CO5050293A1 - Bisindolilmaleimidas sustituidas - Google Patents
Bisindolilmaleimidas sustituidasInfo
- Publication number
- CO5050293A1 CO5050293A1 CO00094815A CO00094815A CO5050293A1 CO 5050293 A1 CO5050293 A1 CO 5050293A1 CO 00094815 A CO00094815 A CO 00094815A CO 00094815 A CO00094815 A CO 00094815A CO 5050293 A1 CO5050293 A1 CO 5050293A1
- Authority
- CO
- Colombia
- Prior art keywords
- group
- substituted
- polyethylene glycol
- chosen
- optionally
- Prior art date
Links
- 239000002202 Polyethylene glycol Substances 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 5
- 229920001223 polyethylene glycol Polymers 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000001424 substituent group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 -OPO3 R1 R2 Chemical group 0.000 abstract 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Un compuesto que tiene la fórmulay sus sales farmacéuticamente aceptables de dichos compuestos, en donde :R se elige del grupo constituido por -PO3 R1 R2 , -CHR3 OCOR4 , -CHR3 OCO2 R4 , -CHR3 OCONHR4 y -COR4 ; R1 y R2 se eligen del grupo constituido por H, Na y NH4 , y son iguales a menos que R1 o R2 sea H, en cuyo caso el otro puede ser diferente, o alternativamente, R1 y R2 juntos representan Ca;R3 se elige del grupo constituido por H o metilo;R4 se elige del grupo constituido por alquilo inferior, que puede estar opcionalmente sustituido por uno o más sustituyentes elegidos del grupo constituido por -CO2 R5 , -NR6 R7 , polietilenglicol, -OPO3 R1 R2 , hidroxilo, alcoxilo y arilo, alquelino, que puede estar opcionalmente sustituido por uno o más sustituyentes elegidos del grupo constituido por -CO2 R5 , -NR6 R7 , polietilenglicol, -OPO3 R1 R2 , hidroxilo, alcoxilo y arilo, cicloalquilo que puede estar opcionalmente sustituido por uno o más sustituyentes elegidos del grupo constituido por por -CO2 R5 , -NR6 R7 , polietilenglicol, -OPO3 R1 R2 , hidroxilo, alcoxilo y arilo, heterociclo, que cuando incluye N como un hetero átomo el N opcionalmente puede estar sustituido por -COR8 , y arilo que opcionalmente puede estar sustituido por uno o más sustituyentes elegidos del grupo constituido por -CO2 R5 , hidroxilo, alcoxilo, polietilenglicol, -OPO3 R1 R2 , y alquilo que puede de por sí estar sustituido por hidroxilo, carboxilo y amino sustituido;R5 se elige del grupo constituido por H, Na , o alquilo inferior,R6 y R7 se eligen cada uno, independientemente , entre H, alquilo inferior y -COR8 , o alternativamente, el grupo -NR6 R7 forma un anillo heterocíclico de 5 o 6 miembros; y R8 es alquilo inferior, que opcionalmente puede estar sustituido por un polietilenglicol.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17105199P | 1999-12-16 | 1999-12-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5050293A1 true CO5050293A1 (es) | 2001-06-27 |
Family
ID=22622296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO00094815A CO5050293A1 (es) | 1999-12-16 | 2000-12-13 | Bisindolilmaleimidas sustituidas |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US6313143B1 (es) |
| EP (1) | EP1242408B1 (es) |
| JP (2) | JP2003516986A (es) |
| KR (1) | KR100507422B1 (es) |
| CN (1) | CN1229374C (es) |
| AR (1) | AR029415A1 (es) |
| AT (1) | ATE306484T1 (es) |
| AU (1) | AU783616B2 (es) |
| BR (1) | BRPI0016329B8 (es) |
| CA (1) | CA2392902C (es) |
| CO (1) | CO5050293A1 (es) |
| CZ (1) | CZ304130B6 (es) |
| DE (1) | DE60023182T2 (es) |
| ES (1) | ES2249314T3 (es) |
| GC (1) | GC0000265A (es) |
| HK (1) | HK1054385B (es) |
| HR (1) | HRP20020513B1 (es) |
| HU (1) | HU230003B1 (es) |
| IL (2) | IL150128A0 (es) |
| JO (1) | JO2296B1 (es) |
| MA (1) | MA26856A1 (es) |
| MX (1) | MXPA02005560A (es) |
| MY (1) | MY126998A (es) |
| NO (1) | NO322240B1 (es) |
| NZ (1) | NZ519173A (es) |
| PE (1) | PE20011034A1 (es) |
| PL (1) | PL200243B1 (es) |
| RS (1) | RS50449B (es) |
| RU (1) | RU2264398C2 (es) |
| TW (1) | TWI274752B (es) |
| UY (1) | UY26485A1 (es) |
| WO (1) | WO2001044234A1 (es) |
| ZA (1) | ZA200204258B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002102373A1 (en) * | 2001-06-15 | 2002-12-27 | F. Hoffmann-La Roche Ag | Method for administration of cancer therapeutic |
| US20030143185A1 (en) * | 2001-10-29 | 2003-07-31 | Shearwater Corporation | Polymer conjugates of protein kinase C inhibitors |
| US9107911B2 (en) | 2010-01-07 | 2015-08-18 | Alkermes Pharma Ireland Limited | Prodrugs of heteraromatic compounds |
| EP2474541A1 (en) * | 2010-12-23 | 2012-07-11 | Johannes- Gutenberg-Universität Mainz | Conjugated 3-(indolyl)- and 3-(azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK75289A3 (en) * | 1988-02-10 | 1998-05-06 | Hoffmann La Roche | Substituted pyrroles, their use for producing a drug, and the drug on their base |
| GB9416467D0 (en) * | 1994-08-13 | 1994-10-05 | Wellcome Found | Compounds for use in medicine |
| WO1997033552A1 (en) * | 1996-03-12 | 1997-09-18 | Pg-Txl Company, L.P. | Water soluble paclitaxel prodrugs |
| TW517067B (en) * | 1996-05-31 | 2003-01-11 | Hoffmann La Roche | Interferon conjugates |
| PE91698A1 (es) * | 1996-07-29 | 1998-12-24 | Hoffmann La Roche | Pirroles sustituidos |
| PE91498A1 (es) * | 1996-07-29 | 1998-12-22 | Hoffmann La Roche | Pirroles sustituidos |
| PE91598A1 (es) | 1996-07-29 | 1998-12-24 | Hoffmann La Roche | Pirroles sustituidos |
| US6943194B1 (en) * | 1998-01-09 | 2005-09-13 | Arizona Board Of Regents, Acting For And On Behalf Of Arizona State University | Synthesis of phenstatin and prodrugs thereof |
| CN1127500C (zh) * | 1998-03-17 | 2003-11-12 | 弗·哈夫曼-拉罗切有限公司 | 抑制细胞增殖的取代双吲哚基马来酰亚胺 |
| US6350786B1 (en) * | 1998-09-22 | 2002-02-26 | Hoffmann-La Roche Inc. | Stable complexes of poorly soluble compounds in ionic polymers |
| DK1224181T3 (da) * | 1999-10-12 | 2004-04-13 | Hoffmann La Roche | Substituerede pyrroler som antiproliferative midler til behandling af cancer |
-
2000
- 2000-11-07 US US09/707,678 patent/US6313143B1/en not_active Expired - Lifetime
- 2000-12-11 JO JO2000198A patent/JO2296B1/en active
- 2000-12-12 MX MXPA02005560A patent/MXPA02005560A/es active IP Right Grant
- 2000-12-12 JP JP2001544724A patent/JP2003516986A/ja not_active Withdrawn
- 2000-12-12 PL PL355856A patent/PL200243B1/pl unknown
- 2000-12-12 EP EP00983288A patent/EP1242408B1/en not_active Expired - Lifetime
- 2000-12-12 CZ CZ20022447A patent/CZ304130B6/cs not_active IP Right Cessation
- 2000-12-12 AU AU20082/01A patent/AU783616B2/en not_active Expired
- 2000-12-12 ES ES00983288T patent/ES2249314T3/es not_active Expired - Lifetime
- 2000-12-12 RU RU2002119209/04A patent/RU2264398C2/ru active
- 2000-12-12 WO PCT/EP2000/012559 patent/WO2001044234A1/en active IP Right Grant
- 2000-12-12 CA CA002392902A patent/CA2392902C/en not_active Expired - Lifetime
- 2000-12-12 CN CNB008170665A patent/CN1229374C/zh not_active Expired - Lifetime
- 2000-12-12 DE DE60023182T patent/DE60023182T2/de not_active Expired - Lifetime
- 2000-12-12 RS YUP-433/02A patent/RS50449B/sr unknown
- 2000-12-12 AT AT00983288T patent/ATE306484T1/de active
- 2000-12-12 HU HU0203696A patent/HU230003B1/hu unknown
- 2000-12-12 KR KR10-2002-7007517A patent/KR100507422B1/ko active IP Right Grant
- 2000-12-12 IL IL15012800A patent/IL150128A0/xx active IP Right Grant
- 2000-12-12 BR BRPI0016329A patent/BRPI0016329B8/pt not_active IP Right Cessation
- 2000-12-12 NZ NZ519173A patent/NZ519173A/en not_active IP Right Cessation
- 2000-12-13 CO CO00094815A patent/CO5050293A1/es unknown
- 2000-12-14 AR ARP000106636A patent/AR029415A1/es active IP Right Grant
- 2000-12-14 PE PE2000001346A patent/PE20011034A1/es not_active IP Right Cessation
- 2000-12-14 MY MYPI20005871A patent/MY126998A/en unknown
- 2000-12-15 UY UY26485A patent/UY26485A1/es not_active Application Discontinuation
- 2000-12-16 TW TW089126995A patent/TWI274752B/zh not_active IP Right Cessation
- 2000-12-16 GC GCP20001101 patent/GC0000265A/en active
-
2002
- 2002-05-28 ZA ZA200204258A patent/ZA200204258B/en unknown
- 2002-06-10 IL IL150128A patent/IL150128A/en unknown
- 2002-06-11 NO NO20022776A patent/NO322240B1/no not_active IP Right Cessation
- 2002-06-12 HR HR20020513A patent/HRP20020513B1/xx not_active IP Right Cessation
- 2002-06-14 MA MA26691A patent/MA26856A1/fr unknown
-
2003
- 2003-09-16 HK HK03106629.3A patent/HK1054385B/zh not_active IP Right Cessation
-
2007
- 2007-01-22 JP JP2007011821A patent/JP4763623B2/ja not_active Expired - Lifetime
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR055144A1 (es) | Inhibidor de secrecion acida | |
| AR011913A1 (es) | Derivados de 4,4-difluoro-2,3,4,5-tetrahidro-1h-1-benzoazepina y composiciones farmaceuticas de los mismos. | |
| ES2221440T3 (es) | Derivados de acido aminofenoxiacetico como neuroprotectores. | |
| AR038703A1 (es) | Derivados de 5-feniltiazol y uso como inhibidor de quinasa p i 3 | |
| CO5160347A1 (es) | Derivados de acido carbamico | |
| AR035548A1 (es) | Compuestos organicos | |
| CO5721002A2 (es) | Derivados de acido 3-(4-benciloxifenil) propanoico | |
| PE20040373A1 (es) | Composiciones herbicidas que comprenden derivados de isoxazolina | |
| AR025386A1 (es) | Moduladores de los receptores activados del proliferador de peroxisomas | |
| AR058562A1 (es) | Derivados de pirimido [4,5 b] (1,4) oxazinas , procedimientos de obtencion y su uso como inhibidores de acetil coa y dgat 1 | |
| CO6160312A2 (es) | Derivados de quiniclidina de acido (hetero) arilcicloheptano carboxilico como antagonistas del receptor muscarinico | |
| PE20070189A1 (es) | COMPUESTO DE AMINO-5-HETEROARILO (5 MIEMBROS) IMIDAZOLONA Y SU USO PARA MODULACION DE LA ß-SECRETASA | |
| CR8808A (es) | Inhibidores de cept | |
| CO5640117A2 (es) | Derivados de 2,4-diamonopirimidina | |
| CO6260132A2 (es) | Derivados de oxadiazol como inhibidores de dgat | |
| ES2191484T3 (es) | Compuestos heterociclicos como inhibidores de enzimas de rotamasa. | |
| AR072166A1 (es) | Derivado de piperidina y su uso como inhibidor de renina superior | |
| AR044629A1 (es) | Derivados de bencimidazol, composiciones que los contienen, preparacion y usos de los mismos. | |
| CO5590924A2 (es) | Derivados de indolilalquilamina como ligandos de 5- hidroxitriptamina-6 | |
| AR076098A1 (es) | Derivados de benzofurano | |
| AR056025A1 (es) | Compuestos de imidazol sustituidos como inhibidores de ksp | |
| AR037907A1 (es) | Derivados de azaindolilalquilamina como ligandos de 5-hidroxitriptamina-6 | |
| AR068538A1 (es) | Compuesto heterociclico de 5 miembros con actividad supresora de la secrecion de acido | |
| AR031597A1 (es) | Compuestos piperidinos,un proceso para su preparacion, composiciones farmaceuticas,y el uso de dichos compuestos para la fabricacion de un medicamento para uso como inhibidores ccr-3 | |
| CO5601021A2 (es) | Derivados de quinazolinona, composiciones farmaceuticas que los contienen y su proceso de preparacion y su uso como antagonistas cb |