PE20001112A1 - Derivados de quinolina como agentes antibacterianos - Google Patents

Derivados de quinolina como agentes antibacterianos

Info

Publication number
PE20001112A1
PE20001112A1 PE1999001028A PE00102899A PE20001112A1 PE 20001112 A1 PE20001112 A1 PE 20001112A1 PE 1999001028 A PE1999001028 A PE 1999001028A PE 00102899 A PE00102899 A PE 00102899A PE 20001112 A1 PE20001112 A1 PE 20001112A1
Authority
PE
Peru
Prior art keywords
antibacterial agents
quinoline derivatives
derivatives
quinoline
mammals
Prior art date
Application number
PE1999001028A
Other languages
English (en)
Inventor
Roger Edward Markwell
Neil David Pearson
Andrew Kenneth Takle
David Thomas Davies
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of PE20001112A1 publication Critical patent/PE20001112A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)

Abstract

SE REFIERE A UN DERIVADOS DE QUINOLINA DE FORMULA I; UNO DE Z1, Z2, Z3, Z4 Y Z5 ES N o CR1a Y EL RESTO ES CH; R1 ES OH, ALCOXI C1-C6 OPCIONALMENTE SUSTITUIDO POR ALCOXI C1-C6, AMINO, PIPERIDILO, GUANIDINO O AMIDINO; O UNO DE Z1, Z2, Z3, Z4 Y Z5 ES N, R1 ES H; R1a ES H, R1; R2 ES H; R3 ESTA EN LA POSICION 2 o 3, ES H, ALQUILO C1-C6, ALQUENILO C2-C6 OPCIONALMENTE SUSTITUIDO CON 1-3 TIOL, HALOGENO, ALQUILTIO, ENTRE OTROS; O SI R3 ESTA EN POSICION 2, R3 Y R4 FORMAN UN ALQUILENO C3-C5 OPCIONALMENTE SUSTITUIDO; O SI R3 ESTA EN LA POSICION 3, R2 Y R3 FORMAN =CR5R6; R5 Y R6 SON H, ALQUILO C1-C6, ALQUENILO C2-C6, ARILALQUILO C1-C6, ARILALQUENILENO C2-C6; R4 ES -CH2-R5; n ES 0-2; A ES NHCONH, NHCOO. SON COMPUESTOS PREFERIDOS 1-AZA-8-(AX)-[(6-METOXIQUINOLIN-4-IL)AMINOCARBONILOXI]-3-(AX)-n-PENTIL-BICICLO[4.4.0]DECANO, 1-AZA-8-(AX)-[(6-METOXIQUINOLIN-4-IL)-AMINOCARBONILOXI]-3-(EQ)-n-PENTIL-BICICLO[4.4.0]DECANO, ENTRE ORTOS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I PUEDE SER UTIL PARA EL TRATAMIENTO DE INFECCIONES
PE1999001028A 1998-10-14 1999-10-12 Derivados de quinolina como agentes antibacterianos PE20001112A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9822440.5A GB9822440D0 (en) 1998-10-14 1998-10-14 Medicaments

Publications (1)

Publication Number Publication Date
PE20001112A1 true PE20001112A1 (es) 2000-10-14

Family

ID=10840577

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999001028A PE20001112A1 (es) 1998-10-14 1999-10-12 Derivados de quinolina como agentes antibacterianos

Country Status (11)

Country Link
US (1) US6602882B1 (es)
EP (1) EP1121355B1 (es)
JP (1) JP2002527434A (es)
AT (1) ATE312831T1 (es)
AU (1) AU6339599A (es)
DE (1) DE69928952T2 (es)
ES (1) ES2255306T3 (es)
GB (1) GB9822440D0 (es)
MA (1) MA25009A1 (es)
PE (1) PE20001112A1 (es)
WO (1) WO2000021952A1 (es)

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EP1320529B1 (en) * 2000-09-21 2006-05-24 Smithkline Beecham Plc Quinoline derivatives as antibacterials
GB0031086D0 (en) * 2000-12-20 2001-01-31 Smithkline Beecham Plc Medicaments
GB0031088D0 (en) * 2000-12-20 2001-01-31 Smithkline Beecham Plc Medicaments
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TW200406413A (en) * 2002-06-26 2004-05-01 Glaxo Group Ltd Compounds
US6900224B2 (en) 2002-07-31 2005-05-31 The Procter & Gamble Company Antimicrobial quinolones, their compositions and uses
JP4704755B2 (ja) * 2002-11-05 2011-06-22 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー 抗菌剤
ATE479683T1 (de) 2002-11-05 2010-09-15 Glaxo Group Ltd Antibakterielle mittel
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AR042486A1 (es) * 2002-12-18 2005-06-22 Glaxo Group Ltd Compuesto de quinolina y naftiridina halosustituido en la posicion 3, procedimiento para preparar el compuesto, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion .
WO2004078749A1 (en) * 2003-03-06 2004-09-16 Glaxo Group Limited Heterocyclic urea derivatives for the treatment of pain
WO2004078744A2 (en) * 2003-03-07 2004-09-16 Glaxo Group Limited Urea derivatives and their use as vanilloid receptor antagonists in the treatment of pain
GB0305426D0 (en) * 2003-03-08 2003-04-16 Glaxo Group Ltd Novel compounds
FR2867472B1 (fr) * 2004-03-12 2008-07-18 Aventis Pharma Sa Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent
EP1773831A1 (en) * 2004-07-08 2007-04-18 Glaxo Group Limited Antibacterial agents
EP1846416A4 (en) 2005-01-25 2009-07-01 Glaxo Group Ltd ANTIBACTERIAL AGENTS
US7709472B2 (en) 2005-01-25 2010-05-04 Glaxo Group Limited Antibacterial agents
EP1846418A4 (en) 2005-01-25 2009-12-23 Glaxo Group Ltd ANTIBACTERIAL ACTIVE SUBSTANCES
WO2006081264A1 (en) 2005-01-25 2006-08-03 Glaxo Group Limited Antibacterial agents
EP1846411A4 (en) * 2005-01-25 2010-08-04 Glaxo Group Ltd ANTIBACTERIAL ACTIVE SUBSTANCES
AU2006230364B2 (en) 2005-03-31 2012-09-13 Janssen Pharmaceutica N.V. Bicyclic pyrazole compounds as antibacterial agents
MY150958A (en) 2005-06-16 2014-03-31 Astrazeneca Ab Compounds for the treatment of multi-drug resistant bacterial infections
CA2635126A1 (en) 2006-01-26 2007-08-02 Actelion Pharmaceuticals Ltd Tetrahydropyrane antibiotics
SMP200800058B (it) 2006-03-28 2009-09-07 Procter & Gamble Sali e polimorfi malati di un acido (3s, 5s) -7- [3-ammino-5-metilpiperidinil]-1-ciclopropil-1,4-diidro-8-metossi-4-osso-3-chinolincarbossilico
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Also Published As

Publication number Publication date
DE69928952D1 (de) 2006-01-19
DE69928952T2 (de) 2007-01-11
EP1121355A1 (en) 2001-08-08
WO2000021952A1 (en) 2000-04-20
GB9822440D0 (en) 1998-12-09
ATE312831T1 (de) 2005-12-15
JP2002527434A (ja) 2002-08-27
EP1121355B1 (en) 2005-12-14
US6602882B1 (en) 2003-08-05
ES2255306T3 (es) 2006-06-16
MA25009A1 (fr) 2000-07-01
AU6339599A (en) 2000-05-01

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