) | 2002-06-04 | 2006-03-14 | Avolix Pharmaceuticals, Inc. | Cell migration inhibiting compositions and methods and compositions for treating cancer |
| RU2547148C2 (ru) | 2005-02-09 | 2015-04-10 | Аркьюл, Инк. | Композиции и способы лечения рака |
| JP2010513386A (ja) * | 2006-12-19 | 2010-04-30 | ノバルティス アーゲー | キナーゼ阻害剤としてのインドリルマレイミド誘導体 |
| EP2173748B1 (en) | 2007-06-22 | 2011-08-31 | ArQule, Inc. | Indolyl pyrrolidines for the treatment of cancer |
| JP5425060B2 (ja) | 2007-06-22 | 2014-02-26 | アークル インコーポレイテッド | ピロリジノン、ピロリジン−２，５−ジオン、ピロリジンおよびチオスクシンイミド誘導体、癌の治療のための組成物および方法 |
| JP2010530885A (ja) | 2007-06-22 | 2010-09-16 | アークル インコーポレイテッド | キナゾリノン化合物およびその使用方法 |
| JP2009035537A (ja) * | 2007-07-10 | 2009-02-19 | Nippon Synthetic Chem Ind Co Ltd:The | Ｎ−置換アニリン誘導体及び１−置換インドール誘導体の製造方法 |
| FR2927075A1 (fr) * | 2008-02-04 | 2009-08-07 | Centre Nat Rech Scient | Molecules comprenant un squelette bis-(heteroaryl)maleimide, et leur utilisation dans l'inhibition d'enzymes |
| GB201111427D0 (en) * | 2011-07-05 | 2011-08-17 | Amakem Nv | Novel bisindolylmaleimides, pan-pkc inhibitors |
| US10167286B2 (en) | 2014-02-11 | 2019-01-01 | Mitokinin, Inc. | Compositions and methods using the same for treatment of neurodegenerative and mitochondrial disease |
| JP2017524739A (ja) | 2014-07-17 | 2017-08-31 | アンセルムＩｎｓｅｒｍ | 神経筋接合部関連疾患の処置方法 |
| WO2016207366A1 (en) | 2015-06-26 | 2016-12-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of viral infections |
| KR20200019228A (ko) | 2017-06-21 | 2020-02-21 | 미토키닌, 인크. | 신경퇴행성 및 미토콘드리아 질환의 치료를 위한 조성물 및 이를 사용하는 방법 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ227850A (en) * | 1988-02-10 | 1991-11-26 | Hoffmann La Roche | Indole substituted pyrrole derivatives; preparatory process and medicaments for use against inflammatory immunological, bronchopulmonary or vascular disorders |
| PT93947B (pt) * | 1989-05-05 | 1996-11-29 | Goedecke Ag | Processo para a preparacao de novos derivados de maleinimidas e de composicoes farmaceuticas que os contem |
| US5380746A (en) * | 1989-05-05 | 1995-01-10 | Goedecke Aktiengesellschaft | Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them |
| DE4005969A1 (de) * | 1990-02-26 | 1991-08-29 | Boehringer Mannheim Gmbh | Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten |
| JPH0539289A (ja) * | 1991-02-15 | 1993-02-19 | Masahiro Irie | 無水マレイン酸誘導体およびその製造方法 |
| EP0630241A1 (en) * | 1992-03-20 | 1994-12-28 | The Wellcome Foundation Limited | Indole derivatives with antiviral activity |
| DE4217964A1 (de) * | 1992-05-30 | 1993-12-02 | Goedecke Ag | Indolocarbazol-Imide und deren Verwendung |
-
1997
- 1997-07-15 PE PE1997000630A patent/PE91698A1/es not_active Application Discontinuation
- 1997-07-19 CN CNB971967768A patent/CN1151149C/zh not_active Expired - Fee Related
- 1997-07-19 AU AU37690/97A patent/AU739742B2/en not_active Ceased
- 1997-07-19 JP JP10508453A patent/JP2000516589A/ja not_active Ceased
- 1997-07-19 CA CA002262092A patent/CA2262092A1/en not_active Abandoned
- 1997-07-19 AT AT97934498T patent/ATE240318T1/de not_active IP Right Cessation
- 1997-07-19 CN CNA031275400A patent/CN1495182A/zh active Pending
- 1997-07-19 BR BR9711605A patent/BR9711605A/pt not_active Application Discontinuation
- 1997-07-19 ES ES97934498T patent/ES2198001T3/es not_active Expired - Lifetime
- 1997-07-19 KR KR1019997000706A patent/KR20000029637A/ko active IP Right Grant
- 1997-07-19 DK DK97934498T patent/DK0915872T3/da active
- 1997-07-19 PT PT97934498T patent/PT915872E/pt unknown
- 1997-07-19 WO PCT/EP1997/003889 patent/WO1998004552A1/en active IP Right Grant
- 1997-07-19 DE DE69722003T patent/DE69722003T2/de not_active Expired - Fee Related
- 1997-07-19 EP EP97934498A patent/EP0915872B1/en not_active Expired - Lifetime
- 1997-07-19 TR TR1999/00157T patent/TR199900157T2/xx unknown
- 1997-07-22 AR ARP970103309A patent/AR008267A1/es not_active Application Discontinuation
- 1997-07-22 ZA ZA9706492A patent/ZA976492B/xx unknown
- 1997-07-24 US US08/899,852 patent/US5856517A/en not_active Expired - Fee Related
- 1997-07-25 CO CO97042581A patent/CO4900055A1/es unknown
- 1997-07-25 HR HR60/022,079A patent/HRP970414A2/hr not_active Application Discontinuation
- 1997-07-29 MA MA24744A patent/MA24287A1/fr unknown
- 1997-10-06 SA SA97180473A patent/SA97180473A/ar unknown
-
1998
- 1998-10-05 US US09/166,766 patent/US6030994A/en not_active Expired - Fee Related
-
2004
- 2004-11-15 CY CY0400081A patent/CY2483B1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US5856517A (en) | 1999-01-05 |
| KR20000029637A (ko) | 2000-05-25 |
| EP0915872A1 (en) | 1999-05-19 |
| CN1151149C (zh) | 2004-05-26 |
| ES2198001T3 (es) | 2004-01-16 |
| AU739742B2 (en) | 2001-10-18 |
| ZA976492B (en) | 1998-01-29 |
| DK0915872T3 (da) | 2003-09-08 |
| PE91698A1 (es) | 1998-12-24 |
| SA97180473A (ar) | 2005-12-03 |
| CN1226247A (zh) | 1999-08-18 |
| AU3769097A (en) | 1998-02-20 |
| DE69722003D1 (de) | 2003-06-18 |
| CY2483B1 (en) | 2005-06-03 |
| CN1495182A (zh) | 2004-05-12 |
| ATE240318T1 (de) | 2003-05-15 |
| EP0915872B1 (en) | 2003-05-14 |
| HRP970414A2 (en) | 1998-06-30 |
| MA24287A1 (fr) | 1998-04-01 |
| CA2262092A1 (en) | 1998-02-05 |
| JP2000516589A (ja) | 2000-12-12 |
| US6030994A (en) | 2000-02-29 |
| DE69722003T2 (de) | 2004-04-01 |
| PT915872E (pt) | 2003-09-30 |
| BR9711605A (pt) | 1999-08-24 |
| CO4900055A1 (es) | 2000-03-27 |
| TR199900157T2 (xx) | 1999-04-21 |
| WO1998004552A1 (en) | 1998-02-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |