NO327896B1 - Tricykliske benzodiazepiner, farmasoytisk sammensetning, anvendelse av forbindelsene samt mellomprodukter som er nyttige ved syntese av forbindelsene - Google Patents
Tricykliske benzodiazepiner, farmasoytisk sammensetning, anvendelse av forbindelsene samt mellomprodukter som er nyttige ved syntese av forbindelsene Download PDFInfo
- Publication number
- NO327896B1 NO327896B1 NO20013515A NO20013515A NO327896B1 NO 327896 B1 NO327896 B1 NO 327896B1 NO 20013515 A NO20013515 A NO 20013515A NO 20013515 A NO20013515 A NO 20013515A NO 327896 B1 NO327896 B1 NO 327896B1
- Authority
- NO
- Norway
- Prior art keywords
- phenyl
- benzodiazepine
- benzamide
- tetrahydro
- ylcarbonyl
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11635899P | 1999-01-19 | 1999-01-19 | |
| US46865099A | 1999-12-21 | 1999-12-21 | |
| PCT/US1999/030423 WO2000043398A2 (en) | 1999-01-19 | 1999-12-21 | Tricyclic benzodiazepines as vasopressin receptor antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20013515D0 NO20013515D0 (no) | 2001-07-16 |
| NO20013515L NO20013515L (no) | 2001-09-17 |
| NO327896B1 true NO327896B1 (no) | 2009-10-12 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20013515A NO327896B1 (no) | 1999-01-19 | 2001-07-16 | Tricykliske benzodiazepiner, farmasoytisk sammensetning, anvendelse av forbindelsene samt mellomprodukter som er nyttige ved syntese av forbindelsene |
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| EP (1) | EP1147115B3 (pt) |
| KR (1) | KR100771184B1 (pt) |
| CN (1) | CN1174986C (pt) |
| AR (1) | AR035837A1 (pt) |
| AT (1) | ATE249465T1 (pt) |
| AU (1) | AU772397B2 (pt) |
| BR (1) | BRPI9917086B8 (pt) |
| CA (1) | CA2360767C (pt) |
| CZ (1) | CZ302647B6 (pt) |
| DE (2) | DE69911259T4 (pt) |
| DK (1) | DK1147115T5 (pt) |
| ES (1) | ES2207333T7 (pt) |
| HK (1) | HK1038361B (pt) |
| HU (1) | HU229074B1 (pt) |
| IL (2) | IL144270A0 (pt) |
| ME (1) | ME00129B (pt) |
| MY (1) | MY128065A (pt) |
| NO (1) | NO327896B1 (pt) |
| NZ (1) | NZ512960A (pt) |
| PL (1) | PL205704B1 (pt) |
| PT (1) | PT1147115E (pt) |
| RS (1) | RS50820B (pt) |
| TR (1) | TR200102069T2 (pt) |
| TW (1) | TWI289564B (pt) |
| UA (1) | UA70984C2 (pt) |
| WO (1) | WO2000043398A2 (pt) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69911259T4 (de) * | 1999-01-19 | 2009-07-09 | Ortho-Mcneil Pharmaceutical, Inc. | Tricyclische benzodiazepine als vasopressin antagonisten |
| CA2357833C (en) * | 2000-10-04 | 2005-11-15 | Warner-Lambert Company | Treatment of pulmonary hypertension using vasopressin antagonist |
| CA2443870A1 (en) | 2001-04-12 | 2002-10-24 | Wyeth | Cyclohexylphenyl vasopressin agonists |
| JP2004530668A (ja) | 2001-04-12 | 2004-10-07 | ワイス | バソプレッシンアゴニストとしてのｎ−ビフェニルカルボニル−およびｎ−フェニルピリジルカルボニル置換二および三環アゼピンおよびジアゼピン |
| HUP0401722A3 (en) * | 2001-10-29 | 2008-07-28 | Ortho Mcneil Pharm Inc | Benzo[e][1,4]diazepine derivatives condensed with bridged bicycle, their preparation and their use as vasopressin receptor antagonists |
| EP1364968A1 (en) * | 2002-05-23 | 2003-11-26 | Bayer Aktiengesellschaft | Diagnostics and therapeutics for diseases associated with arginine vasopressin receptor 1 (AVPR1) |
| US7119088B2 (en) | 2003-02-19 | 2006-10-10 | Pfizer Inc. | Triazole compounds useful in therapy |
| GB0303852D0 (en) * | 2003-02-19 | 2003-03-26 | Pfizer Ltd | Triazole compounds useful in therapy |
| EP1597260B1 (en) * | 2003-02-19 | 2006-12-27 | Pfizer Limited | Triazole compounds useful in therapy |
| US7763605B2 (en) | 2004-10-28 | 2010-07-27 | Janssen Pharmaceutica, N.V. | [1,4]benzodiazepines as vasopressin V2 receptor antagonists |
| DE102005003632A1 (de) | 2005-01-20 | 2006-08-17 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Katheter für die transvaskuläre Implantation von Herzklappenprothesen |
| US20070213813A1 (en) | 2005-12-22 | 2007-09-13 | Symetis Sa | Stent-valves for valve replacement and associated methods and systems for surgery |
| US20090318412A1 (en) * | 2006-07-11 | 2009-12-24 | Takahiro Matsumoto | Tricyclic heterocyclic compound and use thereof |
| US7896915B2 (en) | 2007-04-13 | 2011-03-01 | Jenavalve Technology, Inc. | Medical device for treating a heart valve insufficiency |
| ES2903231T3 (es) | 2008-02-26 | 2022-03-31 | Jenavalve Tech Inc | Stent para el posicionamiento y anclaje de una prótesis valvular en un sitio de implantación en el corazón de un paciente |
| US9044318B2 (en) | 2008-02-26 | 2015-06-02 | Jenavalve Technology Gmbh | Stent for the positioning and anchoring of a valvular prosthesis |
| PT2356123E (pt) * | 2008-11-13 | 2012-10-31 | Hoffmann La Roche | Espiro-5,6-di-hidro-4h-2,3,5,10b-tetra-azabenzo[ e]azulenos |
| ES2391374T3 (es) * | 2008-11-18 | 2012-11-23 | F. Hoffmann-La Roche Ag | Alquilciclohexiléteres de dihidrotetraazabenzoazulenos |
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| US3732212A (en) | 1970-04-20 | 1973-05-08 | Sterling Drug Inc | 1,2,3,10,11,11a-hexahydro-5h-pyrrolo(2,1-c)(1,4)benzodiazepine-5,11-diones |
| US3860600A (en) | 1972-07-10 | 1975-01-14 | Sterling Drug Inc | Octahydropyrrido{8 2,1-c{9 {8 1,4{9 benzodiazepines |
| US3763183A (en) * | 1972-07-10 | 1973-10-02 | Sterling Drug Inc | 1,2,3,10,11,11a-hexahydro-5h-pyrrolo (2,1-c)(1,4)benzodiazepines |
| US5516774A (en) * | 1993-07-29 | 1996-05-14 | American Cyanamid Company | Tricyclic diazepine vasopressin antagonists and oxytocin antagonists |
| US5521173A (en) * | 1995-01-17 | 1996-05-28 | American Home Products Corporation | Tricyclic benzazepine vasopressin antagonists |
| EP0987266A4 (en) | 1997-03-31 | 2000-07-26 | Wakamoto Pharma Co Ltd | BIPHENYL DERIVATIVES AND MEDICAL PREPARATIONS |
| CN1183134C (zh) * | 1997-07-30 | 2005-01-05 | 惠氏公司 | 三环后叶加压素激动剂 |
| DE69911259T4 (de) * | 1999-01-19 | 2009-07-09 | Ortho-Mcneil Pharmaceutical, Inc. | Tricyclische benzodiazepine als vasopressin antagonisten |
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1999
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- 1999-12-21 UA UA2001075136A patent/UA70984C2/uk unknown
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- 1999-12-21 DE DE69911259A patent/DE69911259D1/de not_active Expired - Lifetime
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- 1999-12-21 AT AT99966495T patent/ATE249465T1/de active
- 1999-12-21 DK DK99966495T patent/DK1147115T5/da active
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