CY1114521T1 - Ενωσεις βενζαμιδιου χρησιμες ως αναστολεις αποακετυλασων ιστονων - Google Patents
Ενωσεις βενζαμιδιου χρησιμες ως αναστολεις αποακετυλασων ιστονωνInfo
- Publication number
- CY1114521T1 CY1114521T1 CY20131100650T CY131100650T CY1114521T1 CY 1114521 T1 CY1114521 T1 CY 1114521T1 CY 20131100650 T CY20131100650 T CY 20131100650T CY 131100650 T CY131100650 T CY 131100650T CY 1114521 T1 CY1114521 T1 CY 1114521T1
- Authority
- CY
- Cyprus
- Prior art keywords
- benzamidium
- backgrounds
- compounds useful
- relates
- compounds
- Prior art date
Links
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical class NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000006645 (C3-C4) cycloalkyl group Chemical group 0.000 abstract 1
- 102000003964 Histone deacetylase Human genes 0.000 abstract 1
- 108090000353 Histone deacetylase Proteins 0.000 abstract 1
- 102000006947 Histones Human genes 0.000 abstract 1
- 108010033040 Histones Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000001028 anti-proliverative effect Effects 0.000 abstract 1
- 150000003936 benzamides Chemical class 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 125000003226 pyrazolyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Η εφεύρεση αφορά ενώσεις βενζαμιδίου του τύπου (Ι), όπου το R1 είναι ένας C-συζευγμένος δακτύλιος πυραζολίου, ο οποίος είναι προαιρετικά υποκατεστημένος με μία ή περισσότερες ομάδες που επιλέγονται από C1-4αλκύλιο, C3-4κυκλοαλκύλιο, C1-4αλκοξύ και C3-4κυκλοαλκοξύ · ή ένα φαρμακευτικώς αποδεκτό άλας ή μορφή προφαρμάκου αυτών. Η εφεύρεση αφορά επίσης διαδικασίες για την παρασκευή τέτοιων ενώσεων, φαρμακευτικών συνθέσεων που τις περιέχουν, καθώς και τη χρήση τους στην παρασκευή ενός φαρμάκου για χρήση ως ένας αντιπολλαπλασιαστικός παράγοντας στην πρόληψη ή στη θεραπεία των όγκων ή άλλων πολλαπλασιαστικών παθήσεων, που είναι ευαίσθητες στην αναστολή αποακετυλασών ιστονών (HDAC).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0521244.4A GB0521244D0 (en) | 2005-10-19 | 2005-10-19 | Benzamide compounds |
EP06794783.8A EP1954690B1 (en) | 2005-10-19 | 2006-10-17 | Benzamide compounds useful as histone deacetylase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1114521T1 true CY1114521T1 (el) | 2016-10-05 |
Family
ID=35458263
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20131100650T CY1114521T1 (el) | 2005-10-19 | 2013-07-31 | Ενωσεις βενζαμιδιου χρησιμες ως αναστολεις αποακετυλασων ιστονων |
Country Status (32)
Country | Link |
---|---|
US (2) | US8207202B2 (el) |
EP (1) | EP1954690B1 (el) |
JP (1) | JP5340736B2 (el) |
KR (1) | KR101464004B1 (el) |
CN (1) | CN101331123B (el) |
AR (1) | AR057162A1 (el) |
AU (1) | AU2006303111B2 (el) |
BR (1) | BRPI0617654B8 (el) |
CA (1) | CA2625970C (el) |
CY (1) | CY1114521T1 (el) |
DK (1) | DK1954690T3 (el) |
EC (1) | ECSP088457A (el) |
ES (1) | ES2422859T3 (el) |
GB (1) | GB0521244D0 (el) |
HK (1) | HK1121749A1 (el) |
HR (1) | HRP20130683T1 (el) |
IL (1) | IL190429A (el) |
ME (1) | ME01595B (el) |
MY (1) | MY145569A (el) |
NO (1) | NO340878B1 (el) |
NZ (1) | NZ566944A (el) |
PL (1) | PL1954690T3 (el) |
PT (1) | PT1954690E (el) |
RS (1) | RS52881B (el) |
RU (1) | RU2448965C2 (el) |
SA (1) | SA06270384B1 (el) |
SI (1) | SI1954690T1 (el) |
TW (1) | TWI385162B (el) |
UA (1) | UA98757C2 (el) |
UY (1) | UY29869A1 (el) |
WO (1) | WO2007045844A1 (el) |
ZA (1) | ZA200803096B (el) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102007028198A1 (de) | 2007-06-16 | 2008-12-24 | Schebo (R) . Biotech Ag | Neue Pharmazeutika, Verfahren zu ihrer Herstellung und ihre Verwendung in der Therapie |
JP5564033B2 (ja) | 2008-03-27 | 2014-07-30 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒストンデアセチラーゼの新規インヒビターとしてのアザ−ビシクロヘキシル置換インドリルアルキルアミノ誘導体 |
US9265734B2 (en) | 2008-09-03 | 2016-02-23 | Biomarin Pharmaceutical Inc. | Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors |
US8258316B2 (en) * | 2009-06-08 | 2012-09-04 | Gilead Sciences, Inc. | Alkanoylamino benzamide aniline HDAC inhibitor compounds |
US10059723B2 (en) | 2011-02-28 | 2018-08-28 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
EP2680694B1 (en) | 2011-02-28 | 2019-01-02 | BioMarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
US8957066B2 (en) | 2011-02-28 | 2015-02-17 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
WO2014159214A1 (en) * | 2013-03-14 | 2014-10-02 | Chdi Foundation, Inc. | Histone deacetylase inhibitors and compositions and methods of use thereof |
US9617259B2 (en) | 2013-03-14 | 2017-04-11 | Chdi Foundation, Inc. | Histone deacetylase inhibitors and compositions and methods of use thereof |
EP2968233A4 (en) | 2013-03-14 | 2016-08-03 | Chdi Foundation Inc | HISTON DEACETYLASE HEMMER AND COMPOSITIONS AND METHOD FOR USE THEREOF |
KR20150132345A (ko) | 2013-03-15 | 2015-11-25 | 바이오마린 파머수티컬 인크. | Hdac 저해제 |
PT2991982T (pt) * | 2013-04-29 | 2018-11-28 | Chong Kun Dang Pharmaceutical Corp | Novos compostos para inibidores seletivos de histonadesacetilase e composição farmacêutica que os compreende |
AU2015270926A1 (en) | 2014-06-02 | 2017-01-05 | Chdi Foundation, Inc. | Histone deacetylase inhibitors and compositions and methods of use thereof |
KR102236356B1 (ko) | 2017-11-24 | 2021-04-05 | 주식회사 종근당 | 루푸스의 예방 또는 치료를 위한 조성물 |
GB201914006D0 (en) * | 2019-09-27 | 2019-11-13 | Celleron Therapeutics Ltd | Combination Therapy |
GB201913988D0 (en) * | 2019-09-27 | 2019-11-13 | Celleron Therapeutics Ltd | Novel treatment |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH117273A4 (el) * | 1973-01-26 | 1976-07-15 | ||
CH187973A4 (de) * | 1973-02-09 | 1977-03-31 | Hoechst Ag | Verfahren zum optischen Aufhellen von Textilmaterialien |
DE2918965A1 (de) * | 1979-05-11 | 1980-11-20 | Bayer Ag | Benzofuranverbindungen sowie deren verwendung als optische aufheller |
IT1232252B (it) * | 1989-02-22 | 1992-01-28 | Rotta Research Lab | Derivati della n fenil benzamide ad attivita' antiulcera ed antiallerica e procedimento per la loro preparazione |
JPH05239069A (ja) | 1992-02-28 | 1993-09-17 | Canon Inc | 液晶性化合物、これを含む液晶組成物、それを有する液晶素子、それらを用いた表示方法および表示装置 |
JP4405602B2 (ja) | 1998-04-16 | 2010-01-27 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | ヒストン脱アセチル化酵素阻害剤 |
GB9826412D0 (en) | 1998-12-03 | 1999-01-27 | Glaxo Group Ltd | Chemical compounds |
JP4390024B2 (ja) | 1999-04-23 | 2009-12-24 | アステラス製薬株式会社 | 新規なジアゼパン誘導体又はその塩 |
US6632815B2 (en) * | 1999-09-17 | 2003-10-14 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
NZ517828A (en) | 1999-09-17 | 2003-10-31 | Millennium Pharm Inc | Inhibitors having activity against mammalian factor Xa |
KR20020070285A (ko) | 1999-11-23 | 2002-09-05 | 메틸진, 인크. | 히스톤 디아세틸라제의 억제제 |
AU776053B2 (en) | 2000-03-31 | 2004-08-26 | Astellas Pharma Inc. | Diazepan derivatives or salts thereof |
EP1217000A1 (en) | 2000-12-23 | 2002-06-26 | Aventis Pharma Deutschland GmbH | Inhibitors of factor Xa and factor VIIa |
MXPA04002397A (es) | 2001-09-14 | 2004-12-02 | Methylgene Inc | Inhibidores de histona deacetilasa. |
DE10204115A1 (de) * | 2002-02-01 | 2003-08-07 | Bayer Cropscience Ag | DELTA·1·-Pyrroline |
TWI319387B (en) | 2002-04-05 | 2010-01-11 | Astrazeneca Ab | Benzamide derivatives |
GB0209715D0 (en) * | 2002-04-27 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
US20040072770A1 (en) | 2002-07-03 | 2004-04-15 | Besterman Jeffrey M. | Methods for specifically inhibiting histone deacetylase-7 and 8 |
TW200505902A (en) | 2003-03-20 | 2005-02-16 | Schering Corp | Cannabinoid receptor ligands |
KR101153335B1 (ko) | 2003-09-24 | 2012-07-05 | 메틸진 인코포레이티드 | 히스톤 데아세틸라제의 억제제 |
WO2005092899A1 (en) | 2004-03-26 | 2005-10-06 | Methylgene Inc. | Inhibitors of histone deacetylase |
AR050926A1 (es) | 2004-09-03 | 2006-12-06 | Astrazeneca Ab | Derivados de benzamida como inhibidores de la histonadesacetilasa(hdac) |
GB0427758D0 (en) | 2004-12-18 | 2005-01-19 | Astrazeneca Ab | Novel benzamide compounds |
GB0500828D0 (en) | 2005-01-15 | 2005-02-23 | Astrazeneca Ab | Benzamide derivatives |
GB0501146D0 (en) | 2005-01-20 | 2005-02-23 | Astrazeneca Ab | Novel benzamide derivatives |
GB0526352D0 (en) | 2005-12-23 | 2006-02-01 | Astrazeneca Ab | Benzamide derivatives |
GB0526351D0 (en) | 2005-12-23 | 2006-02-01 | Astrazeneca Ab | Novel benzamide derivatives |
-
2005
- 2005-10-19 GB GBGB0521244.4A patent/GB0521244D0/en not_active Ceased
-
2006
- 2006-10-17 CN CN200680047678.9A patent/CN101331123B/zh active Active
- 2006-10-17 DK DK06794783.8T patent/DK1954690T3/da active
- 2006-10-17 RU RU2008119411/04A patent/RU2448965C2/ru active
- 2006-10-17 NZ NZ566944A patent/NZ566944A/en unknown
- 2006-10-17 KR KR1020087011411A patent/KR101464004B1/ko active IP Right Grant
- 2006-10-17 AU AU2006303111A patent/AU2006303111B2/en active Active
- 2006-10-17 PL PL06794783T patent/PL1954690T3/pl unknown
- 2006-10-17 BR BRPI0617654A patent/BRPI0617654B8/pt active IP Right Grant
- 2006-10-17 PT PT67947838T patent/PT1954690E/pt unknown
- 2006-10-17 UA UAA200805465A patent/UA98757C2/ru unknown
- 2006-10-17 US US12/090,611 patent/US8207202B2/en active Active
- 2006-10-17 SI SI200631627T patent/SI1954690T1/sl unknown
- 2006-10-17 EP EP06794783.8A patent/EP1954690B1/en active Active
- 2006-10-17 ME MEP-2013-85A patent/ME01595B/me unknown
- 2006-10-17 JP JP2008536114A patent/JP5340736B2/ja active Active
- 2006-10-17 RS RS20130325A patent/RS52881B/en unknown
- 2006-10-17 WO PCT/GB2006/003838 patent/WO2007045844A1/en active Application Filing
- 2006-10-17 CA CA2625970A patent/CA2625970C/en active Active
- 2006-10-17 ES ES06794783T patent/ES2422859T3/es active Active
- 2006-10-18 UY UY29869A patent/UY29869A1/es not_active Application Discontinuation
- 2006-10-19 AR ARP060104581A patent/AR057162A1/es active IP Right Grant
- 2006-10-19 TW TW095138558A patent/TWI385162B/zh active
- 2006-10-28 SA SA6270384A patent/SA06270384B1/ar unknown
-
2008
- 2008-03-25 IL IL190429A patent/IL190429A/en active IP Right Grant
- 2008-04-01 NO NO20081582A patent/NO340878B1/no unknown
- 2008-04-08 ZA ZA200803096A patent/ZA200803096B/xx unknown
- 2008-04-16 MY MYPI20081121A patent/MY145569A/en unknown
- 2008-05-17 EC EC2008008457A patent/ECSP088457A/es unknown
- 2008-11-27 HK HK08112997.0A patent/HK1121749A1/xx unknown
-
2012
- 2012-05-15 US US13/472,095 patent/US8735429B2/en active Active
-
2013
- 2013-07-22 HR HRP20130683TT patent/HRP20130683T1/hr unknown
- 2013-07-31 CY CY20131100650T patent/CY1114521T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1114521T1 (el) | Ενωσεις βενζαμιδιου χρησιμες ως αναστολεις αποακετυλασων ιστονων | |
CY1123260T1 (el) | Ενα αλας νατριου του ν-((1,2,3,5,6,7-eξaϋδpo-s-inδaken-4-υλ)καρβαμοϋλ)-1-ισοπροπυλ-1η-πυραζολο-3-σουλφοναμιδιου | |
CY1118232T1 (el) | Διαμορφωτες φαρμακοκινητικων ιδιοτητων θεραπευτικων παραγοντων | |
EA202091491A1 (ru) | Новые бензиламинозамещенные пиридопиримидиноны и производные в качестве ингибиторов sos1 | |
CY1124257T1 (el) | N-[4-ΦΘOPO-5-[[(2S,4S)-2-MEΘYΛO-4-[(5-MEΘYΛO-1,2,4-ΟΞAΔIAZOΛ-3-YΛO)MEΘOΞY]-l-ΠΙΠΕΡΙΔΥΛΟ]ΜΕΘΥΛΟ]ΘΕΙΑΖΟΛ-2-ΥΛΟ]ΑΚΕΤΑΜΙΔΙΟ ΩΣ ΑΝΑΣΤΟΛΕΑΣ OGA | |
CY1122226T1 (el) | Προφαρμακα που περiλαμβανουν συζευγμα εξενδινης αρθρωτη | |
CY1116688T1 (el) | Τροποποιητες φαρμακοκινητικων ιδιοτητων θεραπευτικων ειδων | |
CY1113269T1 (el) | Παραγωγα ινδαζολυλ αμιδιου για τη θεραπευτικη αγωγη διαταραχων διαμεσολαβουμενων υπο υποδοχεα γλυκοκορτικοειδων | |
CY1123627T1 (el) | Παραγωγα διυδροϊμιδαζοπυραζινονης χρησιμα στη θεραπευτικη αντιμετωπιση του καρκινου | |
EA202090688A1 (ru) | Бис-амидные соединения, активирующие саркомер, и варианты их применения | |
CY1117424T1 (el) | Βενζοδιαζεπινικος αναστολεας bromodomain | |
CY1110419T1 (el) | Τρικυκλικες ενωσεις με βαση το 1,6-διυδρο-1,3,5,6-tetpaaza-as-ινδακενιο και φαρμακευτικες συνθεσεις που τις περιεχουν ως αναστολεις της ενζυμικης ενεργοτητας της ικκ | |
CY1119488T1 (el) | Παραγων για θεραπεια ή/και αποτροπη διαταραχης υπνου | |
CY1119730T1 (el) | Παραγωγα καρβοξυλικου οξεος πυρρολιδινης ως αγωνιστες του συζευγμενου με πρωτεϊνή-g υποδοχεα 43 (gpr43), φαρμακευτικη συνθεση και μεθοδοι για χρηση στην αντιμετωπιση μεταβολικων διαταραχων | |
CY1122182T1 (el) | Ανοσοκατασταλτικες φαρμακοτεχνικες μορφες | |
CY1108267T1 (el) | Ενωσεις που επηρεαζουν τη γλυκοκιναση | |
EA201691142A1 (ru) | Ингибиторы мек и способы их применения | |
EA201170441A1 (ru) | Терапевтические противовирусные пептиды | |
CY1108729T1 (el) | 3,11b-cis-διυδpotetpabenazinh για την θεραπευτικη αντιμετωπιση μιας πολλαπλασιαστικης νοσου ή φλεγμονωδους παθησης | |
ATE536172T1 (de) | Ezetimibzusammensetzungen | |
EA202191286A1 (ru) | Ингибитор 15-pgdh | |
CY1115729T1 (el) | Τρικυκλικη ενωση και φαρμακευτικη χρηση αυτης | |
CY1124346T1 (el) | ΠΑΡΑΓΩΓΑ ΧΡΩΜΑΝΙΟΥ, ΙΣΟΧΡΩΜΑΝΙΟΥ ΚΑΙ ΔΙΥΔΡΟΪΣΟΒΕΝΖΟΦΟΥΡΑΝΙΟΥ ΩΣ mGluR2-APNHTIKOI ΑΛΛΟΣΤΕΡΙΚΟΙ ΔΙΑΜΟΡΦΩΤΕΣ, ΣΥΝΘΕΣΕΙΣ, ΚΑΙ ΧΡΗΣΗ ΑΥΤΩΝ | |
CY1123722T1 (el) | Ενεσιμα φαρμακευτικα σκευασματα λεφαμουλινης | |
EA201890221A1 (ru) | Hbed-бисфосфонаты, их конъюгаты с радиометаллом и их применение в качестве лечебно-диагностических агентов |