ATE375334T1 - Harnstoff derivate als entzündungshemmende mittel - Google Patents
Harnstoff derivate als entzündungshemmende mittelInfo
- Publication number
- ATE375334T1 ATE375334T1 AT00978751T AT00978751T ATE375334T1 AT E375334 T1 ATE375334 T1 AT E375334T1 AT 00978751 T AT00978751 T AT 00978751T AT 00978751 T AT00978751 T AT 00978751T AT E375334 T1 ATE375334 T1 AT E375334T1
- Authority
- AT
- Austria
- Prior art keywords
- inflammatory agents
- urea derivatives
- compounds
- disclosed
- useful
- Prior art date
Links
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical class NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 title 1
- 229940121363 anti-inflammatory agent Drugs 0.000 title 1
- 239000002260 anti-inflammatory agent Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 150000001491 aromatic compounds Chemical class 0.000 abstract 1
- 208000037976 chronic inflammation Diseases 0.000 abstract 1
- 208000037893 chronic inflammatory disorder Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
Classifications
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- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
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- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
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- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
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- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
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- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
- C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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-
2000
- 2000-11-16 EP EP00978751A patent/EP1232150B1/de not_active Expired - Lifetime
- 2000-11-16 MX MXPA02004879A patent/MXPA02004879A/es unknown
- 2000-11-16 DE DE60036726T patent/DE60036726T2/de not_active Expired - Lifetime
- 2000-11-16 JP JP2001538892A patent/JP4955171B2/ja not_active Expired - Lifetime
- 2000-11-16 MX MXPA02004594A patent/MXPA02004594A/es active IP Right Grant
- 2000-11-16 AU AU16179/01A patent/AU1617901A/en not_active Abandoned
- 2000-11-16 US US09/714,539 patent/US6492393B1/en not_active Expired - Lifetime
- 2000-11-16 ES ES00978751T patent/ES2292488T3/es not_active Expired - Lifetime
- 2000-11-16 AT AT00978751T patent/ATE375334T1/de active
- 2000-11-16 WO PCT/US2000/031582 patent/WO2001036403A1/en not_active Ceased
- 2000-11-16 CA CA002389360A patent/CA2389360C/en not_active Expired - Lifetime
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2002
- 2002-10-15 US US10/271,301 patent/US7241758B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2389360A1 (en) | 2001-05-25 |
| JP4955171B2 (ja) | 2012-06-20 |
| US6492393B1 (en) | 2002-12-10 |
| US7241758B2 (en) | 2007-07-10 |
| DE60036726D1 (de) | 2007-11-22 |
| MXPA02004879A (es) | 2002-08-30 |
| US20030125354A1 (en) | 2003-07-03 |
| WO2001036403A1 (en) | 2001-05-25 |
| MXPA02004594A (es) | 2002-10-23 |
| ES2292488T3 (es) | 2008-03-16 |
| EP1232150A1 (de) | 2002-08-21 |
| CA2389360C (en) | 2008-06-03 |
| AU1617901A (en) | 2001-05-30 |
| DE60036726T2 (de) | 2008-02-07 |
| EP1232150B1 (de) | 2007-10-10 |
| JP2003514808A (ja) | 2003-04-22 |
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