BR0012294A - Indolazepinas como antagonistas receptores de vasopressina - Google Patents

Indolazepinas como antagonistas receptores de vasopressina

Info

Publication number
BR0012294A
BR0012294A BR0012294-7A BR0012294A BR0012294A BR 0012294 A BR0012294 A BR 0012294A BR 0012294 A BR0012294 A BR 0012294A BR 0012294 A BR0012294 A BR 0012294A
Authority
BR
Brazil
Prior art keywords
receptor antagonists
vasopressin receptor
indolazepines
heart failure
renal
Prior art date
Application number
BR0012294-7A
Other languages
English (en)
Inventor
William J Hoekstra
Michael N Greco
Leonard R Hecker
Bruce Maryanoff
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Publication of BR0012294A publication Critical patent/BR0012294A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

"INDOLAZEPINAS COMO ANTAGONISTAS RECEPTORES DE VASOPRESSINA". A invenção refere-se aos compostos indolazepinas tricíclicas úteis como antagonistas receptores de vasopressina, a composições farmacêuticas que compreendem os compostos da presente invenção e a processos para o tratamento de condições que envolvem maior resistência vascular e insuficiência cardíaca que incluem hipertensão, parada cardíaca congestiva, insuficiência cardíaca, vasoespasmo coronariano, isquemia cardíaca, cirrose do fígado, vasoespasmo renal, insuficiência renal, edema cerebral e isquemia, derrame, trombose ou retenção de água em um indivíduo que necessite o mesmo.
BR0012294-7A 1999-06-17 2000-06-15 Indolazepinas como antagonistas receptores de vasopressina BR0012294A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13962899P 1999-06-17 1999-06-17
US09/592,520 US6765004B1 (en) 1999-06-17 2000-06-12 Indoloazepines as vasopressin receptor antagonists
PCT/US2000/016549 WO2000078762A1 (en) 1999-06-17 2000-06-15 Indoloazepines as vasopressin receptor antagonists

Publications (1)

Publication Number Publication Date
BR0012294A true BR0012294A (pt) 2002-07-02

Family

ID=26837417

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0012294-7A BR0012294A (pt) 1999-06-17 2000-06-15 Indolazepinas como antagonistas receptores de vasopressina

Country Status (20)

Country Link
US (1) US6765004B1 (pt)
EP (1) EP1214323B1 (pt)
JP (1) JP2003502426A (pt)
CN (1) CN1399638A (pt)
AT (1) ATE282621T1 (pt)
AU (1) AU774768B2 (pt)
BR (1) BR0012294A (pt)
CA (1) CA2375268A1 (pt)
DE (1) DE60015997T2 (pt)
DK (1) DK1214323T3 (pt)
ES (1) ES2233402T3 (pt)
HU (1) HUP0201725A3 (pt)
IL (1) IL147130A0 (pt)
MX (1) MXPA01013286A (pt)
NO (1) NO20016155L (pt)
NZ (1) NZ516209A (pt)
PL (1) PL352998A1 (pt)
PT (1) PT1214323E (pt)
TR (1) TR200200560T2 (pt)
WO (1) WO2000078762A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0324269D0 (en) * 2003-10-16 2003-11-19 Pharmagene Lab Ltd EP4 receptor antagonists
US8567448B2 (en) * 2007-12-26 2013-10-29 Smart Pipe Company, Inc. Methods and systems for in situ pipe lining
US8828989B2 (en) 2011-09-26 2014-09-09 Hoffmann-La Roche Inc. Oxy-cyclohexyl-4H,6H-5-oxa-2,3,10b-triaza-benzo[E]azulenes as V1A antagonists
CN112107568B (zh) * 2019-06-19 2022-03-25 北京龙嘉博创医药科技有限公司 二芳基酰胺类化合物及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3314942A (en) * 1964-08-06 1967-04-18 Upjohn Co 3, 4, 5, 6-tetrahydro-1h-azepino(4, 3, 2-cd) indoles
US3249623A (en) * 1964-09-24 1966-05-03 Upjohn Co Derivatives of 3, 4, 5, 6-tetrahydro-1h-azepino [4, 3, 2-cd] indoles
BE795451A (fr) * 1972-02-23 1973-08-16 Pfizer Agents hypoglycemiants aza indoliques tricycliques
DE3525564A1 (de) * 1985-07-15 1987-02-05 Schering Ag Tricyclische verbindungen mit indolstruktur, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
JPS6434988A (en) * 1987-07-30 1989-02-06 Kissei Pharmaceutical Azepinoindole derivative
GB9307527D0 (en) 1993-04-13 1993-06-02 Fujisawa Pharmaceutical Co New venzamide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
NZ268671A (en) * 1993-07-21 1997-09-22 Yamanouchi Pharma Co Ltd Fused benzazepin-1-yl-carbonylphenyl derivatives
DE4438178A1 (de) * 1994-10-26 1996-05-02 Bayer Ag N-Methyl-N-isopropyl-heteroaryloxyacetamide

Also Published As

Publication number Publication date
NO20016155L (no) 2002-02-15
HUP0201725A3 (en) 2003-09-29
ATE282621T1 (de) 2004-12-15
IL147130A0 (en) 2002-08-14
ES2233402T3 (es) 2005-06-16
NZ516209A (en) 2004-01-30
TR200200560T2 (tr) 2003-01-21
EP1214323B1 (en) 2004-11-17
PL352998A1 (en) 2003-09-22
NO20016155D0 (no) 2001-12-17
DE60015997T2 (de) 2005-12-01
JP2003502426A (ja) 2003-01-21
DK1214323T3 (da) 2005-01-10
MXPA01013286A (es) 2003-08-20
US6765004B1 (en) 2004-07-20
CN1399638A (zh) 2003-02-26
WO2000078762A1 (en) 2000-12-28
AU5617000A (en) 2001-01-09
EP1214323A1 (en) 2002-06-19
CA2375268A1 (en) 2000-12-28
PT1214323E (pt) 2005-02-28
HUP0201725A2 (en) 2002-10-28
AU774768B2 (en) 2004-07-08
DE60015997D1 (de) 2004-12-23

Similar Documents

Publication Publication Date Title
BR9917086A (pt) Benzodiazepinas tricìclicas como antagonistas dosreceptores de vasopressina
EA199700117A1 (ru) Трициклические бензазепиновые антагонисты вазопрессина, способ их получения, фармацевтическая композиция и способ лечения млекопитающих с использованием трициклических бензазепинов
BRPI0408996A (pt) saia de inibidores tricìclicos de poli(adpp-ribose) polimerases
PE20010747A1 (es) Uso de dipiridamol o mopidamol para el tratamiento y prevencion de trastornos de la microcirculacion dependientes de fibrina
MA29600B1 (fr) Utilisation de sanglifehrine dans le virus de l'hepatite c
PT1129096E (pt) Antagonistas de receptor de crf e metodos de tratamento relacionados com os mesmos
MA30903B1 (fr) Derives de 2 - phenyl-6-minocarbonyl-pyrimidine
BR0112372A (pt) Espirobenzoazepinas substituìdas por não-peptìdeo como antagonistas de vasopressina
CY1112270T1 (el) Σπειρο βενζαζεπινες χρησιμες ως ανταγωνιστες αγγειοπιεσινης
CR8168A (es) Espirobenzazepinas sustituidas
BR0012294A (pt) Indolazepinas como antagonistas receptores de vasopressina
BR9801132A (pt) N-heterociclos fundidos, substituìdos com benzilóxi, processo para a sua preparação e seu uso como antagonistas de receptor de bradiquinina.
UY26426A1 (es) Nuevos compuestos
WO2006049984A3 (en) Novel [1,4]benzodiazepines as vasopressin v2 receptor antagonists
BR0015299A (pt) Benzotiazepinas substituìdas não-peptìdicas como antagonistas de vasopressina
AR022470A1 (es) Uso de pirazol-carboxamidas
ATE285781T1 (de) Behandlung von angiogenese-abhängigen erkrankungen mit dextrinsulphat
BRPI0409444A (pt) compostos de pirrolo[1,2-b]piridazina e suas utilizações

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1962 DE 12/08/2008.