DE69928952D1 - Chinolin-derivate und ihre verwendung als antibakterielle wirkstoffe - Google Patents

Chinolin-derivate und ihre verwendung als antibakterielle wirkstoffe

Info

Publication number
DE69928952D1
DE69928952D1 DE69928952T DE69928952T DE69928952D1 DE 69928952 D1 DE69928952 D1 DE 69928952D1 DE 69928952 T DE69928952 T DE 69928952T DE 69928952 T DE69928952 T DE 69928952T DE 69928952 D1 DE69928952 D1 DE 69928952D1
Authority
DE
Germany
Prior art keywords
derivatives
chinolin
antibacterial agents
mammals
man
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69928952T
Other languages
English (en)
Other versions
DE69928952T2 (de
Inventor
Thomas Davies
Edward Markwell
David Pearson
Kenneth TAKLE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Application granted granted Critical
Publication of DE69928952D1 publication Critical patent/DE69928952D1/de
Publication of DE69928952T2 publication Critical patent/DE69928952T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Quinoline Compounds (AREA)
DE69928952T 1998-10-14 1999-10-11 Chinolin-derivate und ihre verwendung als antibakterielle wirkstoffe Expired - Fee Related DE69928952T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9822440.5A GB9822440D0 (en) 1998-10-14 1998-10-14 Medicaments
GB9822440 1998-10-14
PCT/EP1999/007766 WO2000021952A1 (en) 1998-10-14 1999-10-11 Quinoline derivatives and their use as antibacterial agents

Publications (2)

Publication Number Publication Date
DE69928952D1 true DE69928952D1 (de) 2006-01-19
DE69928952T2 DE69928952T2 (de) 2007-01-11

Family

ID=10840577

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69928952T Expired - Fee Related DE69928952T2 (de) 1998-10-14 1999-10-11 Chinolin-derivate und ihre verwendung als antibakterielle wirkstoffe

Country Status (11)

Country Link
US (1) US6602882B1 (de)
EP (1) EP1121355B1 (de)
JP (1) JP2002527434A (de)
AT (1) ATE312831T1 (de)
AU (1) AU6339599A (de)
DE (1) DE69928952T2 (de)
ES (1) ES2255306T3 (de)
GB (1) GB9822440D0 (de)
MA (1) MA25009A1 (de)
PE (1) PE20001112A1 (de)
WO (1) WO2000021952A1 (de)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK286420B6 (sk) 1997-09-15 2008-09-05 The Procter & Gamble Company Zlúčenina so štruktúrou chinolónu, farmaceutický prostriedok s jej obsahom a jej použitie
GB9822450D0 (en) * 1998-10-14 1998-12-09 Smithkline Beecham Plc Medicaments
GB9914486D0 (en) * 1999-06-21 1999-08-18 Smithkline Beecham Plc Medicaments
GB9917408D0 (en) * 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
GB9917406D0 (en) * 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
SE9902987D0 (sv) 1999-08-24 1999-08-24 Astra Pharma Prod Novel compounds
US6803369B1 (en) 2000-07-25 2004-10-12 Smithkline Beecham Corporation Compounds and methods for the treatment of neoplastic disease
US6962917B2 (en) * 2000-07-26 2005-11-08 Smithkline Beecham P.L.C. Aminopiperidine quinolines and their azaisosteric analogues with antibacterical activity
EP1719770A3 (de) * 2000-09-21 2008-03-05 Smithkline Beecham Plc Chinolinderivate als antibakterielle Mittel
GB0031088D0 (en) * 2000-12-20 2001-01-31 Smithkline Beecham Plc Medicaments
GB0031086D0 (en) * 2000-12-20 2001-01-31 Smithkline Beecham Plc Medicaments
GB0101577D0 (en) 2001-01-22 2001-03-07 Smithkline Beecham Plc Compounds
GB0104050D0 (en) 2001-02-19 2001-04-04 Astrazeneca Ab Chemical compounds
GB0107228D0 (en) 2001-03-22 2001-05-16 Astrazeneca Ab Chemical compounds
GB0112836D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
GB0112834D0 (en) * 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
GB0118238D0 (en) * 2001-07-26 2001-09-19 Smithkline Beecham Plc Medicaments
EP1450802A2 (de) * 2001-10-30 2004-09-01 The General Hospital Corporation Verfahren zur prävention oder behandlung von bakteriellen und pilzinfektionen
SE0103818D0 (sv) 2001-11-15 2001-11-15 Astrazeneca Ab Chemical compounds
EP2181996A1 (de) 2002-01-29 2010-05-05 Glaxo Group Limited Aminopiperidinderivate
JP4508650B2 (ja) * 2002-01-29 2010-07-21 グラクソ グループ リミテッド アミノピペリジン化合物、当該化合物の製法および当該化合物を含有する医薬組成物
TW200406413A (en) * 2002-06-26 2004-05-01 Glaxo Group Ltd Compounds
AR040336A1 (es) * 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto
US6900224B2 (en) 2002-07-31 2005-05-31 The Procter & Gamble Company Antimicrobial quinolones, their compositions and uses
DE60334016D1 (de) 2002-11-05 2010-10-14 Glaxo Group Ltd Antibakterielle mittel
US7232832B2 (en) 2002-11-05 2007-06-19 Smithkline Beecham Corporation Antibacterial agents
US7491714B2 (en) * 2002-12-04 2009-02-17 Glaxo Group Limited Quinolines and nitrogenated derivatives thereof and their use as antibacterial agents
AR042486A1 (es) * 2002-12-18 2005-06-22 Glaxo Group Ltd Compuesto de quinolina y naftiridina halosustituido en la posicion 3, procedimiento para preparar el compuesto, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion .
ES2330107T3 (es) * 2003-03-06 2009-12-04 Glaxo Group Limited Derivados de urea heterociclicos para el tratamiento del dolor.
JP2006519806A (ja) * 2003-03-07 2006-08-31 グラクソ　グループ　リミテッド 尿素誘導体および疼痛治療におけるバニロイド受容体拮抗剤としてのそれらの使用。
GB0305426D0 (en) * 2003-03-08 2003-04-16 Glaxo Group Ltd Novel compounds
FR2867472B1 (fr) * 2004-03-12 2008-07-18 Aventis Pharma Sa Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent
JP2008505920A (ja) * 2004-07-08 2008-02-28 グラクソ　グループ　リミテッド 抗菌剤
WO2006081289A2 (en) * 2005-01-25 2006-08-03 Glaxo Group Limited Antibacterial agents
WO2006081179A1 (en) * 2005-01-25 2006-08-03 Glaxo Group Limited Antibacterial agents
WO2006081264A1 (en) 2005-01-25 2006-08-03 Glaxo Group Limited Antibacterial agents
EP1846416A4 (de) * 2005-01-25 2009-07-01 Glaxo Group Ltd Antibakterielle wirkstoffe
US7592334B2 (en) 2005-01-25 2009-09-22 Glaxo Group Limited Antibacterial agents
US7842810B2 (en) 2005-03-31 2010-11-30 Janssen Pharmaceutica, Nv Bicyclic pyrazole compounds as antibacterial agents
MY150958A (en) 2005-06-16 2014-03-31 Astrazeneca Ab Compounds for the treatment of multi-drug resistant bacterial infections
CN101374831B (zh) 2006-01-26 2011-04-27 埃科特莱茵药品有限公司 四氢吡喃抗生素
US7456279B2 (en) 2006-03-28 2008-11-25 The Procter & Gamble Company Coupling process for preparing quinolone intermediates
AU2007230630B2 (en) 2006-03-28 2012-12-20 Taigen Biotechnology Co., Ltd Malate salts, and polymorphs of (3S,5S)-7-[3-amino-5-methyl-piperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
AU2008249745B2 (en) * 2007-05-09 2012-01-12 Pfizer Inc. Substituted heterocyclic derivatives and compositions and their pharmaceutical use as antibacterials
EP2332939A1 (de) 2009-11-26 2011-06-15 Æterna Zentaris GmbH Neuartige Naphthyridinderivate und ihre Verwendung als Kinasehemmer
EP3927703B1 (de) 2019-02-19 2023-04-05 Univerza V Ljubljani Antibakterielle substanzen auf basis monocyclischer fragmente, die mit aminopiperidin-naphthyridin-gerüst gekoppelt sind
KR20220087497A (ko) 2019-10-18 2022-06-24 더 리전츠 오브 더 유니버시티 오브 캘리포니아 병원성 혈관을 표적화하기 위한 화합물 및 방법

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4418299Y1 (de) 1965-01-16 1969-08-07
US4472404A (en) * 1982-08-16 1984-09-18 The Dow Chemical Company 8-Quinolinyl carbamates and their use as urinary tract antimicrobials
EP0387510A1 (de) * 1989-02-10 1990-09-19 Bayer Ag Substituierte 8-Carbamoyloxychinolin-Derivate, Verfahren zu deren Herstellung, sowie deren Verwendung zur Bekämpfung von Schädlingen
JPH0495071A (ja) * 1990-08-10 1992-03-27 Kyorin Pharmaceut Co Ltd カルバミン酸誘導体
JP3169188B2 (ja) * 1991-01-31 2001-05-21 杏林製薬株式会社 カルバミン酸誘導体及びその製造方法
WO1994014801A1 (en) 1992-12-29 1994-07-07 Smithkline Beecham Plc Heterocyclic urea derivatives as 5ht2c and 5ht2b antagonists
DE69627985T2 (de) * 1995-02-02 2004-02-19 Daiichi Pharmaceutical Co., Ltd. Heterozyklische verbindungen
EP0876345B1 (de) 1995-10-16 2004-08-18 Fujisawa Pharmaceutical Co., Ltd. Heterocyclische verbindungen als h+-atpasen
JP3933244B2 (ja) 1997-04-04 2007-06-20 株式会社資生堂 アルキレンジアミン誘導体及び抗潰瘍剤、抗菌剤
DE69908555T2 (de) 1998-01-26 2004-05-06 Smithkline Beecham P.L.C., Brentford Chinolinderivate als antibakterielles arzneimittel
FR2798656B1 (fr) 1999-09-17 2004-12-17 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leur preparation et les compositions qui les contiennent

Also Published As

Publication number Publication date
EP1121355A1 (de) 2001-08-08
DE69928952T2 (de) 2007-01-11
ATE312831T1 (de) 2005-12-15
WO2000021952A1 (en) 2000-04-20
PE20001112A1 (es) 2000-10-14
ES2255306T3 (es) 2006-06-16
JP2002527434A (ja) 2002-08-27
MA25009A1 (fr) 2000-07-01
AU6339599A (en) 2000-05-01
GB9822440D0 (en) 1998-12-09
EP1121355B1 (de) 2005-12-14
US6602882B1 (en) 2003-08-05

Similar Documents

Publication Publication Date Title
DE69928952D1 (de) Chinolin-derivate und ihre verwendung als antibakterielle wirkstoffe
ATE255104T1 (de) Quinolin-derivate und deren verwendung als antibakterielle wirkstoffe
ATE344799T1 (de) Piperidinderivate als antibakterielle mittel
DE60221969D1 (de) Durch piperidine-enthaltende gruppen substituierte chinoline und deren stickstoff-enthaltende derivate und ihre verwendung als antibakterielle wirkstoffe
ATE294792T1 (de) Naphthyridine und ihre azaisosteren analoga als antibakterielle mittel
DE60119939D1 (de) Chinolinderivate als antibakterielle mittel
DE60215494D1 (de) Bicyclische, stickstoffhaltige heterocyclische derivate zur verwendung als antibakterielle mittel
DE60022523D1 (de) Aminopiperidinderivate als antibakterielles arzneimittel
DE60123276D1 (de) Piperazinderivate zur behandlung bakterieller infektionen
BR0112750A (pt) Aminopiperidina quinolinas e seus análogos azaisostéricos com atividade antibacteriana
DE60334016D1 (de) Antibakterielle mittel
DE60331849D1 (de) Antibakterielle wirkstoffe
ATE280756T1 (de) Substituierte benzolverbindungen als antiproliferative mittel
ATE433963T1 (de) Fab-i inhibitoren
PT1216256E (pt) Antibioticos macrolidos e tratamento de pasteurelose
DE60324179D1 (de) Chinoline und stickstoffhaltige derivatedavon und deren verwendung als antibakterielle mittel
TR199900661T2 (xx) Cilt enfeksiyonlar�n�n tedavisi amac�yla 1-hidroksi-2-piridonlar�n kullan�m�
TR200003084T2 (tr) Paroxetine askorbat
ECSP993176A (es) Nuevos compuestos y composiciones antibacterianas

Legal Events

Date Code Title Description
8332 No legal effect for de
8370 Indication related to discontinuation of the patent is to be deleted
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee