CY1111351T1 - Παραγωγα κινικλιδινης απο (ετερο) αρυλκυκλοεπτανοκαρβοξυλικο οξυ ως ανταγωνιστες μουσκαρινικου υποδοχεως - Google Patents
Παραγωγα κινικλιδινης απο (ετερο) αρυλκυκλοεπτανοκαρβοξυλικο οξυ ως ανταγωνιστες μουσκαρινικου υποδοχεωςInfo
- Publication number
- CY1111351T1 CY1111351T1 CY20111100315T CY111100315T CY1111351T1 CY 1111351 T1 CY1111351 T1 CY 1111351T1 CY 20111100315 T CY20111100315 T CY 20111100315T CY 111100315 T CY111100315 T CY 111100315T CY 1111351 T1 CY1111351 T1 CY 1111351T1
- Authority
- CY
- Cyprus
- Prior art keywords
- cyclicidin
- arylycyclyecocarboxylic
- muscaric
- products
- acid
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Communicable Diseases (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- AIDS & HIV (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Reproductive Health (AREA)
- Transplantation (AREA)
Abstract
Η εφεύρεση παρέχει ενώσεις του τύπου (I) όπου το R4 είναι μία ομάδα του τύπου (II) ή του (IIIa) ή του (IIIb) και τα R1, R2, R3, R5, a, b και Χ είναι όπως ορίζονται στην περιγραφή, μία διαδικασία για την παρασκευή τους, φαρμακευτικές συνθέσεις που τις περιέχουν, μία διαδικασία για την παρασκευή φαρμακευτικών συνθέσεων, τη χρήση του στη θεραπεία και ενδιάμεσες ενώσεις για χρήση στην παρασκευή τους των (I), (II), (IIIa), (IIIb).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US86566706P | 2006-11-14 | 2006-11-14 | |
US86938406P | 2006-12-11 | 2006-12-11 | |
EP07824574A EP2094694B1 (en) | 2006-11-14 | 2007-11-13 | Quiniclidine derivatives of (hetero) arylcycloheptanecarboxylic acid as muscarinic receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1111351T1 true CY1111351T1 (el) | 2015-08-05 |
Family
ID=39048793
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20111100315T CY1111351T1 (el) | 2006-11-14 | 2011-03-22 | Παραγωγα κινικλιδινης απο (ετερο) αρυλκυκλοεπτανοκαρβοξυλικο οξυ ως ανταγωνιστες μουσκαρινικου υποδοχεως |
Country Status (30)
Country | Link |
---|---|
US (2) | US8207193B2 (el) |
EP (2) | EP2094694B1 (el) |
JP (1) | JP4904402B2 (el) |
KR (1) | KR20090078828A (el) |
AR (1) | AR063804A1 (el) |
AT (1) | ATE496916T1 (el) |
AU (1) | AU2007321019B2 (el) |
BR (1) | BRPI0718750A2 (el) |
CA (1) | CA2669326A1 (el) |
CL (1) | CL2007003260A1 (el) |
CO (1) | CO6160312A2 (el) |
CY (1) | CY1111351T1 (el) |
DE (1) | DE602007012300D1 (el) |
DK (1) | DK2094694T3 (el) |
EC (1) | ECSP099338A (el) |
HK (1) | HK1134091A1 (el) |
HR (1) | HRP20110178T1 (el) |
IL (1) | IL198314A (el) |
MX (1) | MX2009004780A (el) |
MY (1) | MY148392A (el) |
NO (1) | NO20092224L (el) |
NZ (1) | NZ576679A (el) |
PE (1) | PE20081164A1 (el) |
PL (1) | PL2094694T3 (el) |
PT (1) | PT2094694E (el) |
RS (1) | RS51650B (el) |
RU (1) | RU2456286C2 (el) |
SA (1) | SA07280616B1 (el) |
TW (1) | TW200825084A (el) |
WO (1) | WO2008059245A1 (el) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010500973A (ja) * | 2006-07-21 | 2010-01-14 | マース インコーポレーテッド | アルギナーゼ濃度/活性の改善 |
TW200825084A (en) | 2006-11-14 | 2008-06-16 | Astrazeneca Ab | New compounds 521 |
GB0808709D0 (en) * | 2008-05-13 | 2008-06-18 | Astrazeneca Ab | New combination 295 |
GB0808708D0 (en) * | 2008-05-13 | 2008-06-18 | Astrazeneca Ab | New compounds 274 |
MX2010012019A (es) * | 2008-05-13 | 2011-03-04 | Astrazeneca Ab | Producto farmaceutico que comprende un antagonista receptor muscarinico y un agonista de adrenoceptor beta2. |
JP4837800B2 (ja) * | 2008-05-13 | 2011-12-14 | アストラゼネカ・アクチエボラーグ | ムスカリンm3受容体アンタゴニストとしてのキヌクリジン誘導体 |
GB0811099D0 (en) * | 2008-06-17 | 2008-07-23 | Astrazeneca Ab | New combination 376 |
KR20110022611A (ko) * | 2008-06-20 | 2011-03-07 | 아스트라제네카 아베 | 베타2-아드레날린수용체 활성의 조절을 위한, 4-히드록시-2-옥소-2,3-디히드로-1,3-벤조티아졸-7-일 화합물을 포함하는 제약 조성물 |
WO2010008341A1 (en) * | 2008-07-16 | 2010-01-21 | Astrazeneca Ab | A combination of (a) glucocorticoid receptor modulator and (b) a muscarinic antagonist |
GB0814729D0 (en) * | 2008-08-12 | 2008-09-17 | Argenta Discovery Ltd | New combination |
EP2206712A1 (en) * | 2008-12-23 | 2010-07-14 | CHIESI FARMACEUTICI S.p.A. | "Alkaloid aminoester derivatives and medicinal composition thereof" |
TW201036957A (en) | 2009-02-20 | 2010-10-16 | Astrazeneca Ab | Novel salt 628 |
AR076590A1 (es) * | 2009-05-19 | 2011-06-22 | Vivia Biotech Sl | Metodos para proveer pruebas medicinales personalizada ex vivo para neoplasmas hematologicos |
CA2803416A1 (en) * | 2010-06-22 | 2011-12-29 | Chiesi Farmaceutici S.P.A. | Alkaloid aminoester derivatives and medicinal composition thereof |
JP2011195593A (ja) * | 2011-06-30 | 2011-10-06 | Astrazeneca Ab | ムスカリンm3受容体アンタゴニストとしてのキヌクリジン誘導体 |
US11229701B2 (en) | 2012-04-30 | 2022-01-25 | Hibercell, Inc. | Methods for identifying beta-glucan binding to immune cells |
TW201517906A (zh) | 2013-07-25 | 2015-05-16 | Almirall Sa | 含有maba化合物和皮質類固醇之組合 |
TW201617343A (zh) * | 2014-09-26 | 2016-05-16 | 阿爾米雷爾有限公司 | 具有β2腎上腺素促效劑及M3蕈毒拮抗劑活性之新穎雙環衍生物 |
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2007
- 2007-11-02 TW TW096141387A patent/TW200825084A/zh unknown
- 2007-11-12 SA SA07280616A patent/SA07280616B1/ar unknown
- 2007-11-13 CA CA002669326A patent/CA2669326A1/en not_active Abandoned
- 2007-11-13 AT AT07824574T patent/ATE496916T1/de active
- 2007-11-13 PE PE2007001564A patent/PE20081164A1/es not_active Application Discontinuation
- 2007-11-13 MY MYPI20091925A patent/MY148392A/en unknown
- 2007-11-13 NZ NZ576679A patent/NZ576679A/en not_active IP Right Cessation
- 2007-11-13 EP EP07824574A patent/EP2094694B1/en active Active
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- 2007-11-13 RU RU2009115829/04A patent/RU2456286C2/ru not_active IP Right Cessation
- 2007-11-13 JP JP2009536788A patent/JP4904402B2/ja not_active Expired - Fee Related
- 2007-11-13 WO PCT/GB2007/004350 patent/WO2008059245A1/en active Application Filing
- 2007-11-13 EP EP10175910A patent/EP2256117A1/en not_active Withdrawn
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- 2007-11-13 BR BRPI0718750-5A patent/BRPI0718750A2/pt not_active IP Right Cessation
- 2007-11-13 AR ARP070105051A patent/AR063804A1/es not_active Application Discontinuation
- 2007-11-13 DK DK07824574.3T patent/DK2094694T3/da active
- 2007-11-13 MX MX2009004780A patent/MX2009004780A/es active IP Right Grant
- 2007-11-13 AU AU2007321019A patent/AU2007321019B2/en not_active Ceased
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- 2007-11-13 CL CL200703260A patent/CL2007003260A1/es unknown
- 2007-11-13 PT PT07824574T patent/PT2094694E/pt unknown
- 2007-11-13 KR KR1020097009772A patent/KR20090078828A/ko not_active Application Discontinuation
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- 2009-06-09 NO NO20092224A patent/NO20092224L/no not_active Application Discontinuation
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2010
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- 2011-03-22 CY CY20111100315T patent/CY1111351T1/el unknown
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- 2012-05-15 US US13/471,912 patent/US20130005695A1/en not_active Abandoned
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