ES2183346T3 - Sistemas conjugados de bis-fosfonato con restos alquilantes que tienen actividad antitumoral. - Google Patents

Sistemas conjugados de bis-fosfonato con restos alquilantes que tienen actividad antitumoral.

Info

Publication number
ES2183346T3
ES2183346T3 ES98917062T ES98917062T ES2183346T3 ES 2183346 T3 ES2183346 T3 ES 2183346T3 ES 98917062 T ES98917062 T ES 98917062T ES 98917062 T ES98917062 T ES 98917062T ES 2183346 T3 ES2183346 T3 ES 2183346T3
Authority
ES
Spain
Prior art keywords
rental
phosphonate
remains
systems
antitumoral activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98917062T
Other languages
English (en)
Inventor
Valeria Livi
Silvano Spinelli
Marco Conti
Alo' Simonetta D
Ernesto Menta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novuspharma SpA
Original Assignee
Novuspharma SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novuspharma SpA filed Critical Novuspharma SpA
Application granted granted Critical
Publication of ES2183346T3 publication Critical patent/ES2183346T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3869—Polyphosphonic acids containing carboxylic acid or carboxylic acid derivative substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/4046—Esters of poly(thio)phosphonic acids containing carboxylic acid or carboxylic acid derivative substituents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a conjugados de ácidos 3-carboxi- 4,4''-dihidroxifosforilbutenoicos con agentes alquilantes. Dichos derivados están dotados con una actividad antitumoral pronunciada, especialmente contra el mieloma múltiple. La presente invención se refiere también a un procedimiento para la preparación de los dichos compuestos y a composiciones farmacéuticas que los contienen.
ES98917062T 1997-03-27 1998-03-24 Sistemas conjugados de bis-fosfonato con restos alquilantes que tienen actividad antitumoral. Expired - Lifetime ES2183346T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT97MI000730A IT1290444B1 (it) 1997-03-27 1997-03-27 Coniugati di bis-fosfonati con funzionalita' alchilanti aventi attivita' antitumorale

Publications (1)

Publication Number Publication Date
ES2183346T3 true ES2183346T3 (es) 2003-03-16

Family

ID=11376675

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98917062T Expired - Lifetime ES2183346T3 (es) 1997-03-27 1998-03-24 Sistemas conjugados de bis-fosfonato con restos alquilantes que tienen actividad antitumoral.

Country Status (9)

Country Link
US (1) US6207655B1 (es)
EP (1) EP0971939B1 (es)
AT (1) ATE223920T1 (es)
AU (1) AU7040398A (es)
CA (1) CA2284704A1 (es)
DE (1) DE69807857T2 (es)
ES (1) ES2183346T3 (es)
IT (1) IT1290444B1 (es)
WO (1) WO1998043987A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE293450T1 (de) * 1999-05-21 2005-05-15 Novartis Pharma Gmbh Verwendung von biphosphonsäuren zur behandlung von angiogenese
US7354923B2 (en) * 2001-08-10 2008-04-08 Palatin Technologies, Inc. Piperazine melanocortin-specific compounds
EP2270021A1 (en) 2009-06-18 2011-01-05 Centre National de la Recherche Scientifique Phosphonates synthons for the synthesis of phosphonates derivatives showing better bioavailability
WO2022051527A1 (en) * 2020-09-05 2022-03-10 The Board Of Trustees Of The University Of Illinois Phosphonate products and methods

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3425812A1 (de) * 1984-07-13 1986-01-16 Deutsches Krebsforschungszentrum, 6900 Heidelberg Neue 1-hydroxy-1,1-diphosphonsaeureverbindungen, verfahren zu ihrer herstellung und pharmakologische zubereitungen, insbesondere zur behandlung von knochentumoren
FR2611203B1 (fr) 1987-02-20 1989-06-09 Sturtz Georges Analogues gem-diphosphoniques d'amethopterine (methotrexate) et de derives deaza-n-10 amethopterine. leur preparation et les compositions pharmaceutiques qui les contiennent
DE3804686A1 (de) 1988-02-15 1989-08-24 Henkel Kgaa Arzneimittel mit einer kombination von cytostatika bzw. hormontherapeutika und phosphonoderivaten
IT1241674B (it) 1989-10-12 1994-01-27 Boehringer Biochemia Srl Acidi gem-difosfonici, un processo per la loro preparazione e composizioni farmaceutiche che li contengono.
IT1246777B (it) 1991-04-12 1994-11-26 Boehringer Mannheim Italia Aminoacil derivati di acidi gem-difosfonici,un processo per la loro preparazione e composizioni farmaceutiche che li contengono
IT1284070B1 (it) 1996-06-26 1998-05-08 Boehringer Mannheim Italia Derivati di carbossi gem-difosfonati ad attivita' antitumorale, un processo per la loro preparazione e composizioni farmaceutiche che

Also Published As

Publication number Publication date
ATE223920T1 (de) 2002-09-15
DE69807857D1 (de) 2002-10-17
US6207655B1 (en) 2001-03-27
IT1290444B1 (it) 1998-12-03
AU7040398A (en) 1998-10-22
ITMI970730A1 (it) 1998-09-27
DE69807857T2 (de) 2003-05-22
WO1998043987A1 (en) 1998-10-08
EP0971939A1 (en) 2000-01-19
EP0971939B1 (en) 2002-09-11
CA2284704A1 (en) 1998-10-08

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