DE60023182D1 - Substituierte bisindolylmaleimide zur inhibierung der zellproliferation - Google Patents

Substituierte bisindolylmaleimide zur inhibierung der zellproliferation

Info

Publication number
DE60023182D1
DE60023182D1 DE60023182T DE60023182T DE60023182D1 DE 60023182 D1 DE60023182 D1 DE 60023182D1 DE 60023182 T DE60023182 T DE 60023182T DE 60023182 T DE60023182 T DE 60023182T DE 60023182 D1 DE60023182 D1 DE 60023182D1
Authority
DE
Germany
Prior art keywords
cell proliferation
inhibiting cell
bisindolylmaleimides
substituted
substituted bisindolylmaleimides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60023182T
Other languages
English (en)
Other versions
DE60023182T2 (de
Inventor
Nader Fotouhi
Emily Aijun Liu
Allen John Lovey
John Guilfoyle Mullin Jr
Guiseppe Federico Weber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE60023182D1 publication Critical patent/DE60023182D1/de
Application granted granted Critical
Publication of DE60023182T2 publication Critical patent/DE60023182T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE60023182T 1999-12-16 2000-12-12 Substituierte bisindolylmaleimide zur inhibierung der zellproliferation Expired - Lifetime DE60023182T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17105199P 1999-12-16 1999-12-16
US171051P 1999-12-16
PCT/EP2000/012559 WO2001044234A1 (en) 1999-12-16 2000-12-12 Substituted bisindolylmaleimides for the inhibition of cell proliferation

Publications (2)

Publication Number Publication Date
DE60023182D1 true DE60023182D1 (de) 2006-02-23
DE60023182T2 DE60023182T2 (de) 2006-07-06

Family

ID=22622296

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60023182T Expired - Lifetime DE60023182T2 (de) 1999-12-16 2000-12-12 Substituierte bisindolylmaleimide zur inhibierung der zellproliferation

Country Status (33)

Country Link
US (1) US6313143B1 (de)
EP (1) EP1242408B1 (de)
JP (2) JP2003516986A (de)
KR (1) KR100507422B1 (de)
CN (1) CN1229374C (de)
AR (1) AR029415A1 (de)
AT (1) ATE306484T1 (de)
AU (1) AU783616B2 (de)
BR (1) BRPI0016329B8 (de)
CA (1) CA2392902C (de)
CO (1) CO5050293A1 (de)
CZ (1) CZ304130B6 (de)
DE (1) DE60023182T2 (de)
ES (1) ES2249314T3 (de)
GC (1) GC0000265A (de)
HK (1) HK1054385B (de)
HR (1) HRP20020513B1 (de)
HU (1) HU230003B1 (de)
IL (2) IL150128A0 (de)
JO (1) JO2296B1 (de)
MA (1) MA26856A1 (de)
MX (1) MXPA02005560A (de)
MY (1) MY126998A (de)
NO (1) NO322240B1 (de)
NZ (1) NZ519173A (de)
PE (1) PE20011034A1 (de)
PL (1) PL200243B1 (de)
RS (1) RS50449B (de)
RU (1) RU2264398C2 (de)
TW (1) TWI274752B (de)
UY (1) UY26485A1 (de)
WO (1) WO2001044234A1 (de)
ZA (1) ZA200204258B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002102373A1 (en) * 2001-06-15 2002-12-27 F. Hoffmann-La Roche Ag Method for administration of cancer therapeutic
EP1441772A2 (de) * 2001-10-29 2004-08-04 Nektar Therapeutics Al, Corporation Polymerkonjugate von protein-kinase-c-inhibitoren
US9107911B2 (en) 2010-01-07 2015-08-18 Alkermes Pharma Ireland Limited Prodrugs of heteraromatic compounds
EP2474541A1 (de) * 2010-12-23 2012-07-11 Johannes- Gutenberg-Universität Mainz Konjugierte 3-(Indolyl)- und 3-(Azaindolyl)-4-arylmaleinimid-Verbindungen und deren Verwendung bei der Behandlung von Tumoren

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ227850A (en) 1988-02-10 1991-11-26 Hoffmann La Roche Indole substituted pyrrole derivatives; preparatory process and medicaments for use against inflammatory immunological, bronchopulmonary or vascular disorders
GB9416467D0 (en) * 1994-08-13 1994-10-05 Wellcome Found Compounds for use in medicine
CN1304058C (zh) * 1996-03-12 2007-03-14 Pg－Txl有限公司 水溶性紫杉醇产品
TW517067B (en) * 1996-05-31 2003-01-11 Hoffmann La Roche Interferon conjugates
PE91498A1 (es) * 1996-07-29 1998-12-22 Hoffmann La Roche Pirroles sustituidos
PE91598A1 (es) 1996-07-29 1998-12-24 Hoffmann La Roche Pirroles sustituidos
PE91698A1 (es) 1996-07-29 1998-12-24 Hoffmann La Roche Pirroles sustituidos
JP2002500184A (ja) * 1998-01-09 2002-01-08 アリゾナ ボード オブ リーゼンツ フェンスタチンとそのプロドラッグの合成
TR200002580T2 (tr) * 1998-03-17 2000-11-21 F.Hoffmann-La Roche Ag Hücre çoğalmasının engellenmesinde kullanılan ikameli bisindolimaleimitler
US6350786B1 (en) * 1998-09-22 2002-02-26 Hoffmann-La Roche Inc. Stable complexes of poorly soluble compounds in ionic polymers
JP2003511449A (ja) * 1999-10-12 2003-03-25 エフ．ホフマン−ラ ロシュ アーゲー 癌の処理のための抗増殖剤としての置換されたピロール

Also Published As

Publication number Publication date
NO322240B1 (no) 2006-09-04
CZ304130B6 (cs) 2013-11-13
HU230003B1 (en) 2015-04-28
AU783616B2 (en) 2005-11-17
ES2249314T3 (es) 2006-04-01
ZA200204258B (en) 2003-08-28
MA26856A1 (fr) 2004-12-20
HRP20020513A2 (en) 2004-08-31
IL150128A (en) 2006-06-11
UY26485A1 (es) 2001-06-29
US6313143B1 (en) 2001-11-06
JP4763623B2 (ja) 2011-08-31
PL200243B1 (pl) 2008-12-31
CA2392902C (en) 2009-01-13
MY126998A (en) 2006-11-30
CN1229374C (zh) 2005-11-30
WO2001044234A1 (en) 2001-06-21
JO2296B1 (en) 2005-09-12
AR029415A1 (es) 2003-06-25
EP1242408A1 (de) 2002-09-25
BR0016329A (pt) 2002-08-27
GC0000265A (en) 2006-11-01
NO20022776L (no) 2002-06-11
BRPI0016329B8 (pt) 2021-05-25
NO20022776D0 (no) 2002-06-11
ATE306484T1 (de) 2005-10-15
RU2002119209A (ru) 2004-01-10
KR100507422B1 (ko) 2005-08-10
PE20011034A1 (es) 2001-10-12
TWI274752B (en) 2007-03-01
HK1054385A1 (en) 2003-11-28
NZ519173A (en) 2004-06-25
HK1054385B (zh) 2006-02-17
RU2264398C2 (ru) 2005-11-20
EP1242408B1 (de) 2005-10-12
HUP0203696A3 (en) 2004-01-28
RS50449B (sr) 2010-03-02
CZ20022447A3 (cs) 2003-06-18
CO5050293A1 (es) 2001-06-27
HUP0203696A2 (hu) 2003-03-28
DE60023182T2 (de) 2006-07-06
AU2008201A (en) 2001-06-25
JP2007153905A (ja) 2007-06-21
KR20020063215A (ko) 2002-08-01
MXPA02005560A (es) 2002-09-02
BR0016329B1 (pt) 2013-03-19
CA2392902A1 (en) 2001-06-21
CN1409709A (zh) 2003-04-09
PL355856A1 (en) 2004-05-31
YU43302A (sh) 2005-03-15
JP2003516986A (ja) 2003-05-20
IL150128A0 (en) 2002-12-01
HRP20020513B1 (en) 2006-10-31

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