ATE280756T1 - Substituierte benzolverbindungen als antiproliferative mittel - Google Patents

Substituierte benzolverbindungen als antiproliferative mittel

Info

Publication number
ATE280756T1
ATE280756T1 AT98939384T AT98939384T ATE280756T1 AT E280756 T1 ATE280756 T1 AT E280756T1 AT 98939384 T AT98939384 T AT 98939384T AT 98939384 T AT98939384 T AT 98939384T AT E280756 T1 ATE280756 T1 AT E280756T1
Authority
AT
Austria
Prior art keywords
agents
substituted benzene
antiproliferative agents
compositions
benzene compounds
Prior art date
Application number
AT98939384T
Other languages
English (en)
Inventor
Julio Cesar Medina
David Louis Clark
John A Flygare
Terry J Rosen
Bei Shan
Original Assignee
Tularik Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tularik Inc filed Critical Tularik Inc
Application granted granted Critical
Publication of ATE280756T1 publication Critical patent/ATE280756T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT98939384T 1997-08-22 1998-08-13 Substituierte benzolverbindungen als antiproliferative mittel ATE280756T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/917,025 US6284923B1 (en) 1997-08-22 1997-08-22 Substituted benzene compounds as antiproliferative and cholesterol lowering action
PCT/US1998/016781 WO1999010320A1 (en) 1997-08-22 1998-08-13 Substituted benzene compounds as antiproliferative and cholesterol lowering agents

Publications (1)

Publication Number Publication Date
ATE280756T1 true ATE280756T1 (de) 2004-11-15

Family

ID=25438246

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98939384T ATE280756T1 (de) 1997-08-22 1998-08-13 Substituierte benzolverbindungen als antiproliferative mittel

Country Status (10)

Country Link
US (2) US6284923B1 (de)
EP (1) EP1005453B1 (de)
JP (1) JP4309041B2 (de)
AT (1) ATE280756T1 (de)
AU (1) AU748826B2 (de)
CA (1) CA2301842C (de)
DE (1) DE69827267T2 (de)
ES (1) ES2245803T3 (de)
PT (1) PT1005453E (de)
WO (1) WO1999010320A1 (de)

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ES2201313T3 (es) * 1996-07-19 2004-03-16 Tularik, Inc. Pentafluorobencenosulfonamidas y analogos.
WO1999038845A1 (en) 1998-01-29 1999-08-05 Tularik Inc. Ppar-gamma modulators
US6583157B2 (en) 1998-01-29 2003-06-24 Tularik Inc. Quinolinyl and benzothiazolyl modulators
EP1090014B1 (de) * 1998-06-25 2003-09-03 Tularik Inc. Arylsulfonanilid-phosphate
HRP20010414A2 (en) * 1998-12-02 2002-06-30 Pfizer Prod Inc METHODS AND COMPOSITIONS FOR RESTORING CONFORMATIONAL STABILITY OF A PROTEIN OF THE p53 FAMILY
DK1192137T3 (da) * 1999-06-30 2013-11-11 Amgen Inc Forbindelser til modulering af PPAR-gamma aktivitet
US7041691B1 (en) 1999-06-30 2006-05-09 Amgen Inc. Compounds for the modulation of PPARγ activity
US6306615B1 (en) 1999-08-19 2001-10-23 Tularik Inc. Detection method for monitoring β tubulin isotype specific modification
WO2001082916A2 (en) 2000-05-03 2001-11-08 Tularik Inc. Combination therapeutic compositions and methods of use
US20030171399A1 (en) 2000-06-28 2003-09-11 Tularik Inc. Quinolinyl and benzothiazolyl modulators
US20050250854A1 (en) * 2000-11-03 2005-11-10 Amgen Inc. Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents
US6822001B2 (en) 2000-11-03 2004-11-23 Tularik Inc. Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents
JP4448902B2 (ja) * 2001-06-08 2010-04-14 株式会社医薬分子設計研究所 スルホンアミド誘導体
JP2003081937A (ja) * 2001-09-07 2003-03-19 Bayer Ag ベンゼンスルホンアミド誘導体
US7833734B2 (en) * 2002-11-26 2010-11-16 Institute Of Virology Of The Slovak Academy Of Sciences CA IX-specific inhibitors
AU2003295950B2 (en) * 2002-11-26 2007-06-28 Institute Of Virology CA IX-specific inhibitors
US7223761B2 (en) 2003-10-03 2007-05-29 Amgen Inc. Salts and polymorphs of a potent antidiabetic compound
FI20055498A0 (fi) * 2005-09-16 2005-09-16 Biotie Therapies Corp Sulfonamidijohdannaisia
GB0526252D0 (en) * 2005-12-22 2006-02-01 Novartis Ag Organic compounds
JP5860045B2 (ja) 2010-07-09 2016-02-16 ファイザー・リミテッドＰｆｉｚｅｒ Ｌｉｍｉｔｅｄ 化合物
WO2012056319A1 (en) * 2010-10-27 2012-05-03 Dynamix Pharmaceuticals Ltd. Sulfonamides for the modulation of pkm2
US20150291517A1 (en) * 2012-11-28 2015-10-15 Martijn Fiers Benzenesulfonamide compounds for somatic embryogenesis in plants
WO2015031220A1 (en) * 2013-08-28 2015-03-05 Borgwarner Inc. High temperature valve shaft seal
GB201514021D0 (en) 2015-08-07 2015-09-23 Arner Elias Set Jeno Novel Pyridines and their use in the treatment of cancer
KR20190115013A (ko) 2017-02-07 2019-10-10 오블리크 세러퓨틱스 에이비 헤테로아릴설포닐-치환된 피리딘 및 암의 치료에서 이의 용도
MX2019009356A (es) 2017-02-07 2019-09-19 Oblique Therapeutics Ab Sulfinilpiridinas y su uso en el tratamiento del cancer.
EP3580203A1 (de) 2017-02-07 2019-12-18 Oblique Therapeutics AB Hydrocarbylsulfonyl-substituierte pyridine und deren verwendung zur behandlung von krebs
KR20190115012A (ko) 2017-02-07 2019-10-10 오블리크 세러퓨틱스 에이비 헤테로사이클릴설포닐-치환된 피리딘 및 암의 치료에서 이의 용도
WO2020097408A1 (en) * 2018-11-09 2020-05-14 Nimbus Artemis, Inc. Acly inhibitors and uses thereof
GB2606804B (en) 2019-07-17 2023-12-27 2692372 Ontario Inc Benzenesulfonamide derivatives and uses thereof
US20230339851A1 (en) * 2022-03-21 2023-10-26 Chemocentryx, Inc. Cxcr6 sulfonamide compounds
WO2024175999A2 (en) * 2023-02-23 2024-08-29 Dunad Therapeutics Ltd. Benzenesulfonamide derivatives and uses thereof

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Also Published As

Publication number Publication date
WO1999010320A1 (en) 1999-03-04
AU748826B2 (en) 2002-06-13
JP4309041B2 (ja) 2009-08-05
US20020013496A1 (en) 2002-01-31
ES2245803T3 (es) 2006-01-16
US6388131B2 (en) 2002-05-14
WO1999010320A8 (en) 1999-09-23
CA2301842C (en) 2010-04-27
DE69827267T2 (de) 2006-02-02
DE69827267D1 (de) 2004-12-02
AU8782498A (en) 1999-03-16
PT1005453E (pt) 2005-02-28
EP1005453A1 (de) 2000-06-07
EP1005453B1 (de) 2004-10-27
JP2001514167A (ja) 2001-09-11
CA2301842A1 (en) 1999-03-04
US6284923B1 (en) 2001-09-04

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