BR0016329B1 - bis-indolilmaleimidas substituÍdas para inibiÇço de proliferaÇço de cÉlulas, seu processo de preparaÇço e seu uso, bem como composiÇço farmacÊutica. - Google Patents

bis-indolilmaleimidas substituÍdas para inibiÇço de proliferaÇço de cÉlulas, seu processo de preparaÇço e seu uso, bem como composiÇço farmacÊutica.

Info

Publication number
BR0016329B1
BR0016329B1 BRPI0016329-5A BR0016329A BR0016329B1 BR 0016329 B1 BR0016329 B1 BR 0016329B1 BR 0016329 A BR0016329 A BR 0016329A BR 0016329 B1 BR0016329 B1 BR 0016329B1
Authority
BR
Brazil
Prior art keywords
indolylmaleimides
inhibition
well
pharmaceutical composition
cell proliferation
Prior art date
Application number
BRPI0016329-5A
Other languages
English (en)
Other versions
BR0016329A (pt
BRPI0016329B8 (pt
Inventor
Nader Fotouhi
Emily Aijin Liu
Allen John Lovey
John Guilfoyle Mullin Jr
Guiseppe Federico Weber
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of BR0016329A publication Critical patent/BR0016329A/pt
Publication of BR0016329B1 publication Critical patent/BR0016329B1/pt
Publication of BRPI0016329B8 publication Critical patent/BRPI0016329B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
BRPI0016329A 1999-12-16 2000-12-12 bis-indolilmaleimidas substituídas para inibição de proliferação de células, seu processo de preparação e seu uso, bem como composição farmacêutica. BRPI0016329B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17105199P 1999-12-16 1999-12-16
PCT/EP2000/012559 WO2001044234A1 (en) 1999-12-16 2000-12-12 Substituted bisindolylmaleimides for the inhibition of cell proliferation

Publications (3)

Publication Number Publication Date
BR0016329A BR0016329A (pt) 2002-08-27
BR0016329B1 true BR0016329B1 (pt) 2013-03-19
BRPI0016329B8 BRPI0016329B8 (pt) 2021-05-25

Family

ID=22622296

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0016329A BRPI0016329B8 (pt) 1999-12-16 2000-12-12 bis-indolilmaleimidas substituídas para inibição de proliferação de células, seu processo de preparação e seu uso, bem como composição farmacêutica.

Country Status (33)

Country Link
US (1) US6313143B1 (pt)
EP (1) EP1242408B1 (pt)
JP (2) JP2003516986A (pt)
KR (1) KR100507422B1 (pt)
CN (1) CN1229374C (pt)
AR (1) AR029415A1 (pt)
AT (1) ATE306484T1 (pt)
AU (1) AU783616B2 (pt)
BR (1) BRPI0016329B8 (pt)
CA (1) CA2392902C (pt)
CO (1) CO5050293A1 (pt)
CZ (1) CZ304130B6 (pt)
DE (1) DE60023182T2 (pt)
ES (1) ES2249314T3 (pt)
GC (1) GC0000265A (pt)
HK (1) HK1054385B (pt)
HR (1) HRP20020513B1 (pt)
HU (1) HU230003B1 (pt)
IL (2) IL150128A0 (pt)
JO (1) JO2296B1 (pt)
MA (1) MA26856A1 (pt)
MX (1) MXPA02005560A (pt)
MY (1) MY126998A (pt)
NO (1) NO322240B1 (pt)
NZ (1) NZ519173A (pt)
PE (1) PE20011034A1 (pt)
PL (1) PL200243B1 (pt)
RS (1) RS50449B (pt)
RU (1) RU2264398C2 (pt)
TW (1) TWI274752B (pt)
UY (1) UY26485A1 (pt)
WO (1) WO2001044234A1 (pt)
ZA (1) ZA200204258B (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002102373A1 (en) * 2001-06-15 2002-12-27 F. Hoffmann-La Roche Ag Method for administration of cancer therapeutic
EP1441772A2 (en) * 2001-10-29 2004-08-04 Nektar Therapeutics Al, Corporation Polymer conjugates of protein kinase c inhibitors
US9107911B2 (en) 2010-01-07 2015-08-18 Alkermes Pharma Ireland Limited Prodrugs of heteraromatic compounds
EP2474541A1 (en) * 2010-12-23 2012-07-11 Johannes- Gutenberg-Universität Mainz Conjugated 3-(indolyl)- and 3-(azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ227850A (en) 1988-02-10 1991-11-26 Hoffmann La Roche Indole substituted pyrrole derivatives; preparatory process and medicaments for use against inflammatory immunological, bronchopulmonary or vascular disorders
GB9416467D0 (en) * 1994-08-13 1994-10-05 Wellcome Found Compounds for use in medicine
CN1304058C (zh) * 1996-03-12 2007-03-14 Pg－Txl有限公司 水溶性紫杉醇产品
TW517067B (en) * 1996-05-31 2003-01-11 Hoffmann La Roche Interferon conjugates
PE91498A1 (es) * 1996-07-29 1998-12-22 Hoffmann La Roche Pirroles sustituidos
PE91598A1 (es) 1996-07-29 1998-12-24 Hoffmann La Roche Pirroles sustituidos
PE91698A1 (es) 1996-07-29 1998-12-24 Hoffmann La Roche Pirroles sustituidos
JP2002500184A (ja) * 1998-01-09 2002-01-08 アリゾナ ボード オブ リーゼンツ フェンスタチンとそのプロドラッグの合成
TR200002580T2 (tr) * 1998-03-17 2000-11-21 F.Hoffmann-La Roche Ag Hücre çoğalmasının engellenmesinde kullanılan ikameli bisindolimaleimitler
US6350786B1 (en) * 1998-09-22 2002-02-26 Hoffmann-La Roche Inc. Stable complexes of poorly soluble compounds in ionic polymers
JP2003511449A (ja) * 1999-10-12 2003-03-25 エフ．ホフマン−ラ ロシュ アーゲー 癌の処理のための抗増殖剤としての置換されたピロール

Also Published As

Publication number Publication date
NO322240B1 (no) 2006-09-04
CZ304130B6 (cs) 2013-11-13
HU230003B1 (en) 2015-04-28
AU783616B2 (en) 2005-11-17
ES2249314T3 (es) 2006-04-01
ZA200204258B (en) 2003-08-28
MA26856A1 (fr) 2004-12-20
HRP20020513A2 (en) 2004-08-31
IL150128A (en) 2006-06-11
UY26485A1 (es) 2001-06-29
US6313143B1 (en) 2001-11-06
JP4763623B2 (ja) 2011-08-31
PL200243B1 (pl) 2008-12-31
CA2392902C (en) 2009-01-13
DE60023182D1 (de) 2006-02-23
MY126998A (en) 2006-11-30
CN1229374C (zh) 2005-11-30
WO2001044234A1 (en) 2001-06-21
JO2296B1 (en) 2005-09-12
AR029415A1 (es) 2003-06-25
EP1242408A1 (en) 2002-09-25
BR0016329A (pt) 2002-08-27
GC0000265A (en) 2006-11-01
NO20022776L (no) 2002-06-11
BRPI0016329B8 (pt) 2021-05-25
NO20022776D0 (no) 2002-06-11
ATE306484T1 (de) 2005-10-15
RU2002119209A (ru) 2004-01-10
KR100507422B1 (ko) 2005-08-10
PE20011034A1 (es) 2001-10-12
TWI274752B (en) 2007-03-01
HK1054385A1 (en) 2003-11-28
NZ519173A (en) 2004-06-25
HK1054385B (zh) 2006-02-17
RU2264398C2 (ru) 2005-11-20
EP1242408B1 (en) 2005-10-12
HUP0203696A3 (en) 2004-01-28
RS50449B (sr) 2010-03-02
CZ20022447A3 (cs) 2003-06-18
CO5050293A1 (es) 2001-06-27
HUP0203696A2 (hu) 2003-03-28
DE60023182T2 (de) 2006-07-06
AU2008201A (en) 2001-06-25
JP2007153905A (ja) 2007-06-21
KR20020063215A (ko) 2002-08-01
MXPA02005560A (es) 2002-09-02
CA2392902A1 (en) 2001-06-21
CN1409709A (zh) 2003-04-09
PL355856A1 (en) 2004-05-31
YU43302A (sh) 2005-03-15
JP2003516986A (ja) 2003-05-20
IL150128A0 (en) 2002-12-01
HRP20020513B1 (en) 2006-10-31

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

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