DE60215494D1 - Bicyclische, stickstoffhaltige heterocyclische derivate zur verwendung als antibakterielle mittel - Google Patents
Bicyclische, stickstoffhaltige heterocyclische derivate zur verwendung als antibakterielle mittelInfo
- Publication number
- DE60215494D1 DE60215494D1 DE60215494T DE60215494T DE60215494D1 DE 60215494 D1 DE60215494 D1 DE 60215494D1 DE 60215494 T DE60215494 T DE 60215494T DE 60215494 T DE60215494 T DE 60215494T DE 60215494 D1 DE60215494 D1 DE 60215494D1
- Authority
- DE
- Germany
- Prior art keywords
- bicyclic
- antibacterial agents
- heterocyclic derivatives
- nitrogenic
- nitrogenic heterocyclic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 150000003053 piperidines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0112836.2A GB0112836D0 (en) | 2001-05-25 | 2001-05-25 | Medicaments |
GB0112836 | 2001-05-25 | ||
PCT/EP2002/005709 WO2002096907A1 (en) | 2001-05-25 | 2002-05-24 | Bicyclic nitrogen-containing heterocyclic derivatives for use as antibacterials |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60215494D1 true DE60215494D1 (de) | 2006-11-30 |
DE60215494T2 DE60215494T2 (de) | 2007-03-15 |
Family
ID=9915344
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60215494T Expired - Fee Related DE60215494T2 (de) | 2001-05-25 | 2002-05-24 | Bicyclische, stickstoffhaltige heterocyclische derivate zur verwendung als antibakterielle mittel |
Country Status (8)
Country | Link |
---|---|
US (1) | US7186730B2 (de) |
EP (1) | EP1392686B1 (de) |
JP (1) | JP2004534780A (de) |
AT (1) | ATE342901T1 (de) |
DE (1) | DE60215494T2 (de) |
ES (1) | ES2275006T3 (de) |
GB (1) | GB0112836D0 (de) |
WO (1) | WO2002096907A1 (de) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6803369B1 (en) | 2000-07-25 | 2004-10-12 | Smithkline Beecham Corporation | Compounds and methods for the treatment of neoplastic disease |
WO2002008224A1 (en) | 2000-07-26 | 2002-01-31 | Smithkline Beecham P.L.C. | Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity |
EP1320529B1 (de) * | 2000-09-21 | 2006-05-24 | Smithkline Beecham Plc | Chinolinderivate als antibakterielle mittel |
GB0031088D0 (en) * | 2000-12-20 | 2001-01-31 | Smithkline Beecham Plc | Medicaments |
GB0031086D0 (en) * | 2000-12-20 | 2001-01-31 | Smithkline Beecham Plc | Medicaments |
GB0101577D0 (en) | 2001-01-22 | 2001-03-07 | Smithkline Beecham Plc | Compounds |
GB0112834D0 (en) * | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
GB0112836D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
GB0118238D0 (en) * | 2001-07-26 | 2001-09-19 | Smithkline Beecham Plc | Medicaments |
WO2003064421A1 (en) * | 2002-01-29 | 2003-08-07 | Glaxo Group Limited | Aminopiperidine derivatives |
WO2003064431A2 (en) | 2002-01-29 | 2003-08-07 | Glaxo Group Limited | Aminopiperidine compounds, process for their preparation, and pharmaceutical compositions containing them |
TW200406413A (en) | 2002-06-26 | 2004-05-01 | Glaxo Group Ltd | Compounds |
AR040336A1 (es) | 2002-06-26 | 2005-03-30 | Glaxo Group Ltd | Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto |
ATE461928T1 (de) * | 2002-11-05 | 2010-04-15 | Glaxosmithkline Llc | Antibakterielle wirkstoffe |
JP4654035B2 (ja) | 2002-11-05 | 2011-03-16 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 抗菌剤 |
WO2006038172A1 (en) * | 2004-10-05 | 2006-04-13 | Actelion Pharmaceuticals Ltd | New piperidine antibiotics |
EP1846418A4 (de) | 2005-01-25 | 2009-12-23 | Glaxo Group Ltd | Antibakterielle wirkstoffe |
JP2008528598A (ja) | 2005-01-25 | 2008-07-31 | グラクソ グループ リミテッド | 抗菌剤 |
WO2006081178A2 (en) | 2005-01-25 | 2006-08-03 | Glaxo Group Limited | Antibacterial agents |
US7709472B2 (en) * | 2005-01-25 | 2010-05-04 | Glaxo Group Limited | Antibacterial agents |
US7511035B2 (en) * | 2005-01-25 | 2009-03-31 | Glaxo Group Limited | Antibacterial agents |
MY150958A (en) | 2005-06-16 | 2014-03-31 | Astrazeneca Ab | Compounds for the treatment of multi-drug resistant bacterial infections |
DE602006012535D1 (de) * | 2005-10-21 | 2010-04-08 | Glaxo Group Ltd | Peri-kondensierte tricyclische verbindungen verwendbar als antibakterielle mittel |
ATE465163T1 (de) * | 2005-12-22 | 2010-05-15 | Glaxo Group Ltd | Heterocyclische verbindungen, ihre herstellung und ihre verwendung als antibakterielle mittel |
MX2008010671A (es) * | 2006-02-21 | 2008-10-01 | Amgen Inc | Derivados de cinolina como inhibidores de fosfodiesterasa 10. |
AU2007221049A1 (en) * | 2006-02-28 | 2007-09-07 | Amgen Inc. | Cinnoline and quinazoline derivates as phosphodiesterase 10 inhibitors |
EP1996574A1 (de) * | 2006-03-08 | 2008-12-03 | Amgen Inc. | Chinolin- und isochinolinderivate als phosphodiesterase-10-inhibitoren |
US7709483B2 (en) | 2006-04-06 | 2010-05-04 | Glaxo Group Limited | Pyrrolo-quinoxalinone derivatives as antibacterials |
JP2009532504A (ja) | 2006-04-06 | 2009-09-10 | グラクソ グループ リミテッド | 抗菌薬 |
GB0608263D0 (en) * | 2006-04-26 | 2006-06-07 | Glaxo Group Ltd | Compounds |
KR101409261B1 (ko) | 2006-05-26 | 2014-06-18 | 다이쇼 세이야꾸 가부시끼가이샤 | 신규의 복소환 화합물 또는 그 염 및 그 중간체 |
GB0613208D0 (en) | 2006-07-03 | 2006-08-09 | Glaxo Group Ltd | Compounds |
EP1992628A1 (de) | 2007-05-18 | 2008-11-19 | Glaxo Group Limited | Derivate und Analoge von N-Ethylquinolonen und N-Ethylazaquinolonen |
CL2008001003A1 (es) | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana. |
CL2008001002A1 (es) * | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana. |
KR101567096B1 (ko) * | 2007-04-20 | 2015-11-06 | 글락소 그룹 리미티드 | 항균제로서의 트리시클릭 질소 함유 화합물 |
EP2481735A1 (de) | 2007-05-09 | 2012-08-01 | Pfizer Inc. | Substituierte heterocyclische Derivate und Zusammensetzungen und ihre pharmazeutische Verwendung als antibakterielle Mittel |
MX2010006111A (es) | 2007-12-18 | 2010-06-25 | Actelion Pharmaceuticals Ltd | Derivados de 5-aminociclilmetil-oxazolidin-2-ona y su uso como antibacteriales. |
EP2080761A1 (de) | 2008-01-18 | 2009-07-22 | Glaxo Group Limited | Verbindungen |
JP2011529960A (ja) * | 2008-08-04 | 2011-12-15 | アクテリオン ファーマシューティカルズ リミテッド | 三環式アルキルアミノメチルオキサゾリジノン誘導体 |
WO2010043714A1 (en) | 2008-10-17 | 2010-04-22 | Glaxo Group Limited | Tricyclic nitrogen compounds used as antibacterials |
ES2561631T3 (es) | 2009-01-15 | 2016-02-29 | Glaxo Group Limited | Compuestos de naftiridin-2(1H)-ona útiles como agentes antibacterianos |
AR089929A1 (es) | 2012-02-10 | 2014-10-01 | Actelion Pharmaceuticals Ltd | Proceso para manufacturar un derivado de naftiridina |
EA031589B1 (ru) | 2014-08-22 | 2019-01-31 | Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Трициклические азотсодержащие соединения для лечения инфекции, вызываемой neisseria gonorrhoeae |
UY36851A (es) | 2015-08-16 | 2017-03-31 | Glaxosmithkline Ip Dev Ltd | Compuestos para uso en aplicaciones antibacterianas |
AU2020365108A1 (en) | 2019-10-18 | 2022-04-21 | Atengen, Inc. | 3-phenylsulphonyl-quinoline derivatives as agents for treating pathogenic blood vessels disorders |
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US646144A (en) * | 1899-12-16 | 1900-03-27 | Thomas W Gardiner | Last. |
NL7908031A (nl) * | 1979-11-01 | 1981-06-01 | Acf Chemiefarma Nv | Nieuwe chinolinederivaten en farmaceutische preparaten die een dergelijke verbinding bevatten, alsmede werk- wijze voor het bereiden van deze verbindingen. |
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WO1988007035A1 (en) | 1987-03-11 | 1988-09-22 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Hydroxystyrene derivatives |
JPH0674161B2 (ja) | 1987-12-25 | 1994-09-21 | 株式会社日立製作所 | グリーンシートの製造方法 |
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EP0541486A1 (de) | 1991-11-07 | 1993-05-12 | Ciba-Geigy Ag | Polycyclische Konjugate |
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PL179417B1 (en) | 1993-10-01 | 2000-09-29 | Novartis Ag | Pharmacologically active derivatives of pyridine and methods of obtaining them |
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DK0790997T3 (da) | 1994-11-14 | 2000-08-21 | Warner Lambert Co | 6-Aryl-pyrido[2,3-d]pyrimidiner og napthyridiner til hæmning af protein-tyrosin-kinase-fremkaldt celleproliferation |
EP0823429B1 (de) | 1995-04-26 | 2000-07-12 | Kyowa Hakko Kogyo Co., Ltd. | Derivate des radicicols |
GB9514380D0 (en) | 1995-07-13 | 1995-09-13 | Knoll Ag | Therapeutic agents |
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HRP970371A2 (en) | 1996-07-13 | 1998-08-31 | Kathryn Jane Smith | Heterocyclic compounds |
ID19609A (id) | 1996-07-13 | 1998-07-23 | Glaxo Group Ltd | Senyawa-senyawa heterosiklik |
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AU8673598A (en) | 1997-08-01 | 1999-02-22 | University Of Florida | Neuraminidase inhibitors |
CA2318842A1 (en) | 1998-01-26 | 1999-07-29 | Julie Dorothy Warrack | Quinoline derivatives as antibacterials |
ZA99607B (en) | 1998-01-27 | 1999-07-27 | Rhone Poulenc Rorer Pharma | Substituted oxoazaheterocyclyl factor xa inhibitors. |
US6300341B1 (en) | 1998-09-30 | 2001-10-09 | The Procter & Gamble Co. | 2-substituted heterocyclic sulfonamides |
GB9822440D0 (en) | 1998-10-14 | 1998-12-09 | Smithkline Beecham Plc | Medicaments |
GB9822450D0 (en) | 1998-10-14 | 1998-12-09 | Smithkline Beecham Plc | Medicaments |
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AU2437900A (en) | 1999-01-20 | 2000-08-07 | Smithkline Beecham Plc | Piperidinylquinolines as protein tyrosine kinase inhibitors |
GB9914486D0 (en) | 1999-06-21 | 1999-08-18 | Smithkline Beecham Plc | Medicaments |
GB9915616D0 (en) | 1999-07-05 | 1999-09-01 | Knoll Ag | Therapeutic agents |
GB9917408D0 (en) | 1999-07-23 | 1999-09-22 | Smithkline Beecham Plc | Compounds |
GB9917406D0 (en) | 1999-07-23 | 1999-09-22 | Smithkline Beecham Plc | Compounds |
HUP0203375A3 (en) | 1999-07-28 | 2005-03-29 | Aventis Pharm Prod Inc | Substituted oxoazaheterocyclyl compounds |
SE9902987D0 (sv) | 1999-08-24 | 1999-08-24 | Astra Pharma Prod | Novel compounds |
US6403610B1 (en) | 1999-09-17 | 2002-06-11 | Aventis Pharma S.A. | Quinolylpropylpiperidine derivatives, their preparation and the compositions which comprise them |
FR2798656B1 (fr) | 1999-09-17 | 2004-12-17 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, leur preparation et les compositions qui les contiennent |
KR20020047175A (ko) | 1999-09-17 | 2002-06-21 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | Xa 인자의 억제제 |
WO2001044193A1 (en) | 1999-12-16 | 2001-06-21 | Biostream Therapeutics | 1,3,4-substituted piperidine analogs and uses thereof in treating addictions |
AU779442B2 (en) | 2000-01-20 | 2005-01-27 | Eisai Co. Ltd. | Novel piperidine compounds and drugs containing the same |
KR20030009391A (ko) | 2000-03-17 | 2003-01-29 | 브리스톨-마이어스 스퀴브 파마 컴파니 | 기질 금속단백분해효소 및 TNF-α의 억제제인 시클릭β-아미노산 유도체 |
US20020082268A1 (en) | 2000-03-20 | 2002-06-27 | Yun Gao | Therapeutic compounds for the treatment of asthma and allergy, and methods of use thereof |
WO2001072712A1 (en) | 2000-03-24 | 2001-10-04 | Cor Therapeutics, Inc. | ISOQUINOLONE INHIBITORS OF FACTOR Xa |
GB0011838D0 (en) | 2000-05-17 | 2000-07-05 | Astrazeneca Ab | Chemical compounds |
US6803369B1 (en) | 2000-07-25 | 2004-10-12 | Smithkline Beecham Corporation | Compounds and methods for the treatment of neoplastic disease |
WO2002008224A1 (en) | 2000-07-26 | 2002-01-31 | Smithkline Beecham P.L.C. | Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity |
EP1320529B1 (de) | 2000-09-21 | 2006-05-24 | Smithkline Beecham Plc | Chinolinderivate als antibakterielle mittel |
US6603005B2 (en) | 2000-11-15 | 2003-08-05 | Aventis Pharma S.A. | Heterocyclylalkylpiperidine derivatives, their preparation and compositions containing them |
FR2816618B1 (fr) | 2000-11-15 | 2002-12-27 | Aventis Pharma Sa | Derives heterocyclylalcoyl piperidine, leur preparation et les compositions qui les contiennent |
GB0031086D0 (en) | 2000-12-20 | 2001-01-31 | Smithkline Beecham Plc | Medicaments |
GB0031088D0 (en) | 2000-12-20 | 2001-01-31 | Smithkline Beecham Plc | Medicaments |
GB0101577D0 (en) | 2001-01-22 | 2001-03-07 | Smithkline Beecham Plc | Compounds |
FR2822154B1 (fr) | 2001-03-13 | 2005-10-21 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, leur preparation et les compositions qui les contiennent |
US6602884B2 (en) | 2001-03-13 | 2003-08-05 | Aventis Pharma S.A. | Quinolylpropylpiperidine derivatives, their preparation, and compositions containing them |
GB0112834D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
GB0112836D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
US20030203917A1 (en) | 2001-07-25 | 2003-10-30 | Smithkline Beecham Corporation And Smithkline Beecham P.L.C. | Compounds and methods for the treatment of neoplastic disease |
GB0118238D0 (en) | 2001-07-26 | 2001-09-19 | Smithkline Beecham Plc | Medicaments |
KR100395092B1 (ko) * | 2001-07-27 | 2003-08-21 | 삼성전기주식회사 | 무선랜 어댑터 |
WO2003064421A1 (en) | 2002-01-29 | 2003-08-07 | Glaxo Group Limited | Aminopiperidine derivatives |
WO2003064431A2 (en) | 2002-01-29 | 2003-08-07 | Glaxo Group Limited | Aminopiperidine compounds, process for their preparation, and pharmaceutical compositions containing them |
-
2001
- 2001-05-25 GB GBGB0112836.2A patent/GB0112836D0/en not_active Ceased
-
2002
- 2002-05-24 US US10/477,900 patent/US7186730B2/en not_active Expired - Fee Related
- 2002-05-24 EP EP02774022A patent/EP1392686B1/de not_active Expired - Lifetime
- 2002-05-24 AT AT02774022T patent/ATE342901T1/de not_active IP Right Cessation
- 2002-05-24 WO PCT/EP2002/005709 patent/WO2002096907A1/en active IP Right Grant
- 2002-05-24 DE DE60215494T patent/DE60215494T2/de not_active Expired - Fee Related
- 2002-05-24 JP JP2003500086A patent/JP2004534780A/ja active Pending
- 2002-05-24 ES ES02774022T patent/ES2275006T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
WO2002096907A1 (en) | 2002-12-05 |
JP2004534780A (ja) | 2004-11-18 |
ATE342901T1 (de) | 2006-11-15 |
EP1392686A1 (de) | 2004-03-03 |
DE60215494T2 (de) | 2007-03-15 |
US7186730B2 (en) | 2007-03-06 |
EP1392686B1 (de) | 2006-10-18 |
GB0112836D0 (en) | 2001-07-18 |
US20040198755A1 (en) | 2004-10-07 |
ES2275006T3 (es) | 2007-06-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |