CO6160312A2 - Derivados de quiniclidina de acido (hetero) arilcicloheptano carboxilico como antagonistas del receptor muscarinico - Google Patents

Derivados de quiniclidina de acido (hetero) arilcicloheptano carboxilico como antagonistas del receptor muscarinico

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Publication number
CO6160312A2
CO6160312A2 CO09041752A CO09041752A CO6160312A2 CO 6160312 A2 CO6160312 A2 CO 6160312A2 CO 09041752 A CO09041752 A CO 09041752A CO 09041752 A CO09041752 A CO 09041752A CO 6160312 A2 CO6160312 A2 CO 6160312A2
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Colombia
Prior art keywords
alkyl
halogen
optionally substituted
independently selected
substituents independently
Prior art date
Application number
CO09041752A
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English (en)
Inventor
Ford Rhonan
Andrew Mather
Antonio Mete
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Astrazeneca Ab
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Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CO6160312A2 publication Critical patent/CO6160312A2/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
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Abstract

1.- Un compuesto de la fórmula (I),dondeR1 y R2 junto con el átomo de carbono al cual los dos están directamente unidos forman un anillo carbocíclico alifático de 7 miembros el cual puede ser opcionalmente sustituido por uno o más sustituyentes independientemente seleccionados de halógeno, hidroxil, C1-6 alcoxi, NH2, NH(C1-6 alquil), N(C1-6 alquil)2 y C1-6 alquil, dicho C1-6 alquil puede ser opcionalmente sustituido por uno o más sustituyentes independientemente seleccionados de halógeno e hidroxil; R3 representa fenil o un anillo heteroaril de 5 a 6 miembros, cada uno de los cuales puede ser opcionalmente sustituido por uno o más sustituyentes independientemente seleccionados de halógeno, ciano, nitro, SH, S(O)0-2R9, NR10R11, S(O)2NR12R13, C(O)NR14R15, C(O)2R16, NR17S(O)2R18, NR19C(O)R20, NR21C(O)2R22, NR23C(O)NR24R25, OR26 y C1-6 alquil, dicho C1-6 alquil puede ser opcionalmente sustituido por uno o más sustituyentes independientemente seleccionados de halógeno, hidroxil; C1-6 alcoxi, NH2, NH(C1-6 alquil) y N(C1-6 alquil)2; R4 representa un grupo de la fórmula (II) o (lIla) o (IIIb); donde Y es -CH2-, -CH2CH2- o -CH2CH2CH2- y la sustitución en el anillo en el grupo (II) puede ser en la posición 3 ó 4; a es 1 ó 2; b es 1 ó 2; Z es -CH2-; R5 representa un grupo de la fórmula (IV)donde w es 0 ó 1; R6 representa C1-4 alquileno opcionalmente sustituido por uno o más sustituyentes independientemente seleccionados de halógeno, hidroxil, C1-6 alcoxi, NH2, NH(C1-6 alquil) y N(C1-6 alquil)2;cuando w es 0, y es 0; cuando w es 1, y es 0 ó 1; ...
CO09041752A 2006-11-14 2009-04-24 Derivados de quiniclidina de acido (hetero) arilcicloheptano carboxilico como antagonistas del receptor muscarinico CO6160312A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86566706P 2006-11-14 2006-11-14
US86938406P 2006-12-11 2006-12-11

Publications (1)

Publication Number Publication Date
CO6160312A2 true CO6160312A2 (es) 2010-05-20

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ID=39048793

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CO09041752A CO6160312A2 (es) 2006-11-14 2009-04-24 Derivados de quiniclidina de acido (hetero) arilcicloheptano carboxilico como antagonistas del receptor muscarinico

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US (2) US8207193B2 (es)
EP (2) EP2094694B1 (es)
JP (1) JP4904402B2 (es)
KR (1) KR20090078828A (es)
AR (1) AR063804A1 (es)
AT (1) ATE496916T1 (es)
AU (1) AU2007321019B2 (es)
BR (1) BRPI0718750A2 (es)
CA (1) CA2669326A1 (es)
CL (1) CL2007003260A1 (es)
CO (1) CO6160312A2 (es)
CY (1) CY1111351T1 (es)
DE (1) DE602007012300D1 (es)
DK (1) DK2094694T3 (es)
EC (1) ECSP099338A (es)
HK (1) HK1134091A1 (es)
HR (1) HRP20110178T1 (es)
IL (1) IL198314A (es)
MX (1) MX2009004780A (es)
MY (1) MY148392A (es)
NO (1) NO20092224L (es)
NZ (1) NZ576679A (es)
PE (1) PE20081164A1 (es)
PL (1) PL2094694T3 (es)
PT (1) PT2094694E (es)
RS (1) RS51650B (es)
RU (1) RU2456286C2 (es)
SA (1) SA07280616B1 (es)
TW (1) TW200825084A (es)
WO (1) WO2008059245A1 (es)

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