RS50820B - Triciklični benzodiazepini kao antagonisti receptora vazopresina - Google Patents
Triciklični benzodiazepini kao antagonisti receptora vazopresinaInfo
- Publication number
- RS50820B RS50820B YUP-519/01A YUP51901A RS50820B RS 50820 B RS50820 B RS 50820B YU P51901 A YUP51901 A YU P51901A RS 50820 B RS50820 B RS 50820B
- Authority
- RS
- Serbia
- Prior art keywords
- heteroaryl
- alkyl
- c4alkyl
- substituted
- fluorinated
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11635899P | 1999-01-19 | 1999-01-19 | |
US46865099A | 1999-12-21 | 1999-12-21 |
Publications (2)
Publication Number | Publication Date |
---|---|
YU51901A YU51901A (sh) | 2004-03-12 |
RS50820B true RS50820B (sr) | 2010-08-31 |
Family
ID=26814157
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YUP-519/01A RS50820B (sr) | 1999-01-19 | 2000-12-21 | Triciklični benzodiazepini kao antagonisti receptora vazopresina |
Country Status (27)
Country | Link |
---|---|
US (2) | US6713475B2 (sr) |
EP (1) | EP1147115B3 (sr) |
KR (1) | KR100771184B1 (sr) |
CN (1) | CN1174986C (sr) |
AR (1) | AR035837A1 (sr) |
AT (1) | ATE249465T1 (sr) |
AU (1) | AU772397B2 (sr) |
BR (1) | BRPI9917086B8 (sr) |
CA (1) | CA2360767C (sr) |
CZ (1) | CZ302647B6 (sr) |
DE (2) | DE69911259D1 (sr) |
DK (1) | DK1147115T5 (sr) |
ES (1) | ES2207333T7 (sr) |
HK (1) | HK1038361B (sr) |
HU (1) | HU229074B1 (sr) |
IL (2) | IL144270A0 (sr) |
ME (1) | ME00129B (sr) |
MY (1) | MY128065A (sr) |
NO (1) | NO327896B1 (sr) |
NZ (1) | NZ512960A (sr) |
PL (1) | PL205704B1 (sr) |
PT (1) | PT1147115E (sr) |
RS (1) | RS50820B (sr) |
TR (1) | TR200102069T2 (sr) |
TW (1) | TWI289564B (sr) |
UA (1) | UA70984C2 (sr) |
WO (1) | WO2000043398A2 (sr) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU229074B1 (en) * | 1999-01-19 | 2013-07-29 | Ortho Mcneil Pharm Inc | Tricyclic benzodiazepines as vasopressin receptor antagonists |
DE60129518T2 (de) * | 2000-10-04 | 2008-03-20 | Astellas Pharma Inc. | Verwendung von einem Vasopressin-Antagonisten wie Conivaptan zur Herstellung eines Medikaments für die Behandlung der pulmonalen Hypertension |
ATE355843T1 (de) | 2001-04-12 | 2007-03-15 | Wyeth Corp | N-biphenylcarbonyl- und n-phenylpyridylcarbonyl substituierte bi- and tricyclische azepine und diazepine als vasopressin-agonisten |
JP2004526771A (ja) | 2001-04-12 | 2004-09-02 | ワイス | シクロヘキシルフェニルバソプレッシンアゴニスト |
CN1608068A (zh) * | 2001-10-29 | 2005-04-20 | 奥索-麦克尼尔药品公司 | 桥接的双环氨基酸衍生的[1,4]苯并二氮杂䓬加压素受体拮抗剂 |
EP1364968A1 (en) * | 2002-05-23 | 2003-11-26 | Bayer Aktiengesellschaft | Diagnostics and therapeutics for diseases associated with arginine vasopressin receptor 1 (AVPR1) |
GB0303852D0 (en) * | 2003-02-19 | 2003-03-26 | Pfizer Ltd | Triazole compounds useful in therapy |
US7119088B2 (en) | 2003-02-19 | 2006-10-10 | Pfizer Inc. | Triazole compounds useful in therapy |
AU2004213242B2 (en) * | 2003-02-19 | 2007-04-19 | Pfizer Inc. | Triazole compounds useful in therapy |
CA2585449A1 (en) * | 2004-10-28 | 2006-05-11 | Janssen Pharmaceutica N.V. | Novel [1,4]benzodiazepines as vasopressin v2 receptor antagonists |
DE102005003632A1 (de) | 2005-01-20 | 2006-08-17 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Katheter für die transvaskuläre Implantation von Herzklappenprothesen |
US20070213813A1 (en) * | 2005-12-22 | 2007-09-13 | Symetis Sa | Stent-valves for valve replacement and associated methods and systems for surgery |
WO2008007661A1 (fr) * | 2006-07-11 | 2008-01-17 | Takeda Pharmaceutical Company Limited | Composé hétérocyclique tricycique et son utilisation |
US7896915B2 (en) | 2007-04-13 | 2011-03-01 | Jenavalve Technology, Inc. | Medical device for treating a heart valve insufficiency |
US9044318B2 (en) | 2008-02-26 | 2015-06-02 | Jenavalve Technology Gmbh | Stent for the positioning and anchoring of a valvular prosthesis |
WO2011104269A1 (en) | 2008-02-26 | 2011-09-01 | Jenavalve Technology Inc. | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
DK2356123T3 (da) * | 2008-11-13 | 2012-10-15 | Hoffmann La Roche | Spiro-5,6-dihydro-4h-2,3,5,10b-tetraaza-benzo[e]azulener |
EP2358714B1 (en) * | 2008-11-18 | 2012-08-01 | F. Hoffmann-La Roche AG | Alkylcyclohexylethers of dihydrotetraazabenzoazulenes |
BRPI0922303B1 (pt) * | 2008-11-28 | 2019-11-12 | Hoffmann La Roche | arilciclo-hexiléteres de di-hidrotetra-azabenzoazulenos, seu processo de preparação, composição farmacêutica que os compreende e uso |
DE102009033392A1 (de) * | 2009-07-16 | 2011-01-20 | Merck Patent Gmbh | Heterocyclische Verbindungen als Autotaxin-Inhibitoren II |
BR112012006253A2 (pt) * | 2009-09-24 | 2016-05-31 | Shire Movetis N V | benzodiazepinas-[1,4] como antagonistas dos receptores da vasopressina v2 |
US8420633B2 (en) | 2010-03-31 | 2013-04-16 | Hoffmann-La Roche Inc. | Aryl-cyclohexyl-tetraazabenzo[e]azulenes |
US8461151B2 (en) | 2010-04-13 | 2013-06-11 | Hoffmann-La Roche Inc. | Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes |
US8492376B2 (en) | 2010-04-21 | 2013-07-23 | Hoffmann-La Roche Inc. | Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes |
US8481528B2 (en) | 2010-04-26 | 2013-07-09 | Hoffmann-La Roche Inc. | Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes |
US8513238B2 (en) | 2010-05-10 | 2013-08-20 | Hoffmann-La Roche Inc. | Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes |
AU2011257298B2 (en) | 2010-05-25 | 2014-07-31 | Jenavalve Technology Inc. | Prosthetic heart valve and transcatheter delivered endoprosthesis comprising a prosthetic heart valve and a stent |
US8828989B2 (en) | 2011-09-26 | 2014-09-09 | Hoffmann-La Roche Inc. | Oxy-cyclohexyl-4H,6H-5-oxa-2,3,10b-triaza-benzo[E]azulenes as V1A antagonists |
EP4098226A1 (en) | 2013-08-30 | 2022-12-07 | JenaValve Technology, Inc. | Endoprosthesis comprising a radially collapsible frame and a prosthetic valve |
WO2016089797A1 (en) * | 2014-12-05 | 2016-06-09 | Merck Sharp & Dohme Corp. | Novel tricyclic compounds as inhibitors of mutant idh enzymes |
EP3226690B1 (en) * | 2014-12-05 | 2020-05-20 | Merck Sharp & Dohme Corp. | Novel tricyclic compounds as inhibitors of mutant idh enzymes |
US10508108B2 (en) | 2014-12-05 | 2019-12-17 | Merck Sharp & Dohme Corp. | Tricyclic compounds as inhibitors of mutant IDH enzymes |
JP6767388B2 (ja) | 2015-05-01 | 2020-10-14 | イェーナヴァルヴ テクノロジー インコーポレイテッド | 心臓弁置換におけるペースメーカー割合を低減させるデバイス及び方法 |
JP7081749B2 (ja) | 2016-05-13 | 2022-06-07 | イエナバルブ テクノロジー インク | 心臓弁プロテーゼ送達システム |
US11197754B2 (en) | 2017-01-27 | 2021-12-14 | Jenavalve Technology, Inc. | Heart valve mimicry |
EP3875078A1 (en) * | 2020-03-06 | 2021-09-08 | Dompe' Farmaceutici S.P.A. | Compounds for the treatment of covid-19 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3732212A (en) | 1970-04-20 | 1973-05-08 | Sterling Drug Inc | 1,2,3,10,11,11a-hexahydro-5h-pyrrolo(2,1-c)(1,4)benzodiazepine-5,11-diones |
US3763183A (en) * | 1972-07-10 | 1973-10-02 | Sterling Drug Inc | 1,2,3,10,11,11a-hexahydro-5h-pyrrolo (2,1-c)(1,4)benzodiazepines |
US3860600A (en) | 1972-07-10 | 1975-01-14 | Sterling Drug Inc | Octahydropyrrido{8 2,1-c{9 {8 1,4{9 benzodiazepines |
US5516774A (en) * | 1993-07-29 | 1996-05-14 | American Cyanamid Company | Tricyclic diazepine vasopressin antagonists and oxytocin antagonists |
US5521173A (en) * | 1995-01-17 | 1996-05-28 | American Home Products Corporation | Tricyclic benzazepine vasopressin antagonists |
CA2285343A1 (en) | 1997-03-31 | 1998-10-08 | Wakamoto Pharmaceutical Co., Ltd. | Biphenyl derivatives and medicinal compositions |
DK1000062T3 (da) * | 1997-07-30 | 2004-11-22 | Wyeth Corp | Tricykliske vasopressinagonister |
HU229074B1 (en) * | 1999-01-19 | 2013-07-29 | Ortho Mcneil Pharm Inc | Tricyclic benzodiazepines as vasopressin receptor antagonists |
-
1999
- 1999-12-21 HU HU0105034A patent/HU229074B1/hu not_active IP Right Cessation
- 1999-12-21 PL PL349778A patent/PL205704B1/pl unknown
- 1999-12-21 CN CNB998164887A patent/CN1174986C/zh not_active Expired - Fee Related
- 1999-12-21 DE DE69911259A patent/DE69911259D1/de not_active Expired - Lifetime
- 1999-12-21 CZ CZ20012598A patent/CZ302647B6/cs not_active IP Right Cessation
- 1999-12-21 ME MEP-2008-178A patent/ME00129B/me unknown
- 1999-12-21 EP EP99966495A patent/EP1147115B3/en not_active Expired - Lifetime
- 1999-12-21 DK DK99966495T patent/DK1147115T5/da active
- 1999-12-21 NZ NZ512960A patent/NZ512960A/en not_active IP Right Cessation
- 1999-12-21 DE DE69911259T patent/DE69911259T4/de not_active Expired - Lifetime
- 1999-12-21 AU AU22014/00A patent/AU772397B2/en not_active Ceased
- 1999-12-21 IL IL14427099A patent/IL144270A0/xx unknown
- 1999-12-21 KR KR1020017009039A patent/KR100771184B1/ko not_active IP Right Cessation
- 1999-12-21 WO PCT/US1999/030423 patent/WO2000043398A2/en active IP Right Grant
- 1999-12-21 BR BRPI9917086A patent/BRPI9917086B8/pt not_active IP Right Cessation
- 1999-12-21 UA UA2001075136A patent/UA70984C2/uk unknown
- 1999-12-21 AT AT99966495T patent/ATE249465T1/de active
- 1999-12-21 CA CA002360767A patent/CA2360767C/en not_active Expired - Fee Related
- 1999-12-21 ES ES99966495T patent/ES2207333T7/es active Active
- 1999-12-21 PT PT99966495T patent/PT1147115E/pt unknown
- 1999-12-21 TR TR2001/02069T patent/TR200102069T2/xx unknown
-
2000
- 2000-01-18 AR ARP000100214A patent/AR035837A1/es active IP Right Grant
- 2000-01-19 MY MYPI20000169A patent/MY128065A/en unknown
- 2000-02-24 TW TW089100772A patent/TWI289564B/zh not_active IP Right Cessation
- 2000-12-21 RS YUP-519/01A patent/RS50820B/sr unknown
-
2001
- 2001-07-11 IL IL144270A patent/IL144270A/en not_active IP Right Cessation
- 2001-07-16 NO NO20013515A patent/NO327896B1/no not_active IP Right Cessation
- 2001-07-24 US US09/911,605 patent/US6713475B2/en not_active Expired - Lifetime
-
2002
- 2002-01-04 HK HK02100064.9A patent/HK1038361B/zh not_active IP Right Cessation
-
2004
- 2004-02-10 US US10/775,675 patent/US7317005B2/en not_active Expired - Fee Related
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