ATE499373T1 - Diazaspiropiperidinderivate - Google Patents

Diazaspiropiperidinderivate

Info

Publication number
ATE499373T1
ATE499373T1 AT04804426T AT04804426T ATE499373T1 AT E499373 T1 ATE499373 T1 AT E499373T1 AT 04804426 T AT04804426 T AT 04804426T AT 04804426 T AT04804426 T AT 04804426T AT E499373 T1 ATE499373 T1 AT E499373T1
Authority
AT
Austria
Prior art keywords
sub
sup
lower alkyl
diazaspiropiperidine
derivatives
Prior art date
Application number
AT04804426T
Other languages
English (en)
Inventor
Simona Ceccarelli
Synese Jolidon
Emmanuel Pinard
Andrew Thomas
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE499373T1 publication Critical patent/ATE499373T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT04804426T 2004-01-08 2004-12-30 Diazaspiropiperidinderivate ATE499373T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04100033 2004-01-08
PCT/EP2004/014841 WO2005068463A1 (en) 2004-01-08 2004-12-30 Diaza-spiropiperidine derivatives

Publications (1)

Publication Number Publication Date
ATE499373T1 true ATE499373T1 (de) 2011-03-15

Family

ID=34717283

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04804426T ATE499373T1 (de) 2004-01-08 2004-12-30 Diazaspiropiperidinderivate

Country Status (13)

Country Link
US (1) US7173133B2 (de)
EP (1) EP1720873B1 (de)
JP (1) JP4762155B2 (de)
KR (1) KR100849321B1 (de)
CN (1) CN100413865C (de)
AT (1) ATE499373T1 (de)
AU (1) AU2004313693B2 (de)
BR (1) BRPI0418375A (de)
CA (1) CA2552914C (de)
DE (1) DE602004031560D1 (de)
ES (1) ES2359707T3 (de)
RU (1) RU2355690C2 (de)
WO (1) WO2005068463A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2721786A1 (en) * 2008-05-05 2009-11-12 Pfizer Inc. Novel class of spiro piperidines for the treatment of neurodegenerative diseases
US8389539B2 (en) * 2009-12-01 2013-03-05 Hoffman-La Roche Inc. Azacyclic derivatives
US8524909B2 (en) * 2010-02-02 2013-09-03 Hoffmann-La Roche Inc. Tetrahydro-pyran derivatives
BR112015018087B1 (pt) 2013-01-29 2022-09-20 Aptinyx Inc Compostos moduladores de receptor n-metil-d-aspartato (nmda) de espiro-lactama, composição farmacêutica e uso dos mesmos
SG11201900554YA (en) 2016-08-01 2019-02-27 Aptinyx Inc Spiro-lactam nmda modulators and methods of using same
AU2017306152A1 (en) * 2016-08-01 2019-01-31 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
BR112019001921A2 (pt) 2016-08-01 2019-05-14 Aptinyx Inc. moduladores do receptor nmda de espiro-lactama e seus usos
EP3689879B1 (de) 2017-09-29 2025-02-12 Takeda Pharmaceutical Company Limited Heterocyclische verbindung
US11578072B2 (en) 2018-01-31 2023-02-14 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE897058A (fr) * 1982-06-25 1983-12-16 Sandoz Sa Utilisation d'un derive du spiro-succinimide dans le traitement de la demence du type alzheimer
BE900003A (fr) * 1983-06-27 1984-12-27 Sandoz Sa Derives du spirosuccinimide utilisables comme medicaments.
US5102886A (en) * 1990-10-12 1992-04-07 American Home Products Corporation 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors
TWI243173B (en) * 1999-11-17 2005-11-11 Akzo Nobel Nv Spiro[2H-1-benzopyran-2,4'-piperidine] derivatives
US6482829B2 (en) * 2000-06-08 2002-11-19 Hoffmann-La Roche Inc. Substituted heterocyclic siprodecane compound active as an antagonist of neurokinin 1 receptor
GB0118238D0 (en) * 2001-07-26 2001-09-19 Smithkline Beecham Plc Medicaments
US6727247B2 (en) * 2001-12-10 2004-04-27 Hoffman-La Roche Inc. Substituted benzothiazole amide derivatives

Also Published As

Publication number Publication date
WO2005068463A1 (en) 2005-07-28
CA2552914A1 (en) 2005-07-28
ES2359707T3 (es) 2011-05-26
EP1720873A1 (de) 2006-11-15
JP2007518725A (ja) 2007-07-12
US7173133B2 (en) 2007-02-06
RU2006128613A (ru) 2008-02-20
KR20060133546A (ko) 2006-12-26
CA2552914C (en) 2010-09-14
KR100849321B1 (ko) 2008-07-29
CN1902202A (zh) 2007-01-24
DE602004031560D1 (de) 2011-04-07
US20050154001A1 (en) 2005-07-14
CN100413865C (zh) 2008-08-27
AU2004313693A1 (en) 2005-07-28
RU2355690C2 (ru) 2009-05-20
EP1720873B1 (de) 2011-02-23
JP4762155B2 (ja) 2011-08-31
BRPI0418375A (pt) 2007-05-22
AU2004313693B2 (en) 2010-08-26

Similar Documents

Publication Publication Date Title
WO2003080580A3 (en) Quinoline derivatives and their use as 5-ht6 ligands
WO2003106428A8 (fr) Derives d'arylsulfonamides et leur utilisation en tant que antagonistes au recepteur b1 de la bradykinine
BR0209678A (pt) Composto, processo para preparar e uso do mesmo, composição farmacêutica, e, métodos para o tratamento da dor e de distúrbios gastrintestinais funcionais
ATE307810T1 (de) Imidazol-2-carbonsäureamid derivate als raf- kinase-inhibitoren
WO2008111441A1 (ja) 医薬組成物
EA200400466A1 (ru) Производные пиперазина с антагонистической активностью к рецептору ccr1
NO20080877L (no) Fremgangsmater for behandling av substansrelaterte forstyrrelser
WO2008136444A1 (ja) 縮合複素環誘導体
ATE374190T1 (de) Tetrahydrochinazolinderivate als cfr-antagonisten
MXPA04003056A (es) Derivados de 4?piperidin-4-iliden-(3-carbamoilfenil)metil? benzamida y su uso para tratamiento de dolor, lesiones espinales o transtornos gastrointestinales.
AU2003250471A8 (en) Pyrimidine-2,4-dione derivatives as matrix metalloproteinase inhibitors
MX2012008147A (es) Derivados de pirrazolopiridina.
ATE499373T1 (de) Diazaspiropiperidinderivate
BR0209676A (pt) Composto, processo para preparar o mesmo, uso de um composto, composição farmacêutica, e, métodos para o tratamento da dor, de distúrbios gastrintestinais funcionais, e da ansiedade.
BG106806A (bg) Нови съединения
MXPA03010443A (es) Derivados de 4-(fenil-piperidin-4-iliden-metil)-benzamida y su uso para tratar dolor, ansiedad o trastornos gastrointestinales.
WO2006110173A3 (en) Novel compounds
EP1568697A4 (de) 1,3-benzothiazinonderivate, deren herstellungsverfahren und verwendung
MXPA03010437A (es) Derivados de 4-(fenil-piperidin-4-iliden-metil)-benzamida y su uso para tratar dolor, ansiedad o transtornos gastrointestinales.
SE0101769D0 (sv) Novel compounds
BR0209667A (pt) Composto, processo para preparar o mesmo, composição farmacêutica, e, métodos para o tratamento de dor, de distúrbios gastrointestinais funcionais, e de ansiedade
EA200700179A1 (ru) Производные пиррола, их получение и их применение в терапии
SE9904177D0 (sv) Novel compounds
BR0209675A (pt) Composto, processo para preparar o mesmo, uso de um composto, composição farmacêutica, e, métodos para o tratamento da dor, de distúrbios gastrintestinais funcionais, e da ansiedade
SE0101770D0 (sv) Novel compounds

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1720873

Country of ref document: EP