BR9917086B1 - Benzodiazepina tricíclica, suas composições farmacêuticas bem como compostos intermediários. - Google Patents
Benzodiazepina tricíclica, suas composições farmacêuticas bem como compostos intermediários.Info
- Publication number
- BR9917086B1 BR9917086B1 BRPI9917086-8B1A BR9917086A BR9917086B1 BR 9917086 B1 BR9917086 B1 BR 9917086B1 BR 9917086 A BR9917086 A BR 9917086A BR 9917086 B1 BR9917086 B1 BR 9917086B1
- Authority
- BR
- Brazil
- Prior art keywords
- benzodiazepin
- tricyclic
- pharmaceutical compositions
- intermediate compounds
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11635899P | 1999-01-19 | 1999-01-19 | |
US46865099A | 1999-12-21 | 1999-12-21 | |
PCT/US1999/030423 WO2000043398A2 (en) | 1999-01-19 | 1999-12-21 | Tricyclic benzodiazepines as vasopressin receptor antagonists |
Publications (3)
Publication Number | Publication Date |
---|---|
BR9917086A BR9917086A (pt) | 2001-10-30 |
BR9917086B1 true BR9917086B1 (pt) | 2013-12-03 |
BRPI9917086B8 BRPI9917086B8 (pt) | 2016-05-24 |
Family
ID=26814157
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI9917086A BRPI9917086B8 (pt) | 1999-01-19 | 1999-12-21 | benzodiazepina tricíclica, suas composições farmacêuticas bem como compostos intermediários |
Country Status (27)
Country | Link |
---|---|
US (2) | US6713475B2 (pt) |
EP (1) | EP1147115B3 (pt) |
KR (1) | KR100771184B1 (pt) |
CN (1) | CN1174986C (pt) |
AR (1) | AR035837A1 (pt) |
AT (1) | ATE249465T1 (pt) |
AU (1) | AU772397B2 (pt) |
BR (1) | BRPI9917086B8 (pt) |
CA (1) | CA2360767C (pt) |
CZ (1) | CZ302647B6 (pt) |
DE (2) | DE69911259T4 (pt) |
DK (1) | DK1147115T5 (pt) |
ES (1) | ES2207333T7 (pt) |
HK (1) | HK1038361B (pt) |
HU (1) | HU229074B1 (pt) |
IL (2) | IL144270A0 (pt) |
ME (1) | ME00129B (pt) |
MY (1) | MY128065A (pt) |
NO (1) | NO327896B1 (pt) |
NZ (1) | NZ512960A (pt) |
PL (1) | PL205704B1 (pt) |
PT (1) | PT1147115E (pt) |
RS (1) | RS50820B (pt) |
TR (1) | TR200102069T2 (pt) |
TW (1) | TWI289564B (pt) |
UA (1) | UA70984C2 (pt) |
WO (1) | WO2000043398A2 (pt) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI9917086B8 (pt) * | 1999-01-19 | 2016-05-24 | Ortho Mcneil Pharm Inc | benzodiazepina tricíclica, suas composições farmacêuticas bem como compostos intermediários |
ATE367815T1 (de) * | 2000-10-04 | 2007-08-15 | Astellas Pharma Inc | Verwendung von einem vasopressin-antagonisten wie conivaptan zur herstellung eines medikaments für die behandlung der pulmonalen hypertension |
BR0208824A (pt) | 2001-04-12 | 2004-03-09 | Wyeth Corp | Composto, métodos de tratamento de distúrbios que são remediados ou aliviados por atividade de agonista de vasopressina em um mamìfero, e de indução de retardamento temporário de urinação em um mamìfero, e, composição farmacêutica |
EP1381370B1 (en) | 2001-04-12 | 2007-03-07 | Wyeth | N-biphenylcarbonyl- and n-phenylpyridylcarbonyl substituted bi- and tricyclic azepines and diazepines as vasopressing agonists |
ES2287326T3 (es) * | 2001-10-29 | 2007-12-16 | Ortho-Mcneil Pharmaceutical, Inc. | Antagonistas del receptor de vasopresina de (,4) benzodiazepina biciclica enlazada. |
EP1364968A1 (en) * | 2002-05-23 | 2003-11-26 | Bayer Aktiengesellschaft | Diagnostics and therapeutics for diseases associated with arginine vasopressin receptor 1 (AVPR1) |
GEP20074089B (en) * | 2003-02-19 | 2007-04-10 | Pfizer | Triazole compounds useful in therapy |
GB0303852D0 (en) * | 2003-02-19 | 2003-03-26 | Pfizer Ltd | Triazole compounds useful in therapy |
US7119088B2 (en) | 2003-02-19 | 2006-10-10 | Pfizer Inc. | Triazole compounds useful in therapy |
WO2006049984A2 (en) | 2004-10-28 | 2006-05-11 | Janssen Pharmaceutica, N.V. | Novel [1,4]benzodiazepines as vasopressin v2 receptor antagonists |
DE102005003632A1 (de) | 2005-01-20 | 2006-08-17 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Katheter für die transvaskuläre Implantation von Herzklappenprothesen |
US20070213813A1 (en) | 2005-12-22 | 2007-09-13 | Symetis Sa | Stent-valves for valve replacement and associated methods and systems for surgery |
US20090318412A1 (en) * | 2006-07-11 | 2009-12-24 | Takahiro Matsumoto | Tricyclic heterocyclic compound and use thereof |
US7896915B2 (en) | 2007-04-13 | 2011-03-01 | Jenavalve Technology, Inc. | Medical device for treating a heart valve insufficiency |
US9044318B2 (en) | 2008-02-26 | 2015-06-02 | Jenavalve Technology Gmbh | Stent for the positioning and anchoring of a valvular prosthesis |
ES2903231T3 (es) | 2008-02-26 | 2022-03-31 | Jenavalve Tech Inc | Stent para el posicionamiento y anclaje de una prótesis valvular en un sitio de implantación en el corazón de un paciente |
CN102216305B (zh) * | 2008-11-13 | 2013-12-18 | 弗·哈夫曼-拉罗切有限公司 | 螺-5,6-二氢-4H-2,3,5,10b-四氮杂-苯并[e]薁类 |
AU2009317386B2 (en) * | 2008-11-18 | 2013-07-25 | F. Hoffmann-La Roche Ag | Alkylcyclohexylethers of dihydrotetraazabenzoazulenes |
ES2431279T3 (es) * | 2008-11-28 | 2013-11-25 | F. Hoffmann-La Roche Ag | Arilciclohexiléteres de dihidro-tetraazabenzoazulenos para uso como antagonistas del receptor V1A de la vasopresina |
DE102009033392A1 (de) * | 2009-07-16 | 2011-01-20 | Merck Patent Gmbh | Heterocyclische Verbindungen als Autotaxin-Inhibitoren II |
CN102510859A (zh) * | 2009-09-24 | 2012-06-20 | 希里-莫韦蒂斯有限公司 | 用作为加压素v2受体拮抗剂的[1,4]-苯二氮 |
US8420633B2 (en) | 2010-03-31 | 2013-04-16 | Hoffmann-La Roche Inc. | Aryl-cyclohexyl-tetraazabenzo[e]azulenes |
US8461151B2 (en) | 2010-04-13 | 2013-06-11 | Hoffmann-La Roche Inc. | Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes |
US8492376B2 (en) | 2010-04-21 | 2013-07-23 | Hoffmann-La Roche Inc. | Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes |
US8481528B2 (en) | 2010-04-26 | 2013-07-09 | Hoffmann-La Roche Inc. | Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes |
US8513238B2 (en) | 2010-05-10 | 2013-08-20 | Hoffmann-La Roche Inc. | Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes |
BR112012029896A2 (pt) | 2010-05-25 | 2017-06-20 | Jenavalve Tech Inc | válcula cardíaca protética para endoprótese e endoprótese |
US8828989B2 (en) | 2011-09-26 | 2014-09-09 | Hoffmann-La Roche Inc. | Oxy-cyclohexyl-4H,6H-5-oxa-2,3,10b-triaza-benzo[E]azulenes as V1A antagonists |
CN105491978A (zh) | 2013-08-30 | 2016-04-13 | 耶拿阀门科技股份有限公司 | 用于假体瓣膜的径向可折叠框架及其制造方法 |
WO2016089830A1 (en) * | 2014-12-05 | 2016-06-09 | Merck Sharp & Dohme Corp. | Novel tricyclic compounds as inhibitors of mutant idh enzymes |
WO2016089797A1 (en) * | 2014-12-05 | 2016-06-09 | Merck Sharp & Dohme Corp. | Novel tricyclic compounds as inhibitors of mutant idh enzymes |
WO2016089833A1 (en) * | 2014-12-05 | 2016-06-09 | Merck Sharp & Dohme Corp. | Novel tricyclic compounds as inhibitors of mutant idh enzymes |
EP3288495B1 (en) | 2015-05-01 | 2019-09-25 | JenaValve Technology, Inc. | Device with reduced pacemaker rate in heart valve replacement |
US11065138B2 (en) | 2016-05-13 | 2021-07-20 | Jenavalve Technology, Inc. | Heart valve prosthesis delivery system and method for delivery of heart valve prosthesis with introducer sheath and loading system |
WO2018138658A1 (en) | 2017-01-27 | 2018-08-02 | Jenavalve Technology, Inc. | Heart valve mimicry |
EP3875078A1 (en) * | 2020-03-06 | 2021-09-08 | Dompe' Farmaceutici S.P.A. | Compounds for the treatment of covid-19 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3732212A (en) | 1970-04-20 | 1973-05-08 | Sterling Drug Inc | 1,2,3,10,11,11a-hexahydro-5h-pyrrolo(2,1-c)(1,4)benzodiazepine-5,11-diones |
US3763183A (en) * | 1972-07-10 | 1973-10-02 | Sterling Drug Inc | 1,2,3,10,11,11a-hexahydro-5h-pyrrolo (2,1-c)(1,4)benzodiazepines |
US3860600A (en) | 1972-07-10 | 1975-01-14 | Sterling Drug Inc | Octahydropyrrido{8 2,1-c{9 {8 1,4{9 benzodiazepines |
US5516774A (en) * | 1993-07-29 | 1996-05-14 | American Cyanamid Company | Tricyclic diazepine vasopressin antagonists and oxytocin antagonists |
US5521173A (en) * | 1995-01-17 | 1996-05-28 | American Home Products Corporation | Tricyclic benzazepine vasopressin antagonists |
CA2285343A1 (en) | 1997-03-31 | 1998-10-08 | Wakamoto Pharmaceutical Co., Ltd. | Biphenyl derivatives and medicinal compositions |
PT1000062E (pt) * | 1997-07-30 | 2004-12-31 | Wyeth Corp | Agonistas triciclicos de vasopressina |
BRPI9917086B8 (pt) * | 1999-01-19 | 2016-05-24 | Ortho Mcneil Pharm Inc | benzodiazepina tricíclica, suas composições farmacêuticas bem como compostos intermediários |
-
1999
- 1999-12-21 BR BRPI9917086A patent/BRPI9917086B8/pt not_active IP Right Cessation
- 1999-12-21 NZ NZ512960A patent/NZ512960A/en not_active IP Right Cessation
- 1999-12-21 KR KR1020017009039A patent/KR100771184B1/ko not_active IP Right Cessation
- 1999-12-21 AU AU22014/00A patent/AU772397B2/en not_active Ceased
- 1999-12-21 CZ CZ20012598A patent/CZ302647B6/cs not_active IP Right Cessation
- 1999-12-21 CA CA002360767A patent/CA2360767C/en not_active Expired - Fee Related
- 1999-12-21 TR TR2001/02069T patent/TR200102069T2/xx unknown
- 1999-12-21 HU HU0105034A patent/HU229074B1/hu not_active IP Right Cessation
- 1999-12-21 ME MEP-2008-178A patent/ME00129B/me unknown
- 1999-12-21 DE DE69911259T patent/DE69911259T4/de not_active Expired - Lifetime
- 1999-12-21 AT AT99966495T patent/ATE249465T1/de active
- 1999-12-21 CN CNB998164887A patent/CN1174986C/zh not_active Expired - Fee Related
- 1999-12-21 UA UA2001075136A patent/UA70984C2/uk unknown
- 1999-12-21 DK DK99966495T patent/DK1147115T5/da active
- 1999-12-21 DE DE69911259A patent/DE69911259D1/de not_active Expired - Lifetime
- 1999-12-21 ES ES99966495T patent/ES2207333T7/es active Active
- 1999-12-21 WO PCT/US1999/030423 patent/WO2000043398A2/en active IP Right Grant
- 1999-12-21 IL IL14427099A patent/IL144270A0/xx unknown
- 1999-12-21 EP EP99966495A patent/EP1147115B3/en not_active Expired - Lifetime
- 1999-12-21 PT PT99966495T patent/PT1147115E/pt unknown
- 1999-12-21 PL PL349778A patent/PL205704B1/pl unknown
-
2000
- 2000-01-18 AR ARP000100214A patent/AR035837A1/es active IP Right Grant
- 2000-01-19 MY MYPI20000169A patent/MY128065A/en unknown
- 2000-02-24 TW TW089100772A patent/TWI289564B/zh not_active IP Right Cessation
- 2000-12-21 RS YUP-519/01A patent/RS50820B/sr unknown
-
2001
- 2001-07-11 IL IL144270A patent/IL144270A/en not_active IP Right Cessation
- 2001-07-16 NO NO20013515A patent/NO327896B1/no not_active IP Right Cessation
- 2001-07-24 US US09/911,605 patent/US6713475B2/en not_active Expired - Lifetime
-
2002
- 2002-01-04 HK HK02100064.9A patent/HK1038361B/zh not_active IP Right Cessation
-
2004
- 2004-02-10 US US10/775,675 patent/US7317005B2/en not_active Expired - Fee Related
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Legal Events
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B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B07B | Technical examination (opinion): publication cancelled [chapter 7.2 patent gazette] |
Free format text: REFERENTE A RPI 1988 DE 10/12/2009. |
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B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFERIDO O PEDIDO COM BASE NOS ARTIGOS 8O, 13, 24 E 25 DA LPI. |
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B12B | Appeal against refusal [chapter 12.2 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
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Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 03/12/2013, OBSERVADAS AS CONDICOES LEGAIS. |
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B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: REFERENTE A PUBLICACAO NA RPI 2239 DE 03/12/2013 QUANTO A FORMATACAO DO DOCUMENTO. |
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B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
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B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2545 DE 15-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |