ATE294792T1 - Naphthyridine und ihre azaisosteren analoga als antibakterielle mittel - Google Patents

Naphthyridine und ihre azaisosteren analoga als antibakterielle mittel

Info

Publication number
ATE294792T1
ATE294792T1 AT99947781T AT99947781T ATE294792T1 AT E294792 T1 ATE294792 T1 AT E294792T1 AT 99947781 T AT99947781 T AT 99947781T AT 99947781 T AT99947781 T AT 99947781T AT E294792 T1 ATE294792 T1 AT E294792T1
Authority
AT
Austria
Prior art keywords
azaisosterene
analogas
naphthyridines
antibacterial agents
pharmaceutically acceptable
Prior art date
Application number
AT99947781T
Other languages
English (en)
Inventor
Ian Keith Hatton
Neil David Pearson
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Application granted granted Critical
Publication of ATE294792T1 publication Critical patent/ATE294792T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT99947781T 1998-10-14 1999-10-11 Naphthyridine und ihre azaisosteren analoga als antibakterielle mittel ATE294792T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9822450.4A GB9822450D0 (en) 1998-10-14 1998-10-14 Medicaments
PCT/GB1999/003366 WO2000021948A1 (en) 1998-10-14 1999-10-11 Naphthrydine compounds and their azaisosteric analogues as antibacterials

Publications (1)

Publication Number Publication Date
ATE294792T1 true ATE294792T1 (de) 2005-05-15

Family

ID=10840584

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99947781T ATE294792T1 (de) 1998-10-14 1999-10-11 Naphthyridine und ihre azaisosteren analoga als antibakterielle mittel

Country Status (9)

Country Link
US (1) US20030212084A1 (de)
EP (1) EP1127057B1 (de)
JP (1) JP2002527431A (de)
AT (1) ATE294792T1 (de)
AU (1) AU6114699A (de)
DE (1) DE69925150T2 (de)
ES (1) ES2242419T3 (de)
GB (1) GB9822450D0 (de)
WO (1) WO2000021948A1 (de)

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GB0101577D0 (en) 2001-01-22 2001-03-07 Smithkline Beecham Plc Compounds
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GB0107228D0 (en) 2001-03-22 2001-05-16 Astrazeneca Ab Chemical compounds
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GB0112834D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
GB0118238D0 (en) * 2001-07-26 2001-09-19 Smithkline Beecham Plc Medicaments
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US7312212B2 (en) 2002-01-29 2007-12-25 Glaxo Group Limited Aminopiperidine derivatives
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FR2867472B1 (fr) * 2004-03-12 2008-07-18 Aventis Pharma Sa Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent
DE602005021133D1 (de) * 2004-10-05 2010-06-17 Actelion Pharmaceuticals Ltd Neue piperidin-antibiotika
JP2008528598A (ja) 2005-01-25 2008-07-31 グラクソ グループ リミテッド 抗菌剤
WO2006081182A2 (en) 2005-01-25 2006-08-03 Glaxo Group Limited Antibacterial agents
US7511035B2 (en) 2005-01-25 2009-03-31 Glaxo Group Limited Antibacterial agents
EP1845995A4 (de) 2005-01-25 2010-03-03 Glaxo Group Ltd Antibakterielle wirkstoffe
JP2008528586A (ja) 2005-01-25 2008-07-31 グラクソ グループ リミテッド 抗菌剤
MX2007014507A (es) * 2005-05-24 2008-02-07 Astrazeneca Ab Aminopiperidin quinolinas y sus analogos azaisostericos con actividad antibacteriana.
MY150958A (en) 2005-06-16 2014-03-31 Astrazeneca Ab Compounds for the treatment of multi-drug resistant bacterial infections
ATE536351T1 (de) 2006-01-26 2011-12-15 Actelion Pharmaceuticals Ltd Tetrahydropyran-antibiotika
ES2353829T3 (es) 2006-02-15 2011-03-07 Actelion Pharmaceuticals Ltd. Derivados antibioticos de etanol o de 1,2-etanodiolciclohexilo.
US20070287707A1 (en) * 2006-02-28 2007-12-13 Arrington Mark P Phosphodiesterase 10 inhibitors
WO2007118130A2 (en) 2006-04-06 2007-10-18 Glaxo Group Limited Antibacterial agents
CN101679357A (zh) 2007-05-09 2010-03-24 辉瑞大药厂 取代的杂环衍生物及其组合物和作为抗菌剂的药物用途
DK2344495T3 (en) 2008-10-07 2015-02-02 Actelion Pharmaceuticals Ltd TRICYCLIC OXAZOLIDINON ANTIBIOTIC COMPOUNDS
AU2009325902B2 (en) 2008-12-12 2015-01-29 Idorsia Pharmaceuticals Ltd 5-amino-2-(1-hydroxy-ethyl)-tetrahydropyran derivatives
JP2017001954A (ja) * 2013-11-08 2017-01-05 石原産業株式会社 含窒素飽和複素環化合物
KR20220087497A (ko) 2019-10-18 2022-06-24 더 리전츠 오브 더 유니버시티 오브 캘리포니아 병원성 혈관을 표적화하기 위한 화합물 및 방법
US12590298B2 (en) 2019-10-18 2026-03-31 The Regents Of The University Of California Ex vivo tumor angiogenesis model
WO2023278564A1 (en) 2021-07-02 2023-01-05 Mirati Therapeutics, Inc. Aminopyridine-based mta-cooperative prmt5 inhibitors

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Also Published As

Publication number Publication date
DE69925150D1 (de) 2005-06-09
EP1127057A1 (de) 2001-08-29
EP1127057B1 (de) 2005-05-04
JP2002527431A (ja) 2002-08-27
ES2242419T3 (es) 2005-11-01
WO2000021948A1 (en) 2000-04-20
GB9822450D0 (en) 1998-12-09
US20030212084A1 (en) 2003-11-13
AU6114699A (en) 2000-05-01
DE69925150T2 (de) 2006-01-12

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties