PE20001112A1 - Derivados de quinolina como agentes antibacterianos - Google Patents
Derivados de quinolina como agentes antibacterianosInfo
- Publication number
- PE20001112A1 PE20001112A1 PE1999001028A PE00102899A PE20001112A1 PE 20001112 A1 PE20001112 A1 PE 20001112A1 PE 1999001028 A PE1999001028 A PE 1999001028A PE 00102899 A PE00102899 A PE 00102899A PE 20001112 A1 PE20001112 A1 PE 20001112A1
- Authority
- PE
- Peru
- Prior art keywords
- antibacterial agents
- quinoline derivatives
- derivatives
- quinoline
- mammals
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Abstract
SE REFIERE A UN DERIVADOS DE QUINOLINA DE FORMULA I; UNO DE Z1, Z2, Z3, Z4 Y Z5 ES N o CR1a Y EL RESTO ES CH; R1 ES OH, ALCOXI C1-C6 OPCIONALMENTE SUSTITUIDO POR ALCOXI C1-C6, AMINO, PIPERIDILO, GUANIDINO O AMIDINO; O UNO DE Z1, Z2, Z3, Z4 Y Z5 ES N, R1 ES H; R1a ES H, R1; R2 ES H; R3 ESTA EN LA POSICION 2 o 3, ES H, ALQUILO C1-C6, ALQUENILO C2-C6 OPCIONALMENTE SUSTITUIDO CON 1-3 TIOL, HALOGENO, ALQUILTIO, ENTRE OTROS; O SI R3 ESTA EN POSICION 2, R3 Y R4 FORMAN UN ALQUILENO C3-C5 OPCIONALMENTE SUSTITUIDO; O SI R3 ESTA EN LA POSICION 3, R2 Y R3 FORMAN =CR5R6; R5 Y R6 SON H, ALQUILO C1-C6, ALQUENILO C2-C6, ARILALQUILO C1-C6, ARILALQUENILENO C2-C6; R4 ES -CH2-R5; n ES 0-2; A ES NHCONH, NHCOO. SON COMPUESTOS PREFERIDOS 1-AZA-8-(AX)-[(6-METOXIQUINOLIN-4-IL)AMINOCARBONILOXI]-3-(AX)-n-PENTIL-BICICLO[4.4.0]DECANO, 1-AZA-8-(AX)-[(6-METOXIQUINOLIN-4-IL)-AMINOCARBONILOXI]-3-(EQ)-n-PENTIL-BICICLO[4.4.0]DECANO, ENTRE ORTOS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I PUEDE SER UTIL PARA EL TRATAMIENTO DE INFECCIONES
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9822440.5A GB9822440D0 (en) | 1998-10-14 | 1998-10-14 | Medicaments |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20001112A1 true PE20001112A1 (es) | 2000-10-14 |
Family
ID=10840577
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1999001028A PE20001112A1 (es) | 1998-10-14 | 1999-10-12 | Derivados de quinolina como agentes antibacterianos |
Country Status (11)
Country | Link |
---|---|
US (1) | US6602882B1 (es) |
EP (1) | EP1121355B1 (es) |
JP (1) | JP2002527434A (es) |
AT (1) | ATE312831T1 (es) |
AU (1) | AU6339599A (es) |
DE (1) | DE69928952T2 (es) |
ES (1) | ES2255306T3 (es) |
GB (1) | GB9822440D0 (es) |
MA (1) | MA25009A1 (es) |
PE (1) | PE20001112A1 (es) |
WO (1) | WO2000021952A1 (es) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1015445B1 (en) | 1997-09-15 | 2009-02-25 | The Procter & Gamble Company | Antimicrobial quinolones, their compositions and uses |
GB9822450D0 (en) * | 1998-10-14 | 1998-12-09 | Smithkline Beecham Plc | Medicaments |
GB9914486D0 (en) * | 1999-06-21 | 1999-08-18 | Smithkline Beecham Plc | Medicaments |
GB9917408D0 (en) * | 1999-07-23 | 1999-09-22 | Smithkline Beecham Plc | Compounds |
GB9917406D0 (en) | 1999-07-23 | 1999-09-22 | Smithkline Beecham Plc | Compounds |
SE9902987D0 (sv) | 1999-08-24 | 1999-08-24 | Astra Pharma Prod | Novel compounds |
US6803369B1 (en) | 2000-07-25 | 2004-10-12 | Smithkline Beecham Corporation | Compounds and methods for the treatment of neoplastic disease |
KR20030019621A (ko) * | 2000-07-26 | 2003-03-06 | 스미스클라인비이참피이엘시이 | 항균 활성을 갖는 아미노피페리딘 퀴놀린 및 그의아자이소스테릭 유사체 |
EP1320529B1 (en) * | 2000-09-21 | 2006-05-24 | Smithkline Beecham Plc | Quinoline derivatives as antibacterials |
GB0031086D0 (en) * | 2000-12-20 | 2001-01-31 | Smithkline Beecham Plc | Medicaments |
GB0031088D0 (en) * | 2000-12-20 | 2001-01-31 | Smithkline Beecham Plc | Medicaments |
GB0101577D0 (en) * | 2001-01-22 | 2001-03-07 | Smithkline Beecham Plc | Compounds |
GB0104050D0 (en) | 2001-02-19 | 2001-04-04 | Astrazeneca Ab | Chemical compounds |
GB0107228D0 (en) | 2001-03-22 | 2001-05-16 | Astrazeneca Ab | Chemical compounds |
GB0112836D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
GB0112834D0 (en) * | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
GB0118238D0 (en) * | 2001-07-26 | 2001-09-19 | Smithkline Beecham Plc | Medicaments |
US20050119302A1 (en) * | 2001-10-30 | 2005-06-02 | Rahme Laurence G. | Methods for the prevention or treament of bacterial and fungal infections |
SE0103818D0 (sv) | 2001-11-15 | 2001-11-15 | Astrazeneca Ab | Chemical compounds |
AR038240A1 (es) | 2002-01-29 | 2005-01-05 | Glaxo Group Ltd | Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para su preparacion |
JP4508650B2 (ja) * | 2002-01-29 | 2010-07-21 | グラクソ グループ リミテッド | アミノピペリジン化合物、当該化合物の製法および当該化合物を含有する医薬組成物 |
AR040336A1 (es) * | 2002-06-26 | 2005-03-30 | Glaxo Group Ltd | Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto |
TW200406413A (en) * | 2002-06-26 | 2004-05-01 | Glaxo Group Ltd | Compounds |
US6900224B2 (en) | 2002-07-31 | 2005-05-31 | The Procter & Gamble Company | Antimicrobial quinolones, their compositions and uses |
JP4704755B2 (ja) * | 2002-11-05 | 2011-06-22 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 抗菌剤 |
ATE479683T1 (de) | 2002-11-05 | 2010-09-15 | Glaxo Group Ltd | Antibakterielle mittel |
ES2312839T3 (es) * | 2002-12-04 | 2009-03-01 | Glaxo Group Limited | Quinolinas y sus derivados nitrogenados y su uso como agentes antibacterianos. |
AR042486A1 (es) * | 2002-12-18 | 2005-06-22 | Glaxo Group Ltd | Compuesto de quinolina y naftiridina halosustituido en la posicion 3, procedimiento para preparar el compuesto, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion . |
WO2004078749A1 (en) * | 2003-03-06 | 2004-09-16 | Glaxo Group Limited | Heterocyclic urea derivatives for the treatment of pain |
WO2004078744A2 (en) * | 2003-03-07 | 2004-09-16 | Glaxo Group Limited | Urea derivatives and their use as vanilloid receptor antagonists in the treatment of pain |
GB0305426D0 (en) * | 2003-03-08 | 2003-04-16 | Glaxo Group Ltd | Novel compounds |
FR2867472B1 (fr) * | 2004-03-12 | 2008-07-18 | Aventis Pharma Sa | Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent |
EP1773831A1 (en) * | 2004-07-08 | 2007-04-18 | Glaxo Group Limited | Antibacterial agents |
EP1846416A4 (en) | 2005-01-25 | 2009-07-01 | Glaxo Group Ltd | ANTIBACTERIAL AGENTS |
US7709472B2 (en) | 2005-01-25 | 2010-05-04 | Glaxo Group Limited | Antibacterial agents |
EP1846418A4 (en) | 2005-01-25 | 2009-12-23 | Glaxo Group Ltd | ANTIBACTERIAL ACTIVE SUBSTANCES |
WO2006081264A1 (en) | 2005-01-25 | 2006-08-03 | Glaxo Group Limited | Antibacterial agents |
EP1846411A4 (en) * | 2005-01-25 | 2010-08-04 | Glaxo Group Ltd | ANTIBACTERIAL ACTIVE SUBSTANCES |
AU2006230364B2 (en) | 2005-03-31 | 2012-09-13 | Janssen Pharmaceutica N.V. | Bicyclic pyrazole compounds as antibacterial agents |
MY150958A (en) | 2005-06-16 | 2014-03-31 | Astrazeneca Ab | Compounds for the treatment of multi-drug resistant bacterial infections |
CA2635126A1 (en) | 2006-01-26 | 2007-08-02 | Actelion Pharmaceuticals Ltd | Tetrahydropyrane antibiotics |
SMP200800058B (it) | 2006-03-28 | 2009-09-07 | Procter & Gamble | Sali e polimorfi malati di un acido (3s, 5s) -7- [3-ammino-5-metilpiperidinil]-1-ciclopropil-1,4-diidro-8-metossi-4-osso-3-chinolincarbossilico |
US7456279B2 (en) | 2006-03-28 | 2008-11-25 | The Procter & Gamble Company | Coupling process for preparing quinolone intermediates |
EP2481735A1 (en) * | 2007-05-09 | 2012-08-01 | Pfizer Inc. | Substituted heterocyclic derivatives and compositions and their pharmaceutical use as antibacterials |
EP2332939A1 (en) | 2009-11-26 | 2011-06-15 | Æterna Zentaris GmbH | Novel Naphthyridine derivatives and the use thereof as kinase inhibitors |
WO2020169593A1 (en) | 2019-02-19 | 2020-08-27 | Univerza V Ljubljani | Antibacterials based on monocyclic fragments coupled to aminopiperidine naphthyridine scaffold |
JP2022552019A (ja) | 2019-10-18 | 2022-12-14 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 病的血管障害の治療のための作用物質としての3-フェニルスルホニル-キノリン誘導体 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4418299Y1 (es) | 1965-01-16 | 1969-08-07 | ||
US4472404A (en) | 1982-08-16 | 1984-09-18 | The Dow Chemical Company | 8-Quinolinyl carbamates and their use as urinary tract antimicrobials |
EP0387510A1 (de) | 1989-02-10 | 1990-09-19 | Bayer Ag | Substituierte 8-Carbamoyloxychinolin-Derivate, Verfahren zu deren Herstellung, sowie deren Verwendung zur Bekämpfung von Schädlingen |
JPH0495071A (ja) | 1990-08-10 | 1992-03-27 | Kyorin Pharmaceut Co Ltd | カルバミン酸誘導体 |
JP3169188B2 (ja) * | 1991-01-31 | 2001-05-21 | 杏林製薬株式会社 | カルバミン酸誘導体及びその製造方法 |
WO1994014801A1 (en) | 1992-12-29 | 1994-07-07 | Smithkline Beecham Plc | Heterocyclic urea derivatives as 5ht2c and 5ht2b antagonists |
EP1304329B1 (en) * | 1995-02-02 | 2008-10-15 | Daiichi Sankyo Company, Limited | Pyridonecarboxylic acid derivatives and their use as antibacterial agents |
WO1997014681A1 (en) | 1995-10-16 | 1997-04-24 | Fujisawa Pharmaceutical Co., Ltd. | Heterocyclic compounds as h+-atpases |
JP3933244B2 (ja) | 1997-04-04 | 2007-06-20 | 株式会社資生堂 | アルキレンジアミン誘導体及び抗潰瘍剤、抗菌剤 |
WO1999037635A1 (en) * | 1998-01-26 | 1999-07-29 | Smithkline Beecham Plc | Quinoline derivatives as antibacterials |
FR2798656B1 (fr) | 1999-09-17 | 2004-12-17 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, leur preparation et les compositions qui les contiennent |
-
1998
- 1998-10-14 GB GBGB9822440.5A patent/GB9822440D0/en not_active Ceased
-
1999
- 1999-10-11 WO PCT/EP1999/007766 patent/WO2000021952A1/en active IP Right Grant
- 1999-10-11 AU AU63395/99A patent/AU6339599A/en not_active Abandoned
- 1999-10-11 AT AT99950730T patent/ATE312831T1/de not_active IP Right Cessation
- 1999-10-11 DE DE69928952T patent/DE69928952T2/de not_active Expired - Fee Related
- 1999-10-11 ES ES99950730T patent/ES2255306T3/es not_active Expired - Lifetime
- 1999-10-11 US US09/807,341 patent/US6602882B1/en not_active Expired - Fee Related
- 1999-10-11 EP EP99950730A patent/EP1121355B1/en not_active Expired - Lifetime
- 1999-10-11 JP JP2000575858A patent/JP2002527434A/ja active Pending
- 1999-10-12 PE PE1999001028A patent/PE20001112A1/es not_active Application Discontinuation
- 1999-10-12 MA MA25816A patent/MA25009A1/fr unknown
Also Published As
Publication number | Publication date |
---|---|
DE69928952D1 (de) | 2006-01-19 |
DE69928952T2 (de) | 2007-01-11 |
EP1121355A1 (en) | 2001-08-08 |
WO2000021952A1 (en) | 2000-04-20 |
GB9822440D0 (en) | 1998-12-09 |
ATE312831T1 (de) | 2005-12-15 |
JP2002527434A (ja) | 2002-08-27 |
EP1121355B1 (en) | 2005-12-14 |
US6602882B1 (en) | 2003-08-05 |
ES2255306T3 (es) | 2006-06-16 |
MA25009A1 (fr) | 2000-07-01 |
AU6339599A (en) | 2000-05-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Refusal |