ITRM20000570A0 - Derivati triciclici dell'indolo ad attivita' antiagiogenica. - Google Patents
Derivati triciclici dell'indolo ad attivita' antiagiogenica.Info
- Publication number
- ITRM20000570A0 ITRM20000570A0 IT2000RM000570A ITRM20000570A ITRM20000570A0 IT RM20000570 A0 ITRM20000570 A0 IT RM20000570A0 IT 2000RM000570 A IT2000RM000570 A IT 2000RM000570A IT RM20000570 A ITRM20000570 A IT RM20000570A IT RM20000570 A0 ITRM20000570 A0 IT RM20000570A0
- Authority
- IT
- Italy
- Prior art keywords
- antiagiogenic
- indel
- tricyclic
- derivatives
- activity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Priority Applications (21)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2000RM000570A IT1317926B1 (it) | 2000-11-03 | 2000-11-03 | Derivati triciclici dell'indolo ad attivita' antiangiogenica. |
KR10-2003-7005651A KR20030042030A (ko) | 2000-11-03 | 2001-10-16 | 혈관형성 억제 활성을 갖는 인돌의 트리사이클릭 유도체 |
ES01983768T ES2247182T3 (es) | 2000-11-03 | 2001-10-16 | Derivados triciclicos de indol con actividad antigiogenica. |
CNB018181996A CN1247589C (zh) | 2000-11-03 | 2001-10-16 | 具有抗血管生成活性的吲哚的三环衍生物 |
HU0400546A HUP0400546A3 (en) | 2000-11-03 | 2001-10-16 | Tricyclic derivatives of indole with antiangiogenic activity and pharmaceutical compositions containing them |
AT01983768T ATE302780T1 (de) | 2000-11-03 | 2001-10-16 | Trizyklische indolderivate mit antiangiogenischer wirkung |
DE60112966T DE60112966T2 (de) | 2000-11-03 | 2001-10-16 | Trizyklische indolderivate mit antiangiogenischer wirkung |
DK01983768T DK1343789T3 (da) | 2000-11-03 | 2001-10-16 | Tricykliske derivater af indol med antiangiogen aktivitet |
CA002427568A CA2427568A1 (en) | 2000-11-03 | 2001-10-16 | Tricyclic derivatives of indole with antiangiogenic activity |
PL01364908A PL364908A1 (en) | 2000-11-03 | 2001-10-16 | Tricyclic derivatives of indole with antiangiogenic activity |
CZ20031042A CZ297299B6 (cs) | 2000-11-03 | 2001-10-16 | Tricyklické deriváty indolu s antiangiogenními úcinky |
PCT/IT2001/000526 WO2002036597A1 (en) | 2000-11-03 | 2001-10-16 | Tricyclic derivatives of indole with antiangiogenic activity |
SK534-2003A SK5342003A3 (en) | 2000-11-03 | 2001-10-16 | Tricyclic derivatives of indole with antiangiogenic activity |
EP01983768A EP1343789B1 (en) | 2000-11-03 | 2001-10-16 | Tricyclic derivatives of indole with antiangiogenic activity |
US10/415,896 US6887892B2 (en) | 2000-11-03 | 2001-10-16 | Tricyclic derivatives of indole with antiangiogenic activity |
BR0115119-3A BR0115119A (pt) | 2000-11-03 | 2001-10-16 | Derivados tricìclicos de indol com atividade antiangiogênica |
MXPA03003798A MXPA03003798A (es) | 2000-11-03 | 2001-10-16 | Derivados triciclicos de indol con actividad antiangiogenica. |
JP2002539355A JP2004513130A (ja) | 2000-11-03 | 2001-10-16 | 抗血管新生活性を有するインドールの三環系誘導体 |
AU1518602A AU1518602A (en) | 2000-11-03 | 2001-10-16 | Tricyclic derivatives of indole with antiangiogenic activity |
HK04104343A HK1061244A1 (en) | 2000-11-03 | 2004-06-16 | Tricyclic derivatives of indole with antiangiogenic activity |
US11/032,068 US20050124647A1 (en) | 2000-11-03 | 2005-01-11 | Tricyclic derivatives of indole with antiangiogenic activity |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2000RM000570A IT1317926B1 (it) | 2000-11-03 | 2000-11-03 | Derivati triciclici dell'indolo ad attivita' antiangiogenica. |
Publications (3)
Publication Number | Publication Date |
---|---|
ITRM20000570A0 true ITRM20000570A0 (it) | 2000-11-03 |
ITRM20000570A1 ITRM20000570A1 (it) | 2002-05-03 |
IT1317926B1 IT1317926B1 (it) | 2003-07-15 |
Family
ID=11454976
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT2000RM000570A IT1317926B1 (it) | 2000-11-03 | 2000-11-03 | Derivati triciclici dell'indolo ad attivita' antiangiogenica. |
Country Status (20)
Country | Link |
---|---|
US (2) | US6887892B2 (it) |
EP (1) | EP1343789B1 (it) |
JP (1) | JP2004513130A (it) |
KR (1) | KR20030042030A (it) |
CN (1) | CN1247589C (it) |
AT (1) | ATE302780T1 (it) |
AU (1) | AU1518602A (it) |
BR (1) | BR0115119A (it) |
CA (1) | CA2427568A1 (it) |
CZ (1) | CZ297299B6 (it) |
DE (1) | DE60112966T2 (it) |
DK (1) | DK1343789T3 (it) |
ES (1) | ES2247182T3 (it) |
HK (1) | HK1061244A1 (it) |
HU (1) | HUP0400546A3 (it) |
IT (1) | IT1317926B1 (it) |
MX (1) | MXPA03003798A (it) |
PL (1) | PL364908A1 (it) |
SK (1) | SK5342003A3 (it) |
WO (1) | WO2002036597A1 (it) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6849656B1 (en) | 1999-09-17 | 2005-02-01 | Baylor University | Indole-containing and combretastatin-related anti-mitotic and anti-tubulin polymerization agents |
US7632955B2 (en) | 2001-12-13 | 2009-12-15 | National Health Research Institutes | Indole compounds |
US7528165B2 (en) | 2001-12-13 | 2009-05-05 | National Health Research Institutes | Indole compounds |
US6800655B2 (en) | 2002-08-20 | 2004-10-05 | Sri International | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents |
US7456289B2 (en) | 2004-12-31 | 2008-11-25 | National Health Research Institutes | Anti-tumor compounds |
BRPI0608353A2 (pt) * | 2005-02-17 | 2009-12-01 | Wyeth Corp | derivados de indol, benzotiofeno, benzofurano e indeno cicloalquilfundidos |
DE502007005017D1 (de) * | 2006-04-25 | 2010-10-28 | Merck Patent Gmbh | Hexahydro-dibenzofuranderivate |
FR2928645A1 (fr) * | 2008-03-14 | 2009-09-18 | Sanofi Aventis Sa | Nouveaux derives de carbazole inhibiteurs d'hsp90, compositions les contenant et utilisation |
EP2895462A1 (en) * | 2012-09-13 | 2015-07-22 | Baden-Württemberg Stiftung gGmbH | Specific inhibitors of protein p21 as therapeutic agents |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5100891A (en) * | 1991-01-18 | 1992-03-31 | Hoechst-Roussel Pharmaceuticals Inc. | Substituted 1,2,3,4-tetrahydrocyclopent[b]indoles, 1,2,3,3a,4,8a-hexahydrocyclopent[B]indoles and related compounds |
US5350762A (en) * | 1993-03-08 | 1994-09-27 | Hoechst-Roussel Pharmaceuticals Incorporated | Tetrahydrocyclopent[B]indole methanamines and related compounds |
-
2000
- 2000-11-03 IT IT2000RM000570A patent/IT1317926B1/it active
-
2001
- 2001-10-16 KR KR10-2003-7005651A patent/KR20030042030A/ko not_active Application Discontinuation
- 2001-10-16 BR BR0115119-3A patent/BR0115119A/pt not_active IP Right Cessation
- 2001-10-16 ES ES01983768T patent/ES2247182T3/es not_active Expired - Lifetime
- 2001-10-16 CA CA002427568A patent/CA2427568A1/en not_active Abandoned
- 2001-10-16 MX MXPA03003798A patent/MXPA03003798A/es active IP Right Grant
- 2001-10-16 EP EP01983768A patent/EP1343789B1/en not_active Expired - Lifetime
- 2001-10-16 DE DE60112966T patent/DE60112966T2/de not_active Expired - Fee Related
- 2001-10-16 AU AU1518602A patent/AU1518602A/xx not_active Withdrawn
- 2001-10-16 SK SK534-2003A patent/SK5342003A3/sk not_active Application Discontinuation
- 2001-10-16 PL PL01364908A patent/PL364908A1/xx unknown
- 2001-10-16 US US10/415,896 patent/US6887892B2/en not_active Expired - Fee Related
- 2001-10-16 CZ CZ20031042A patent/CZ297299B6/cs not_active IP Right Cessation
- 2001-10-16 WO PCT/IT2001/000526 patent/WO2002036597A1/en active IP Right Grant
- 2001-10-16 JP JP2002539355A patent/JP2004513130A/ja active Pending
- 2001-10-16 CN CNB018181996A patent/CN1247589C/zh not_active Expired - Fee Related
- 2001-10-16 AT AT01983768T patent/ATE302780T1/de not_active IP Right Cessation
- 2001-10-16 HU HU0400546A patent/HUP0400546A3/hu unknown
- 2001-10-16 DK DK01983768T patent/DK1343789T3/da active
-
2004
- 2004-06-16 HK HK04104343A patent/HK1061244A1/xx not_active IP Right Cessation
-
2005
- 2005-01-11 US US11/032,068 patent/US20050124647A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ES2247182T3 (es) | 2006-03-01 |
BR0115119A (pt) | 2003-09-30 |
CA2427568A1 (en) | 2002-05-10 |
IT1317926B1 (it) | 2003-07-15 |
DK1343789T3 (da) | 2005-12-27 |
CN1471535A (zh) | 2004-01-28 |
AU1518602A (en) | 2002-05-15 |
CN1247589C (zh) | 2006-03-29 |
DE60112966D1 (de) | 2005-09-29 |
ATE302780T1 (de) | 2005-09-15 |
US6887892B2 (en) | 2005-05-03 |
US20050124647A1 (en) | 2005-06-09 |
DE60112966T2 (de) | 2006-05-24 |
ITRM20000570A1 (it) | 2002-05-03 |
EP1343789A1 (en) | 2003-09-17 |
WO2002036597A1 (en) | 2002-05-10 |
SK5342003A3 (en) | 2003-10-07 |
HUP0400546A3 (en) | 2007-08-28 |
HUP0400546A2 (hu) | 2004-06-28 |
MXPA03003798A (es) | 2004-04-20 |
PL364908A1 (en) | 2004-12-27 |
EP1343789B1 (en) | 2005-08-24 |
CZ20031042A3 (cs) | 2003-10-15 |
CZ297299B6 (cs) | 2006-11-15 |
JP2004513130A (ja) | 2004-04-30 |
KR20030042030A (ko) | 2003-05-27 |
US20040034052A1 (en) | 2004-02-19 |
HK1061244A1 (en) | 2004-09-10 |
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