ATE344799T1 - Piperidinderivate als antibakterielle mittel - Google Patents

Piperidinderivate als antibakterielle mittel

Info

Publication number
ATE344799T1
ATE344799T1 AT02764786T AT02764786T ATE344799T1 AT E344799 T1 ATE344799 T1 AT E344799T1 AT 02764786 T AT02764786 T AT 02764786T AT 02764786 T AT02764786 T AT 02764786T AT E344799 T1 ATE344799 T1 AT E344799T1
Authority
AT
Austria
Prior art keywords
piperidine derivatives
antibacterial agents
derivatives
piperidine
mammals
Prior art date
Application number
AT02764786T
Other languages
English (en)
Inventor
David Thomas Davies
Graham Elgin Jones
Roger Edward Markwell
Neil David Pearson
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Application granted granted Critical
Publication of ATE344799T1 publication Critical patent/ATE344799T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT02764786T 2001-07-26 2002-07-25 Piperidinderivate als antibakterielle mittel ATE344799T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0118238.5A GB0118238D0 (en) 2001-07-26 2001-07-26 Medicaments

Publications (1)

Publication Number Publication Date
ATE344799T1 true ATE344799T1 (de) 2006-11-15

Family

ID=9919236

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02764786T ATE344799T1 (de) 2001-07-26 2002-07-25 Piperidinderivate als antibakterielle mittel

Country Status (9)

Country Link
US (1) US20040198756A1 (de)
EP (1) EP1419155B1 (de)
JP (1) JP2005504747A (de)
AT (1) ATE344799T1 (de)
AU (1) AU2002328972A1 (de)
DE (1) DE60215951T2 (de)
ES (1) ES2274999T3 (de)
GB (1) GB0118238D0 (de)
WO (1) WO2003010138A2 (de)

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EP1719770A3 (de) * 2000-09-21 2008-03-05 Smithkline Beecham Plc Chinolinderivate als antibakterielle Mittel
GB0031088D0 (en) * 2000-12-20 2001-01-31 Smithkline Beecham Plc Medicaments
GB0031086D0 (en) * 2000-12-20 2001-01-31 Smithkline Beecham Plc Medicaments
GB0101577D0 (en) * 2001-01-22 2001-03-07 Smithkline Beecham Plc Compounds
GB0112836D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
GB0112834D0 (en) * 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
EP2181996A1 (de) 2002-01-29 2010-05-05 Glaxo Group Limited Aminopiperidinderivate
EP1470131A2 (de) 2002-01-29 2004-10-27 Glaxo Group Limited "aminopiperidinverbindugen, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen "
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TW200409637A (en) 2002-06-26 2004-06-16 Glaxo Group Ltd Compounds
DE50312598D1 (de) 2002-10-10 2010-05-20 Morphochem Ag Komb Chemie Neue verbindungen mit antibakterieller aktivität
AU2003291227A1 (en) 2002-11-05 2004-06-07 Smithkline Beecham Corporation Antibacterial agents
EP1560821B8 (de) 2002-11-05 2010-05-19 Glaxo Group Limited Antibakterielle wirkstoffe
TW200427688A (en) * 2002-12-18 2004-12-16 Glaxo Group Ltd Antibacterial agents
WO2005068463A1 (en) 2004-01-08 2005-07-28 F. Hoffmann-La Roche Ag Diaza-spiropiperidine derivatives
FR2867472B1 (fr) * 2004-03-12 2008-07-18 Aventis Pharma Sa Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent
TWI350168B (en) 2004-05-07 2011-10-11 Incyte Corp Amido compounds and their use as pharmaceuticals
US7687665B2 (en) 2004-06-24 2010-03-30 Incyte Corporation 2-methylprop anamides and their use as pharmaceuticals
JP2008506695A (ja) * 2004-07-13 2008-03-06 グラクソ　グループ　リミテッド 抗細菌剤
ATE397582T1 (de) * 2004-10-22 2008-06-15 Bioprojet Soc Civ Neue dicarbonsäurederivate
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US7709472B2 (en) 2005-01-25 2010-05-04 Glaxo Group Limited Antibacterial agents
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CA2643044A1 (en) * 2006-02-28 2007-09-07 Amgen Inc. Cinnoline and quinazoline derivates as phosphodiesterase 10 inhibitors
CA2644850A1 (en) * 2006-03-08 2007-09-13 Amgen Inc. Quinoline and isoquinoline derivatives as phosphodiesterase 10 inhibitors
EP2007377A4 (de) 2006-04-06 2011-08-17 Glaxo Group Ltd Antibakterielle wirkstoffe
JP2009532423A (ja) 2006-04-06 2009-09-10 グラクソ グループ リミテッド 抗菌剤としてのピロロ−キノキサリノン誘導体
GB0613208D0 (en) 2006-07-03 2006-08-09 Glaxo Group Ltd Compounds
EP1992628A1 (de) 2007-05-18 2008-11-19 Glaxo Group Limited Derivate und Analoge von N-Ethylquinolonen und N-Ethylazaquinolonen
CL2007002958A1 (es) * 2006-10-12 2008-05-09 Epix Delaware Inc Compuestos derivados de heteroaril-carboxamida, antagonistas del receptor de quimioquina; composicion farmaceutica; y uso para el tratamiento o prevencion de enfermedades tales como rechazo de transplante de organos, artritis reumatoidea, lupus, entr
US8389524B2 (en) * 2007-04-20 2013-03-05 Glaxo Group Limited Tricyclic nitrogen containing compounds as antibacterial agents
CN101679357A (zh) 2007-05-09 2010-03-24 辉瑞大药厂 取代的杂环衍生物及其组合物和作为抗菌剂的药物用途
CL2008001839A1 (es) 2007-06-21 2009-01-16 Incyte Holdings Corp Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades.
KR20100102646A (ko) 2007-12-11 2010-09-24 가부시키가이샤 사이토파스파인더 카르복스아미드 화합물 및 케모카인 수용체 길항제로서의 이의 용도
EP2080761A1 (de) 2008-01-18 2009-07-22 Glaxo Group Limited Verbindungen
EP2285770B1 (de) * 2008-06-02 2015-05-20 Cipla Limited Verfahren zur herstellung von arformoterol
US20110275661A1 (en) 2008-10-17 2011-11-10 Glaxo Group Limited Tricyclic nitrogen compounds used as antibacterials
US8318940B2 (en) 2009-01-15 2012-11-27 Glaxo Group Limited Naphthyridin-2 (1 H)-one compounds useful as antibacterials
TW201209056A (en) * 2010-05-25 2012-03-01 Taisho Pharmaceutical Co Ltd Novel heterocyclic compound or salt thereof
CN102267995A (zh) * 2010-06-04 2011-12-07 艾琪康医药科技（上海）有限公司 一种制备二氮杂螺环化合物的方法
US9120818B2 (en) * 2010-12-14 2015-09-01 Merck Sharp & Dohme Corp. Process and intermediates for preparing macrolactams
AR089929A1 (es) 2012-02-10 2014-10-01 Actelion Pharmaceuticals Ltd Proceso para manufacturar un derivado de naftiridina
WO2013160431A1 (en) * 2012-04-27 2013-10-31 Janssen Pharmaceutica Nv Antibacterial quinoline derivatives
DK2841425T3 (en) * 2012-04-27 2016-06-27 Janssen Pharmaceutica Nv ANTIBACTERIAL QUINOLIN DERIVATIVES
PE20170501A1 (es) 2014-08-22 2017-04-27 Glaxosmithkline Ip Dev Ltd Un procedimiento que comprende compuestos que administran a un sujeto infectado con neisseria gonorrhoeae
UY36851A (es) 2015-08-16 2017-03-31 Glaxosmithkline Ip Dev Ltd Compuestos para uso en aplicaciones antibacterianas
US11884647B2 (en) 2019-10-18 2024-01-30 The Regents Of The University Of California Compounds and methods for targeting pathogenic blood vessels
CN116102537B (zh) * 2021-11-10 2024-10-01 四川大学 一种喹啉酮类衍生物及其制备方法和用途

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NL7908031A (nl) * 1979-11-01 1981-06-01 Acf Chemiefarma Nv Nieuwe chinolinederivaten en farmaceutische preparaten die een dergelijke verbinding bevatten, alsmede werk- wijze voor het bereiden van deze verbindingen.
EP0541486A1 (de) * 1991-11-07 1993-05-12 Ciba-Geigy Ag Polycyclische Konjugate
US5977134A (en) * 1996-12-05 1999-11-02 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
GB9822450D0 (en) * 1998-10-14 1998-12-09 Smithkline Beecham Plc Medicaments
GB9822440D0 (en) * 1998-10-14 1998-12-09 Smithkline Beecham Plc Medicaments
AU2437900A (en) * 1999-01-20 2000-08-07 Smithkline Beecham Plc Piperidinylquinolines as protein tyrosine kinase inhibitors
GB9914486D0 (en) * 1999-06-21 1999-08-18 Smithkline Beecham Plc Medicaments
GB9917408D0 (en) * 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
GB9917406D0 (en) * 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
US6403610B1 (en) * 1999-09-17 2002-06-11 Aventis Pharma S.A. Quinolylpropylpiperidine derivatives, their preparation and the compositions which comprise them
US6803369B1 (en) * 2000-07-25 2004-10-12 Smithkline Beecham Corporation Compounds and methods for the treatment of neoplastic disease
HUP0300721A3 (en) * 2000-07-26 2006-02-28 Smithkline Beecham Plc Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity, process for producing them, pharmaceutical compositions containing them and use thereof
EP1719770A3 (de) * 2000-09-21 2008-03-05 Smithkline Beecham Plc Chinolinderivate als antibakterielle Mittel
US6603005B2 (en) * 2000-11-15 2003-08-05 Aventis Pharma S.A. Heterocyclylalkylpiperidine derivatives, their preparation and compositions containing them
FR2816618B1 (fr) * 2000-11-15 2002-12-27 Aventis Pharma Sa Derives heterocyclylalcoyl piperidine, leur preparation et les compositions qui les contiennent
GB0031088D0 (en) * 2000-12-20 2001-01-31 Smithkline Beecham Plc Medicaments
GB0031086D0 (en) * 2000-12-20 2001-01-31 Smithkline Beecham Plc Medicaments
GB0101577D0 (en) * 2001-01-22 2001-03-07 Smithkline Beecham Plc Compounds
US6602884B2 (en) * 2001-03-13 2003-08-05 Aventis Pharma S.A. Quinolylpropylpiperidine derivatives, their preparation, and compositions containing them
GB0112834D0 (en) * 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
GB0112836D0 (en) * 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
US20030203917A1 (en) * 2001-07-25 2003-10-30 Smithkline Beecham Corporation And Smithkline Beecham P.L.C. Compounds and methods for the treatment of neoplastic disease
EP2181996A1 (de) * 2002-01-29 2010-05-05 Glaxo Group Limited Aminopiperidinderivate
EP1470131A2 (de) * 2002-01-29 2004-10-27 Glaxo Group Limited "aminopiperidinverbindugen, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen "
GB0217294D0 (en) * 2002-07-25 2002-09-04 Glaxo Group Ltd Medicaments

Also Published As

Publication number Publication date
DE60215951D1 (de) 2006-12-21
DE60215951T2 (de) 2007-04-26
EP1419155B1 (de) 2006-11-08
WO2003010138A2 (en) 2003-02-06
WO2003010138A3 (en) 2003-12-04
ES2274999T3 (es) 2007-06-01
JP2005504747A (ja) 2005-02-17
GB0118238D0 (en) 2001-09-19
EP1419155A2 (de) 2004-05-19
AU2002328972A1 (en) 2003-02-17
US20040198756A1 (en) 2004-10-07

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties