ZA984845B - New class of cationic transfecting agents for nucleic acids - Google Patents

New class of cationic transfecting agents for nucleic acids

Info

Publication number
ZA984845B
ZA984845B ZA984845A ZA984845A ZA984845B ZA 984845 B ZA984845 B ZA 984845B ZA 984845 A ZA984845 A ZA 984845A ZA 984845 A ZA984845 A ZA 984845A ZA 984845 B ZA984845 B ZA 984845B
Authority
ZA
South Africa
Prior art keywords
transfecting agents
nucleic acids
new class
cationic
cationic transfecting
Prior art date
Application number
ZA984845A
Inventor
Michael Bessodes
Daniel Scherman
Jean Herscovici
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of ZA984845B publication Critical patent/ZA984845B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention concerns a novel class of nucleic acid cationic transfecting agents, characterised in that the transfecting agents comprise at least a lipophilic region associated with a cationic hydrophilic region, said cationic hydrophilic region consisting of a heterocycle with 5 or 6 atoms substituted by amino groups.
ZA984845A 1997-06-06 1998-06-04 New class of cationic transfecting agents for nucleic acids ZA984845B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9707014A FR2764304B1 (en) 1997-06-06 1997-06-06 NEW CLASS OF CATIONIC NUCLEIC ACID TRANSFECTANTS

Publications (1)

Publication Number Publication Date
ZA984845B true ZA984845B (en) 1998-12-29

Family

ID=9507684

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA984845A ZA984845B (en) 1997-06-06 1998-06-04 New class of cationic transfecting agents for nucleic acids

Country Status (18)

Country Link
EP (1) EP0986568B1 (en)
JP (1) JP2002504815A (en)
KR (1) KR20010013312A (en)
CN (1) CN1259134A (en)
AT (1) ATE214708T1 (en)
AU (1) AU737579B2 (en)
BR (1) BR9809953A (en)
CA (1) CA2292837A1 (en)
DE (1) DE69804302T2 (en)
DK (1) DK0986568T3 (en)
ES (1) ES2174445T3 (en)
FR (1) FR2764304B1 (en)
HU (1) HUP0004577A3 (en)
NO (1) NO314147B1 (en)
PL (1) PL337177A1 (en)
PT (1) PT986568E (en)
WO (1) WO1998055490A1 (en)
ZA (1) ZA984845B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999012945A2 (en) * 1997-09-08 1999-03-18 Valentis,Inc. Hydrophobic glycosylamine derivatives, compositions, and methods for use
DE19942864A1 (en) * 1999-09-08 2001-03-15 Knoell Hans Forschung Ev New O-aminoalkyl monosaccharide derivatives useful for control of bacterial, especially mycobacterial, and fungal infections
JP4629333B2 (en) * 2001-08-29 2011-02-09 アベンティス・ファーマ・ソシエテ・アノニム Lipid derivatives of aminoglycosides
FR2829136B1 (en) * 2001-08-29 2006-11-17 Aventis Pharma Sa LIPID DERIVATIVES OF AMINOGLYCOSIDES
DK2027137T3 (en) 2005-06-08 2015-05-18 Amicus Therapeutics Inc Imino and aminosugar PURIFICATION
WO2008081686A1 (en) * 2006-12-28 2008-07-10 Konica Minolta Holdings, Inc. Cholesterol derivative, liposome, method for forming liposome and contrast agent for x-ray
WO2017151733A1 (en) * 2016-03-01 2017-09-08 Molecular Transfer, Inc. Plant virus movement proteins and methods of using the same
CN112384523A (en) * 2018-05-16 2021-02-19 川斯勒佰尔公司 Cationic lipid of ribose
JP2021534196A (en) 2018-08-23 2021-12-09 シージェン インコーポレイテッド Anti-TIGIT antibody

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2774417B2 (en) * 1991-08-07 1998-07-09 株式会社ディ・ディ・エス研究所 Branched-chain saccharide complex having peptide skeleton and fine particle carrier
DE4329093A1 (en) * 1993-08-30 1995-03-02 Bayer Ag Substituted aminoalkylglycosides
AU4923696A (en) * 1995-02-10 1996-08-27 Nexstar Pharmaceuticals, Inc. Lipid constructs for cytoplasmic delivery of agents

Also Published As

Publication number Publication date
AU737579B2 (en) 2001-08-23
EP0986568A1 (en) 2000-03-22
AU8025098A (en) 1998-12-21
EP0986568B1 (en) 2002-03-20
FR2764304B1 (en) 1999-07-16
HUP0004577A3 (en) 2003-03-28
NO995858L (en) 1999-11-30
BR9809953A (en) 2000-08-01
CN1259134A (en) 2000-07-05
ES2174445T3 (en) 2002-11-01
WO1998055490A1 (en) 1998-12-10
FR2764304A1 (en) 1998-12-11
DK0986568T3 (en) 2002-06-10
ATE214708T1 (en) 2002-04-15
PT986568E (en) 2002-08-30
JP2002504815A (en) 2002-02-12
NO995858D0 (en) 1999-11-30
KR20010013312A (en) 2001-02-26
CA2292837A1 (en) 1998-12-10
NO314147B1 (en) 2003-02-03
DE69804302D1 (en) 2002-04-25
HUP0004577A1 (en) 2001-04-28
DE69804302T2 (en) 2002-10-17
PL337177A1 (en) 2000-08-14

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