BR9917086A - Benzodiazepinas tricìclicas como antagonistas dosreceptores de vasopressina - Google Patents

Benzodiazepinas tricìclicas como antagonistas dosreceptores de vasopressina

Info

Publication number
BR9917086A
BR9917086A BR9917086-8A BR9917086A BR9917086A BR 9917086 A BR9917086 A BR 9917086A BR 9917086 A BR9917086 A BR 9917086A BR 9917086 A BR9917086 A BR 9917086A
Authority
BR
Brazil
Prior art keywords
antagonists
tricyclic
vasopressin receptors
heart failure
benzodiazepines
Prior art date
Application number
BR9917086-8A
Other languages
English (en)
Other versions
BR9917086B1 (pt
BRPI9917086B8 (pt
Inventor
William J Hoekstra
Alexey B Dyatkin
Bruce E Maryanoff
Jay M Matthews
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Publication of BR9917086A publication Critical patent/BR9917086A/pt
Publication of BR9917086B1 publication Critical patent/BR9917086B1/pt
Publication of BRPI9917086B8 publication Critical patent/BRPI9917086B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Patente de Invenção: "BENZODIAZEPINAS TRICìCLICAS COMOANTAGONISTAS DOS RECEPTORES DE VASOPRESSINA". Ainvenção refere-se a benzodiazepinas tricíclicas úteis comoantagonistas de receptores de vasopressina para tratar condiçõesque envolvem resistência vascular aumentada e insuficiênciacardíaca. Composições farmacêuticas compreendendo asbenzodiazepinas tricíclicas da presente invenção e métodos parao tratamento de condições tais como hipertensão, insuficiênciacardíaca congestiva, insuficiência cardíaca, vasospasmocoronário, isquemia cardíaca, cirrose hepática, vasospasmo renal,insuficiência renal, edema e isquemia cerebral, acidente vascularcerebral, trombose ou retenção de líquido também estão descritos.
BRPI9917086A 1999-01-19 1999-12-21 benzodiazepina tricíclica, suas composições farmacêuticas bem como compostos intermediários BRPI9917086B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11635899P 1999-01-19 1999-01-19
US46865099A 1999-12-21 1999-12-21
PCT/US1999/030423 WO2000043398A2 (en) 1999-01-19 1999-12-21 Tricyclic benzodiazepines as vasopressin receptor antagonists

Publications (3)

Publication Number Publication Date
BR9917086A true BR9917086A (pt) 2001-10-30
BR9917086B1 BR9917086B1 (pt) 2013-12-03
BRPI9917086B8 BRPI9917086B8 (pt) 2016-05-24

Family

ID=26814157

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9917086A BRPI9917086B8 (pt) 1999-01-19 1999-12-21 benzodiazepina tricíclica, suas composições farmacêuticas bem como compostos intermediários

Country Status (27)

Country Link
US (2) US6713475B2 (pt)
EP (1) EP1147115B3 (pt)
KR (1) KR100771184B1 (pt)
CN (1) CN1174986C (pt)
AR (1) AR035837A1 (pt)
AT (1) ATE249465T1 (pt)
AU (1) AU772397B2 (pt)
BR (1) BRPI9917086B8 (pt)
CA (1) CA2360767C (pt)
CZ (1) CZ302647B6 (pt)
DE (2) DE69911259T4 (pt)
DK (1) DK1147115T5 (pt)
ES (1) ES2207333T7 (pt)
HK (1) HK1038361B (pt)
HU (1) HU229074B1 (pt)
IL (2) IL144270A0 (pt)
ME (1) ME00129B (pt)
MY (1) MY128065A (pt)
NO (1) NO327896B1 (pt)
NZ (1) NZ512960A (pt)
PL (1) PL205704B1 (pt)
PT (1) PT1147115E (pt)
RS (1) RS50820B (pt)
TR (1) TR200102069T2 (pt)
TW (1) TWI289564B (pt)
UA (1) UA70984C2 (pt)
WO (1) WO2000043398A2 (pt)

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PT1147115E (pt) * 1999-01-19 2004-02-27 Ortho Mcneil Pharm Inc Benzodiazepinas triciclicas como antagonistas do receptor da vasopressina
CA2357833C (en) * 2000-10-04 2005-11-15 Warner-Lambert Company Treatment of pulmonary hypertension using vasopressin antagonist
US7053083B2 (en) 2001-04-12 2006-05-30 Wyeth Cyclohexylphenyl vasopressin agonists
MXPA03009158A (es) 2001-04-12 2004-02-12 Wyeth Corp Azepinas y diazepinas bi y triciclicas substituidas de n-bifenilcarbonil y n-fenilpiridilcarbonil como agonistas de la vasopresion.
ES2287326T3 (es) 2001-10-29 2007-12-16 Ortho-Mcneil Pharmaceutical, Inc. Antagonistas del receptor de vasopresina de (,4) benzodiazepina biciclica enlazada.
EP1364968A1 (en) * 2002-05-23 2003-11-26 Bayer Aktiengesellschaft Diagnostics and therapeutics for diseases associated with arginine vasopressin receptor 1 (AVPR1)
US7119088B2 (en) 2003-02-19 2006-10-10 Pfizer Inc. Triazole compounds useful in therapy
MXPA05008923A (es) * 2003-02-19 2006-03-09 Pfizer Compuestos de triazol utiles en terapia.
GB0303852D0 (en) * 2003-02-19 2003-03-26 Pfizer Ltd Triazole compounds useful in therapy
JP2008518915A (ja) * 2004-10-28 2008-06-05 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ バソプレシンｖ２受容体アンタゴニストとしての新規な［１，４］ベンゾジアゼピン
DE102005003632A1 (de) 2005-01-20 2006-08-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Katheter für die transvaskuläre Implantation von Herzklappenprothesen
US20070213813A1 (en) 2005-12-22 2007-09-13 Symetis Sa Stent-valves for valve replacement and associated methods and systems for surgery
WO2008007661A1 (fr) * 2006-07-11 2008-01-17 Takeda Pharmaceutical Company Limited Composé hétérocyclique tricycique et son utilisation
US7896915B2 (en) 2007-04-13 2011-03-01 Jenavalve Technology, Inc. Medical device for treating a heart valve insufficiency
ES2903231T3 (es) 2008-02-26 2022-03-31 Jenavalve Tech Inc Stent para el posicionamiento y anclaje de una prótesis valvular en un sitio de implantación en el corazón de un paciente
US9044318B2 (en) 2008-02-26 2015-06-02 Jenavalve Technology Gmbh Stent for the positioning and anchoring of a valvular prosthesis
PT2356123E (pt) * 2008-11-13 2012-10-31 Hoffmann La Roche Espiro-5,6-di-hidro-4h-2,3,5,10b-tetra-azabenzo[ e]azulenos
CN102216304B (zh) * 2008-11-18 2014-07-09 弗·哈夫曼-拉罗切有限公司 二氢四氮杂苯并薁的烷基环己基醚
SG171846A1 (en) * 2008-11-28 2011-07-28 Hoffmann La Roche Arylcyclohexylethers of dihydrotetraazabenzoazulenes for use as vasopressin via receptor antagonists
DE102009033392A1 (de) * 2009-07-16 2011-01-20 Merck Patent Gmbh Heterocyclische Verbindungen als Autotaxin-Inhibitoren II
AU2010299916A1 (en) * 2009-09-24 2012-03-08 Shire-Movetis N.V. [1,4]-benzodiazepines as vasopressin V2 receptor antagonists
US8420633B2 (en) 2010-03-31 2013-04-16 Hoffmann-La Roche Inc. Aryl-cyclohexyl-tetraazabenzo[e]azulenes
US8461151B2 (en) 2010-04-13 2013-06-11 Hoffmann-La Roche Inc. Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes
US8492376B2 (en) 2010-04-21 2013-07-23 Hoffmann-La Roche Inc. Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8481528B2 (en) 2010-04-26 2013-07-09 Hoffmann-La Roche Inc. Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8513238B2 (en) 2010-05-10 2013-08-20 Hoffmann-La Roche Inc. Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes
JP2013526388A (ja) 2010-05-25 2013-06-24 イエナバルブ テクノロジー インク 人工心臓弁、及び人工心臓弁とステントを備える経カテーテル搬送体内プロテーゼ
US8828989B2 (en) 2011-09-26 2014-09-09 Hoffmann-La Roche Inc. Oxy-cyclohexyl-4H,6H-5-oxa-2,3,10b-triaza-benzo[E]azulenes as V1A antagonists
JP6563394B2 (ja) 2013-08-30 2019-08-21 イェーナヴァルヴ テクノロジー インコーポレイテッド 人工弁のための径方向に折り畳み自在のフレーム及び当該フレームを製造するための方法
EP3226688B1 (en) 2014-12-05 2020-07-01 Merck Sharp & Dohme Corp. Tricyclic compounds as inhibitors of mutant idh enzymes
EP3226690B1 (en) * 2014-12-05 2020-05-20 Merck Sharp & Dohme Corp. Novel tricyclic compounds as inhibitors of mutant idh enzymes
WO2016089830A1 (en) * 2014-12-05 2016-06-09 Merck Sharp & Dohme Corp. Novel tricyclic compounds as inhibitors of mutant idh enzymes
EP4403138A3 (en) 2015-05-01 2024-10-09 JenaValve Technology, Inc. Device and method with reduced pacemaker rate in heart valve replacement
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PT1147115E (pt) * 1999-01-19 2004-02-27 Ortho Mcneil Pharm Inc Benzodiazepinas triciclicas como antagonistas do receptor da vasopressina

Also Published As

Publication number Publication date
UA70984C2 (uk) 2004-11-15
US20040242866A1 (en) 2004-12-02
MY128065A (en) 2007-01-31
IL144270A0 (en) 2002-05-23
PL349778A1 (en) 2002-09-09
AU772397C (en) 2000-08-07
US20020103373A1 (en) 2002-08-01
BR9917086B1 (pt) 2013-12-03
NO20013515L (no) 2001-09-17
RS50820B (sr) 2010-08-31
ES2207333T7 (es) 2009-06-18
ME00129B (me) 2010-10-10
EP1147115B3 (en) 2008-12-24
MEP17808A (en) 2010-06-10
DK1147115T3 (da) 2004-01-12
ATE249465T1 (de) 2003-09-15
BRPI9917086B8 (pt) 2016-05-24
TR200102069T2 (tr) 2001-11-21
AR035837A1 (es) 2004-07-21
IL144270A (en) 2010-04-29
YU51901A (sh) 2004-03-12
NO327896B1 (no) 2009-10-12
DE69911259T4 (de) 2009-07-09
CZ20012598A3 (cs) 2002-08-14
KR100771184B1 (ko) 2007-10-29
WO2000043398A2 (en) 2000-07-27
CZ302647B6 (cs) 2011-08-17
TWI289564B (en) 2007-11-11
AU2201400A (en) 2000-08-07
PL205704B1 (pl) 2010-05-31
DE69911259D1 (de) 2003-10-16
ES2207333T3 (es) 2004-05-16
WO2000043398A3 (en) 2001-01-11
NZ512960A (en) 2004-01-30
CA2360767A1 (en) 2000-07-27
AU772397B2 (en) 2004-04-29
DE69911259T2 (de) 2004-12-02
PT1147115E (pt) 2004-02-27
KR20010101577A (ko) 2001-11-14
CN1339038A (zh) 2002-03-06
CA2360767C (en) 2009-11-03
HU229074B1 (en) 2013-07-29
DK1147115T5 (da) 2008-12-08
HK1038361B (zh) 2004-05-07
HUP0105034A2 (hu) 2002-04-29
HUP0105034A3 (en) 2004-11-29
EP1147115B1 (en) 2003-09-10
HK1038361A1 (en) 2002-03-15
EP1147115A2 (en) 2001-10-24
US7317005B2 (en) 2008-01-08
CN1174986C (zh) 2004-11-10
NO20013515D0 (no) 2001-07-16
US6713475B2 (en) 2004-03-30

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