CY1113898T1 - Συντηγμενο ετεροκυκλικο παραγωγο, φαρμακευτικη συνθεση η οποια το περιεχει και η χρηση του στην ιατρικη - Google Patents
Συντηγμενο ετεροκυκλικο παραγωγο, φαρμακευτικη συνθεση η οποια το περιεχει και η χρηση του στην ιατρικηInfo
- Publication number
- CY1113898T1 CY1113898T1 CY20131100276T CY131100276T CY1113898T1 CY 1113898 T1 CY1113898 T1 CY 1113898T1 CY 20131100276 T CY20131100276 T CY 20131100276T CY 131100276 T CY131100276 T CY 131100276T CY 1113898 T1 CY1113898 T1 CY 1113898T1
- Authority
- CY
- Cyprus
- Prior art keywords
- carbamoyl
- alkyl
- pharmaceutical composition
- heteroaryl
- hydrocyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Gynecology & Obstetrics (AREA)
- Anesthesiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Η παρούσα εφεύρεση παρέχει μία ένωση η οποία είναι χρήσιμη ως ένας παράγοντας για την πρόληψη ή τη θεραπευτική αντιμετώπιση μίας νόσου που εξαρτάται από τις φυλετικές ορμόνες ή μία παρόμοια νόσο. Δηλαδή, η παρούσα εφεύρεση παρέχει ένα συντηγμένο ετεροκυκλικό παράγωγο το οποίο αντιπροσωπεύει ο ακόλουθος γενικός τύπος (I), μία φαρμακευτική σύνθεση η οποία το περιέχει, την χρήση του στην ιατρική και λοιπά. Στον τύπο (I), ο δακτύλιος Α αντιπροσωπεύει έναν ακόρεστο κυκλικό υδρογονάνθρακα με 5- μέλη ή ένα ετεροαρύλιο με 5- μέλη, το RA αντιπροσωπεύει τα αλογόνο, αλκύλιο, αλκενύλιο, αλκυνύλιο, καρβοξύλιο, αλκοξύλιο, καρβαμοΰλιο, αλκυλοκαρβαμοΰλιο και λοιπά, ο δακτύλιος Β αντιπροσωπεύει το αρύλιο και το ετεροαρύλιο, το RB αντιπροσωπεύει τα αλογόνο, αλκύλιο, καρβοξύλιο, αλκοξύλιο, καρβαμοΰλιο, αλκυλο-καρβαμοΰλιο και λοιπά, το Ε1 κι το Ε2 αντιπροσωπεύουν ένα άτομο οξυγόνου και λοιπά, το U αντιπροσωπεύει ένα μονό δεσμό ή ένα αλκυλένιο, το Χ αντιπροσωπεύει μία ομάδα που αντιπροσωπεύουν τα Υ, -SO2-Y, O-(αλκυλενο)-Υ, Ο-Ζ στα οποία το Υ αντιπροσωπεύει το Ζ, μία αμινοομάδα και λοιπά, το Ζ αντιπροσωπεύει τα κυκλοαλκύλιο, ετεροκυκλοαλκύλιο, αρύλιο, ετεροαρύλιο και λοιπά.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005304395 | 2005-10-19 | ||
| JP2006147019 | 2006-05-26 | ||
| EP06811925.4A EP1939204B3 (en) | 2005-10-19 | 2006-10-17 | Fused heterocyclic derivative, medicinal composition containing the same, and medicinal use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1113898T1 true CY1113898T1 (el) | 2016-07-27 |
Family
ID=37962485
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20131100276T CY1113898T1 (el) | 2005-10-19 | 2013-04-02 | Συντηγμενο ετεροκυκλικο παραγωγο, φαρμακευτικη συνθεση η οποια το περιεχει και η χρηση του στην ιατρικη |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US9040693B2 (el) |
| EP (1) | EP1939204B3 (el) |
| JP (2) | JP4955566B2 (el) |
| KR (1) | KR101384132B1 (el) |
| AU (1) | AU2006305271B2 (el) |
| BR (1) | BRPI0617436B8 (el) |
| CA (1) | CA2624492C (el) |
| CY (1) | CY1113898T1 (el) |
| DK (1) | DK1939204T6 (el) |
| ES (1) | ES2398917T7 (el) |
| HK (1) | HK1125110A1 (el) |
| IL (1) | IL190754A (el) |
| NL (1) | NL301202I2 (el) |
| NO (1) | NO343185B1 (el) |
| NZ (1) | NZ567300A (el) |
| PL (1) | PL1939204T6 (el) |
| PT (1) | PT1939204E (el) |
| RU (1) | RU2418803C2 (el) |
| SI (1) | SI1939204T1 (el) |
| TW (1) | TWI400074B (el) |
| WO (1) | WO2007046392A1 (el) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008124614A1 (en) * | 2007-04-06 | 2008-10-16 | Neurocrine Biosciences, Inc. | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
| NZ580457A (en) * | 2007-04-06 | 2012-03-30 | Neurocrine Biosciences Inc | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
| EP2145889A4 (en) * | 2007-04-18 | 2012-04-18 | Kissei Pharmaceutical | HETEROCYCLIC FUSED CORE DERIVATIVE, PHARMACEUTICAL COMPOSITION COMPRISING THE DERIVATIVE, AND USE OF THE COMPOSITION FOR MEDICAL PURPOSES |
| US8426427B2 (en) | 2007-04-18 | 2013-04-23 | Kissei Pharmaceutical Co., Ltd. | Fused heterocyclic derivative, pharmaceutical composition comprising the derivative, and use of the composition for medical purposes |
| WO2011099507A1 (ja) * | 2010-02-10 | 2011-08-18 | キッセイ薬品工業株式会社 | 縮合複素環誘導体の塩及びその結晶 |
| EP2889291A4 (en) | 2012-08-24 | 2015-10-14 | Takeda Pharmaceutical | HETEROCYCLIC CONNECTION |
| WO2014042176A1 (ja) * | 2012-09-14 | 2014-03-20 | キッセイ薬品工業株式会社 | 縮合複素環誘導体の製造方法およびその製造中間体 |
| US9771320B2 (en) * | 2014-01-06 | 2017-09-26 | Bristol-Myers Squibb Company | Carbocyclic sulfone RORγ modulators |
| EP3498280B1 (en) * | 2016-08-08 | 2024-04-03 | Kissei Pharmaceutical Co., Ltd. | Administration and dosage of therapeutic agent for endometriosis |
| CN110234336A (zh) * | 2017-01-31 | 2019-09-13 | 维鲁公司 | 用于促性腺激素释放激素(GnRH)拮抗剂的长效释放的组合物和方法 |
| JP7292566B2 (ja) | 2017-06-05 | 2023-06-19 | キッセイ薬品工業株式会社 | 子宮筋腫を治療し、月経失血を低下させるゴナドトロピン放出ホルモンアンタゴニスト投与計画 |
| EA201992612A1 (ru) | 2017-06-05 | 2020-05-20 | Обсева С.А. | Схемы применения антагониста гонадотропин-высвобождающего гормона для лечения эндометриоза |
| CN112105608B (zh) * | 2018-01-30 | 2023-07-14 | 因赛特公司 | 制备(1-(3-氟-2-(三氟甲基)异烟碱基)哌啶-4-酮)的方法 |
| AU2019373349A1 (en) | 2018-10-29 | 2021-05-20 | Kissei Pharmaceutical Co., Ltd. | Compositions and methods for the treatment of adenomyosis and rectovaginal endometriosis |
| SG11202104053TA (en) | 2018-11-07 | 2021-05-28 | ObsEva SA | Compositions and methods for the treatment of estrogen-dependent disorders |
| JP2022543308A (ja) | 2019-08-08 | 2022-10-11 | オブセヴァ エス．エー． | エストロゲン依存性障害の治療のための組成物及び方法 |
| KR20220045198A (ko) * | 2019-08-08 | 2022-04-12 | 옵스에파 에스에이 | 에스트로겐-의존성 장애의 치료를 위한 gnrh 길항제 |
| CN116940575A (zh) * | 2021-02-23 | 2023-10-24 | 深圳市康哲药业有限公司 | 噻吩并嘧啶二酮类化合物及其应用 |
| WO2022179476A1 (zh) * | 2021-02-23 | 2022-09-01 | 南京明德新药研发有限公司 | 多并环取代的5-羧酸噻吩并嘧啶二酮类化合物及其应用 |
| TW202342054A (zh) | 2022-02-04 | 2023-11-01 | 日商橘生藥品工業股份有限公司 | 經口固形製劑 |
| WO2024037532A1 (zh) * | 2022-08-16 | 2024-02-22 | 深圳市康哲生物科技有限公司 | 一种噻吩并嘧啶酮衍生物的盐型及晶型 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0781774B1 (en) * | 1995-12-08 | 2002-07-31 | Takeda Chemical Industries, Ltd. | Prolactin production inhibitory agents |
| WO1997040846A1 (en) | 1996-04-30 | 1997-11-06 | Takeda Chemical Industries, Ltd. | COMBINED USE OF GnRH AGONIST AND ANTAGONIST |
| US6150352A (en) * | 1996-05-20 | 2000-11-21 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| GB0124627D0 (en) * | 2001-10-15 | 2001-12-05 | Smithkline Beecham Plc | Novel compounds |
| WO2005049613A1 (en) | 2003-11-14 | 2005-06-02 | Merck Sharp & Dohme Limited | Bicyclic pyrimidin-4-(3h)-ones and analogues and derivatives thereof which modulate the function of the vanilloid-1 receptor (vr1) |
| CA2547746A1 (en) * | 2003-12-19 | 2005-07-07 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
| JPWO2006083005A1 (ja) * | 2005-02-03 | 2008-06-26 | 武田薬品工業株式会社 | 縮合ピリミジン誘導体およびその用途 |
-
2006
- 2006-10-17 US US12/089,674 patent/US9040693B2/en active Active
- 2006-10-17 SI SI200631557T patent/SI1939204T1/sl unknown
- 2006-10-17 NZ NZ567300A patent/NZ567300A/en unknown
- 2006-10-17 DK DK06811925.4T patent/DK1939204T6/da active
- 2006-10-17 PT PT68119254T patent/PT1939204E/pt unknown
- 2006-10-17 KR KR1020087010997A patent/KR101384132B1/ko active IP Right Grant
- 2006-10-17 RU RU2008119462/04A patent/RU2418803C2/ru active
- 2006-10-17 CA CA2624492A patent/CA2624492C/en active Active
- 2006-10-17 JP JP2007540993A patent/JP4955566B2/ja active Active
- 2006-10-17 EP EP06811925.4A patent/EP1939204B3/en active Active
- 2006-10-17 BR BRPI0617436A patent/BRPI0617436B8/pt active IP Right Grant
- 2006-10-17 ES ES06811925T patent/ES2398917T7/es active Active
- 2006-10-17 PL PL06811925.4T patent/PL1939204T6/pl unknown
- 2006-10-17 WO PCT/JP2006/320681 patent/WO2007046392A1/ja active Application Filing
- 2006-10-17 AU AU2006305271A patent/AU2006305271B2/en active Active
- 2006-10-19 TW TW095138520A patent/TWI400074B/zh active
-
2008
- 2008-04-09 IL IL190754A patent/IL190754A/en active IP Right Grant
- 2008-05-19 NO NO20082249A patent/NO343185B1/no unknown
-
2009
- 2009-04-09 HK HK09103380.3A patent/HK1125110A1/xx unknown
-
2012
- 2012-01-19 JP JP2012008680A patent/JP5319797B2/ja active Active
-
2013
- 2013-04-02 CY CY20131100276T patent/CY1113898T1/el unknown
-
2022
- 2022-11-01 NL NL301202C patent/NL301202I2/nl unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1113898T1 (el) | Συντηγμενο ετεροκυκλικο παραγωγο, φαρμακευτικη συνθεση η οποια το περιεχει και η χρηση του στην ιατρικη | |
| CY1108267T1 (el) | Ενωσεις που επηρεαζουν τη γλυκοκιναση | |
| CY1110419T1 (el) | Τρικυκλικες ενωσεις με βαση το 1,6-διυδρο-1,3,5,6-tetpaaza-as-ινδακενιο και φαρμακευτικες συνθεσεις που τις περιεχουν ως αναστολεις της ενζυμικης ενεργοτητας της ικκ | |
| CY1124222T1 (el) | Ενωσεις πυριδινονης-πυριδινυλιου υποκατεστημενες με μεθυλο/φθορο-πυριδινυλο-μεθοξυ και ενωσεις πυριδινονης-πυριδινυλιου υποκατεστημενες με φθορο-πυριδινυλο-μεθοξυ | |
| CY1111351T1 (el) | Παραγωγα κινικλιδινης απο (ετερο) αρυλκυκλοεπτανοκαρβοξυλικο οξυ ως ανταγωνιστες μουσκαρινικου υποδοχεως | |
| CY1119488T1 (el) | Παραγων για θεραπεια ή/και αποτροπη διαταραχης υπνου | |
| CY1114521T1 (el) | Ενωσεις βενζαμιδιου χρησιμες ως αναστολεις αποακετυλασων ιστονων | |
| CY1111526T1 (el) | Αναστολεις κυκλοπροπυλ συντηγμενης ινδολοβενζαζεπινης της ns5b του hcv | |
| CY1117615T1 (el) | Ενωσεις θειαζολης σουλφοναμιδης και οξαζολης | |
| CY1106297T1 (el) | Παραγωγα πυραζολης χρησιμα ως αναστολεις κινασης πρωτεϊνης | |
| CY1113684T1 (el) | Anti-mikρobiaka πεπτιδια που περιλαμβανουν μια αργινινη (arginine)- kai/ή λυσινη (lysine)- που περιεχουν υποκινητη | |
| CY1108714T1 (el) | Ανταγωνιστες υποδοχεα cgrp | |
| CY1108183T1 (el) | Θειαζολυλο-διυδρο-ινδαζολια | |
| DE602006020152D1 (de) | Arylalkyl- und heteroarylalkyl-derivate von cyclosporin a bei der behandlung und vorbeugung einer virusinfektion | |
| CY1110530T1 (el) | Ανοσοσφαιρινες που εξουδετερωνουν το nogoa για τη θεραπεια νευρολογικων ασθενειων | |
| ATE447562T1 (de) | Verstärker von glutamat-rezeptoren | |
| SE0302811D0 (sv) | Novel compounds | |
| CY1107419T1 (el) | Προφαρμακα αντι-ιικων μεσων απο πιπεραζινη και υποκατεστημενη πιπεριδινη | |
| CY1106640T1 (el) | Αναστολεις κρουζιπαϊνης και αλλων πρωτεασων κυστεϊνης | |
| DE602006008447D1 (de) | 2 aminocarbonyl-substituierte piperazin- oder diaza-cyclische verbindungen als apoptose-protein-inhibitor (iap)-modulatoren | |
| CY1108894T1 (el) | Νεα παραγωγα βενζιμιδαζολης | |
| CY1112376T1 (el) | Παραγωγα 2,3,4,9-τετραϋδρο-1η-καρβαζολης ως ανταγωνιστες του υποδοχεα crth2 | |
| CL2004000270A1 (es) | Compuestos derivados de pirazol, sus sales de adicion acidas,trastornos de vih y virus geneticamente relacionados. hidratos, solvatos; composiciones farmaceuticas; y su uso en el tramiento de trastornos del vih y virus geneticamente relacionados. | |
| CY1112919T1 (el) | Παραγωγα β-αμινοξεων για τη θεραπευτικη αντιμετωπιση του διαβητη | |
| CY1109544T1 (el) | Παραγωγα της οξαζολιδινονης και η χρηση τους σαν αντιβιοτικα |