HK1038361B - 作為血管升壓素受體拮抗劑的三環苯並二氮雜䓬類 - Google Patents

作為血管升壓素受體拮抗劑的三環苯並二氮雜䓬類

Info

Publication number
HK1038361B
HK1038361B HK02100064.9A HK02100064A HK1038361B HK 1038361 B HK1038361 B HK 1038361B HK 02100064 A HK02100064 A HK 02100064A HK 1038361 B HK1038361 B HK 1038361B
Authority
HK
Hong Kong
Prior art keywords
receptor antagonists
vasopressin receptor
tricyclic benzodiazepines
benzodiazepines
tricyclic
Prior art date
Application number
HK02100064.9A
Other languages
English (en)
Other versions
HK1038361A1 (en
Inventor
J Hoekstra William
B Dyatkin Alexey
E Maryanoff Bruce
M Matthews Jay
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Publication of HK1038361A1 publication Critical patent/HK1038361A1/xx
Publication of HK1038361B publication Critical patent/HK1038361B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK02100064.9A 1999-01-19 2002-01-04 作為血管升壓素受體拮抗劑的三環苯並二氮雜䓬類 HK1038361B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11635899P 1999-01-19 1999-01-19
US46865099A 1999-12-21 1999-12-21
PCT/US1999/030423 WO2000043398A2 (en) 1999-01-19 1999-12-21 Tricyclic benzodiazepines as vasopressin receptor antagonists

Publications (2)

Publication Number Publication Date
HK1038361A1 HK1038361A1 (en) 2002-03-15
HK1038361B true HK1038361B (zh) 2004-05-07

Family

ID=26814157

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02100064.9A HK1038361B (zh) 1999-01-19 2002-01-04 作為血管升壓素受體拮抗劑的三環苯並二氮雜䓬類

Country Status (27)

Country Link
US (2) US6713475B2 (zh)
EP (1) EP1147115B3 (zh)
KR (1) KR100771184B1 (zh)
CN (1) CN1174986C (zh)
AR (1) AR035837A1 (zh)
AT (1) ATE249465T1 (zh)
AU (1) AU772397B2 (zh)
BR (1) BRPI9917086B8 (zh)
CA (1) CA2360767C (zh)
CZ (1) CZ302647B6 (zh)
DE (2) DE69911259T4 (zh)
DK (1) DK1147115T5 (zh)
ES (1) ES2207333T7 (zh)
HK (1) HK1038361B (zh)
HU (1) HU229074B1 (zh)
IL (2) IL144270A0 (zh)
ME (1) ME00129B (zh)
MY (1) MY128065A (zh)
NO (1) NO327896B1 (zh)
NZ (1) NZ512960A (zh)
PL (1) PL205704B1 (zh)
PT (1) PT1147115E (zh)
RS (1) RS50820B (zh)
TR (1) TR200102069T2 (zh)
TW (1) TWI289564B (zh)
UA (1) UA70984C2 (zh)
WO (1) WO2000043398A2 (zh)

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ES2207333T7 (es) * 1999-01-19 2009-06-18 Orto-Mcneil Pharmaceutical, Inc. Benzodiazepinas triciclicas utilizadas como antagonistas del receptor de la vasopresina.
IL145684A (en) * 2000-10-04 2007-06-17 Warner Lambert Co Medications for the treatment of pulmonary hypertension
DE60222879T2 (de) 2001-04-12 2008-07-24 Wyeth Cyclohexylphenyl vasopressin agonisten
DK1381370T3 (da) 2001-04-12 2007-05-21 Wyeth Corp N-Biphenylcarbonyl- og N-phenylpyridylcarbonyl-substituerede bi- og tricykliske azepiner og diazepiner som vasopressin-agonister
DE60220305T2 (de) * 2001-10-29 2008-01-17 Ortho-Mcneil Pharmaceutical, Inc. Verbrückte bicyclische (1,4) benzodiazepine als vasopressinrezeptorantagonisten
EP1364968A1 (en) * 2002-05-23 2003-11-26 Bayer Aktiengesellschaft Diagnostics and therapeutics for diseases associated with arginine vasopressin receptor 1 (AVPR1)
GB0303852D0 (en) * 2003-02-19 2003-03-26 Pfizer Ltd Triazole compounds useful in therapy
US7119088B2 (en) 2003-02-19 2006-10-10 Pfizer Inc. Triazole compounds useful in therapy
PT1597260E (pt) * 2003-02-19 2007-01-31 Pfizer Composto de triazole úteis em terapia
CA2585449A1 (en) 2004-10-28 2006-05-11 Janssen Pharmaceutica N.V. Novel [1,4]benzodiazepines as vasopressin v2 receptor antagonists
DE102005003632A1 (de) 2005-01-20 2006-08-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Katheter für die transvaskuläre Implantation von Herzklappenprothesen
US20070213813A1 (en) * 2005-12-22 2007-09-13 Symetis Sa Stent-valves for valve replacement and associated methods and systems for surgery
WO2008007661A1 (fr) * 2006-07-11 2008-01-17 Takeda Pharmaceutical Company Limited Composé hétérocyclique tricycique et son utilisation
US7896915B2 (en) 2007-04-13 2011-03-01 Jenavalve Technology, Inc. Medical device for treating a heart valve insufficiency
US9044318B2 (en) 2008-02-26 2015-06-02 Jenavalve Technology Gmbh Stent for the positioning and anchoring of a valvular prosthesis
BR112012021347A2 (pt) 2008-02-26 2019-09-24 Jenavalve Tecnology Inc stent para posicionamento e ancoragem de uma prótese valvular em um local de implantação no coração de um paciente
PL2356123T3 (pl) * 2008-11-13 2013-03-29 Hoffmann La Roche Spiro-5,6-dihudro-4h-2,3,5,10b- tetraazabenzo[e]azuleny
DK2358714T3 (da) * 2008-11-18 2012-08-20 Hoffmann La Roche Alkylcyclohexylethere af dihydrotetraazabenzoazulener
BRPI0922303B1 (pt) 2008-11-28 2019-11-12 Hoffmann La Roche arilciclo-hexiléteres de di-hidrotetra-azabenzoazulenos, seu processo de preparação, composição farmacêutica que os compreende e uso
DE102009033392A1 (de) * 2009-07-16 2011-01-20 Merck Patent Gmbh Heterocyclische Verbindungen als Autotaxin-Inhibitoren II
CN102510859A (zh) 2009-09-24 2012-06-20 希里-莫韦蒂斯有限公司 用作为加压素v2受体拮抗剂的[1,4]-苯二氮
US8420633B2 (en) 2010-03-31 2013-04-16 Hoffmann-La Roche Inc. Aryl-cyclohexyl-tetraazabenzo[e]azulenes
US8461151B2 (en) 2010-04-13 2013-06-11 Hoffmann-La Roche Inc. Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes
US8492376B2 (en) 2010-04-21 2013-07-23 Hoffmann-La Roche Inc. Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8481528B2 (en) 2010-04-26 2013-07-09 Hoffmann-La Roche Inc. Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8513238B2 (en) 2010-05-10 2013-08-20 Hoffmann-La Roche Inc. Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes
WO2011147849A1 (en) 2010-05-25 2011-12-01 Jenavalve Technology Inc. Prosthetic heart valve and transcatheter delivered endoprosthesis comprising a prosthetic heart valve and a stent
US8828989B2 (en) 2011-09-26 2014-09-09 Hoffmann-La Roche Inc. Oxy-cyclohexyl-4H,6H-5-oxa-2,3,10b-triaza-benzo[E]azulenes as V1A antagonists
EP4098226A1 (en) 2013-08-30 2022-12-07 JenaValve Technology, Inc. Endoprosthesis comprising a radially collapsible frame and a prosthetic valve
WO2016089833A1 (en) * 2014-12-05 2016-06-09 Merck Sharp & Dohme Corp. Novel tricyclic compounds as inhibitors of mutant idh enzymes
WO2016089797A1 (en) * 2014-12-05 2016-06-09 Merck Sharp & Dohme Corp. Novel tricyclic compounds as inhibitors of mutant idh enzymes
US10508108B2 (en) 2014-12-05 2019-12-17 Merck Sharp & Dohme Corp. Tricyclic compounds as inhibitors of mutant IDH enzymes
CN107530168B (zh) 2015-05-01 2020-06-09 耶拿阀门科技股份有限公司 在心脏瓣膜替换中具有降低的起搏器比例的装置和方法
EP4183371A1 (en) 2016-05-13 2023-05-24 JenaValve Technology, Inc. Heart valve prosthesis delivery system and method for delivery of heart valve prosthesis with introducer sheath and loading system
CN110392557A (zh) 2017-01-27 2019-10-29 耶拿阀门科技股份有限公司 心脏瓣膜模拟
EP3875078A1 (en) * 2020-03-06 2021-09-08 Dompe' Farmaceutici S.P.A. Compounds for the treatment of covid-19

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US3732212A (en) 1970-04-20 1973-05-08 Sterling Drug Inc 1,2,3,10,11,11a-hexahydro-5h-pyrrolo(2,1-c)(1,4)benzodiazepine-5,11-diones
US3860600A (en) 1972-07-10 1975-01-14 Sterling Drug Inc Octahydropyrrido{8 2,1-c{9 {8 1,4{9 benzodiazepines
US3763183A (en) * 1972-07-10 1973-10-02 Sterling Drug Inc 1,2,3,10,11,11a-hexahydro-5h-pyrrolo (2,1-c)(1,4)benzodiazepines
US5516774A (en) * 1993-07-29 1996-05-14 American Cyanamid Company Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
US5521173A (en) * 1995-01-17 1996-05-28 American Home Products Corporation Tricyclic benzazepine vasopressin antagonists
WO1998043976A1 (fr) * 1997-03-31 1998-10-08 Wakamoto Pharmaceutical Co., Ltd. Derives de biphenyle et compositions medicinales
ES2229525T3 (es) * 1997-07-30 2005-04-16 Wyeth Agonistas triciclicos de la vasopresina.
ES2207333T7 (es) * 1999-01-19 2009-06-18 Orto-Mcneil Pharmaceutical, Inc. Benzodiazepinas triciclicas utilizadas como antagonistas del receptor de la vasopresina.

Also Published As

Publication number Publication date
ES2207333T7 (es) 2009-06-18
NO327896B1 (no) 2009-10-12
ME00129B (me) 2010-10-10
DE69911259T4 (de) 2009-07-09
CN1339038A (zh) 2002-03-06
ATE249465T1 (de) 2003-09-15
NO20013515L (no) 2001-09-17
BR9917086B1 (pt) 2013-12-03
HUP0105034A2 (hu) 2002-04-29
WO2000043398A3 (en) 2001-01-11
CN1174986C (zh) 2004-11-10
PT1147115E (pt) 2004-02-27
HK1038361A1 (en) 2002-03-15
AU2201400A (en) 2000-08-07
PL205704B1 (pl) 2010-05-31
YU51901A (sh) 2004-03-12
EP1147115B1 (en) 2003-09-10
CA2360767A1 (en) 2000-07-27
NO20013515D0 (no) 2001-07-16
TR200102069T2 (tr) 2001-11-21
BR9917086A (pt) 2001-10-30
IL144270A0 (en) 2002-05-23
MEP17808A (en) 2010-06-10
RS50820B (sr) 2010-08-31
CZ20012598A3 (cs) 2002-08-14
HU229074B1 (en) 2013-07-29
KR100771184B1 (ko) 2007-10-29
CZ302647B6 (cs) 2011-08-17
PL349778A1 (en) 2002-09-09
DK1147115T5 (da) 2008-12-08
CA2360767C (en) 2009-11-03
DE69911259T2 (de) 2004-12-02
AU772397B2 (en) 2004-04-29
WO2000043398A2 (en) 2000-07-27
US7317005B2 (en) 2008-01-08
DK1147115T3 (da) 2004-01-12
US20020103373A1 (en) 2002-08-01
NZ512960A (en) 2004-01-30
DE69911259D1 (de) 2003-10-16
EP1147115B3 (en) 2008-12-24
ES2207333T3 (es) 2004-05-16
KR20010101577A (ko) 2001-11-14
HUP0105034A3 (en) 2004-11-29
EP1147115A2 (en) 2001-10-24
IL144270A (en) 2010-04-29
MY128065A (en) 2007-01-31
AR035837A1 (es) 2004-07-21
TWI289564B (en) 2007-11-11
US6713475B2 (en) 2004-03-30
BRPI9917086B8 (pt) 2016-05-24
AU772397C (en) 2000-08-07
UA70984C2 (uk) 2004-11-15
US20040242866A1 (en) 2004-12-02

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20101221