ATE223920T1 - Antitumorale bisphosphonate mit alkylierenden einheiten - Google Patents

Antitumorale bisphosphonate mit alkylierenden einheiten

Info

Publication number
ATE223920T1
ATE223920T1 AT98917062T AT98917062T ATE223920T1 AT E223920 T1 ATE223920 T1 AT E223920T1 AT 98917062 T AT98917062 T AT 98917062T AT 98917062 T AT98917062 T AT 98917062T AT E223920 T1 ATE223920 T1 AT E223920T1
Authority
AT
Austria
Prior art keywords
antitumoral
bisphosphonates
alkylating
units
relates
Prior art date
Application number
AT98917062T
Other languages
English (en)
Inventor
Valeria Livi
Silvano Spinelli
Marco Conti
Alo' Simonetta D
Ernesto Menta
Original Assignee
Novuspharma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novuspharma Spa filed Critical Novuspharma Spa
Application granted granted Critical
Publication of ATE223920T1 publication Critical patent/ATE223920T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839Polyphosphonic acids
    • C07F9/3869Polyphosphonic acids containing carboxylic acid or carboxylic acid derivative substituents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025Esters of poly(thio)phosphonic acids
    • C07F9/4046Esters of poly(thio)phosphonic acids containing carboxylic acid or carboxylic acid derivative substituents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT98917062T 1997-03-27 1998-03-24 Antitumorale bisphosphonate mit alkylierenden einheiten ATE223920T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT97MI000730A IT1290444B1 (it) 1997-03-27 1997-03-27 Coniugati di bis-fosfonati con funzionalita' alchilanti aventi attivita' antitumorale
PCT/EP1998/001707 WO1998043987A1 (en) 1997-03-27 1998-03-24 Bis-phosphonate confugates with alkylating moieties having antitumor activity

Publications (1)

Publication Number Publication Date
ATE223920T1 true ATE223920T1 (de) 2002-09-15

Family

ID=11376675

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98917062T ATE223920T1 (de) 1997-03-27 1998-03-24 Antitumorale bisphosphonate mit alkylierenden einheiten

Country Status (9)

Country Link
US (1) US6207655B1 (de)
EP (1) EP0971939B1 (de)
AT (1) ATE223920T1 (de)
AU (1) AU7040398A (de)
CA (1) CA2284704A1 (de)
DE (1) DE69807857T2 (de)
ES (1) ES2183346T3 (de)
IT (1) IT1290444B1 (de)
WO (1) WO1998043987A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL351674A1 (en) * 1999-05-21 2003-05-19 Novartis Ag Use of bisphosphonic acids for treating angiogenesis
US7354923B2 (en) * 2001-08-10 2008-04-08 Palatin Technologies, Inc. Piperazine melanocortin-specific compounds
EP2270021A1 (de) 2009-06-18 2011-01-05 Centre National de la Recherche Scientifique Phosphonatsynthone zur Synthese von Phosphonat-Derivaten mit besserer Bioverfügbarkeit
US20230357291A1 (en) * 2020-09-05 2023-11-09 The Board Of Trustees Of The University Of Illinois Phosphonate products and methods

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3425812A1 (de) * 1984-07-13 1986-01-16 Deutsches Krebsforschungszentrum, 6900 Heidelberg Neue 1-hydroxy-1,1-diphosphonsaeureverbindungen, verfahren zu ihrer herstellung und pharmakologische zubereitungen, insbesondere zur behandlung von knochentumoren
FR2611203B1 (fr) * 1987-02-20 1989-06-09 Sturtz Georges Analogues gem-diphosphoniques d'amethopterine (methotrexate) et de derives deaza-n-10 amethopterine. leur preparation et les compositions pharmaceutiques qui les contiennent
DE3804686A1 (de) * 1988-02-15 1989-08-24 Henkel Kgaa Arzneimittel mit einer kombination von cytostatika bzw. hormontherapeutika und phosphonoderivaten
IT1241674B (it) * 1989-10-12 1994-01-27 Boehringer Biochemia Srl Acidi gem-difosfonici, un processo per la loro preparazione e composizioni farmaceutiche che li contengono.
IT1246777B (it) * 1991-04-12 1994-11-26 Boehringer Mannheim Italia Aminoacil derivati di acidi gem-difosfonici,un processo per la loro preparazione e composizioni farmaceutiche che li contengono
IT1284070B1 (it) * 1996-06-26 1998-05-08 Boehringer Mannheim Italia Derivati di carbossi gem-difosfonati ad attivita' antitumorale, un processo per la loro preparazione e composizioni farmaceutiche che

Also Published As

Publication number Publication date
ITMI970730A1 (it) 1998-09-27
AU7040398A (en) 1998-10-22
ES2183346T3 (es) 2003-03-16
WO1998043987A1 (en) 1998-10-08
DE69807857D1 (de) 2002-10-17
US6207655B1 (en) 2001-03-27
IT1290444B1 (it) 1998-12-03
CA2284704A1 (en) 1998-10-08
EP0971939A1 (de) 2000-01-19
EP0971939B1 (de) 2002-09-11
DE69807857T2 (de) 2003-05-22

Similar Documents

Publication Publication Date Title
PL337329A1 (en) Oxazolydinone based antibacterial agents comprising a thiocarbonyl functional group
MY113733A (en) Salts of an anti-migraine indole derivative
TNSN95083A1 (fr) Heteroaryl-oxazolidinones a 5 membres
MY118508A (en) Antigestagenically active steroids with a fluorinated 17(alfa)- alkyl chain.
BG104315A (en) Prostaglandine agonists and their application for the treatment of osteal diseases
DE69628306D1 (de) Lysomale proteine, hergestellt in der milch von nichtmenschlichen transgenen tieren
AU5162796A (en) Novel peptide derivatives
IL117091A0 (en) Methylphenyloxazolidinone derivatives pharmaceutical compositions containing the same and processes for the preparation thereof
HK1005361A1 (en) Nodulisporic acid derivatives
PL337499A1 (en) Novel 2-(iminomethyl)aminophenylic derivatives, their production and application as drugs and pharmaceutic agents containing such derivatives
MX9503529A (es) Derivados de glicinamida, procedimiento para su preparacion y medicamentos que los contienen.
DK0544812T3 (da) Bisphosphonsyrederivater som anti-arthritiske midler
IL109720A0 (en) N-alkylthio polyamide derivatives as radioprotective agents
ITBO990309A0 (it) Macchina per la realizzazione di sacchetti - filtro di prodotti da inf usione .
ATE223920T1 (de) Antitumorale bisphosphonate mit alkylierenden einheiten
HK1040237A1 (en) Fused polycyclic amino acids as pharmaceutical agents.
ZA984845B (en) New class of cationic transfecting agents for nucleic acids
FR2766489B1 (fr) Derives de streptogramines, leur preparation et les compositions qui les contiennent
FI981337A (fi) Menetelmä virusturvallisten farmaseuttisten koostumusten valmistamiseksi
BG103779A (en) Crystallohydrate sodium salt of (e)-4,6-dichloro-3-(2-oxo-1-phenylpyrrolidine-3-ilidenmethyl)-1h-i ndole-2-carboxylic acid
SE9803107D0 (sv) Novel Compunds
ZA978406B (en) Nodulisporic acid derivatives.
ID28292A (id) Senyawa 2,3,3a,4,9,9a-heksahidro-8-hidroksi-1h-benz (f) indol baru metoda untuk memproduksinya dan penggunaannya sebagai obat-obatan
BR9915898A (pt) Compostos, composição farmacêutica, e, utilização de um composto
ZA9610513B (en) New phospholipid derivatives of phosphonocarboxylic acids, the production thereof as well as their use as antiviral pharmaceutical agents.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee