DK1147115T5 - Tricycliske benzodiazepiner som vasopressinreceptorantagonister - Google Patents

Tricycliske benzodiazepiner som vasopressinreceptorantagonister

Info

Publication number
DK1147115T5
DK1147115T5 DK99966495T DK99966495T DK1147115T5 DK 1147115 T5 DK1147115 T5 DK 1147115T5 DK 99966495 T DK99966495 T DK 99966495T DK 99966495 T DK99966495 T DK 99966495T DK 1147115 T5 DK1147115 T5 DK 1147115T5
Authority
DK
Denmark
Prior art keywords
receptor antagonists
vasopressin receptor
tricyclic benzodiazepines
benzodiazepines
tricyclic
Prior art date
Application number
DK99966495T
Other languages
Danish (da)
English (en)
Other versions
DK1147115T3 (da
Inventor
Jay M Matthews
William J Hoekstra
Alexey B Dyatkin
Bruce E Maryanoff
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Application granted granted Critical
Publication of DK1147115T3 publication Critical patent/DK1147115T3/da
Publication of DK1147115T5 publication Critical patent/DK1147115T5/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DK99966495T 1999-01-19 1999-12-21 Tricycliske benzodiazepiner som vasopressinreceptorantagonister DK1147115T5 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11635899P 1999-01-19 1999-01-19
US46865099A 1999-12-21 1999-12-21
PCT/US1999/030423 WO2000043398A2 (en) 1999-01-19 1999-12-21 Tricyclic benzodiazepines as vasopressin receptor antagonists

Publications (2)

Publication Number Publication Date
DK1147115T3 DK1147115T3 (da) 2004-01-12
DK1147115T5 true DK1147115T5 (da) 2008-12-08

Family

ID=26814157

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99966495T DK1147115T5 (da) 1999-01-19 1999-12-21 Tricycliske benzodiazepiner som vasopressinreceptorantagonister

Country Status (27)

Country Link
US (2) US6713475B2 (zh)
EP (1) EP1147115B3 (zh)
KR (1) KR100771184B1 (zh)
CN (1) CN1174986C (zh)
AR (1) AR035837A1 (zh)
AT (1) ATE249465T1 (zh)
AU (1) AU772397B2 (zh)
BR (1) BRPI9917086B8 (zh)
CA (1) CA2360767C (zh)
CZ (1) CZ302647B6 (zh)
DE (2) DE69911259D1 (zh)
DK (1) DK1147115T5 (zh)
ES (1) ES2207333T7 (zh)
HK (1) HK1038361B (zh)
HU (1) HU229074B1 (zh)
IL (2) IL144270A0 (zh)
ME (1) ME00129B (zh)
MY (1) MY128065A (zh)
NO (1) NO327896B1 (zh)
NZ (1) NZ512960A (zh)
PL (1) PL205704B1 (zh)
PT (1) PT1147115E (zh)
RS (1) RS50820B (zh)
TR (1) TR200102069T2 (zh)
TW (1) TWI289564B (zh)
UA (1) UA70984C2 (zh)
WO (1) WO2000043398A2 (zh)

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HU229074B1 (en) * 1999-01-19 2013-07-29 Ortho Mcneil Pharm Inc Tricyclic benzodiazepines as vasopressin receptor antagonists
DE60129518T2 (de) * 2000-10-04 2008-03-20 Astellas Pharma Inc. Verwendung von einem Vasopressin-Antagonisten wie Conivaptan zur Herstellung eines Medikaments für die Behandlung der pulmonalen Hypertension
ATE355843T1 (de) 2001-04-12 2007-03-15 Wyeth Corp N-biphenylcarbonyl- und n-phenylpyridylcarbonyl substituierte bi- and tricyclische azepine und diazepine als vasopressin-agonisten
JP2004526771A (ja) 2001-04-12 2004-09-02 ワイス シクロヘキシルフェニルバソプレッシンアゴニスト
CN1608068A (zh) * 2001-10-29 2005-04-20 奥索-麦克尼尔药品公司 桥接的双环氨基酸衍生的[1,4]苯并二氮杂䓬加压素受体拮抗剂
EP1364968A1 (en) * 2002-05-23 2003-11-26 Bayer Aktiengesellschaft Diagnostics and therapeutics for diseases associated with arginine vasopressin receptor 1 (AVPR1)
GB0303852D0 (en) * 2003-02-19 2003-03-26 Pfizer Ltd Triazole compounds useful in therapy
US7119088B2 (en) 2003-02-19 2006-10-10 Pfizer Inc. Triazole compounds useful in therapy
AU2004213242B2 (en) * 2003-02-19 2007-04-19 Pfizer Inc. Triazole compounds useful in therapy
CA2585449A1 (en) * 2004-10-28 2006-05-11 Janssen Pharmaceutica N.V. Novel [1,4]benzodiazepines as vasopressin v2 receptor antagonists
DE102005003632A1 (de) 2005-01-20 2006-08-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Katheter für die transvaskuläre Implantation von Herzklappenprothesen
US20070213813A1 (en) * 2005-12-22 2007-09-13 Symetis Sa Stent-valves for valve replacement and associated methods and systems for surgery
WO2008007661A1 (fr) * 2006-07-11 2008-01-17 Takeda Pharmaceutical Company Limited Composé hétérocyclique tricycique et son utilisation
US7896915B2 (en) 2007-04-13 2011-03-01 Jenavalve Technology, Inc. Medical device for treating a heart valve insufficiency
US9044318B2 (en) 2008-02-26 2015-06-02 Jenavalve Technology Gmbh Stent for the positioning and anchoring of a valvular prosthesis
WO2011104269A1 (en) 2008-02-26 2011-09-01 Jenavalve Technology Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
DK2356123T3 (da) * 2008-11-13 2012-10-15 Hoffmann La Roche Spiro-5,6-dihydro-4h-2,3,5,10b-tetraaza-benzo[e]azulener
EP2358714B1 (en) * 2008-11-18 2012-08-01 F. Hoffmann-La Roche AG Alkylcyclohexylethers of dihydrotetraazabenzoazulenes
BRPI0922303B1 (pt) * 2008-11-28 2019-11-12 Hoffmann La Roche arilciclo-hexiléteres de di-hidrotetra-azabenzoazulenos, seu processo de preparação, composição farmacêutica que os compreende e uso
DE102009033392A1 (de) * 2009-07-16 2011-01-20 Merck Patent Gmbh Heterocyclische Verbindungen als Autotaxin-Inhibitoren II
BR112012006253A2 (pt) * 2009-09-24 2016-05-31 Shire Movetis N V benzodiazepinas-[1,4] como antagonistas dos receptores da vasopressina v2
US8420633B2 (en) 2010-03-31 2013-04-16 Hoffmann-La Roche Inc. Aryl-cyclohexyl-tetraazabenzo[e]azulenes
US8461151B2 (en) 2010-04-13 2013-06-11 Hoffmann-La Roche Inc. Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes
US8492376B2 (en) 2010-04-21 2013-07-23 Hoffmann-La Roche Inc. Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8481528B2 (en) 2010-04-26 2013-07-09 Hoffmann-La Roche Inc. Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8513238B2 (en) 2010-05-10 2013-08-20 Hoffmann-La Roche Inc. Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes
AU2011257298B2 (en) 2010-05-25 2014-07-31 Jenavalve Technology Inc. Prosthetic heart valve and transcatheter delivered endoprosthesis comprising a prosthetic heart valve and a stent
US8828989B2 (en) 2011-09-26 2014-09-09 Hoffmann-La Roche Inc. Oxy-cyclohexyl-4H,6H-5-oxa-2,3,10b-triaza-benzo[E]azulenes as V1A antagonists
EP4098226A1 (en) 2013-08-30 2022-12-07 JenaValve Technology, Inc. Endoprosthesis comprising a radially collapsible frame and a prosthetic valve
WO2016089797A1 (en) * 2014-12-05 2016-06-09 Merck Sharp & Dohme Corp. Novel tricyclic compounds as inhibitors of mutant idh enzymes
EP3226690B1 (en) * 2014-12-05 2020-05-20 Merck Sharp & Dohme Corp. Novel tricyclic compounds as inhibitors of mutant idh enzymes
US10508108B2 (en) 2014-12-05 2019-12-17 Merck Sharp & Dohme Corp. Tricyclic compounds as inhibitors of mutant IDH enzymes
JP6767388B2 (ja) 2015-05-01 2020-10-14 イェーナヴァルヴ テクノロジー インコーポレイテッド 心臓弁置換におけるペースメーカー割合を低減させるデバイス及び方法
JP7081749B2 (ja) 2016-05-13 2022-06-07 イエナバルブ テクノロジー インク 心臓弁プロテーゼ送達システム
US11197754B2 (en) 2017-01-27 2021-12-14 Jenavalve Technology, Inc. Heart valve mimicry
EP3875078A1 (en) * 2020-03-06 2021-09-08 Dompe' Farmaceutici S.P.A. Compounds for the treatment of covid-19

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US3732212A (en) 1970-04-20 1973-05-08 Sterling Drug Inc 1,2,3,10,11,11a-hexahydro-5h-pyrrolo(2,1-c)(1,4)benzodiazepine-5,11-diones
US3763183A (en) * 1972-07-10 1973-10-02 Sterling Drug Inc 1,2,3,10,11,11a-hexahydro-5h-pyrrolo (2,1-c)(1,4)benzodiazepines
US3860600A (en) 1972-07-10 1975-01-14 Sterling Drug Inc Octahydropyrrido{8 2,1-c{9 {8 1,4{9 benzodiazepines
US5516774A (en) * 1993-07-29 1996-05-14 American Cyanamid Company Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
US5521173A (en) * 1995-01-17 1996-05-28 American Home Products Corporation Tricyclic benzazepine vasopressin antagonists
CA2285343A1 (en) 1997-03-31 1998-10-08 Wakamoto Pharmaceutical Co., Ltd. Biphenyl derivatives and medicinal compositions
DK1000062T3 (da) * 1997-07-30 2004-11-22 Wyeth Corp Tricykliske vasopressinagonister
HU229074B1 (en) * 1999-01-19 2013-07-29 Ortho Mcneil Pharm Inc Tricyclic benzodiazepines as vasopressin receptor antagonists

Also Published As

Publication number Publication date
EP1147115B1 (en) 2003-09-10
US6713475B2 (en) 2004-03-30
BR9917086A (pt) 2001-10-30
AU772397C (en) 2000-08-07
CN1174986C (zh) 2004-11-10
ATE249465T1 (de) 2003-09-15
HUP0105034A3 (en) 2004-11-29
PL349778A1 (en) 2002-09-09
AU2201400A (en) 2000-08-07
MY128065A (en) 2007-01-31
TWI289564B (en) 2007-11-11
CA2360767C (en) 2009-11-03
EP1147115A2 (en) 2001-10-24
WO2000043398A3 (en) 2001-01-11
KR20010101577A (ko) 2001-11-14
HK1038361B (zh) 2004-05-07
KR100771184B1 (ko) 2007-10-29
US20020103373A1 (en) 2002-08-01
WO2000043398A2 (en) 2000-07-27
DE69911259T4 (de) 2009-07-09
DE69911259D1 (de) 2003-10-16
TR200102069T2 (tr) 2001-11-21
NO327896B1 (no) 2009-10-12
NO20013515L (no) 2001-09-17
ES2207333T7 (es) 2009-06-18
ES2207333T3 (es) 2004-05-16
NZ512960A (en) 2004-01-30
BRPI9917086B8 (pt) 2016-05-24
HK1038361A1 (en) 2002-03-15
ME00129B (me) 2010-10-10
CZ20012598A3 (cs) 2002-08-14
HU229074B1 (en) 2013-07-29
RS50820B (sr) 2010-08-31
YU51901A (sh) 2004-03-12
US7317005B2 (en) 2008-01-08
DE69911259T2 (de) 2004-12-02
DK1147115T3 (da) 2004-01-12
CA2360767A1 (en) 2000-07-27
MEP17808A (en) 2010-06-10
CN1339038A (zh) 2002-03-06
BR9917086B1 (pt) 2013-12-03
IL144270A (en) 2010-04-29
AR035837A1 (es) 2004-07-21
EP1147115B3 (en) 2008-12-24
AU772397B2 (en) 2004-04-29
UA70984C2 (uk) 2004-11-15
US20040242866A1 (en) 2004-12-02
NO20013515D0 (no) 2001-07-16
CZ302647B6 (cs) 2011-08-17
IL144270A0 (en) 2002-05-23
PL205704B1 (pl) 2010-05-31
PT1147115E (pt) 2004-02-27
HUP0105034A2 (hu) 2002-04-29

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